Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Leucine metabolite <i>β</i> -hydroxy- <i>β</i> -methyl-butyrate alleviates cisplatin-induced peripheral neuropathy by destabilizing CTR1 in dorsal root ganglia. Local targets link to admitted publications; unresolved targets remain external evidence.
Can cisplatin therapy be improved? pathways that can be targeted
10.3390/ijms23137241 · 2022 · External reference
Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response
10.1093/neuonc/noaa151 · 2021 · External reference
Sirt2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair
10.1172/jci123159 · 2020 · External reference
Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy
10.1200/jco.2016.71.3552 · 2017 · External reference
Platinum-induced peripheral neurotoxicity: from pathogenesis to treatment
10.1111/jns.12335 · 2019 · External reference
Corneal nerve changes following treatment with neurotoxic anticancer drugs
10.1016/j.jtos.2021.06.007 · 2021 · External reference
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update
10.1200/jco.20.01399 · 2020 · External reference
Recent advances in small molecule nav 1.7 inhibitors for cancer pain management
10.1016/j.bioorg.2024.107605 · 2024 · External reference
Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents
10.1016/j.fct.2019.111079 · 2020 · External reference
Insights into platinum-induced peripheral neuropathy-current perspective
10.4103/1673-5374.276321 · 2020 · External reference
Current understanding of membrane transporters as regulators or targets for cisplatin-induced hearing loss
10.1124/molpharm.121.000274 · 2021 · External reference
Cellular mechanisms accounting for the refractoriness of colorectal carcinoma to pharmacological treatment
10.3390/cancers12092605 · 2020 · External reference
Dynamic and cell specific transport networks for intracellular copper ions
10.1242/jcs.240523 · 2021 · External reference
Interference between copper transport systems and platinum drugs
10.1016/j.semcancer.2021.05.023 · 2021 · External reference
Drug resistance in ovarian cancer: from mechanism to clinical trial
10.1186/s12943-024-01967-3 · 2024 · External reference
Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions
10.1002/jcsm.12208 · 2017 · External reference
Benefits of beta-hydroxy-beta-methylbutyrate supplementation in trained and untrained individuals
10.1080/15438627.2018.1533470 · 2019 · External reference
Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research
10.1002/jcsm.12954 · 2022 · External reference
The effects of beta-hydroxy-beta-methylbutyrate or HMB-rich nutritional supplements on sarcopenia patients: a systematic review and meta-analysis
10.3389/fmed.2024.1348212 · 2024 · External reference
Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats
10.1016/j.neurobiolaging.2016.01.004 · 2016 · External reference
Effects of beta-hydroxy-beta-methyl butyrate on working memory and cognitive flexibility in an animal model of aging
10.1080/1028415x.2016.1145376 · 2017 · External reference
Sesamol epigenetically induces estrogen receptor alpha re-expression by upregulating miR-370-3p in estrogen receptor alpha-negative breast cancer
10.1021/acs.jafc.1c03159 · 2021 · External reference
Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy
10.3390/biom11070940 · 2021 · External reference
Dose translation between laboratory animals and human in preclinical and clinical phases of drug development
10.1002/ddr.21461 · 2018 · External reference
Knockdown of miR-1293 attenuates lung adenocarcinoma angiogenesis via SPRY4 upregulation-mediated ERK1/2 signaling inhibition
10.1016/j.bcp.2024.116414 · 2024 · External reference
Advances in toxicological research of the anticancer drug cisplatin
10.1021/acs.chemrestox.9b00204 · 2019 · External reference
Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons
10.1016/j.neuro.2018.09.001 · 2018 · External reference
The drug-resistance mechanisms of five platinum-based antitumor agents
10.3389/fphar.2020.00343 · 2020 · External reference
Role of ubiquitination in the occurrence and development of osteoporosis (review)
10.3892/ijmm.2024.5392 · 2024 · External reference
Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner
10.1002/advs.202004303 · 2021 · External reference
Mechanism of action and the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on different types of physical performance-a systematic review
10.2478/hukin-2019-0070 · 2019 · External reference
Effects of β-hydroxy β-methylbutyrate (HMB) supplementation on muscle mass, function, and other outcomes in patients with cancer: a systematic review
10.1002/jcsm.12952 · 2022 · External reference
International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)
10.1080/15502783.2024.2434734 · 2025 · External reference
Modulating metabolism to improve cancer-induced muscle wasting
10.1155/2018/7153610 · 2018 · External reference
Cell-specific role of histone deacetylase 6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers
10.1097/j.pain.0000000000001667 · 2019 · External reference
Clinical and preclinical perspectives on chemotherapy-induced peripheral neuropathy (CIPN): a narrative review
10.1093/bja/aex229 · 2017 · External reference
Recommendations for prevention and management of chemotherapy-induced peripheral neuropathy
10.1001/jama.2021.7458 · 2021 · External reference
Comparison of the anticatabolic effects of leucine and Ca-beta-hydroxy-beta-methylbutyrate in experimental models of cancer cachexia
10.1016/j.nut.2013.11.012 · 2014 · External reference
Transport mechanisms for the nutritional supplement beta-hydroxy-beta-methylbutyrate (HMB) in mammalian cells
10.1007/s11095-019-2626-3 · 2019 · External reference
Dietary approaches for controlling cancer by limiting the Warburg effect: a review
10.1093/nutrit/nuad130 · 2024 · External reference
Novel nonsymmetrical 1,4-dihydropyridines as inhibitors of nonsymmetrical MRP-efflux pumps for anticancer therapy
10.3390/ph13070146 · 2020 · External reference