Research graph
References from From gut to brain: pioneering microbial strategies against Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Response of the microbiome-gut-brain axis in Drosophila to amino acid deficit
10.1038/s41586-021-03522-2 · 2021 · External reference
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases
10.1038/s41392-024-01743-1 · 2024 · External reference
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
New insights into atypical Alzheimer’s disease in the era of biomarkers
10.1016/s1474-4422(20)30440-3 · 2021 · External reference
Risk factor for Alzheimer’s disease breaks the blood-brain barrier
10.1038/d41586-020-01152-8 · 2020 · External reference
Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
10.1136/gutjnl-2021-326269 · 2022 · External reference
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease
10.1126/scitranslmed.abo2984 · 2023 · External reference
Risk of bias in overviews of reviews: a scoping review of methodological guidance and four-item checklist
10.1002/jrsm.1229 · 2017 · External reference
Updated methodological guidance for the conduct of scoping reviews
10.11124/jbies-20-00167 · 2020 · External reference
Implications of gut microbiota in neurodegenerative diseases
10.3389/fimmu.2022.785644 · 2022 · External reference
The microbiota-gut-brain axis in neuropsychiatric disorders: pathophysiological mechanisms and novel treatments
10.2174/1570159x15666170915141036 · 2018 · External reference
Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis
10.1038/s42255-024-01108-6 · 2024 · External reference
Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
10.1186/s40168-020-00988-6 · 2021 · External reference
Berberine alleviates Alzheimer’s disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance
10.1016/j.phymed.2024.155624 · 2024 · External reference
Implications of microbe-derived γ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer’s disease
10.1080/19490976.2024.2371950 · 2024 · External reference
The gut microbiota modulates neuroinflammation in Alzheimer’s disease: elucidating crucial factors and mechanistic underpinnings
10.1111/cns.70091 · 2024 · External reference
Transfer of a healthy microbiota reduces amyloid and Tau pathology in an Alzheimer’s disease animal model
10.1136/gutjnl-2018-317431 · 2020 · External reference
The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids
10.1186/s40168-022-01255-6 · 2022 · External reference
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
10.1038/s41467-020-14676-4 · 2020 · External reference
Mechanisms of blood-brain barrier protection by microbiota-derived short-chain fatty acids
10.3390/cells12040657 · 2023 · External reference
Therapeutic potential of gut microbiota modulation in epilepsy: a focus on short-chain fatty acids
10.1016/j.nbd.2025.106880 · 2025 · External reference
The neuroactive potential of the human gut microbiota in quality of life and depression
10.1038/s41564-018-0337-x · 2019 · External reference
Associations between gut microbiota and Alzheimer’s disease, major depressive disorder, and schizophrenia
10.1186/s12974-020-01961-8 · 2020 · External reference
Relationship between plasma lipopolysaccharides, gut microbiota, and dementia: a cross-sectional study
10.3233/jad-215653 · 2022 · External reference
Transcranial focal electrical stimulation modifies biogenic amines’ alterations induced by 6-hydroxydopamine in rat brain
10.3390/ph14080706 · 2021 · External reference
Extra-virgin olive oil in Alzheimer’s disease: a comprehensive review of cellular, animal, and clinical studies
10.3390/ijms25031914 · 2024 · External reference
Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation
10.1186/s40168-022-01452-3 · 2023 · External reference
Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study
10.1186/s12974-023-02999-0 · 2024 · External reference
Exploring the microbiota-gut-brain axis: impact on brain structure and function
10.3389/fnana.2025.1504065 · 2025 · External reference
The microbiota-gut-brain axis and neurological disorders: a comprehensive review
10.3390/life14101234 · 2024 · External reference
Mechanisms of microbiota-gut-brain axis communication in anxiety disorders
10.3389/fnins.2024.1501134 · 2024 · External reference
Role of microbiota-gut-brain axis in natural aging-related alterations in behavior
10.3389/fnins.2024.1362239 · 2024 · External reference
Microbiota-gut-brain axis in age-related neurodegenerative diseases
10.2174/1570159x23666241101093436 · 2025 · External reference
Perturbations in the microbiota-gut-brain axis shaped by social status loss
10.1038/s42003-025-07850-1 · 2025 · External reference
Psychobiotics and the microbiota-gut-brain axis: where do we go from here?
