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References from Integrated microbiome and metabolomic analysis uncover the amelioration mechanisms of <i>Prunella vulgaris</i> L. polysaccharides on gut health of ulcerative colitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Temporal trends of inflammatory bowel disease burden in China from 1990 to 2030 with comparisons to Japan, South Korea, the European Union, the United States of America, and the world
10.2147/clep.s402718 · 2023 · External reference
Effects of Pinus massoniana pollen polysaccharides on intestinal microenvironment and colitis in mice
10.1039/d0fo02190c · 2021 · External reference
Integrated microbiome and metabolomic analysis reveal the repair mechanisms of ovalbumin on the intestine barrier of colitis mice
10.1021/acs.jafc.2c08897 · 2023 · External reference
Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
10.1038/s41467-022-29589-7 · 2022 · External reference
Ascophyllum nodosum polysaccharide regulates gut microbiota metabolites to protect against colonic inflammation in mice
10.1039/d2fo02964b · 2023 · External reference
A novel Sagittaria sagittifolia L. polysaccharides mitigate DSS-induced colitis via modulation of gut microbiota and MAPK/NF-κB signaling pathways
10.1016/j.ijbiomac.2023.127835 · 2024 · External reference
Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides
10.1080/10408398.2022.2025535 · 2023 · External reference
Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism
10.1016/j.ijbiomac.2021.03.137 · 2021 · External reference
Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota
10.1016/j.foodres.2023.112630 · 2023 · External reference
Mesona chinensis benth polysaccharides alleviate DSS-induced ulcerative colitis via inhibiting of TLR4/MAPK/NF-κB signaling pathways and modulating intestinal microbiota
10.1002/mnfr.202200047 · 2022 · External reference
Prunella vulgaris L.: An updated overview of botany, chemical composition, extraction methods, and biological activities
10.3390/ph16081106 · 2023 · External reference
Prunella vulgaris: a comprehensive review of chemical constituents, pharmacological effects and clinical applications
10.2174/1381612825666190313121608 · 2019 · External reference
Research progress on Prunella vulgaris and its monomers in protecting against ulcerative colitis
10.1016/j.jhip.2023.11.002 · 2023 · External reference
Preparation, characterization and in vitro antioxidant activities of a homogeneous polysaccharide from Prunella vulgaris
10.1016/j.fitote.2024.106371 · 2025 · External reference
Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-κB activation
10.1186/s13020-023-00865-y · 2024 · External reference
GC-MS-based metabolomics research on the anti-hyperlipidaemic activity of Prunella vulgaris L. polysaccharides
10.1016/j.ijbiomac.2020.05.003 · 2020 · External reference
Extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, applications, and quality assessments of Prunella vulgaris L. polysaccharides: A review
10.1016/j.ijbiomac.2025.141665 · 2025 · External reference
Regulatory effects of crude polysaccharides from Prunella vulgaris L. on inflammatory responses induced by cadmium in renal tubular epithelial cells
10.13982/j.mfst.1673-9078.2021.6.0138 · 2021 · External reference
An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats
10.1016/j.fct.2023.114005 · 2023 · External reference
An aqueous extract of Prunella vulgaris L. inhibits the growth of papillary thyroid carcinoma by inducing autophagy in vivo and in vitro
10.1002/ptr.7015 · 2021 · External reference
Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms
10.1016/j.jep.2020.113280 · 2021 · External reference
Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo
10.1007/s00204-021-03157-2 · 2021 · External reference
Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation
10.1016/j.ijbiomac.2022.08.032 · 2022 · External reference
Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: a review
10.1016/j.ijbiomac.2022.04.208 · 2022 · External reference
Polysaccharides from natural resources exhibit great potential in the treatment of ulcerative colitis: a review
10.1016/j.carbpol.2020.117189 · 2021 · External reference
Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation
10.1016/j.ijbiomac.2019.03.230 · 2019 · External reference
Gut-liver axis: liver sinusoidal endothelial cells function as the hepatic barrier in colitis-induced liver injury
10.3389/fcell.2021.702890 · 2021 · External reference
NLRP3 inflammasome activation contributes to the pathogenesis of cardiocytes aging
10.18632/aging.203435 · 2021 · External reference
Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice
10.1039/c9fo02719j · 2020 · External reference
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis
10.1016/j.ijbiomac.2024.131251 · 2024 · External reference
Pectic polysaccharide from Smilax china L. ameliorated ulcerative colitis by inhibiting the galectin-3/NLRP3 inflammasome pathway
10.1016/j.carbpol.2021.118864 · 2022 · External reference
Natural products modulate NLRP3 in ulcerative colitis
10.3389/fphar.2023.1265825 · 2023 · External reference
Mucus and mucins: the underappreciated host defence system
10.3389/fcimb.2022.856962 · 2022 · External reference
Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites
