Research graph
References from Chrysin alleviate obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Changing the global obesity narrative to recognize and reduce weight stigma: a position statement from the World Obesity Federation
10.1111/obr.13642 · 2023 · External reference
Global evolution of obesity research in children and youths: setting priorities for interventions and policies
10.1159/000497121 · 2019 · External reference
Epidemiology and determinants of obesity in China
10.1016/s2213-8587(21)00045-0 · 2021 · External reference
New advances in metabolic syndrome, from prevention to treatment: the role of diet and food
10.3390/nu15030640 · 2023 · External reference
Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms
10.1039/d2np00075j · 2023 · External reference
The mutual interplay of gut microbiota, diet and human disease
10.1111/febs.15217 · 2020 · External reference
Gut microbiome and health: mechanistic insights
10.1136/gutjnl-2021-326789 · 2022 · External reference
Role of the intestine and its gut microbiota in metabolic syndrome and obesity
10.14309/ajg.0000000000002730 · 2024 · External reference
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
10.1073/pnas.0605374104 · 2007 · External reference
A core microbiome signature as an indicator of health
10.1016/j.cell.2024.09.019 · 2024 · External reference
A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut
10.1136/gutjnl-2022-327365 · 2023 · External reference
NF-κB in biology and targeted therapy: new insights and translational implications
10.1038/s41392-024-01757-9 · 2024 · External reference
Intracellular Toll-like receptors
10.1016/j.immuni.2010.03.012 · 2010 · External reference
Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway
10.26599/fshw.2023.9250053 · 2024 · External reference
Targeting AMPK related signaling pathways: a feasible approach for natural herbal medicines to intervene non-alcoholic fatty liver disease
10.1016/j.jpha.2024.101052 · 2025 · External reference
AMPK as a therapeutic target for treating metabolic diseases
10.1016/j.tem.2017.05.004 · 2017 · External reference
Sulforaphane regulates glucose and lipid metabolisms in obese mice by restraining JNK and activating insulin and FGF21 signal pathways
10.1021/acs.jafc.1c04933 · 2021 · External reference
Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway
10.1016/j.ijbiomac.2023.126172 · 2023 · External reference
Chrysin: sources, beneficial pharmacological activities, and molecular mechanism of action
10.1016/j.phytochem.2017.09.016 · 2018 · External reference
An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances
10.1016/j.biopha.2017.06.003 · 2017 · External reference
Chrysin: pharmacological and therapeutic properties
10.1016/j.lfs.2019.116797 · 2019 · External reference
Chrysin improves glucose and lipid metabolism disorders by regulating the AMPK/PI3K/AKT signaling pathway in insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice
10.1021/acs.jafc.1c01109 · 2021 · External reference
Chrysin suppressed inflammatory responses and the inducible nitric oxide synthase pathway after spinal cord injury in rats
10.3390/ijms150712270 · 2014 · External reference
The interaction between flavonoids and intestinal microbes: a review
10.3390/foods12020320 · 2023 · External reference
Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota
10.3390/ijms24043813 · 2023 · External reference
Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats
10.1039/c9fo01142k · 2019 · External reference
Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats
10.1111/jfbc.14349 · 2022 · External reference
De novo synthesis of chrysin in Saccharomyces cerevisiae
10.1021/acs.jafc.3c09820 · 2024 · External reference
Chrysin mitigated obesity by regulating energy intake and expenditure in rats
10.1016/j.jtcme.2019.09.002 · 2020 · External reference
Fecal microbiota transplantation: indications, methods, evidence, and future directions
10.1007/s11894-013-0337-1 · 2013 · External reference
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
10.1038/s41587-019-0209-9 · 2019 · External reference
Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice
10.1111/jfbc.14284 · 2022 · External reference
Multi-omics analysis of western-style diet increased susceptibility to experimental colitis in mice
10.2147/jir.s361039 · 2022 · External reference
Obesity: global epidemiology and pathogenesis
10.1038/s41574-019-0176-8 · 2019 · External reference
Gut microbiota in human metabolic health and disease
10.1038/s41579-020-0433-9 · 2021 · External reference
Proteomic screening identifies the direct targets of chrysin anti-lipid depot in adipocytes
10.1016/j.jep.2020.113361 · 2021 · External reference
Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution
10.1016/j.cmet.2020.12.004 · 2021 · External reference
The anti-obesity and anti-steatotic effects of chrysin in a rat model of obesity mediated through modulating the hepatic AMPK/mTOR/lipogenesis pathways
10.3390/molecules28041734 · 2023 · External reference
Chrysin stimulates subcutaneous fat thermogenesis in mice by regulating PDGFRα and microRNA expressions
10.1021/acs.jafc.1c01130 · 2021 · External reference
Hepatic glucose metabolism in the steatotic liver
10.1038/s41575-023-00888-8 · 2024 · External reference
Effects of chrysin on intestinal inflammation and gut microbiota in lipopolysaccharides-induced mice
10.1096/fasebj.2019.33.1_supplement.785.6 · 2019 · External reference
The abundance of bifidobacterium in relation to visceral obesity and serum uric acid
10.1038/s41598-022-17417-3 · 2022 · External reference
Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids
10.1016/j.celrep.2018.12.028 · 2019 · External reference
Different dietary fibers unequally remodel gut microbiota and charge up anti-obesity effects
10.1016/j.foodhyd.2023.108617 · 2023 · External reference
Mechanisms regulating intestinal barrier integrity and its pathological implications
10.1038/s12276-018-0126-x · 2018 · External reference
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
10.1007/s11739-023-03374-w · 2024 · External reference
Short-chain fatty acids in control of body weight and insulin sensitivity
10.1038/nrendo.2015.128 · 2015 · External reference
Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
10.1038/s41598-017-11734-8 · 2017 · External reference
Metabolic endotoxemia with obesity: is it real and is it relevant
10.1016/j.biochi.2015.06.020 · 2016 · External reference
Role of metabolic endotoxemia in systemic inflammation and potential interventions
10.3389/fimmu.2020.594150 · 2021 · External reference
Indole-3-aldehyde alleviates high-fat diet-induced gut barrier disruption by increasing intestinal stem cell expansion
10.1021/acs.jafc.4c02381 · 2024 · External reference
Identification of a novel strain Lactobacillus reuteri and anti-obesity effect through metabolite indole-3-carboxaldehyde in diet-induced obese mice
10.1021/acs.jafc.2c05764 · 2023 · External reference
Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
10.1016/j.cmet.2016.05.005 · 2016 · External reference
Bacteroides and related species: The keystone taxa of the human gut microbiota
10.1016/j.anaerobe.2024.102819 · 2024 · External reference
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
10.1038/s41579-022-00805-x · 2023 · External reference
Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice
10.1038/nm.4363 · 2017 · External reference
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
10.1136/gutjnl-2012-302578 · 2013 · External reference
Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation
10.1016/j.chom.2020.01.021 · 2020 · External reference
Targeting farnesoid X receptor (FXR) for developing novel therapeutics against cancer
10.1186/s43556-021-00035-2 · 2021 · External reference
Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine
10.1016/j.bbadis.2011.04.005 · 2011 · External reference
