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References from Beyond antioxidants: context-selective reprogramming of ferroptosis by natural polyphenols in chronic disease intervention. Local targets link to admitted publications; unresolved targets remain external evidence.
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DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid beta proteotoxicity
10.1016/j.freeradbiomed.2024.09.034 · 2024 · External reference
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
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Targeting the labile iron pool with engineered DFO nanosheets to inhibit ferroptosis for Parkinson’s disease therapy
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Ferroptosis and endoplasmic reticulum stress in ischemic stroke
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Mitochondria regulation in ferroptosis
10.1016/j.ejcb.2019.151058 · 2020 · External reference
Oxidative damage and antioxidant defense in ferroptosis
10.3389/fcell.2020.586578 · 2020 · External reference
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis
10.1016/j.cell.2017.11.048 · 2018 · External reference
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
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System Xc-/GSH/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
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Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
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FSP1: a key regulator of ferroptosis
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Ferroptosis regulation through NRF2 and implications for neurodegenerative diseases
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Inhibitory effect and mechanism of action of quercetin and quercetin diels-alder anti-dimer on erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells
10.3390/antiox9030205 · 2020 · External reference
Review and chemoinformatic analysis of ferroptosis modulators with a focus on natural plant products
10.3390/molecules28020475 · 2023 · External reference
Phenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction
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10.3390/ijms22179109 · 2021 · External reference
Comparison of ferroptosis-inhibitory mechanisms between ferrostatin-1 and dietary stilbenes (piceatannol and astringin)
10.3390/molecules26041092 · 2021 · External reference
Structure-activity relationship and mechanism of four monostilbenes with respect to ferroptosis inhibition
10.1039/d0ra04896h · 2020 · External reference
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10.1016/j.foodchem.2005.05.044 · 2006 · External reference
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10.3390/antiox12030630 · 2023 · External reference
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Mechanisms of ferroptosis and emerging links to the pathology of neurodegenerative diseases
10.3389/fnagi.2022.904152 · 2022 · External reference
Bridging neurotrophic factors and bioactive peptides to Alzheimer’s disease
10.1016/j.arr.2023.102177 · 2024 · External reference
Emerging links between ferroptosis and neurodegeneration: implications for disease mechanisms and nutraceutical interventions
10.1002/fsn3.70385 · 2025 · External reference
Neuroferroptosis in health and diseases
10.1038/s41583-025-00930-5 · 2025 · External reference
Anti-ferroptotic effects of natural polyphenols in nervous system injury: a narrative literature review
10.1080/1028415x.2024.2448924 · 2025 · External reference
Can polyphenols inhibit ferroptosis?
10.3390/antiox11010150 · 2022 · External reference
Challenges and opportunities of deferoxamine delivery for treatment of Alzheimer’s disease, Parkinson’s disease, and intracerebral hemorrhage
10.1021/acs.molpharmaceut.0c00474 · 2021 · External reference
Multi-target neuroprotection of thiazolidinediones on Alzheimer’s disease via neuroinflammation and ferroptosis
10.3233/jad-230593 · 2023 · External reference
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Inhibition of ferroptosis underlies EGCG mediated protection against Parkinson’s disease in a Drosophila model
10.1016/j.freeradbiomed.2023.12.005 · 2024 · External reference
Liquiritin in Chaihu-shugan-san alleviates Parkinson’s disease via PPARalpha-mediated inhibition of SCD1/FADS2-dependent ferroptosis
10.1016/j.phymed.2025.157262 · 2025 · External reference
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10.3390/ijms20040830 · 2019 · External reference
Targeting ferroptosis: acteoside as a neuroprotective agent in Salsolinol-induced Parkinson’s disease models
10.31083/fbl26679 · 2025 · External reference
Acteoside alleviates lipid peroxidation by enhancing NRF2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson’s disease
10.1016/j.freeradbiomed.2024.07.018 · 2024 · External reference
Salidroside mediated the NRF2/GPX4 pathway to attenuates ferroptosis in Parkinson’s disease
10.1007/s11064-024-04116-w · 2024 · External reference
Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the NRF2/GPX4 axis in SAMP8 mice
10.1016/j.phymed.2023.154762 · 2023 · External reference
Salidroside attenuates neuronal ferroptosis by activating the NRF2/HO1 signaling pathway in Aβ1-42-induced Alzheimer’s disease mice and glutamate-injured HT22 cells