10.1016/j.ijbiomac.2023.127335 · 2023 · External reference
Selenium-containing tea polysaccharides ameliorate DSS-induced ulcerative colitis via enhancing the intestinal barrier and regulating the gut microbiota
10.1016/j.ijbiomac.2022.04.028 · 2022 · External reference
Eurotium cristatum, a probiotic fungus from Fuzhuan Brick tea, and its polysaccharides ameliorated DSS-induced ulcerative colitis in mice by modulating the gut microbiota
10.1021/acs.jafc.1c08301 · 2022 · External reference
Polysaccharide from Gracilaria lemaneiformis prevents colitis in Balb/c mice via enhancing intestinal barrier function and attenuating intestinal inflammation
10.1016/j.foodhyd.2020.106048 · 2020 · External reference
Polysaccharide from flammuliana velutipes improves colitis via regulation of colonic microbial dysbiosis and inflammatory responses
10.1016/j.ijbiomac.2020.02.044 · 2020 · External reference
Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition
10.1016/j.biopha.2022.113767 · 2022 · External reference
Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment
10.1111/1751-2980.12849 · 2020 · External reference
The microbiota in inflammatory bowel disease
10.1007/s00535-015-1064-1 · 2015 · External reference
Cordyceps militaris polysaccharide alleviates diabetic symptoms by regulating gut microbiota against TLR4/NF-κB pathway
10.1016/j.ijbiomac.2023.123241 · 2023 · External reference
Gut microbiome–serum metabolic profiles: insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice
10.1039/d3fo02040a · 2023 · External reference
Mixed Lactiplantibacillus plantarum strains alleviated DSS-induced intestinal inflammation of Balb/c mice via the 5-HT/5-HT7R/NF-κB signaling pathway
10.1016/j.jff.2023.105435 · 2023 · External reference
The dietary supplement Rhodiola crenulata extract alleviates dextran sulfate sodium-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the gut microbiome
10.1039/d0fo03061a · 2021 · External reference
The Lactobacillus gasseri G098 strain mitigates symptoms of DSS-induced inflammatory bowel disease in mice
10.3390/nu14183745 · 2022 · External reference
Combined effects of microplastics and chlortetracycline on the intestinal barrier, gut microbiota, and antibiotic resistome of Muscovy ducks (Cairina moschata)
10.1016/j.scitotenv.2023.164050 · 2023 · External reference
Regulation of viable/inactivated/lysed probiotic Lactobacillus plantarum H6 on intestinal microbiota and metabolites in hypercholesterolemic mice
10.1038/s41538-022-00167-x · 2022 · External reference
Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism
10.1021/acs.jafc.2c06417 · 2022 · External reference
Inhibitory effects of peroxidase from foxtail millet bran on colitis-associated colorectal carcinogenesis by the blockage of glycerophospholipid metabolism
10.1021/acs.jafc.0c03257 · 2020 · External reference
The intestinal barrier: a fundamental role in health and disease
10.1080/17474124.2017.1343143 · 2017 · External reference
Fat of the gut: epithelial phospholipids in inflammatory bowel diseases
10.3390/ijms222111682 · 2021 · External reference
Gut microbiome structure and metabolic activity in inflammatory bowel disease
10.1038/s41564-018-0306-4 · 2019 · External reference
Insights into Q-markers and molecular mechanism of Sanguisorba saponins in treating ulcerative colitis based on lipid metabolism regulation
10.1016/j.phymed.2023.154870 · 2023 · External reference
Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial
10.7326/0003-4819-147-9-200711060-00004 · 2007 · External reference
Lysophosphatidylcholine as a prognostic marker in community-acquired pneumonia requiring hospitalization: a pilot study
10.1007/s10096-014-2234-4 · 2015 · External reference
Protective effect of l-theanine against DSS-induced colitis by regulating the lipid metabolism and reducing inflammation via the NF-κB signaling pathway
10.1021/acs.jafc.1c05839 · 2021 · External reference
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach
10.3389/fphar.2022.1014117 · 2022 · External reference
Integrated metabonomics and network pharmacology to reveal the action mechanism effect of Shaoyao decoction on ulcerative colitis
10.2147/dddt.s375281 · 2022 · External reference
Study on the plasma metabolomics of Schisandra chinensis polysaccharide against ulcerative colitis and its correlation with gut microbes metabolism
10.1016/j.cjac.2023.100244 · 2023 · External reference
The expanded role of fatty acid metabolism in cancer: new aspects and targets
10.1093/pcmedi/pbz017 · 2019 · External reference
the lipid status in patients with ulcerative colitis: sphingolipids are disease-dependent regulated
10.3390/jcm8070971 · 2019 · External reference
Dihydromyricetin alleviates intestinal inflammation by changing intestinal microbial metabolites and inhibiting the expression of the MyD88/NF-κB signaling pathway
10.1002/aro2.21 · 2023 · External reference
Dietary and endogenous sphingolipid metabolism in chronic inflammation
10.3390/nu9111180 · 2017 · External reference
Integrated analysis of the gut microbiome and metabolome in a mouse model of inflammation-induced colorectal tumors
10.3389/fmicb.2022.1082835 · 2023 · External reference
Serine alleviates dextran sulfate sodium-induced colitis and regulates the gut microbiota in Mice
10.3389/fmicb.2018.03062 · 2018 · External reference