Research graph
References from A high-fat diet rescues muscle atrophy by restoring adiponectin and attenuating systemic inflammation in cachectic mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer-associated cachexia
10.1038/nrdp.2017.105 · 2018 · External reference
Cancer cachexia: molecular mechanisms and treatment strategies
10.1186/s13045-023-01454-0 · 2023 · External reference
Cachexia: a systemic consequence of progressive, unresolved disease
10.1016/j.cell.2023.03.028 · 2023 · External reference
Adipose tissue: between the extremes
10.15252/embj.201696206 · 2017 · External reference
Whole-body and adipose tissue metabolic phenotype in cancer patients
10.1002/jcsm.12918 · 2022 · External reference
Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin
10.1172/jci.insight.121221 · 2018 · External reference
Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin
10.1002/jcsm.12904 · 2022 · External reference
Mechanisms of metabolic dysfunction in cancer-associated cachexia
10.1101/gad.276733.115 · 2016 · External reference
Cancer cachexia: more than skeletal muscle wasting
10.1016/j.trecan.2018.10.001 · 2018 · External reference
Metabolic reprogramming in adipose tissue during cancer cachexia
10.3389/fonc.2022.848394 · 2022 · External reference
Ketogenic diet in the treatment of cancer - where do we stand?
10.1016/j.molmet.2019.06.026 · 2020 · External reference
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
10.1038/s41392-021-00831-w · 2022 · External reference
The ketogenic diet: pros and cons
10.1016/j.atherosclerosis.2019.11.021 · 2020 · External reference
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
10.1038/nm.4171 · 2016 · External reference
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
10.1038/nature13528 · 2014 · External reference
An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia
10.1073/pnas.2112840119 · 2022 · External reference
Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion
10.1016/j.metabol.2020.154169 · 2020 · External reference
Splenic volume as a predictor of treatment response in patients with non-small cell lung cancer receiving immunotherapy
10.1371/journal.pone.0270950 · 2022 · External reference
The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
10.1186/s12864-023-09462-7 · 2023 · External reference
Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice
10.1016/j.celrep.2022.111934 · 2023 · External reference
Targeting obesity and cachexia: identification of the GFRAL receptor-MIC-1/GDF15 pathway
10.1016/j.molmed.2017.10.005 · 2017 · External reference
Structural and biochemical characteristics of various white adipose tissue depots
10.1111/j.1748-1716.2012.02409.x · 2012 · External reference
Adiponectin regulation and function
10.1002/cphy.c170046 · 2018 · External reference
Adiponectin and its mimics on skeletal muscle: insulin sensitizers, fat burners, exercise mimickers
10.3390/ijms21072620 · 2020 · External reference
The regulatory roles of PPARs in skeletal muscle fuel metabolism and inflammation: impact of PPAR agonism on muscle in chronic disease, contraction and sepsis
10.3390/ijms22189775 · 2021 · External reference
Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise
10.1038/s41574-020-0405-1 · 2020 · External reference
Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care-correlations with food intake, metabolism, exercise capacity, and hormones
10.1002/cncr.21013 · 2005 · External reference
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
10.1002/jcsm.12901 · 2022 · External reference
Fiber types in mammalian skeletal muscles
10.1152/physrev.00031.2010 · 2011 · External reference
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
10.1016/j.cmet.2023.05.008 · 2023 · External reference
Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia
10.1002/jcsm.13391 · 2024 · External reference
Systemic ketone replacement does not improve survival or cancer cachexia in mice with lung cancer
10.3389/fonc.2022.903157 · 2022 · External reference
Hypermetabolism is an independent prognostic factor of survival in metastatic non-small cell lung cancer patients
10.1016/j.clnu.2019.08.003 · 2020 · External reference
Body composition and lung cancer-associated cachexia in TRACERx
10.1038/s41591-023-02232-8 · 2023 · External reference
Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients
10.1016/j.cyto.2012.10.023 · 2013 · External reference
Cancer cachexia: new insights and future directions
10.3390/cancers15235590 · 2023 · External reference
Adipose triglyceride lipase contributes to cancer-associated cachexia
10.1126/science.1198973 · 2011 · External reference
