Research graph
References from <i>Astragali Radix</i> prevents hypertension in SHRs <i>via</i> suppressing inflammation and modulating serum metabolism: integrated <i>in vivo</i> pharmacological validation, network pharmacology, molecular docking, and metabolomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Angiotensin-converting enzyme 2 in the rostral ventrolateral medulla regulates cholinergic signaling and cardiovascular and sympathetic responses in hypertensive rats
10.1007/s12264-018-0298-3 · 2019 · External reference
The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation
10.3389/fcvm.2022.928701 · 2022 · External reference
Association between dietary carbohydrate intake and control of blood pressure in patients with essential hypertension
10.3390/healthcare10112245 · 2022 · External reference
Identification, characterization and antihypertensive effect in vivo of a novel ACE-inhibitory heptapeptide from defatted areca nut kernel globulin hydrolysates
10.3390/molecules26113308 · 2021 · External reference
Tissue distribution comparison of six active ingredients from an eucommiae cortex extract between normal and spontaneously hypertensive rats
10.1155/2020/2049059 · 2020 · External reference
Study on semi-bionic extraction of Astragalus polysaccharide and its anti-aging activity in vivo
10.3389/fnut.2023.1201919 · 2023 · External reference
Optimizing the scale-up production of fermented astragalus and its benefits to the performance and egg quality of laying hens
10.3389/fmicb.2023.1165644 · 2023 · External reference
Astragali Radix (Huangqi): a promising edible immunomodulatory herbal medicine
10.1016/j.jep.2020.112895 · 2020 · External reference
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury
10.7150/ijbs.78097 · 2023 · External reference
Phytochemistry and cardiovascular protective effects of Huang-Qi (Astragali Radix)
10.1002/med.21785 · 2021 · External reference
Biological active ingredients of Astragali Radix and its mechanisms in treating cardiovascular and cerebrovascular diseases
10.1016/j.phymed.2021.153918 · 2022 · External reference
Regularity of traditional Chinese medicine prescriptions for same treatment for cardiovascular and cerebrovascular diseases
10.19540/j.cnki.cjcmm.20181101.007 · 2019 · External reference
A network pharmacology prediction and molecular docking-based strategy to explore the potential pharmacological mechanism of Astragalus membranaceus for Glioma
10.3390/ijms242216306 · 2023 · External reference
Study on the mechanism of Radix Astragali against renal aging based on network pharmacology
10.1155/2022/6987677 · 2022 · External reference
Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking
10.1097/md.0000000000034945 · 2023 · External reference
Exploring the molecular mechanism of schisandrin C for the treatment of atherosclerosis via the PI3K/AKT/mTOR autophagy pathway
10.1021/acsomega.4c03738 · 2024 · External reference
Network pharmacology: a crucial approach in traditional Chinese medicine research
10.1186/s13020-024-01056-z · 2025 · External reference
Metabolites and hypertension: insights into hypertension as a metabolic disorder: 2019 harriet dustan award
10.1161/hypertensionaha.120.13896 · 2020 · External reference
Hypertensive disorders of pregnancy and the risk of chronic kidney disease: a Swedish registry-based cohort study
10.1371/journal.pmed.1003255 · 2020 · External reference
Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
10.1016/j.redox.2020.101474 · 2020 · External reference
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
10.1038/s41467-021-24077-w · 2021 · External reference
Serum metabolites of hypertension among Chinese adolescents aged 1217 years
10.1038/s41371-021-00602-8 · 2022 · External reference
Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis
10.1016/j.biopha.2020.110855 · 2020 · External reference
Targeted intervention of natural medicinal active ingredients and traditional Chinese medicine on epigenetic modification: possible strategies for prevention and treatment of atherosclerosis
10.1016/j.phymed.2023.155139 · 2024 · External reference
