References

Mechanisms of diabetic kidney disease and established and emerging treatments

10.1038/s41574-025-01171-3 · 2026 · External reference

Chronic kidney disease and risk management: Standards of care in diabetes-2025

10.2337/dc25-s011 · 2025 · External reference

IDF diabetes atlas 11th edition 2025: Global prevalence and projections for 2050

10.1093/ndt/gfaf177 · 2026 · External reference

KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease

10.1016/j.kint.2023.10.018 · 2024 · External reference

Use of glucose-lowering agents in diabetes and CKD

10.1016/j.ekir.2022.09.018 · 2022 · External reference

Pharmacological targeting of mitochondria in diabetic kidney disease

10.1124/pharmrev.122.000560 · 2023 · External reference

Combination therapy for kidney disease in people with diabetes mellitus

10.1038/s41581-024-00827-z · 2024 · External reference

Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis

10.1016/j.diabres.2022.109821 · 2022 · External reference

Metformin: Mechanisms in human obesity and weight loss

10.1007/s13679-019-00335-3 · 2019 · External reference

Molecular mechanisms and therapeutic targets for diabetic kidney disease

10.1016/j.kint.2022.05.012 · 2022 · External reference

Kidney disease in diabetes: From mechanisms to clinical presentation and treatment strategies

10.1016/j.metabol.2021.154890 · 2021 · External reference

Targeting inflammation to treat diabetic kidney disease: The road to 2030

10.1016/j.kint.2022.10.030 · 2023 · External reference

Glucose-responsive injectable hydrogel for enhanced sonodynamic-antibacterial cascade therapy of diabetic abscess

10.1002/adfm.202514543 · 2026 · External reference

Adaptive antioxidant nanomedicines inhibit ferroptosis in renal tubular epithelial cells to alleviate diabetic kidney disease

10.1002/advs.202505168 · 2025 · External reference

Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action

10.1016/j.phrs.2022.106481 · 2022 · External reference

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

10.1016/j.apsb.2020.12.020 · 2021 · External reference

Multiple target and regulatory pathways of berberine

10.1016/j.phymed.2025.157030 · 2025 · External reference

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

10.1016/j.phymed.2023.155258 · 2024 · External reference

Unveiling the therapeutic potential of berberine: Its therapeutic role and molecular mechanisms in kidney diseases

10.3389/fphar.2025.1549462 · 2025 · External reference

Berberine protects glomerular podocytes via inhibiting drp1-mediated mitochondrial fission and dysfunction

10.7150/thno.30640 · 2019 · External reference

Berberine protects against diabetic kidney disease via promoting PGC-1α-regulated mitochondrial energy homeostasis

10.1111/bph.14935 · 2020 · External reference

Time-dose response and mechanistic specificity of berberine in renal fibrosis from a multi-model integration perspective: A systematic review and meta-analysis on animal models

10.3389/fphar.2025.1600408 · 2025 · External reference

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: A double blinded placebo controlled randomized study

10.1080/19490976.2021.2003176 · 2022 · External reference

A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes

10.1038/s41467-021-25701-5 · 2021 · External reference

Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

10.1016/j.apsb.2022.12.010 · 2023 · External reference

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

10.1038/s41467-020-18414-8 · 2020 · External reference

Pharmacokinetics and pharmacological activities of berberine in diabetes mellitus treatment

10.1155/2021/9987097 · 2021 · External reference

Berberine: A review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases

10.3389/fphar.2021.762654 · 2021 · External reference

Acute toxicity of berberine and its correlation with the blood concentration in mice

10.1016/j.fct.2010.01.033 · 2010 · External reference

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches

10.1038/s41467-025-56223-z · 2025 · External reference

Ultrasmall polyphenol-NAD+ nanoparticle-mediated renal delivery for mitochondrial repair and anti-inflammatory treatment of AKI-to-CKD progression

10.1002/adma.202310731 · 2024 · External reference

Isoquercitrin alleviates diabetic nephropathy by inhibiting STAT3 phosphorylation and dimerization

10.1002/advs.202414587 · 2025 · External reference

Nano strategies for berberine delivery, a natural alkaloid of Berberis

10.1016/j.biopha.2018.05.067 · 2018 · External reference

Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics

10.1038/s41467-025-57488-0 · 2025 · External reference

Berberine and chlorogenic acid-assembled nanoparticles for highly efficient inhibition of multidrug-resistant Staphylococcus aureus

