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References from Mechanisms of apigenin in mitigating APAP-induced hepatocyte pyroptosis and liver injury <i>via</i> TRPV4 activation and ESCRT-mediated membrane repair. Local targets link to admitted publications; unresolved targets remain external evidence.
An immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure
10.1016/j.cgh.2016.09.007 · 2017 · External reference
c-Jun NH(2)-terminal protein kinase phosphorylates the Nrf2-ECH homology 6 domain of nuclear factor erythroid 2-related factor 2 and downregulates cytoprotective genes in acetaminophen-induced liver injury in mice
10.1002/hep.31116 · 2020 · External reference
Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid
10.1016/j.jpha.2019.11.003 · 2020 · External reference
Network pharmacology-based prediction and pharmacological validation of effects of Astragali Radix on acetaminophen-induced liver injury
10.3389/fmed.2022.697644 · 2022 · External reference
Quercitrin from Toona sinensis (Juss.) M. Roem. attenuates acetaminophen-induced acute liver toxicity in HepG2 cells and mice through induction of antioxidant machinery and inhibition of inflammation
10.3390/nu8070431 · 2016 · External reference
Retinol-binding protein 4 promotes cardiac injury after myocardial infarction via inducing cardiomyocyte pyroptosis through an interaction with NLRP3
10.1161/jaha.121.022011 · 2021 · External reference
p53 up-regulated modulator of apoptosis induction mediates acetaminophen-induced necrosis and liver injury in mice
10.1002/hep.30422 · 2019 · External reference
Peroxiredoxin 3 inhibits acetaminophen-induced liver pyroptosis through the regulation of mitochondrial ROS
10.3389/fimmu.2021.652782 · 2021 · External reference
3,4-Dihydroxyphenylethyl alcohol glycoside reduces acetaminophen-induced acute liver failure in mice by inhibiting hepatocyte ferroptosis and pyroptosis
10.7717/peerj.13082 · 2022 · External reference
Galangin prevents against ethanol-induced intestinal barrier dysfunction and NLRP3 inflammasome activation via NF-κB/MAPK signaling pathways in mice and Caco-2 cells
10.1021/acs.jafc.4c00747 · 2024 · External reference
Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages
10.1038/s41401-021-00842-x · 2022 · External reference
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
10.1038/nm1603 · 2007 · External reference
Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity
10.1038/cmi.2017.22 · 2018 · External reference
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
10.1038/s41467-020-16143-6 · 2020 · External reference
Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery
10.1016/j.tibs.2016.08.016 · 2017 · External reference
ESCRT-Ⅲ mediates budding across the inner nuclear membrane and regulates its integrity
10.1038/s41467-018-05889-9 · 2018 · External reference
A bibliometric analysis of pyroptosis from 2001 to 2021
10.3389/fimmu.2021.731933 · 2021 · External reference
ESCRT-Ⅲ acts downstream of MLKL to regulate necroptotic cell death and its consequences
10.1016/j.cell.2017.03.020 · 2017 · External reference
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise
10.1016/j.sjbs.2019.06.001 · 2019 · External reference
Transient receptor potential vanilloid-4 channels are involved in diminished myogenic tone in brain parenchymal arterioles in response to chronic hypoperfusion in mice
10.1111/apha.13181 · 2019 · External reference
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury
10.1161/01.str.0000221308.94473.14 · 2006 · External reference
Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx
10.1161/atvbaha.109.196584 · 2010 · External reference
Role of apigenin in cancer prevention via the induction of apoptosis and autophagy
10.15430/jcp.2016.21.4.216 · 2016 · External reference
Flavonoids as cytokine modulators: a possible therapy for inflammation-related diseases
10.3390/ijms17060921 · 2016 · External reference
Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension
10.1042/cs20160780 · 2017 · External reference
Dietary apigenin ameliorates obesity-related hypertension through TRPV4-dependent vasorelaxation and TRPV4-independent adiponectin secretion
10.1016/j.bbadis.2024.167488 · 2024 · External reference
Preventive effect of Citrus aurantium peel extract on high-fat diet-induced non-alcoholic fatty liver in mice
10.1248/bpb.b18-00702 · 2019 · External reference
Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway
10.3389/fphar.2020.00514 · 2020 · External reference
Apigenin attenuates acetaminophen-induced hepatotoxicity by activating AMP-activated protein kinase/carnitine palmitoyltransferase I pathway
10.3389/fphar.2020.549057 · 2020 · External reference
NLRP3 deficiency protects against acetaminophen-induced liver injury by inhibiting hepatocyte pyroptosis
10.3892/mmr.2024.13185 · 2024 · External reference
Hinokiflavone exerts dual regulation on apoptosis and pyroptosis via the SIX4/Stat3/Akt pathway to alleviate APAP-induced liver injury
10.1016/j.lfs.2024.122968 · 2024 · External reference
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice
10.1016/j.bbr.2022.114223 · 2023 · External reference
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway
10.1016/j.phymed.2021.153585 · 2021 · External reference
Apigenin alleviated high-fat-diet-induced hepatic pyroptosis by mitophagy-ROS-CTSB-NLRP3 pathway in mice and AML12 cells
10.1021/acs.jafc.2c07581 · 2023 · External reference
Structure and assembly of ESCRT-Ⅲ helical Vps24 filaments
10.1126/sciadv.aba4897 · 2020 · External reference
Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration
10.1111/cpr.12445 · 2018 · External reference
The relevance of pyroptosis in the pathogenesis of liver diseases
10.1016/j.lfs.2019.02.060 · 2019 · External reference
NLRP3 inflammasome may regulate inflammatory response of human periodontal ligament fibroblasts in an apoptosis-associated speck-like protein containing a CARD (ASC)-dependent manner
10.1111/iej.12722 · 2017 · External reference
Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils
10.1038/s41598-020-78651-1 · 2020 · External reference
Platelet-rich Fibrin reduces IL-1β release from macrophages undergoing pyroptosis
10.3390/ijms23158306 · 2022 · External reference
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury
10.1007/s10565-021-09624-x · 2022 · External reference
Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury
10.1021/acsami.2c10506 · 2022 · External reference