10.1186/s13020-022-00634-3 · 2022 · External reference
Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD
10.3389/fphar.2022.983623 · 2022 · External reference
Ferroptosis-related biomarkers for Alzheimer’s disease: identification by bioinformatic analysis in hippocampus
10.3389/fncel.2022.1023947 · 2022 · External reference
Tetrahydroxy stilbene glycoside ameliorates Alzheimer’s disease in APP/PS1 mice via glutathione peroxidase related ferroptosis
10.1016/j.intimp.2021.108002 · 2021 · External reference
Forsythoside A mitigates Alzheimer’s-like pathology by inhibiting ferroptosis-mediated neuroinflammation via NRF2/GPX4 axis activation
10.7150/ijbs.69714 · 2022 · External reference
Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated NRF2 activation
10.1186/s10020-022-00442-3 · 2022 · External reference
A natural polyphenol activates and enhances GPX4 to mitigate amyloid-beta induced ferroptosis in Alzheimer’s disease
10.1039/d3sc02350h · 2023 · External reference
Dual targeting of FSP1 and xCT: Potential mechanism of anthocyanins in alleviating neuronal ferroptosis in vascular dementia
10.1016/j.phymed.2025.156608 · 2025 · External reference
Gastrodin ameliorates cognitive dysfunction in vascular dementia rats by suppressing ferroptosis via the regulation of the NRF2/Keap1-GPx4 signaling pathway
10.3390/molecules27196311 · 2022 · External reference
Dihydromyricetin ameliorates neurotoxicity induced by high glucose through restraining ferroptosis by inhibiting JNK-inflammation pathway in HT22 cells
10.1016/j.neuroscience.2024.11.061 · 2025 · External reference
Quercetin: a promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis
10.1016/j.phymed.2023.154887 · 2024 · External reference
Resveratrol alleviates diabetic adipose tissue-derived extracellular vesicles-induced hippocampal ferroptosis and cognitive dysfunction via inhibiting miR-9-3p/SLC7A11 axis
10.1007/s12035-025-04922-5 · 2025 · External reference
Protocatechuic acid relieves ferroptosis in hepatic lipotoxicity and steatosis via regulating NRF2 signaling pathway
10.1007/s10565-024-09953-7 · 2024 · External reference
Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis
10.3389/fphar.2023.1148814 · 2023 · External reference
Targeting mitochondrial ROS-mediated ferroptosis by quercetin alleviates high-fat diet-induced hepatic lipotoxicity
10.3389/fphar.2022.876550 · 2022 · External reference
Global, regional, and national burden of metabolic dysfunction-associated steatohepatitis-related liver cancer in older adults: trends and cross-national inequality based on the global burden of disease study 2021
10.1007/s12672-025-03399-x · 2025 · External reference
Proanthocyanidin and mitoglitazone suppress lipogenesis by targeting ferroptosis in metabolic dysfunction-associated steatohepatitis
10.1007/s00210-025-04271-z · 2025 · External reference
Echinacoside alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis via NRF2/HMOX1 pathway
10.3390/biomedicines12122728 · 2024 · External reference
Protective effect of curcumin on hepatolenticular degeneration through copper excretion and inhibition of ferroptosis
10.1016/j.phymed.2022.154539 · 2023 · External reference
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting NRF2
10.1016/j.jep.2024.119290 · 2025 · External reference
Ferroptosis: an important player in the inflammatory response in diabetic nephropathy
10.3389/fimmu.2023.1294317 · 2023 · External reference
Quercetin ameliorates diabetic kidney injury by inhibiting ferroptosis via activating NRF2/HO-1 signaling pathway
10.1142/s0192415x23500465 · 2023 · External reference
Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the NRF2 in streptozotocin-induced diabetic rats
10.1080/0886022x.2024.2327495 · 2024 · External reference
Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways
10.1186/s10020-022-00481-w · 2022 · External reference
Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway
10.1016/j.fct.2022.112892 · 2022 · External reference
Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy
10.1186/s10020-025-01318-y · 2025 · External reference
Schisandrin A from Schisandra chinensis attenuates ferroptosis and NLRP3 inflammasome-mediated pyroptosis in diabetic nephropathy through mitochondrial damage by AdipoR1 ubiquitination
10.1155/2022/5411462 · 2022 · External reference
Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis
10.1080/13880209.2022.2067572 · 2022 · External reference
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
10.1038/s41420-021-00579-w · 2021 · External reference
Targeting ferroptosis in cardio-metabolic-diseases: mechanisms and therapeutic prospects
10.1002/med.21934 · 2023 · External reference
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
10.1038/s41569-022-00735-4 · 2023 · External reference
Role of ferroptosis in the pathogenesis of heart disease
10.3389/fphys.2024.1450656 · 2024 · External reference
Ferroptosis in cardiovascular diseases: role and mechanism
10.1186/s13578-023-01169-2 · 2023 · External reference
Unlocking resveratrol’s potential: targeting ferroptosis in atherosclerosis through MAPK1
10.1002/fsn3.70466 · 2025 · External reference
Catechin inhibits ox-LDL-induced ferroptosis in vascular smooth muscle cells to alleviate and stabilize atherosclerosis
10.3389/fnut.2025.1594708 · 2025 · External reference
