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References from The potential of flavonoids as microbiota-directed foods regulating lipid metabolism <i>via</i> the gut-liver axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Recent advances in cancer chemoprevention with phytochemicals
10.1016/j.jfda.2019.11.001 · 2020 · External reference
Flavonoids as natural phenolic compounds and their role in therapeutics: an overview
10.1186/s43094-020-00161-8 · 2021 · External reference
The great potential of flavonoids as candidate drugs for NAFLD
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Flavonoids: food associations, therapeutic mechanisms, metabolism and nanoformulations
10.1016/j.foodres.2022.111442 · 2022 · External reference
Microbial flavonoid metabolism: a cardiometabolic disease perspective
10.1146/annurev-nutr-120420-030424 · 2021 · External reference
Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections—a review
10.1016/j.foodres.2015.06.021 · 2015 · External reference
Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development
10.3390/molecules25030762 · 2020 · External reference
Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
10.1016/j.redox.2018.05.012 · 2018 · External reference
Berry polyphenols inhibit pancreatic lipase activity in vitro
10.1016/j.foodchem.2008.11.093 · 2009 · External reference
Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells
10.1021/jf900730e · 2009 · External reference
Flavonoids as potential anti-inflammatory molecules: a review
10.3390/molecules27092901 · 2022 · External reference
Lonicerin attenuates high-fat diet-induced hepatic steatosis through modulation of the gut microbiota-bile acid-FXR axis in mice
10.1016/j.jff.2024.106466 · 2024 · External reference
Kaempferol and nicotiflorin ameliorated alcohol-induced liver injury in mice by miR-138-5p/SIRT1/FXR and gut microbiota
10.1016/j.heliyon.2023.e23336 · 2024 · External reference
Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota
10.1186/s40104-023-00900-w · 2023 · External reference
Anti-inflammatory effects of Scutellaria baicalensis water extract in LPS-induced THP-1 macrophages through metabolomics study
10.1016/j.arabjc.2022.104507 · 2023 · External reference
Multiple responses of rhizobia to flavonoids during legume root infection
10.1016/s0065-2296(04)41001-5 · 2004 · External reference
Anthocyanins are converted into anthocyanidins and phenolic acids and effectively absorbed in the jejunum and ileum
10.1021/acs.jafc.0c07771 · 2021 · External reference
Starch-anthocyanins complex: characterization, digestibility, and mechanism
10.1016/j.foodhyd.2024.109797 · 2024 · External reference
Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health
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Absorption, metabolism and bioavailability of flavonoids: a review
10.1080/10408398.2021.1917508 · 2021 · External reference
Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans
10.1093/jac/dkh046 · 2004 · External reference
The anti-hepatitis B virus activity of sea buckthorn is attributed to quercetin, kaempferol and isorhamnetin
10.3892/br.2022.1573 · 2022 · External reference
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
10.1016/s0014-5793(00)01211-4 · 2000 · External reference
Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review
10.1080/10408398.2021.1947772 · 2023 · External reference
Chemistry and biological activities of flavonoids: an overview
10.1155/2013/162750 · 2013 · External reference
Flavonoid bioavailability and attempts for bioavailability enhancement
10.3390/nu5093367 · 2013 · External reference
Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro
10.1021/jf0108056 · 2002 · External reference
Citrus flavonoids and lipid metabolism
10.1097/mol.0b013e32835c07fd · 2013 · External reference
The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility
10.3390/nu8020078 · 2016 · External reference
Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota
10.3390/ijms24043813 · 2023 · External reference
Modern nanocarriers as a factor in increasing the bioavailability and pharmacological activity of flavonoids
10.1134/s0003683822090149 · 2022 · External reference
Flavonoids loaded in nanocarriers: an opportunity to increase oral bioavailability and bioefficacy
10.4236/fns.2014.513132 · 2014 · External reference
Available technologies on improving the stability of polyphenols in food processing
10.1002/fft2.65 · 2021 · External reference
Physical and chemical stability of anthocyanin-rich black carrot extract-loaded liposomes during storage
10.1016/j.foodres.2018.03.071 · 2018 · External reference
