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References from <i>Atractylodes macrocephala</i> water extract exerts a protective effect against high fat and high sugar diet-induced NAFLD by inhibiting the TRAF1/ASK1/JNK pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Test-retest reliability of the assessment of fatty liver disease using low-dose computed tomography in cardiac patients
10.3389/fmed.2021.656658 · 2021 · External reference
Exposure to plasma from non-alcoholic fatty liver disease patients affects hepatocyte viability, generates mitochondrial dysfunction, and modulates pathways involved in fat accumulation and inflammation
10.3389/fmed.2021.693997 · 2021 · External reference
How western diet and lifestyle drive the pandemic of obesity and civilization diseases
10.2147/dmso.s216791 · 2019 · External reference
Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)
10.3389/fendo.2022.1087260 · 2023 · External reference
Exercise intervention mitigates pathological liver changes in NAFLD zebrafish by activating SIRT1/AMPK/NRF2 signaling
10.3390/ijms222010940 · 2021 · External reference
Hepatocyte TMEM16A deletion retards NAFLD progression by ameliorating hepatic glucose metabolic disorder
10.1002/advs.201903657 · 2020 · External reference
Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis
10.1016/j.redox.2020.101710 · 2020 · External reference
Comparative effects of pterostilbene and its parent compound resveratrol on oxidative stress and inflammation in steatohepatitis induced by high-fat high-fructose feeding
10.3390/antiox9111042 · 2020 · External reference
Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD
10.1039/d0fo02736g · 2021 · External reference
Dietary platycodon grandiflorus attenuates hepatic insulin resistance and oxidative stress in high-fat-diet induced non-alcoholic fatty liver disease
10.3390/nu12020480 · 2020 · External reference
Effects of Dillenia indica L. fruit extract on hepatic Cyp7a1 gene expression in a rat model of streptozotocin-induced diabetes-associated dyslipidemia
10.1016/j.ctmp.2026.200289 · 2026 · External reference
Immunomodulatory properties of polysaccharides from the coral Pseudopterogorgia americana in macrophages
10.3390/cells10123531 · 2021 · External reference
TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation
10.1016/j.bbrc.2019.01.041 · 2019 · External reference
TRAF1 exacerbates myocardial ischemia reperfusion injury via ASK1-JNK/p38 signaling
10.1161/jaha.119.012575 · 2019 · External reference
Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation
10.1016/j.phymed.2022.154283 · 2022 · External reference
Azadirachtin attenuates lipopolysaccharide-induced ROS production
10.3390/biomedicines9121943 · 2021 · External reference
Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma
10.1111/cas.13875 · 2019 · External reference
Indole-3-carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury in mice by inhibiting inflammatory response, apoptosis and regulating oxidative stress
10.3390/ijms21062048 · 2020 · External reference
Baicalein alleviates non-alcoholic fatty liver disease in mice by ameliorating intestinal barrier dysfunction
10.1039/d2fo03015b · 2023 · External reference
The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury
10.1155/2019/7283104 · 2019 · External reference
Regulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease
10.3748/wjg.v25.i34.5105 · 2019 · External reference
Influence of nutrient (NPK) factors on growth
10.3389/fpls.2022.799201 · 2022 · External reference
Polysaccharide from Atractylodes macrocephala Koidz binding with zinc oxide nanoparticles: characterization, immunological effect and mechanism
10.3389/fnut.2022.992502 · 2022 · External reference
The development of regulations of Chinese herbal medicines for both medicinal and food uses
10.1016/j.tifs.2005.12.005 · 2006 · External reference
Yifei Sanjie formula treats chronic obstructive pulmonary disease by remodeling pulmonary microbiota
10.3389/fmed.2022.927607 · 2022 · External reference
Anti-Obesity effects of a mixture of Atractylodes macrocephala and Amomum villosum extracts on 3T3-L1 adipocytes and high-fat diet-induced obesity in mice
10.3390/molecules27030906 · 2022 · External reference
Polysaccharide of Atractylodes macrocephala Koidz alleviate lipopolysaccharide-induced liver injury in goslings via the p53 and FOXO pathways
10.1016/j.psj.2023.102480 · 2023 · External reference
Mixture of five fermented herbs (Zhihuasi Tk) alters the intestinal microbiota and promotes the growth performance in piglets
10.3389/fmicb.2021.725196 · 2021 · External reference
Unlocking the potential of atractylenolide Ⅱ: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay
10.1016/j.jpha.2025.101318 · 2025 · External reference
Chemical constitution, pharmacological effects and the underlying mechanism of atractylenolides: a review
10.3390/molecules28103987 · 2023 · External reference
The antitumor properties of atractylenolides: molecular mechanisms and signaling pathways
10.1016/j.biopha.2022.113699 · 2022 · External reference
Hepatic IRS1 and β-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients
10.1007/s00535-018-1472-0 · 2018 · External reference
Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine
10.1016/j.ctmp.2024.200167 · 2024 · External reference
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) alleviates cyclophosphamide-induced immunosuppression in mice by upregulating CD28/IP3R/PLCγ-1/AP-1/NFAT signal pathway
10.3389/fphar.2020.529657 · 2020 · External reference
Atractylenolide Ⅰ enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
