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References from Plant sterol ester of <i>α</i> -linolenic acid alleviates hepatic steatosis associated with improving lysosomal function and promoting autophagy <i>via</i> inhibiting mTORC1. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation
10.1097/tp.0000000000002484 · 2019 · External reference
MASLD and cardiovascular diseases: a clinical review
10.1007/s00392-020-01709-7 · 2021 · External reference
Non-alcoholic fatty liver disease (MASLD)-pathogenesis, classification, and effect on drug metabolizing enzymes and transporters
10.1080/03602532.2017.1293683 · 2017 · External reference
Autophagy in liver diseases: time for translation
10.1016/j.jhep.2019.01.026 · 2019 · External reference
Autophagy in the liver: functions in health and disease
10.1038/nrgastro.2016.185 · 2017 · External reference
Autophagy, MASLD and MASLD-Related HCC
10.1007/978-981-10-8684-7_10 · 2018 · External reference
Lipid accumulation impairs lysosomal acid lipase activity in hepatocytes: evidence in MASLD patients and cell cultures
10.1016/j.bbalip.2019.158523 · 2019 · External reference
Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy
10.1016/j.jnutbio.2019.07.005 · 2019 · External reference
When lipid homeostasis runs havoc: lipotoxicity links lysosomal dysfunction to autophagy
10.1016/j.matbio.2020.11.005 · 2021 · External reference
Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects
10.1016/j.jri.2017.12.001 · 2018 · External reference
Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis
10.1111/obr.12159 · 2014 · External reference
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex
10.1126/science.aag1417 · 2017 · External reference
Phytosterols: nutritional health players in the management of obesity and its related disorders
10.3390/antiox9121266 · 2020 · External reference
Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner
10.1016/j.lfs.2015.07.019 · 2015 · External reference
Plant sterols: chemical and enzymatic structural modifications and effects on their cholesterol-lowering activity
10.1021/acs.jafc.8b00059 · 2018 · External reference
Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling
10.1039/d0fo02623a · 2021 · External reference
Chemical synthesis of phytosterol esters of polyunsaturated fatty acids with ideal oxidative stability
10.1002/ejlt.201000090 · 2011 · External reference
Mouse models of nonalcoholic fatty liver disease (MASLD): pathomechanisms and pharmacotherapies
10.7150/ijbs.65044 · 2022 · External reference
Salidroside activates the AMP-activated protein kinase pathway to suppress nonalcoholic steatohepatitis in mice
10.1002/hep.32066 · 2021 · External reference
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death
10.1080/15548627.2021.1920818 · 2022 · External reference
Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition
10.1042/cs20190672 · 2019 · External reference
Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells
10.1016/j.atherosclerosis.2005.01.031 · 2005 · External reference
Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines
10.1016/j.nutres.2012.11.014 · 2013 · External reference
α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes
10.1186/1476-511x-10-81 · 2011 · External reference
Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: implications for hepatotoxicity
10.1016/j.redox.2020.101751 · 2020 · External reference
Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates MASLD in mice fed a high-fat Western-style diet
10.1016/j.bbalip.2018.08.004 · 2018 · External reference
Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat
10.1016/j.metabol.2005.08.024 · 2006 · External reference
Phytosterols alleviate hyperlipidemia by regulating gut microbiota and cholesterol metabolism in mice
10.1155/2023/6409385 · 2023 · External reference
Plant sterol ester of α-linolenic acid attenuates nonalcoholic fatty liver disease by rescuing the adaption to endoplasmic reticulum stress and enhancing mitochondrial biogenesis
10.1155/2019/8294141 · 2019 · External reference
Plant sterol ester of α-linolenic acid improves MASLD through modulating gut microbiota and attenuating lipopolysaccharide-induced inflammation via regulating TLR4/NF-κB signaling pathway
10.1016/j.jff.2022.105137 · 2022 · External reference
Stigmasterol: an enigmatic plant stress sterol with versatile functions