10.3390/microorganisms12040634 · 2024 · External reference
Microbiota-gut-brain-axis: a new target of acupuncture therapy for post-stroke cognitive impairment
10.3389/fmicb.2025.1425054 · 2025 · External reference
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
10.1038/s41422-019-0216-x · 2019 · External reference
Immunoregulatory role of the gut microbiota in inflammatory depression
10.1038/s41467-024-47273-w · 2024 · External reference
The gut microbiota influences blood-brain barrier permeability in mice
10.1126/scitranslmed.3009759 · 2014 · External reference
Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer’s disease and vascular dementia
10.1016/j.arr.2024.102250 · 2024 · External reference
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health
10.1080/19490976.2021.1897212 · 2021 · External reference
Gut microbiota-driven metabolic alterations reveal gut-brain communication in Alzheimer’s disease model mice
10.1080/19490976.2024.2302310 · 2024 · External reference
β-Glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice
10.1186/s40168-020-00920-y · 2020 · External reference
Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice
10.1186/s12974-020-01760-1 · 2020 · External reference
Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer’s disease
10.1002/alz.13007 · 2023 · External reference
Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
10.1186/s13195-021-00783-x · 2021 · External reference
APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology
10.1096/fj.201900071r · 2019 · External reference
Murine gut microbiome association with APOE alleles
10.3389/fimmu.2020.00200 · 2020 · External reference
Drinking water temperature affects cognitive function and progression of Alzheimer’s disease in a mouse model
10.1038/s41401-020-0407-5 · 2021 · External reference
Akkermansia muciniphila improve cognitive dysfunction by regulating BDNF and serotonin pathway in gut-liver-brain axis
10.1186/s40168-024-01924-8 · 2024 · External reference
A tissue-like neurotransmitter sensor for the brain and gut
10.1038/s41586-022-04615-2 · 2022 · External reference
Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice
10.1016/j.apsb.2019.07.001 · 2020 · External reference
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
10.1016/j.cmet.2021.10.010 · 2021 · External reference
Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer’s disease mouse model via regulating the gut microbiota-brain axis
10.1016/j.bbi.2021.04.005 · 2021 · External reference
Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models
10.1172/jci154612 · 2023 · External reference
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease
10.1186/s12974-023-02915-6 · 2023 · External reference
Multi-strain probiotics ameliorate Alzheimer’s-like cognitive impairment and pathological changes through the AKT/GSK-3β pathway in senescence-accelerated mouse prone 8 mice
10.1016/j.bbi.2024.03.031 · 2024 · External reference
Gut microbiome-targeted therapies for Alzheimer’s disease
10.1080/19490976.2023.2271613 · 2023 · External reference
A combinational therapy for preventing and delaying the onset of Alzheimer’s disease: a focus on probiotic and vitamin co-supplementation
10.3390/antiox13020202 · 2024 · External reference
Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews
10.1093/nutrit/nuad013 · 2023 · External reference
Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial
10.1093/gerona/glaa090 · 2021 · External reference
DW2009 elevates the efficacy of donepezil against cognitive impairment in mice
10.3390/nu13093273 · 2021 · External reference
Do herbal supplements and probiotics complement antibiotics and diet in the management of SIBO? A randomized clinical trial
10.3390/nu16071083 · 2024 · External reference
Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats
10.1186/s12974-018-1055-2 · 2018 · External reference
Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics
10.1007/s00253-021-11646-8 · 2022 · External reference
Probiotics, prebiotics, synbiotics and insulin sensitivity
10.1017/s095442241700018x · 2018 · External reference
Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives
10.1007/s13679-020-00379-w · 2020 · External reference
Probiotics, prebiotics and synbiotics in inflammatory bowel diseases
10.3390/jcm10112466 · 2021 · External reference
Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer’s disease-related pathology
10.3389/fphar.2023.1338804 · 2023 · External reference
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
10.1186/s40168-022-01430-9 · 2022 · External reference
Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology
10.1186/s12967-023-04137-z · 2023 · External reference
Treadmill exercise modulates intestinal microbes and suppresses LPS displacement to alleviate neuroinflammation in the brains of APP/PS1 mice
10.3390/nu14194134 · 2022 · External reference
Gut microbiota modulation in Alzheimer’s disease: focus on lipid metabolism
10.1016/j.clnu.2022.01.025 · 2022 · External reference
Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment
10.1016/j.ebiom.2019.08.032 · 2019 · External reference
Mediterranean and Western diet effects on Alzheimer’s disease biomarkers, cerebral perfusion, and cognition in mid-life: a randomized trial
10.1002/alz.12421 · 2022 · External reference
Association of Mediterranean-DASH intervention for neurodegenerative delay and mediterranean diets with Alzheimer disease pathology
10.1212/wnl.0000000000207176 · 2023 · External reference
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries
10.1136/gutjnl-2019-319654 · 2020 · External reference
Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: rationale, methods, and baseline characteristics
10.3389/fnut.2022.1037842 · 2022 · External reference
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
10.1186/s12979-023-00381-5 · 2023 · External reference
Role of dietary fiber in the recovery of the human gut microbiome and its metabolome
10.1016/j.chom.2020.12.012 · 2021 · External reference
Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid
10.1038/s41564-023-01418-7 · 2023 · External reference
Tea polyphenols regulate gut microbiota dysbiosis induced by antibiotic in mice
10.1016/j.foodres.2021.110153 · 2021 · External reference
Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats
10.1039/d0fo03457f · 2021 · External reference
The impact of a dried fruit and vegetable supplement and fiber rich shake on gut and health parameters in female healthcare workers: a placebo-controlled, double-blind, randomized clinical trial
10.3390/microorganisms9040843 · 2021 · External reference
Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
10.1016/j.bbi.2024.01.216 · 2024 · External reference
Trial of the MIND diet for prevention of cognitive decline in older persons
10.1056/nejmoa2302368 · 2023 · External reference
Dietary polyphenols as therapeutic intervention for Alzheimer’s disease: a mechanistic insight
10.3390/antiox11030554 · 2022 · External reference
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
10.1186/s13195-024-01482-z · 2024 · External reference
Genistein, a phytoestrogen, delays the transition to dementia in prodromal Alzheimer’s disease patients
10.3233/jad-240308 · 2024 · External reference
Mediterranean diet related metabolite profiles and cognitive performance
10.1016/j.clnu.2022.12.012 · 2023 · External reference
Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease: a pilot study
10.1016/j.neurobiolaging.2019.09.015 · 2020 · External reference
Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
10.1186/s40168-020-0792-5 · 2020 · External reference
Fecal microbiota transplantation donor and dietary fiber intervention collectively contribute to gut health in a mouse model
10.3389/fimmu.2022.842669 · 2022 · External reference
Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
10.15252/embj.2022111515 · 2023 · External reference
Fecal microbiota transplantation for treatment of parkinson disease: a randomized clinical trial
10.1001/jamaneurol.2024.2305 · 2024 · External reference
Gut microbiota composition is related to AD pathology
10.3389/fimmu.2021.794519 · 2021 · External reference
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
10.1093/brain/awad303 · 2023 · External reference
Transplantation of gut microbiota derived from Alzheimer’s disease mouse model impairs memory function and neurogenesis in C57BL/6 mice
10.1016/j.bbi.2021.09.002 · 2021 · External reference
Application of dominant gut microbiota promises to replace fecal microbiota transplantation as a new treatment for Alzheimer’s disease
10.3390/microorganisms11122854 · 2023 · External reference