10.1016/j.jhazmat.2024.134680 · 2024 · External reference

State-of-the-art, insights, and perspectives for MOFs-nanocomposites and MOF-derived (nano)materials

10.1002/adma.202415399 · 2025 · External reference

Multi-bioactive poly(amino acid)-metal-organic framework nanocomposite for reinforced cascading photodynamic immunotherapy of cancer

10.1016/j.biomaterials.2025.123488 · 2026 · External reference

Synthetic polymers for drug, gene, and vaccine delivery

10.1021/polymscitech.5c00010 · 2025 · External reference

Immunologically effective chiral polymers to potentiate anti-cancer immune responses

10.1021/polymscitech.5c00110 · 2025 · External reference

Thermo-sensitive poly(amino acid) hydrogel mediates cytoprotection through an antioxidant mechanism

10.1016/j.cclet.2024.110433 · 2025 · External reference

Nanomaterials via ZIF-8: Preparations, catalytic and drug delivery applications

10.1016/j.cej.2025.160663 · 2025 · External reference

Lubricating and dual-responsive injectable hydrogels formulated from ZIF-8 facilitate osteoarthritis treatment by remodeling the microenvironment

10.1002/smll.202407885 · 2025 · External reference

Functional polymeric membrane materials: A perspective from versatile methods and modification to potential applications

10.1021/polymscitech.4c00030 · 2025 · External reference

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

10.1038/ncomms8240 · 2015 · External reference

A multifunctional injectable hydrogel for boosted diabetic wound healing assisted by Quercetin-ZIF system

10.1016/j.cej.2024.153425 · 2024 · External reference

Intelligent responsive zeolitic imidazolate framework-8@copper oxide nanocomposite 3D-printed scaffolds for efficient repair of infected bone defects

10.1021/acsnano.5c13201 · 2025 · External reference

Oral delivery systems of dietary bioactive compounds based on metal-organic frameworks: A review

10.1111/1541-4337.70272 · 2025 · External reference

Oral microbiota-responsive ZIF nanoplatform via double-layer glycans modified combined with PD-1 inhibitor for treatment of microsatellite-stable colorectal cancer

10.1016/j.mtbio.2025.102565 · 2025 · External reference

Zinc nanoparticles from oral supplements accumulate in renal tumours and stimulate antitumour immune responses

10.1038/s41563-024-02093-7 · 2025 · External reference

Hydrogel-encapsulated medium chain lipid-modified zeolite imidazole framework-90 as a promising platform for oral delivery of proteins

10.1016/j.jconrel.2024.01.014 · 2024 · External reference

Self-assembling metal-polyphenol-protein nanocomplex enhancing islet graft survival and transplantation outcome

10.1016/j.cej.2025.171188 · 2025 · External reference

Glutathione-induced in situ michael addition between nanoparticles for pyroptosis and immunotherapy

10.1002/anie.202301866 · 2023 · External reference

Robust injectable hydrogels for hemophilic arthropathy via anti-inflammation, iron removal and cartilage protection

10.1002/adfm.202500271 · 2025 · External reference

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

10.1007/s12274-022-4792-6 · 2023 · External reference

Innovations and challenges of polyphenol-based smart drug delivery systems

10.1007/s12274-022-4430-3 · 2022 · External reference

Versatile polyphenolic platforms in regulating cell biology

10.1039/d1cs01165k · 2022 · External reference

Polyphenolic platform ameliorated sanshool for skin photoprotection

10.1002/advs.202310012 · 2024 · External reference

Natural polyphenolic nanodots for Alzheimer's disease treatment

10.1002/adma.202308393 · 2024 · External reference

Visible light-responsive polyphenolic bio-glues for oral mucosal wound healing

10.1002/adfm.202408462 · 2024 · External reference

Polyphenols as a versatile component in tissue engineering

10.1016/j.actbio.2020.11.004 · 2021 · External reference

Sprayable self-assembled curcumin-metal-polyphenol nanomedicine with anti-inflammatory, ROS-scavenging and pro-angiogenesis effects for promoting diabetic wound healing

10.26599/nr.2025.94908001 · 2025 · External reference