Encapsulation of polyphenols–a review
10.1016/j.tifs.2010.08.003 · 2010 · External reference
Nanoencapsulation of food ingredients using carbohydrate based delivery systems
10.1016/j.tifs.2014.06.007 · 2014 · External reference
Nanoencapsulation of hydrophobic and low-soluble food bioactive compounds within different nanocarriers
10.1016/j.foodhyd.2018.10.003 · 2019 · External reference
A novel ultradeformable liposomes of naringin for anti-inflammatory therapy
10.1016/j.colsurfb.2017.11.068 · 2018 · External reference
Effects of pH on the ability of flavonoids to act as pickering emulsion stabilizers
10.1016/j.colsurfb.2011.11.027 · 2012 · External reference
Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer
10.1016/j.bioelechem.2016.02.013 · 2016 · External reference
Interaction between phenolics and gut microbiota: role in human health
10.1021/jf902107d · 2009 · External reference
Design strategies of polysaccharide, protein and lipid-based nano-delivery systems in improving the bioavailability of polyphenols and regulating gut homeostasis
10.1016/j.ijbiomac.2024.137463 · 2024 · External reference
Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: a novel delivery system perspective
10.1016/j.foodchem.2023.137115 · 2024 · External reference
Nanotechnology and flavonoids: current research and future perspectives on cardiovascular health
10.1016/j.jff.2024.106355 · 2024 · External reference
Nanotechnology in food packaging with implications for sustainable outlook and safety concerns
10.1016/j.fbio.2024.103625 · 2024 · External reference
Gut microbes and the liver circadian clock partition glucose and lipid metabolism
10.1172/jci162515 · 2023 · External reference
Effects of natural flavonoid isoorientin on growth performance and gut microbiota of mice
10.1021/acs.jafc.8b03568 · 2018 · External reference
The gut-liver axis and gut microbiota in health and liver disease
10.1038/s41579-023-00904-3 · 2023 · External reference
Bile acids, the microbiome, immunity, and liver tumors
10.1056/nejmcibr1807106 · 2018 · External reference
Flavonoids from whole-grain oat alleviated high-fat diet-induced hyperlipidemia via regulating bile acid metabolism and gut microbiota in mice
10.1021/acs.jafc.1c01813 · 2021 · External reference
On estrogen, cholesterol metabolism, and breast cancer
10.1056/nejmcibr1315176 · 2014 · External reference
New insights into the mechanisms of high-fat diet mediated gut microbiota in chronic diseases
10.1002/imt2.69 · 2023 · External reference
Role of bile acids in the gut-liver axis
10.1016/j.jhep.2017.11.025 · 2018 · External reference
Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial
10.1093/ajcn/nqz282 · 2020 · External reference
Polysaccharides and flavonoids from Cyclocarya paliurus modulate gut microbiota and attenuate hepatic steatosis, hyperglycemia, and hyperlipidemia in nonalcoholic fatty liver disease rats with type 2 diabetes mellitus
10.1007/s13410-022-01080-5 · 2023 · External reference
Polyphenol effects on cholesterol metabolism via bile acid biosynthesis, CYP7A1: a review
10.3390/nu11112588 · 2019 · External reference
An extract from date palm fruit (Phoenix dactylifera) acts as a co-agonist ligand for the nuclear receptor FXR and differentially modulates FXR target-gene expression in vitro
10.1371/journal.pone.0190210 · 2018 · External reference
Effect of standardized grape powder consumption on the gut microbiome of healthy subjects: a pilot study
10.3390/nu13113965 · 2021 · External reference
Polyphenol-induced improvements in glucose metabolism are associated with bile acid signaling to intestinal farnesoid X receptor
10.1136/bmjdrc-2020-001386 · 2020 · External reference
Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid
10.1016/j.aca.2022.339885 · 2022 · External reference
Cytochrome P450 7A1 cholesterol 7α-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction
10.1074/jbc.m110.193409 · 2011 · External reference
Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO
10.1016/j.bbi.2023.11.021 · 2024 · External reference
The enzymes, regulation, and genetics of bile acid synthesis
10.1146/annurev.biochem.72.121801.161712 · 2003 · External reference
Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion
10.1016/s0024-3205(99)00607-4 · 1999 · External reference
Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2
10.1016/j.tox.2012.10.018 · 2013 · External reference
Hypocholesterolemic metabolism of dietary red pericarp glutinous rice rich in phenolic compounds in mice fed a high cholesterol diet
10.4162/nrp.2014.8.6.632 · 2014 · External reference
Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1
10.1042/bj20110022 · 2011 · External reference
Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
10.1073/pnas.0804437105 · 2008 · External reference
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
10.1016/j.cmet.2013.01.003 · 2013 · External reference
Untangling the 2-way relationship between red wine polyphenols and gut microbiota
10.1053/j.gastro.2019.10.015 · 2020 · External reference
Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
10.3945/ajcn.111.027847 · 2012 · External reference
Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats
10.1016/j.mrfmmm.2005.04.022 · 2005 · External reference
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
10.1038/nrgastro.2017.119 · 2018 · External reference
Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance
10.1002/hep.32289 · 2022 · External reference
An intestinal microbiota-farnesoid X receptor axis modulates metabolic disease
10.1053/j.gastro.2016.08.057 · 2016 · External reference
Flavonoids as antiobesity agents: a review
10.1002/med.21740 · 2021 · External reference
Insights on dietary polyphenols as agents against metabolic disorders: obesity as a target disease
10.3390/antiox12020416 · 2023 · External reference
Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism
10.1126/sciadv.aax6208 · 2020 · External reference
Gut microbes controlling blood sugar: no fire required!
10.1016/j.cmet.2020.02.007 · 2020 · External reference
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
10.1038/s41579-022-00805-x · 2023 · External reference
Non-alcoholic fatty liver disease
10.1016/s0140-6736(20)32511-3 · 2021 · External reference
A new bile acid treatment for non-alcoholic fatty liver disease
10.1016/s2468-1253(19)30183-9 · 2019 · External reference
Natural flavonoids: potential therapeutic strategies for non-alcoholic fatty liver disease
10.3389/fphar.2022.1005312 · 2022 · External reference
Dysregulation of lipid and glucose metabolism in nonalcoholic fatty liver disease
10.3390/nu15102323 · 2023 · External reference
PPAR-γ signaling in nonalcoholic fatty liver disease: pathogenesis and therapeutic targets
10.1016/j.pharmthera.2023.108391 · 2023 · External reference
Tetrahydropalmatine ameliorates hepatic steatosis in nonalcoholic fatty liver disease by switching lipid metabolism via AMPK-SREBP-1c-Sirt1 signaling axis
10.1016/j.phymed.2023.155005 · 2023 · External reference
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway
10.1016/j.phymed.2024.155437 · 2024 · External reference
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway
10.1016/j.fct.2021.112029 · 2021 · External reference
Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism
10.1016/j.cmet.2023.11.017 · 2024 · External reference
Inhibition of plasmodium falciparum fatty acid biosynthesis (FAS-Ⅱ pathway) by natural flavonoids: a computer-aided drug designing approach
10.1007/s42250-022-00449-7 · 2022 · External reference
Neddylation of sterol regulatory element-binding protein 1c is a potential therapeutic target for nonalcoholic fatty liver treatment
10.1038/s41419-020-2472-6 · 2020 · External reference
Non-alcoholic fatty liver disease in irritable bowel syndrome: more than a coincidence
10.4254/wjh.v13.i12.1816 · 2021 · External reference
What does irritable bowel syndrome share with non-alcoholic fatty liver disease
10.3748/wjg.v19.i33.5402 · 2013 · External reference
Effects of soothing liver and invigorating spleen recipe on lipid metabolism disorders in kupffer cells of NAFLD rats by LXRα/SREBP-1c signal pathway
10.1016/s1674-6384(14)60045-9 · 2014 · External reference
Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease
10.1136/gutjnl-2018-316307 · 2019 · External reference
Enhanced neuron-glia network in the submucosa and increased neuron outgrowth into the mucosa are associated with distinctive expressions of neuronal factors in the colon of rat IBS model
10.1111/nmo.14595 · 2023 · External reference
The flavonoid kurarinone regulates macrophage functions via aryl hydrocarbon receptor and alleviates intestinal inflammation in irritable bowel syndrome
10.2147/jir.s329091 · 2021 · External reference
Postprandial plasma concentrations of individual bile acids and FGF-19 in patients with type 2 diabetes
10.1210/jc.2016-1607 · 2016 · External reference
Intestinal crosstalk between bile acids and microbiota in irritable bowel syndrome
10.1111/jgh.16159 · 2023 · External reference
Phytopharmacological strategies in the management of type 2 diabetes mellitus
10.3390/foods9030271 · 2020 · External reference
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