Anti-hypertensive and angiotensin-converting enzyme inhibitory effects of Radix Astragali and its bioactive peptide AM-1
10.1016/j.jep.2020.112724 · 2020 · External reference
Tail-Cuff technique and its influence on central blood pressure in the mouse
10.1161/jaha.116.005204 · 2017 · External reference
Hematoxylin and eosin staining of intact tissues via delipidation and ultrasound
10.1038/s41598-018-30755-5 · 2018 · External reference
Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites
10.1007/s11418-017-1144-z · 2018 · External reference
A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model
10.1186/s13020-021-00507-1 · 2021 · External reference
Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy
10.1016/j.phymed.2021.153526 · 2021 · External reference
Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking and experimental evaluations
10.1016/j.phymed.2022.154195 · 2022 · External reference
Network pharmacology-based screening of the active ingredients and mechanisms of Huangqi against aging
10.1097/md.0000000000025660 · 2021 · External reference
PubChem in 2021: new data content and improved web interfaces
10.1093/nar/gkaa971 · 2021 · External reference
V. Zoete. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
UniProt: the universal protein knowledgebase in 2021
10.1093/nar/gkaa1100 · 2021 · External reference
Online mendelian inheritance in Man (OMIM®): Victor McKusick’s magnum opus
10.1002/ajmg.a.62407 · 2021 · External reference
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics
10.1093/nar/gkz981 · 2020 · External reference
Cytoscape StringApp: network analysis and visualization of proteomics data
10.1021/acs.jproteome.8b00702 · 2019 · External reference
Protein function prediction based on PPI networks: network reconstruction vs edge enrichment
10.3389/fgene.2021.758131 · 2021 · External reference
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
10.1093/nar/gky1131 · 2019 · External reference
RCSB Protein Data bank: tools for visualizing and understanding biological macromolecules in 3D
10.1002/pro.4482 · 2022 · External reference
High-resolution protein-protein docking by global optimization: recent advances and future challenges
10.1016/j.sbi.2015.08.001 · 2015 · External reference
Integrated network pharmacology, metabolomics, and transcriptomics of Huanglian-Hongqu herb pair in non-alcoholic fatty liver disease
10.1016/j.jep.2024.117828 · 2024 · External reference
In vivo and in vitro anticoccidial efficacy of Astragalus membranaceus against Eimeria papillata infection
10.1016/j.jksus.2020.03.016 · 2020 · External reference
Anti-stress effect of astragaloside Ⅳ in immobilized mice
10.1016/j.jep.2014.03.068 · 2014 · External reference
Pharmacology, phytochemistry, and traditional uses of Scrophularia ningpoensis Hemsl
10.1016/j.jep.2020.113688 · 2021 · External reference
Pulmonary arterial hypertension and flavonoids: A role in treatment
10.4103/cjp.cjp_25_21 · 2021 · External reference
Pharmacological effects of astragaloside Ⅳ: a review
10.3390/molecules28166118 · 2023 · External reference
The PI3K/Akt pathway in meta-inflammation
10.3390/ijms232315330 · 2022 · External reference
Akt1 is involved in tubular apoptosis and inflammatory response during renal ischemia-reperfusion injury
10.1007/s11033-020-06021-1 · 2020 · External reference
Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
10.4161/cc.21572 · 2012 · External reference
Hypertension and cardiometabolic disease
10.2741/s506 · 2018 · External reference
Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders
10.1111/micc.12423 · 2018 · External reference
Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study
10.1186/s12872-023-03567-3 · 2023 · External reference
Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype
10.1186/s12931-017-0699-2 · 2018 · External reference
Hypertension as one of the main non-myocardial infarction-related causes of increased cardiospecific troponins: from mechanisms to significance in current medical practice
10.14740/jocmr4796 · 2022 · External reference
Hypertension and heart failure: from pathophysiology to treatment
10.3390/ijms25126661 · 2024 · External reference
Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4