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway
10.3389/fphar.2025.1524736 · 2025 · External reference
Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway
10.1111/bph.70200 · 2025 · External reference
Epigallocatechin-3-gallate from green tea reduces vascular aging and endothelial cell senescence by modifying autophagy and ferroptosis through the Sirtuin 1 signaling pathway
10.1021/acsomega.5c03880 · 2025 · External reference
Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition
10.1016/j.jconrel.2025.113598 · 2025 · External reference
Pterostilbene attenuates heart failure by inhibiting myocardial ferroptosis through SIRT1/GSK-3β/GPX4 signaling pathway
10.1016/j.heliyon.2024.e24562 · 2024 · External reference
Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation
10.1111/jcmm.17874 · 2023 · External reference
Exploring the mechanism of Ling-Gui-Zhu-Gan decoction in metabolic cardiomyopathy via inhibiting ferroptosis
10.1016/j.phymed.2024.156234 · 2024 · External reference
In vivo and in vitro investigations of schisandrin B against angiotensin Ⅱ induced ferroptosis and atrial fibrosis by regulation of the SIRT1 pathway
10.1038/s41598-025-89895-0 · 2025 · External reference
Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways
10.2337/db22-0553 · 2023 · External reference
Kaempferol rescues vascular endothelial ferroptosis by inhibiting lipid peroxidation
10.15419/bmrat.v11i4.880 · 2024 · External reference
Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway
10.1016/j.jff.2025.106684 · 2025 · External reference
Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis
10.1186/s12967-024-06042-5 · 2025 · External reference
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-κB pathway
10.1016/j.biopha.2024.116556 · 2024 · External reference
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress
10.3389/fphar.2025.1501725 · 2025 · External reference
A new direction for delaying intervertebral disc degeneration: resveratrol inhibits ferroptosis in nucleus pulposus cells
10.1007/s12013-025-01874-4 · 2025 · External reference
Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis
10.1016/j.freeradbiomed.2023.01.006 · 2023 · External reference
Urolithin A protects mice against osteoarthritis by inhibiting chondrocyte ferroptosis through activating AMPK/mTOR/HIF-1alpha signaling pathway
10.1016/j.jnutbio.2025.110111 · 2025 · External reference
Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating NRF2
10.1016/j.heliyon.2023.e20163 · 2023 · External reference
Curcumin-loaded biomimetic nanosponges for osteoarthritis alleviation by synergistically suppressing inflammation and ferroptosis
10.1016/j.cej.2024.152132 · 2024 · External reference
Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis
10.1016/j.bioactmat.2023.09.020 · 2024 · External reference
Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression
10.1016/j.jot.2024.10.005 · 2025 · External reference
Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
10.1016/j.intimp.2024.112010 · 2024 · External reference
Symptom management and lifestyle interventions for people with fibromyalgia
10.1016/j.aehs.2024.09.004 · 2024 · External reference
Baicalein improves renal interstitial fibrosis by inhibiting the ferroptosis in vivo and in vitro
10.1016/j.heliyon.2024.e28954 · 2024 · External reference
Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1α/FABP4 signaling axis
10.1016/j.phymed.2025.156738 · 2025 · External reference
Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis
10.1016/j.ejphar.2024.176999 · 2024 · External reference
Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the NRF2/GPX4 signaling axis
10.1016/j.jff.2024.106579 · 2024 · External reference
Luteolin alleviated calcium oxalate crystal induced kidney injury by inhibiting Nr4a1-mediated ferroptosis
10.1016/j.phymed.2024.156302 · 2025 · External reference
Ferroptosis is involved in quercetin-mediated alleviation of ochratoxin A-induced kidney damage
10.1016/j.fct.2024.114877 · 2024 · External reference
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
10.1038/s41586-025-08677-w · 2025 · External reference
Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis
10.1016/j.redox.2024.103029 · 2024 · External reference
Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
10.1002/ptr.7558 · 2022 · External reference
Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation
10.1016/j.redox.2022.102435 · 2022 · External reference
Schisandrin B promotes hepatic stellate cell ferroptosis via Wnt pathway-mediated Ly6C(lo) macrophages
10.1021/acs.jafc.3c03409 · 2023 · External reference
Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy
10.1016/j.phrs.2021.105580 · 2021 · External reference
Encapsulation of natural polyphenolic compounds; a review
10.3390/pharmaceutics3040793 · 2011 · External reference
Sensory nutrition and bitterness and astringency of polyphenols
10.3390/biom14020234 · 2024 · External reference
Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers
10.1271/bbb.67.856 · 2003 · External reference
Role of the blood-brain barrier in the nutrition of the central nervous system
10.1016/j.arcmed.2014.11.018 · 2014 · External reference
Chelation of iron and copper by quercetin B-ring methyl metabolites, isorhamnetin and tamarixetin, and their effect on metal-based fenton chemistry