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Flavonoids and their anti-diabetic effects: cellular mechanisms and effects to improve blood sugar levels
10.3390/biom9090430 · 2019 · External reference
Unraveling the regulation of hepatic metabolism by insulin
10.1016/j.tem.2017.03.003 · 2017 · External reference
Flavonoid subclasses and type 2 diabetes mellitus risk: a meta-analysis of prospective cohort studies
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Effect of citrus fruit and juice consumption on risk of developing type 2 diabetes: evidence on polyphenols from epidemiological and intervention studies
10.1016/j.tifs.2021.06.038 · 2021 · External reference
Profiles of polyphenol intake and type 2 diabetes risk in 60,586 women followed for 20 years: results from the E3N cohort study
10.3390/nu12071934 · 2020 · External reference
Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
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The role of anthocyanins as antidiabetic agents: from molecular mechanisms to in vivo and human studies
10.1007/s13105-020-00739-z · 2021 · External reference
Antilipogenesis effect of rutin-loaded liposomes using a microneedle delivery system
10.1021/acsami.3c12795 · 2023 · External reference
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway
10.1016/j.cellsig.2021.110023 · 2021 · External reference
Efficacy of polyphenols in the management of dyslipidemia: a focus on clinical studies
10.3390/nu13020672 · 2021 · External reference
Oryzanol modifies high fat diet-induced obesity, liver gene expression profile, and inflammation response in mice
10.1021/acs.jafc.7b03230 · 2017 · External reference
MDG-1, an ophiopogon polysaccharide, alleviates hyperlipidemia in mice based on metabolic profile of bile acids
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Contribution of mutations in low density lipoprotein receptor (LDLR) and lipoprotein lipase (LPL) genes to familial combined hyperlipidemia (FCHL): a reappraisal by using a resequencing approach
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Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia
10.1007/s11883-009-0078-7 · 2010 · External reference
Bile acid metabolism and signaling, the microbiota, and metabolic disease
10.1016/j.pharmthera.2022.108238 · 2022 · External reference
Bile acid metabolism and signaling: emerging pharmacological targets of dietary polyphenols
10.1016/j.pharmthera.2023.108457 · 2023 · External reference
Quercetin regulates hepatic cholesterol metabolism by promoting cholesterol-to-bile acid conversion and cholesterol efflux in rats
10.1016/j.nutres.2015.11.019 · 2016 · External reference
Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
10.1016/j.lfs.2006.01.016 · 2006 · External reference
Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57BL/6J mice
10.1016/j.ejphar.2007.09.036 · 2008 · External reference
Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats
10.1021/jf0618168 · 2006 · External reference
Influence of the gut microbiome, diet, and environment on risk of colorectal cancer
10.1053/j.gastro.2019.06.048 · 2020 · External reference
Food and microbiota in the FDA regulatory framework
10.1126/science.aan0836 · 2017 · External reference
Understanding of the efficacy of gut microbiota-directed foods on human health
10.1016/j.tifs.2023.04.005 · 2023 · External reference
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders
10.1038/s41575-020-0269-9 · 2020 · External reference
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
10.1126/science.aao5774 · 2018 · External reference
Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota
10.1080/10408398.2018.1536646 · 2019 · External reference
Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites
10.1080/10408398.2022.2123444 · 2024 · External reference
Functional interactions between gut microbiota transplantation, quercetin, and high-fat diet determine non-alcoholic fatty liver disease development in germ-free mice
10.1002/mnfr.201800930 · 2019 · External reference
Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota
10.1016/j.celrep.2021.109641 · 2021 · External reference
Mulberry leaves ameliorate obesity through enhancing brown adipose tissue activity and modulating gut microbiota
10.1039/c9fo00883g · 2019 · External reference
Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats
10.1016/j.jff.2018.04.070 · 2018 · External reference
Antidiabetic potential of green seaweed Enteromorpha prolifera flavonoids regulating insulin signaling pathway and gut microbiota in type 2 diabetic mice
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