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References from Luteolin prevents cholesterol gallstone formation in mice by downregulating NRF2-mediated NPC1L1 expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Gallstone disease and risk of conventional adenomas and serrated polyps: a prospective study
10.1158/1055-9965.epi-21-0515 · 2021 · External reference
Gallstones
10.1038/nrdp.2016.24 · 2016 · External reference
Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids
10.1194/jlr.s091199 · 2019 · External reference
Fast morphological gallbladder changes triggered by a hypercholesterolemic diet
10.5604/01.3001.0012.3160 · 2018 · External reference
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
10.1126/sciadv.abb1989 · 2020 · External reference
Effect of inhibition of intestinal cholesterol absorption on the prevention of cholesterol gallstone formation
10.2174/1573406413666170209122851 · 2017 · External reference
Dietary plant sterols prevented cholesterol gallstone formation in mice
10.1039/d1fo02695j · 2021 · External reference
Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice
10.1186/s12929-023-00933-3 · 2023 · External reference
Luteolin, a flavonoid, as an anticancer agent: a review, Biomed
10.1016/j.biopha.2019.108612 · 2019 · External reference
Polyphenols: food sources and bioavailability
10.1093/ajcn/79.5.727 · 2004 · External reference
Advances in flavonoid research since 1992
10.1016/s0031-9422(00)00235-1 · 2000 · External reference
A case series of a luteolin formulation (neuroprotek®) in children with autism spectrum disorders
10.1177/039463201202500201 · 2012 · External reference
The effect of polyphenols on hypercholesterolemia through inhibiting the transport and expression of Niemann-Pick C1-Like 1
10.3390/ijms20194939 · 2019 · External reference
Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet
10.1016/j.biopha.2017.11.131 · 2017 · External reference
Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter Niemann-Pick C1-Like 1 in Caco-2 cells and rats
10.1371/journal.pone.0097901 · 2014 · External reference
Effect of luteolin on the expression of intestinal cholesterol transporters
10.1016/j.jff.2017.07.008 · 2017 · External reference
Cholesterol gallstones in alloxan-diabetic mice
10.1016/0162-0134(86)80024-1 · 1986 · External reference
A simple method for the isolation and purification of total lipides from animal tissues
10.1016/s0021-9258(18)64849-5 · 1957 · External reference
Critical tables for calculating the cholesterol saturation of native bile
10.1016/s0022-2275(20)40677-7 · 1978 · External reference
Alteration of gut microbiota in association with cholesterol gallstone formation in mice
10.1186/s12876-017-0629-2 · 2017 · External reference
Ezetimibe in combination with simvastatin reduces remnant cholesterol without affecting biliary lipid concentrations in gallstone patients
10.1161/jaha.118.009876 · 2018 · External reference
Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats
10.1016/0005-2760(92)90269-2 · 1992 · External reference
Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats
10.1021/jf1015285 · 2010 · External reference
Effect of phenolic compounds from Cymbopogon citratus (DC) Stapf. leaves on micellar solubility of cholesterol
10.3390/molecules27217338 · 2022 · External reference
Niemann-Pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport
10.1146/annurev-physiol-012110-142233 · 2011 · External reference
Extracellular loop C of NPC1L1 is important for binding to ezetimibe
10.1073/pnas.0800936105 · 2008 · External reference
NPC1L1 and ABCG5/8 induction explain synergistic fecal cholesterol excretion in ob/ob mice co-treated with PPAR-α and LXR agonists
10.1007/s11010-020-03826-3 · 2020 · External reference
Advances and challenges in therapeutic targeting of NRF2
10.1016/j.tips.2022.12.003 · 2023 · External reference
Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
10.1016/j.freeradbiomed.2011.03.008 · 2011 · External reference
Epigenetic regulation of NRF2/KEAP1 by phytochemicals
10.3390/antiox9090865 · 2020 · External reference
The ABCs of sterol transport
10.1194/jlr.r800044-jlr200 · 2009 · External reference
Consequences of bile salt biotransformations by intestinal bacteria
10.1080/19490976.2015.1127483 · 2016 · External reference
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
10.1073/pnas.1323599111 · 2014 · External reference
Intestinal transit, deoxycholic acid and the cholesterol saturation of bile: three inter-related factors
10.1136/gut.27.5.550 · 1986 · External reference
Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion
10.1038/s41467-021-27758-8 · 2022 · External reference
Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice
10.1016/j.bbrc.2024.150088 · 2024 · External reference
Isolation of luteolin and luteolin-7-O-glucoside from Ramat Tzvel and their pharmacokinetics in rats
10.1021/jf505848z · 2015 · External reference
Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis
10.1016/j.bioorg.2021.104966 · 2021 · External reference
Identification of the flavonoid luteolin as a repressor of the transcription factor hepatocyte nuclear factor 4α
10.1074/jbc.m115.645200 · 2015 · External reference
Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats
10.1016/j.heliyon.2023.e17613 · 2023 · External reference
Anti-inflammatory effects of luteolin: a review of in vitro, in vivo, and in silico studies
10.1016/j.jep.2018.05.019 · 2018 · External reference