10.1021/acs.jafc.1c01729 · 2021 · External reference
Plant extracts rich in polyphenols as potent modulators in the growth of probiotic and pathogenic intestinal microorganisms
10.3389/fnut.2021.688843 · 2021 · External reference
Biomarkers of (poly)phenol intake: a systematic review
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Dietary polyphenol, gut microbiota, and health benefits
10.3390/antiox11061212 · 2022 · External reference
Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: a state-of-the-art review
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Tea polyphenol-gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner
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Polyphenols: food sources and bioavailability
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Curcumin uptake and metabolism
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Dietary modulation of CYP3A4 and its impact on statins and antidiabetic drugs: a narrative review
10.3390/ph18091351 · 2025 · External reference
Dietary polyphenols inhibit the cytochrome P450 monooxygenase branch of the arachidonic acid cascade with remarkable structure-dependent selectivity and potency
10.1021/acs.jafc.0c04690 · 2020 · External reference
Dietary polyphenol intake and risk of overall and site-specific cancers: the Japan public health center-based prospective study
10.1016/j.tjnut.2025.04.028 · 2025 · External reference
Effect of green tea and its polyphenols on mouse liver
10.1016/j.fitote.2013.07.014 · 2013 · External reference
Cysteine depletion induces pancreatic tumor ferroptosis in mice
10.1126/science.aaw9872 · 2020 · External reference
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
10.1038/s41586-025-09389-x · 2025 · External reference
Redox imbalance in cystine/glutamate transporter-deficient mice
10.1074/jbc.m506439200 · 2005 · External reference
The molecular machinery of regulated cell death
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Unraveling precision exercise: a journey from efficacy to molecular insights
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Precision prevention in exercise: integrating OMICS biomarkers and artificial intelligence for injury risk assessment
10.1016/j.aehs.2025.09.001 · 2025 · External reference
Network pharmacology, molecular docking and experimental study on the mechanism of curcumin’s anti-ferroptosis in melanocytes
10.1016/j.bbrc.2024.150871 · 2024 · External reference
ToxDP2 database: toxicity prediction of dietary polyphenols
10.1016/j.foodchem.2021.131350 · 2022 · External reference
Beyond mortality: exploring the influence of plant phenolics on modulating ferroptosis-a systematic review
10.3390/antiox13030334 · 2024 · External reference
Recommendations for robust and reproducible research on ferroptosis
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Natural polyphenols for drug delivery and tissue engineering construction: a review
10.1016/j.ejmech.2024.116141 · 2024 · External reference
Polyphenol-chitosan conjugates: synthesis, characterization, and applications
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Naringenin enhances the efficacy of ferroptosis inducers by attenuating aerobic glycolysis by activating the AMPK-PGC1α signalling axis in liver cancer
10.1016/j.heliyon.2024.e32288 · 2024 · External reference
Polyphenols and metabolism: from present knowledge to future challenges
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A network pharmacology-based investigation into the mechanism of quercetin combined with rosuvastatin in delaying diabetic nephropathy via inhibiting NRK-52E cell ferroptosis
10.2147/dmso.s524983 · 2025 · External reference
Propofol and salvianolic acid A synergistically attenuated cardiac ischemia-reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway
10.1093/burnst/tkad055 · 2024 · External reference
Propofol and salvianolic acid A synergistically attenuated hypoxia/reoxygenation induced H92 cells injury under high-glucose and high-fat condition via modulating CD36
10.1124/jpet.122.171910 · 2023 · External reference
Drug pair-derived synergistic therapy of flavonoids luteolin and astragaloside Ⅳ promote neural repair following spinal cord injury via antioxidant and neuroprotective effect
10.1093/pcmedi/pbaf037 · 2025 · External reference
Exerkines: potential regulators of ferroptosis
10.1016/j.jshs.2025.101032 · 2025 · External reference
Quercetin in sports and exercise: a review
10.70252/gqok2958 · 2023 · External reference
Trans-resveratrol and hesperidin supplementation with treadmill exercise alleviates methylglyoxal-induced skeletal muscle dysfunction
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Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via NRF2/GPX4 signaling
10.1186/s12876-025-04052-1 · 2025 · External reference
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/NRF2 pathway
10.1007/s10522-023-10042-1 · 2023 · External reference
Exercise-induced irisin attenuates ferroptosis in polycystic ovary syndrome by modulating the NCOA4-FTH pathway
10.1016/j.bbadis.2025.168108 · 2025 · External reference
Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention
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Polyphenols and exercise in mitochondrial biogenesis: focus on age-related CNS disorders
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