10.3390/ijms25158122 · 2024 · External reference
Phase transitions, solubility, and crystallization kinetics of phytosterols and phytosterol-oil blends
10.1021/jf0624289 · 2007 · External reference
Enzymatic preparation of phytosterol esters with fatty acids from high-oleic sunflower seed oil using response surface methodology
10.1039/d1ra01486b · 2021 · External reference
Effects of α-linolenic acid intake on blood lipid profiles: a systematic review and meta-analysis of randomized controlled trials
10.1080/10408398.2020.1790496 · 2021 · External reference
Protective effect of α-linolenic acid on non-alcoholic hepatic steatosis and interleukin-6 and -10 in Wistar rats
10.3390/nu12010009 · 2019 · External reference
Combined effect of n-3 fatty acids and phytosterol esters on alleviating hepatic steatosis in non-alcoholic fatty liver disease subjects: a double-blind placebo-controlled clinical trial
10.1017/s0007114520000495 · 2020 · External reference
Cholesterol-lowering bioactive foods and nutraceuticals in pediatrics: clinical evidence of efficacy and safety
10.3390/nu16101526 · 2024 · External reference
Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
10.1111/hepr.12282 · 2014 · External reference
Metformin alleviates hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced nonalcoholic fatty liver disease by promoting transcription factor EB-dependent autophagy
10.3389/fphar.2021.689111 · 2021 · External reference
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of MASLD
10.1038/cddis.2014.162 · 2014 · External reference
LC3 and autophagy
10.1038/cddis.2014.162 · 2008 · External reference
p62 links autophagy and Nrf2 signaling
10.1016/j.freeradbiomed.2015.06.014 · 2015 · External reference
Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation
10.5582/bst.2018.01293 · 2019 · External reference
Reduced liver autophagy in high-fat diet induced liver steatosis in New Zealand obese mice
10.3390/antiox10040501 · 2021 · External reference
Altered lipid content inhibits autophagic vesicular fusion
10.1096/fj.09-144519 · 2010 · External reference
Lipids, lysosomes, and autophagy
10.1194/jlr.r067520 · 2016 · External reference
Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p
10.1016/j.yexcr.2019.111738 · 2020 · External reference
Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis
10.1096/fj.201601393r · 2018 · External reference
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases
10.1016/j.tcb.2023.06.005 · 2024 · External reference
Advances and prospects on acid phosphatase biosenso
10.1016/j.bios.2020.112671 · 2020 · External reference
Quantification of lysosomal membrane permeabilization by cytosolic cathepsin and β-N-acetyl-glucosaminidase activity measurements
10.1101/pdb.prot086165 · 2015 · External reference
The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: molecular mechanism and promising therapeutic targets
10.1016/j.lfs.2020.117418 · 2020 · External reference
Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons
10.1016/j.bbrep.2016.01.010 · 2016 · External reference
The role of lysosomal membrane proteins in autophagy and related diseases
10.1111/febs.16820 · 2024 · External reference
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
10.1016/j.molcel.2023.06.004 · 2023 · External reference
mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells
10.1016/j.jinorgbio.2020.111231 · 2020 · External reference
β-Sitosterol modulates osteogenic and adipogenic balance in BMSCs to suppress osteoporosis via regulating mTOR-IMP1-Adipoq axis
10.1016/j.phymed.2025.156400 · 2025 · External reference
Stigmasterol simultaneously induces apoptosis and protective autophagy by inhibiting Akt/mTOR pathway in gastric cancer cells
10.3389/fonc.2021.629008 · 2021 · External reference
α-Linolenic acid-enriched cold-pressed perilla oil suppress high-fat diet-induced hepatic steatosis through amelioration of the ER stress-mediated autophagy
10.3390/molecules25112662 · 2020 · External reference
The mammalian ULK1 complex and autophagy initiation
10.1042/ebc20170021 · 2017 · External reference
Fine-Tuning of mTORC1-ULK1-PP2A regulatory triangle is crucial for robust autophagic response upon cellular stress
10.3390/biom12111587 · 2022 · External reference
AMPK and autophagy
10.1007/978-981-15-0602-4_4 · 2019 · External reference
