Research graph
References from A cRGD-engineered EV-liposome hybrid nanoplatform for targeted FAT1 mRNA delivery suppresses thyroid carcinoma metastasis by reprogramming the immunosuppressive microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Thyroid cancer: A review
10.1001/jama.2023.26348 · 2024 · External reference
Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
10.1007/s00262-023-03549-6 · 2023 · External reference
Combinatory actions of cytokines induce M2-like macrophages in anaplastic thyroid cancer
10.62347/quwq3794 · 2024 · External reference
Roles and new insights of macrophages in the tumor microenvironment of thyroid cancer
10.3389/fphar.2022.875384 · 2022 · External reference
M2-like tumour-associated macrophage-secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway
10.3892/mmr.2021.12249 · 2021 · External reference
Cross-talk between cancer and its cellular environment-A role in cancer progression
10.3390/cells14060403 · 2025 · External reference
Thyroid cancer stem-like cells: From microenvironmental niches to therapeutic strategies
10.3390/jcm10071455 · 2021 · External reference
Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages
10.1158/1078-0432.ccr-22-3273 · 2023 · External reference
Macrophages are a double-edged sword: Molecular crosstalk between tumor-associated macrophages and cancer stem cells
10.3390/biom12060850 · 2022 · External reference
Modulation of tumor-associated macrophages to overcome immune suppression in the hepatocellular carcinoma microenvironment
10.3390/cancers17010066 · 2024 · External reference
The role of macrophage polarization in ovarian cancer: From molecular mechanism to therapeutic potentials
10.3389/fimmu.2025.1543096 · 2025 · External reference
IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (review)
10.3892/ijo.2015.3234 · 2016 · External reference
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression
10.1016/j.pharmthera.2020.107692 · 2021 · External reference
The diverse functions of FAT1 in cancer progression: Good, bad, or ugly
10.1186/s13046-022-02461-8 · 2022 · External reference
Recent advances in the role of atypical cadherin FAT1 in tumorigenesis (review)
10.3892/ol.2024.14856 · 2025 · External reference
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis
10.1038/s41586-020-03046-1 · 2021 · External reference
Role of FAT1 in health and disease (review)
10.3892/ol.2021.12659 · 2021 · External reference
A pan-cancer analysis of the FAT1 in human tumors
10.1038/s41598-022-26008-1 · 2022 · External reference
NFкB is a critical transcriptional regulator of atypical cadherin FAT1 in glioma
10.1186/s12885-019-6435-1 · 2020 · External reference
mRNA vaccine era-Mechanisms, drug platform and clinical prospection
10.3390/ijms21186582 · 2020 · External reference
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
10.1073/pnas.2109256118 · 2021 · External reference
Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion
10.1186/s11658-025-00769-9 · 2025 · External reference
Upregulation of atypical cadherin FAT1 promotes an immunosuppressive tumor microenvironment via TGF-β
10.3389/fimmu.2022.813888 · 2022 · External reference
FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells
10.1038/onc.2012.393 · 2013 · External reference
Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases
10.7150/thno.15625 · 2017 · External reference
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis
10.1080/10717544.2022.2057617 · 2022 · External reference
An in vivo mouse model of metastatic human thyroid cancer
10.1089/thy.2013.0149 · 2014 · External reference
METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via m6A-CD70-mediated immune suppression in thyroid cancer
10.1038/s41418-023-01217-x · 2023 · External reference
Novel dual-action targeted nanomedicine in mice with metastatic thyroid cancer and pancreatic neuroendocrine tumors
10.1093/jnci/djy003 · 2018 · External reference
Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8
10.1093/carcin/bgu060 · 2014 · External reference
Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma
10.1007/s11684-023-0999-5 · 2023 · External reference
CXCL8 induces M2 macrophage polarization and inhibits CD8+ T cell infiltration to generate an immunosuppressive microenvironment in colorectal cancer
10.1096/fj.202201982rrr · 2023 · External reference
Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst
10.1002/gcc.22836 · 2020 · External reference
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
10.1016/j.cytogfr.2009.11.005 · 2010 · External reference
NF-κB signaling pathway in tumor microenvironment
10.3389/fimmu.2024.1476030 · 2024 · External reference
Persistently activated Stat3 maintains constitutive NF-κB activity in tumors
10.1016/j.ccr.2009.02.015 · 2009 · External reference