10.1016/j.jare.2024.08.012 · 2024 · External reference
Blood pressure variability and cerebral small vessel disease: a systematic review and meta-analysis of population-based cohorts
10.1161/strokeaha.119.026739 · 2020 · External reference
Cerebral hemorrhage: pathophysiology, treatment, and future directions
10.1161/circresaha.121.319949 · 2022 · External reference
Epigenetics of hypertensive nephropathy
10.3390/biomedicines12112622 · 2024 · External reference
Hypertension as cardiovascular risk factor in chronic kidney disease
10.1161/circresaha.122.321762 · 2023 · External reference
Hypertensive retinopathy
10.1056/nejmra032865 · 2004 · External reference
Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine
10.1007/s13167-021-00248-z · 2021 · External reference
Physiological and pathological roles of Ang Ⅱ and Ang-(1-7) in the female reproductive system
10.3389/fendo.2022.1080285 · 2022 · External reference
The left ventricular pressure-volume area and stroke work in porcine model of ascending compared to descending thoracic aorta stenosis creating a chronic early vs. late left ventricular afterload increase
10.2478/prilozi-2022-0024 · 2022 · External reference
The effects of Ginkgo biloba on metabolic syndrome: A review, Phytother
10.1002/ptr.6646 · 2020 · External reference
Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats
10.1016/j.jep.2013.04.053 · 2013 · External reference
Natural products in the treatment of pulmonary emphysema: therapeutic effects and mechanisms of action
10.1016/j.phymed.2022.153988 · 2022 · External reference
The antihypertensive effects of quercetin in a salt-sensitive model of hypertension
10.1097/fjc.0b013e318162011f · 2008 · External reference
Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension
10.1007/s00210-010-0546-1 · 2010 · External reference
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension
10.1016/j.atherosclerosis.2018.01.031 · 2018 · External reference
Quercetin improves vascular endothelial function through promotion of autophagy in hypertensive rats
10.1016/j.lfs.2020.118106 · 2020 · External reference
Network Pharmacology identifies the mechanisms of action of taohongsiwu decoction against essential hypertension
10.12659/msm.920682 · 2020 · External reference
Ziziphus Oxyphylla hydro-methanolic extract ameliorates hypertension in L-NAME induced hypertensive rats through NO/cGMP pathway and suppression of oxidative stress related inflammatory biomarkers
10.12659/msm.920682 · 2022 · External reference
Bauhinia forficata link, a Brazilian medicinal plant traditionally used to treat cardiovascular disorders, exerts endothelium-dependent and independent vasorelaxation in thoracic aorta of normotensive and hypertensive rats
10.1016/j.jep.2019.112118 · 2019 · External reference
LncRNA and mRNA expression profiles and functional networks of hyposalivation of the submandibular gland in hypertension
10.1038/s41598-020-70853-x · 2020 · External reference
Inflammation in hypertension
10.1016/j.cjca.2020.01.013 · 2020 · External reference
Quercetin improves contrast-induced acute kidney injury through the HIF-1α/lncRNA NEAT1/HMGB1 pathway
10.1080/13880209.2022.2058558 · 2022 · External reference
Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway
10.1016/j.phymed.2020.153385 · 2021 · External reference
Luteolin attenuates hypertension via inhibiting NF-κB-mediated inflammation and PI3K/Akt signaling pathway in the hypothalamic paraventricular nucleus
10.3390/nu15030502 · 2023 · External reference
Targeting endothelial ENO1 (Alpha-Enolase)-PI3K-Akt-mTOR axis alleviates hypoxic pulmonary hypertension
10.1161/hypertensionaha.122.19857 · 2023 · External reference
Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway
10.1016/j.biopha.2022.113040 · 2022 · External reference
Macrophages under pressure: the role of macrophage polarization in hypertension
10.1016/j.trsl.2017.10.011 · 2018 · External reference
Akt signaling pathway in macrophage activation and M1/M2 polarization
10.4049/jimmunol.1601515 · 2017 · External reference
The mechanism of peach kernel and safflower herb-pair for the treatment of liver fibrosis based on network pharmacology and molecular docking technology: a review