10.1172/jci146832 · 2021 · External reference
Atractylenolide Ⅲ improves mitochondrial function and protects against ulcerative colitis by activating AMPK/SIRT1/PGC-1α
10.1155/2022/9129984 · 2022 · External reference
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
10.3748/wjg.v26.i18.2203 · 2020 · External reference
Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation
10.1016/j.apsb.2021.11.017 · 2022 · External reference
Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation
10.1186/s13578-021-00701-6 · 2021 · External reference
Phytochemicals from the cocoa shell modulate mitochondrial function, lipid and glucose metabolism in hepatocytes via activation of FGF21/ERK
10.3390/antiox11010136 · 2022 · External reference
Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy
10.1038/s41467-021-27869-2 · 2022 · External reference
PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity
10.1111/jcmm.14453 · 2019 · External reference
Long-term high-fat high-fructose diet induces type 2 diabetes in rats through oxidative stress
10.3390/nu14112181 · 2022 · External reference
From population to neuron: exploring common mediators for metabolic problems and mental illnesses
10.1038/s41380-020-00939-5 · 2021 · External reference
Stem cells from human exfoliated deciduous teeth ameliorate type Ⅱ diabetic mellitus in Goto-Kakizaki rats
10.1186/s13098-019-0417-y · 2019 · External reference
High-fiber diet or combined with acarbose alleviates heterogeneous phenotypes of polycystic ovary syndrome by regulating gut microbiota
10.3389/fendo.2021.806331 · 2022 · External reference
Rice bran protein hydrolysates improve insulin resistance and decrease pro-inflammatory cytokine gene expression in rats fed a high carbohydrate-high fat diet
10.3390/nu7085292 · 2015 · External reference
The wingless-related integration site-5a/secreted frizzled-related protein-5 system is dysregulated in human sepsis
10.1111/cei.12484 · 2015 · External reference
P-Hydroxybenzyl alcohol alleviates oxidative stress in a nonalcoholic fatty liver disease larval zebrafish model and a BRL-3A hepatocyte via the Nrf2 pathway
10.3389/fphar.2021.646239 · 2021 · External reference
Protective effects and mechanisms of polyethylene glycol loxenatide against hyperglycemia and liver injury in db/db diabetic mice
10.3389/fphar.2021.781856 · 2021 · External reference
tBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitate
10.1155/2020/3123268 · 2020 · External reference
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2
10.3892/ijmm.2018.3996 · 2019 · External reference
Protective effects of sesamol against liver oxidative stress and inflammation in high-fat diet-induced hepatic steatosis
10.3390/nu13124484 · 2021 · External reference
Comparative proteomic analysis revealed the mechanism of tea tree oil targeting lipid metabolism and antioxidant system to protect hepatopancreatic health in Macrobrachium rosenbergii
10.3389/fimmu.2022.906435 · 2022 · External reference
Effects of low-molecular-weight fucoidan and high stability fucoxanthin on glucose homeostasis, lipid metabolism, and liver function in a mouse model of type Ⅱ diabetes
10.3390/md15040113 · 2017 · External reference
Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila
10.7554/elife.35368 · 2018 · External reference
Venetoclax-resistant MV4-11 leukemic cells activate PI3K/AKT pathway for metabolic reprogramming and redox adaptation for survival
10.3390/antiox11030461 · 2022 · External reference
β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy
10.1111/acel.12371 · 2015 · External reference
Mitochondrial defects in the respiratory complex Ⅰ contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons
10.1186/s40478-020-01101-6 · 2020 · External reference
Increasing pyruvate concentration enhances conidial thermotolerance in the entomopathogenic fungus Metarhizium robertsii
10.3389/fmicb.2019.00519 · 2019 · External reference
Upregulation of BCL-2 by acridone derivative through gene promoter Ⅰ-motif for alleviating liver damage of NAFLD/NASH
10.1093/nar/gkaa615 · 2020 · External reference
Loss of TRIM67 attenuates the progress of obesity-induced non-alcoholic fatty liver disease
10.3390/ijms23137475 · 2022 · External reference
Effects of antioxidants in reducing accumulation of fat in hepatocyte
10.3390/ijms19092563 · 2018 · External reference
Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways
10.1080/15384101.2019.1653106 · 2019 · External reference
Palmitate-TLR4 signaling regulates the histone demethylase
10.1002/eji.202048651 · 2020 · External reference
Inhibiting ceramide synthesis attenuates hepatic steatosis and fibrosis in rats with non-alcoholic fatty liver disease
10.3389/fendo.2019.00665 · 2019 · External reference
Fermented ginseng
10.1016/j.jgr.2017.10.002 · 2019 · External reference
Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways
10.1016/j.phymed.2023.154797 · 2023 · External reference
Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis
10.3892/ijmm.2019.4265 · 2019 · External reference
Paeoniflorin exerts neuroprotective effects against glutamate-induced PC12 cellular cytotoxicity by inhibiting apoptosis
10.3892/ijmm.2017.3076 · 2017 · External reference
Exploring the induction of endometrial epithelial cell apoptosis in clinical-type endometritis in yaks through the Cyt-c/caspase-3 signaling axis
10.1016/j.micpath.2023.106470 · 2024 · External reference
Protective effect of Ganoderma atrum polysaccharide on acrolein-induced apoptosis and autophagic flux in IEC-6 cells
10.3390/foods11020240 · 2022 · External reference