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References from Multi-omics reveal mechanisms of Lachnospiraceae bacterium mediated intestinal protective effect of paeoniflorin in diarrhea-predominant irritable bowel syndrome. Local targets link to admitted publications; unresolved targets remain external evidence.
Diarrhea predominant-irritable bowel syndrome (IBS-D): effects of different nutritional patterns on intestinal dysbiosis and symptoms
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Global burden of irritable bowel syndrome: trends, predictions and risk factors
10.1038/s41575-020-0286-8 · 2020 · External reference
Irritable bowel syndrome
10.1016/s0140-6736(20)31548-8 · 2020 · External reference
Recent advances in the treatment of irritable bowel syndrome
10.20452/pamw.16067 · 2021 · External reference
Diagnosis and treatment of irritable bowel syndrome: a review
10.1001/jama.2020.22532 · 2021 · External reference
Diet in irritable bowel syndrome (IBS): interaction with gut microbiota and gut hormones
10.3390/nu11081824 · 2019 · External reference
Molecular mechanisms of microbiota-mediated pathology in irritable bowel syndrome
10.3390/ijms21228664 · 2020 · External reference
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
10.1136/gutjnl-2011-301501 · 2012 · External reference
Meta-analyses of studies of the human microbiota
10.1101/gr.151803.112 · 2013 · External reference
Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome
10.1136/gutjnl-2017-314308 · 2018 · External reference
Is fecal microbiota transplantation the answer for irritable bowel syndrome A single-center experience
10.1038/ajg.2014.295 · 2014 · External reference
Fecal microbiota transfer for bowel disorders: efficacy or hype?
10.1016/j.coph.2018.08.012 · 2018 · External reference
Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony
10.1016/j.pharmthera.2019.107452 · 2020 · External reference
Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a mouse neuropathic pain model
10.1007/s00213-015-4108-6 · 2016 · External reference
Anti-tumor effects of paeoniflorin on epithelial-to-mesenchymal transition in human colorectal cancer cells
10.12659/msm.912227 · 2018 · External reference
Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats
10.1016/j.jep.2019.112051 · 2019 · External reference
Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis
10.1016/j.phrs.2022.106309 · 2022 · External reference
Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice
10.1016/j.phymed.2020.153345 · 2020 · External reference
Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration
10.1016/j.intimp.2021.107667 · 2021 · External reference
Paeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway
10.1080/21655979.2021.2003676 · 2021 · External reference
Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress
10.1016/j.neulet.2013.02.029 · 2013 · External reference
Paeoniflorin ameliorates depressive-like behavior in prenatally stressed offspring by restoring the HPA axis- and glucocorticoid receptor- associated dysfunction
10.1016/j.jad.2020.05.078 · 2020 · External reference
Antibiotics-induced disruption of gut microbiota increases systemic exposure of clopidogrel active metabolite in type 2 diabetic rats
10.1124/dmd.122.000906 · 2022 · External reference
Poly-beta-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin
10.1007/s11427-022-2213-6 · 2023 · External reference
The Effect of Tong-Xie-Yao-Fang on Intestinal Mucosal Mast Cells in postinfectious irritable bowel syndrome rats
10.1155/2017/9086034 · 2017 · External reference
Herbal prescription Chang’an Ⅱ repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome
10.1038/aps.2014.170 · 2015 · External reference
Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model
10.1186/s12906-016-1479-0 · 2016 · External reference
Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway
10.1186/s40104-023-00845-0 · 2023 · External reference
Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern
10.1016/j.phrs.2023.106714 · 2023 · External reference
Gut microbiota utilize immunoglobulin A for mucosal colonization
10.1126/science.aaq0926 · 2018 · External reference
Guild-based analysis for understanding gut microbiome in human health and diseases
10.1186/s13073-021-00840-y · 2021 · External reference
Earth microbial co-occurrence network reveals interconnection pattern across microbiomes
10.1186/s40168-020-00857-2 · 2020 · External reference
The characteristics of intestinal flora of IBS-D with different syndromes
10.1002/iid3.348 · 2020 · External reference
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-kappaB pathway
10.1016/j.phymed.2021.153743 · 2021 · External reference
Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS
10.1371/journal.pone.0181863 · 2017 · External reference
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis
10.1016/j.coph.2021.11.009 · 2022 · External reference
Functional gastrointestinal disorders: advances in understanding and management
10.1016/s0140-6736(20)32115-2 · 2020 · External reference
The role of inflammation in irritable bowel syndrome (IBS)
10.1016/s0140-6736(20)32115-2 · 2018 · External reference
Tight junctions and IBS-the link between epithelial permeability, low-grade inflammation, and symptom generation?
10.1111/nmo.12315 · 2014 · External reference
The role of mast cells in irritable bowel syndrome
10.1155/2016/2031480 · 2016 · External reference
Leveraging human microbiome features to diagnose and stratify children with irritable bowel syndrome
10.1016/j.jmoldx.2019.01.006 · 2019 · External reference
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
10.1053/j.gastro.2011.06.072 · 2011 · External reference
Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
10.1053/j.gastro.2011.07.043 · 2011 · External reference
The controversial role of human gut Lachnospiraceae
10.3390/microorganisms8040573 · 2020 · External reference
Gut microbiota changes in patients with major depressive disorder treated with vortioxetine
10.3389/fpsyt.2021.641491 · 2021 · External reference
Kefir ameliorates specific microbiota-gut-brain axis impairments in a mouse model relevant to autism spectrum disorder
10.1016/j.bbi.2021.07.004 · 2021 · External reference
Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis
10.1080/13880209.2023.2193595 · 2023 · External reference
Baizhu shaoyao decoction restores the intestinal barrier and brain-gut axis balance to alleviate diarrhea-predominant irritable bowel syndrome via FoxO1/FoxO3a
10.1016/j.phymed.2023.155163 · 2024 · External reference