10.1097/md.0000000000033593 · 2023 · External reference
“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis
10.1186/s12951-022-01598-0 · 2022 · External reference
MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT
10.1016/j.redox.2022.102469 · 2022 · External reference
The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways
10.26599/fshw.2023.9250011 · 2024 · External reference
Targeting IL-6 trans-signalling: past, present and future prospects
10.1038/s41577-023-00856-y · 2023 · External reference
TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property
10.1186/s13287-022-03178-3 · 2022 · External reference
Paeonol inhibits IL-1β-induced inflammation via PI3K/Akt/NF-κB pathways: in vivo and vitro studies
10.1007/s10753-017-0611-8 · 2017 · External reference
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice
10.1016/j.biopha.2020.110479 · 2020 · External reference
Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway
10.1016/j.biopha.2023.115653 · 2023 · External reference
Kaempferol inhibits cervical cancer cells by inducing apoptosis and autophagy via inactivation of the PI3K/AKT/mTOR signaling pathway
10.21873/anticanres.17108 · 2024 · External reference
Acute inflammation and metabolism
10.1007/s10753-018-0739-1 · 2018 · External reference
Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review
10.3390/nu13010144 · 2021 · External reference
Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease
10.1111/bph.14095 · 2018 · External reference
Deoxycholic acid and coronary artery calcification in the chronic renal insufficiency cohort
10.1161/jaha.121.022891 · 2022 · External reference
The activities and mechanisms of intestinal microbiota metabolites of TCM herbal ingredients could be illustrated by a strategy integrating spectrum-effects, network pharmacology, metabolomics and molecular docking analysis: platycodin D as an example
10.1016/j.phymed.2023.154831 · 2023 · External reference
Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells
10.1007/s12032-017-0969-3 · 2017 · External reference
Linoleic acid and the pathogenesis of obesity
10.1016/j.prostaglandins.2016.06.003 · 2016 · External reference
Impact of α-linolenic acid, the vegetable ω-3 fatty acid, on cardiovascular disease and cognition
10.1093/advances/nmac016 · 2022 · External reference
Effects of arachidonic acid metabolites on cardiovascular health and disease
10.3390/ijms222112029 · 2021 · External reference
LC-MS-based lipidomic analysis of liver tissue sample from spontaneously hypertensive rats treated with extract hawthorn fruits
10.3389/fphar.2022.963280 · 2022 · External reference
Global plasma metabolomics to identify potential biomarkers of blood pressure progression
10.1161/atvbaha.120.314356 · 2020 · External reference
Phenylalanine induces pulmonary hypertension through calcium-sensing receptor activation
10.1152/ajplung.00215.2020 · 2020 · External reference
4-Chloro-DL-phenylalanine protects against monocrotaline-induced pulmonary vascular remodeling and lung inflammation
10.3892/ijmm.2013.1591 · 2014 · External reference
Protective role of taurine against oxidative stress
10.3892/mmr.2021.12242 · 2021 · External reference
Developmental programming and reprogramming of hypertension and kidney disease: impact of tryptophan metabolism
10.3390/ijms21228705 · 2020 · External reference
Gut microbiota regulation of tryptophan metabolism in health and disease
10.1016/j.chom.2018.05.003 · 2018 · External reference
Associations between maternal nutrition in pregnancy and child blood pressure at 46 years: a prospective study in a community-based pregnancy cohort
10.1093/jn/nxaa395 · 2021 · External reference
The recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 and systolic blood pressure variability in coronary heart disease patients with hyperhomocysteinemia: a single-center prospective cohort study
10.1097/md.0000000000023573 · 2020 · External reference
Porphyrin-induced protein oxidation and aggregation as a mechanism of porphyria-associated cell injury
10.1016/j.jcmgh.2019.06.006 · 2019 · External reference