Preliminary evidence for developing safe and efficient fecal microbiota transplantation as potential treatment for aged related cognitive impairments
10.3389/fcimb.2023.1103189 · 2023 · External reference
Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice
10.1038/s41398-019-0525-3 · 2019 · External reference
Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer’s disease
10.1016/j.redox.2023.102690 · 2023 · External reference
Fecal microbiota transplantation improves cognitive function of a mouse model of Alzheimer’s disease
10.1111/cns.70259 · 2025 · External reference
Fecal microbiota transplantation in Alzheimer’s disease: mechanistic insights through the microbiota-gut-brain axis and therapeutic prospects
10.3390/microorganisms13081956 · 2025 · External reference
Fecal microbiota transplantation derived from Alzheimer’s disease mice worsens brain trauma outcomes in wild-type controls
10.3390/ijms23094476 · 2022 · External reference
Chronic arsenic exposure causes Alzheimer’s disease characteristic effects and the intervention of fecal microbiota transplantation in rats
10.1002/jat.4782 · 2025 · External reference
Fecal microbiota transplantation role in the treatment of Alzheimer’s disease: a systematic review
10.7759/cureus.29968 · 2022 · External reference
Fecal microbiota transplantation reduces pathology and improves cognition in a mouse model of Alzheimer’s disease
10.3390/cells12010119 · 2022 · External reference
Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota
10.1016/j.phrs.2019.104403 · 2019 · External reference
Effect of altered gene expression in lipid metabolism on cognitive improvement in patients with Alzheimer’s dementia following fecal microbiota transplantation: a preliminary study
10.1177/17562864231218181 · 2024 · External reference
Fecal microbiota transplantation: current challenges and future landscapes
10.1128/cmr.00060-22 · 2024 · External reference
Fecal microbiota transplantation: indications, methods, and challenges
10.1007/s12275-024-00184-3 · 2024 · External reference
‘Does this fecal microbiota transplant work?’ quality assurance of capsule based fecal microbiota transplant production
10.1080/00365521.2024.2401460 · 2024 · External reference
Encapsulation protocol for fecal microbiota transplantation
10.3389/fcimb.2024.1424376 · 2024 · External reference
Assessing microbiome engraftment extent following fecal microbiota transplant with q2-fmt
10.1371/journal.pcbi.1013299 · 2025 · External reference
European consensus conference on faecal microbiota transplantation in clinical practice
10.1136/gutjnl-2016-313017 · 2017 · External reference
Protocol for a randomised, placebo-controlled pilot study for assessing feasibility and efficacy of faecal microbiota transplantation in a paediatric ulcerative colitis population: PediFETCh trial
10.1136/bmjopen-2017-016698 · 2017 · External reference
Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles
10.1038/s41593-023-01361-0 · 2023 · External reference
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice
10.1186/s40168-023-01589-9 · 2023 · External reference
Ultrafast and accurate 16S rRNA microbial community analysis using Kraken 2
10.1186/s40168-020-00900-2 · 2020 · External reference
Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life
10.1038/s41564-018-0321-5 · 2019 · External reference
Large-scale association analyses identify host factors influencing human gut microbiome composition
10.1038/s41588-020-00763-1 · 2021 · External reference
The gut microbiota-brain axis in behaviour and brain disorders
10.1038/s41579-020-00460-0 · 2021 · External reference
metaProbiotics: a tool for mining probiotic from metagenomic binning data based on a language model
10.1093/bib/bbae085 · 2024 · External reference
Harnessing the polysaccharide production potential to optimize and expand the application of probiotics
10.1016/j.carbpol.2024.122951 · 2025 · External reference
Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review
10.1186/s13098-024-01561-z · 2024 · External reference
Microbiome-based therapies for Parkinson’s disease
10.3389/fnut.2024.1496616 · 2024 · External reference
Ketogenic diets and Chronic disease: weighing the benefits against the risks
10.3389/fnut.2021.702802 · 2021 · External reference
Illnesses associated with ketosis including diabetic ketoacidosis during very low carbohydrate and ketogenic diets
10.1111/dom.16252 · 2025 · External reference
