Research graph
References from Anhydrosafflor yellow B ameliorates oxeiptosis and FUNDC1-mediated mitophagy through activation of mTOR signaling pathway in cerebral ischemia/reperfusion injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Phytochemistry and pharmacology of Carthamus tinctorius L.
10.1142/s0192415x16500130 · 2016 · External reference
Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
10.1016/j.jep.2021.114590 · 2022 · External reference
Optimized separation of carthamin from safflower by macroporous adsorption resins and its protective effects on PC12 cells injured by OGD/R via Nrf2 signaling pathway
10.1021/acs.jafc.3c05285 · 2023 · External reference
Mechanisms and status of research on the protective effects of traditional Chinese medicine against ischemic brain injury
10.53388/tmr20211021250 · 2022 · External reference
Protective potential of hydroxysafflor yellow A in cerebral ischemia and reperfusion injury: an overview of evidence from experimental studies
10.3389/fphar.2022.1063035 · 2022 · External reference
Hydroxysafflor yellow A: a systematical review on botanical resources, physicochemical properties, drug delivery system, pharmacokinetics, and pharmacological effects
10.3389/fphar.2020.579332 · 2020 · External reference
Bioactive substances in safflower flowers and their applicability in medicine and health-promoting foods
10.1155/2021/6657639 · 2021 · External reference
ROS and diseases: role in metabolism and energy supply
10.1007/s11010-019-03667-9 · 2020 · External reference
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release
10.1152/physrev.00026.2013 · 2014 · External reference
Interleukins and ischemic stroke
10.3389/fimmu.2022.828447 · 2022 · External reference
Management of acute ischemic stroke
10.1097/ccm.0000000000004597 · 2020 · External reference
Diverse roles of mitochondria in ischemic stroke
10.1016/j.redox.2018.03.002 · 2018 · External reference
Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy
10.1016/j.phymed.2022.154111 · 2022 · External reference
Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation
10.1016/j.freeradbiomed.2020.06.034 · 2020 · External reference
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway
10.1038/s41590-017-0013-y · 2018 · External reference
Oxeiptosis-a cell death pathway to mitigate damage caused by radicals
10.1038/s41418-018-0134-3 · 2018 · External reference
Oxeiptosis: a discreet way to respond to radicals
10.1016/j.coi.2018.10.006 · 2019 · External reference
The molecular machinery of regulated cell death
10.1038/s41422-019-0164-5 · 2019 · External reference
Mitochondria ROS and mitophagy in acute kidney injury
10.1080/15548627.2022.2084862 · 2023 · External reference
Protective effects of gypenoside XVⅡ against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy
10.1186/s12967-022-03830-9 · 2022 · External reference
The pathways of mitophagy for quality control and clearance of mitochondria
10.1038/cdd.2012.81 · 2013 · External reference
Mitophagy in cerebral ischemia and ischemia/reperfusion injury
10.3389/fnagi.2021.687246 · 2021 · External reference
Mitophagy in neurological disorders
10.1186/s12974-021-02334-5 · 2021 · External reference
Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
10.1016/j.redox.2022.102288 · 2022 · External reference
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
10.1136/svn-2023-002606 · 2024 · External reference
Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
10.1038/s41467-020-16312-7 · 2020 · External reference
Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control
10.1016/j.redox.2020.101777 · 2021 · External reference
A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
10.1016/j.redox.2021.102186 · 2021 · External reference
Calycosin alleviates cerebral ischemia/reperfusion injury by repressing autophagy via STAT3/FOXO3a signaling pathway
10.1016/j.phymed.2023.154845 · 2023 · External reference
Hydroxysafflor yellow A and anhydrosafflor yellow B protect against cerebral ischemia/reperfusion injury by attenuating oxidative stress and apoptosis via the silent information regulator 1 signaling pathway
10.3389/fphar.2021.739864 · 2021 · External reference
Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia/reperfusion injury
10.1111/cns.14130 · 2023 · External reference
Reversible middle cerebral artery occlusion without craniectomy in rats
10.1161/01.str.20.1.84 · 1989 · External reference
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
10.1186/s12974-022-02400-6 · 2022 · External reference
Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12 cells injured by OGD/R
10.1016/j.freeradbiomed.2021.12.262 · 2022 · External reference
Neuroprotective strategies for stroke by natural products: advances and perspectives
10.2174/1570159x21666230717144752 · 2023 · External reference
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: applications for natural compounds from medicinal herbs
10.1016/j.biopha.2022.112719 · 2022 · External reference
Natural medicine in neuroprotection for ischemic stroke: challenges and prospective
10.1016/j.pharmthera.2020.107695 · 2020 · External reference
Carthamin yellow improves cerebral ischemia-reperfusion injury by attenuating inflammation and ferroptosis in rats
10.3892/ijmm.2021.4885 · 2021 · External reference
Protective cerebrovascular effects of hydroxysafflor yellow A (HSYA) on ischemic stroke
10.1016/j.ejphar.2017.11.033 · 2018 · External reference
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis
10.1186/s40779-022-00383-2 · 2022 · External reference
The blood-brain barrier in aging and neurodegeneration
10.1038/s41380-022-01511-z · 2022 · External reference
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury
10.1016/j.redox.2020.101792 · 2021 · External reference
Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway
10.1016/j.envint.2020.106298 · 2021 · External reference
Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by regulating mitophagy via mTOR-ULK1/FUNDC1 axis in rats
10.1016/j.jstrokecerebrovasdis.2021.106202 · 2022 · External reference
Electroacupuncture preconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting mitophagy mediated by the mTORC1-ULK1-FUNDC1 pathway
10.1016/j.biopha.2020.110148 · 2020 · External reference
