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References from MXene-based hydrogel disrupts bacterial biofilms and reprograms immune cell metabolism via photothermal-electron transfer effects to reverse bone resorption in periodontitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
10.1038/s41577-020-00488-6 · 2021 · External reference
Oral hygiene behaviors and periodontitis among patients with chronic diseases and its impact on tooth loss and oral health-related quality of life: A cross-sectional study of data from the ComPaRe e-cohort
10.1007/s00784-024-05903-z · 2024 · External reference
An update on periodontal inflammation and bone loss
10.3389/fimmu.2024.1385436 · 2024 · External reference
Global, regional, and national burden of periodontal diseases from 1990 to 2021 and predictions to 2040: An analysis of the global burden of disease study 2021
10.3389/froh.2025.1627746 · 2025 · External reference
Fusobacterium nucleatum metabolically integrates commensals and pathogens in oral biofilms
10.1128/msystems.00170-22 · 2022 · External reference
Biochemistry of bacterial biofilm: Insights into antibiotic resistance mechanisms and therapeutic intervention
10.3390/life15010049 · 2025 · External reference
Regulating periodontal disease with smart stimuli-responsive systems: Antimicrobial activity, immunomodulation, periodontium regeneration
10.1016/j.mtbio.2025.101863 · 2025 · External reference
Biofilm removal from difficult-to-reach places via secondary cavitation within a constrained geometry mimicking a periodontal/peri-implant pocket
10.1016/j.ultsonch.2024.106832 · 2024 · External reference
The role of reactive oxygen species (ROS) in periodontitis: A potential therapeutic target
10.1002/iid3.70301 · 2025 · External reference
Periodontitis: From microbial immune subversion to systemic inflammation
10.1038/nri3785 · 2015 · External reference
Metabolic reprogramming shapes post-translational modification in macrophages
10.1016/j.mam.2025.101338 · 2025 · External reference
Glycolytic reprogramming in macrophage polarization: New horizons in the treatment of tumor diseases
10.1016/j.cellsig.2025.111940 · 2025 · External reference
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · 2013 · External reference
Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS
10.1016/j.apsb.2024.07.008 · 2024 · External reference
Mitochondrial dysfunction prevents repolarization of inflammatory macrophages
10.1016/j.celrep.2016.09.008 · 2016 · External reference
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway
10.1016/j.intimp.2023.110192 · 2023 · External reference
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
10.1038/s41467-024-54497-3 · 2024 · External reference
A new direction in periodontitis treatment: Biomaterial-mediated macrophage immunotherapy
10.1186/s12951-024-02592-4 · 2024 · External reference
Pro-inflammatory and anti-inflammatory interleukins in periodontitis: Molecular roles, immune crosstalk, and therapeutic perspectives
10.3390/ijms262010094 · 2025 · External reference
Improved synthesis of Ti3C2Tx MXenes resulting in exceptional electrical conductivity, high synthesis yield, and enhanced capacitance
10.1039/d0nr06671k · 2021 · External reference
Two-dimensional nanocrystals produced by exfoliation of Ti3 AlC2
10.1002/adma.201102306 · 2011 · External reference
Maximizing light-to-heat conversion of Ti3C2Tx MXene metamaterials with wrinkled surfaces for artificial actuators
10.1038/s41467-024-54802-0 · 2024 · External reference
A MXene-based nanothermal knife inhibits aggresome-mediated persister formation for preventing dental caries
10.1002/advs.202501501 · 2025 · External reference
MXenzyme-reinforced hydrogel enhances stem cell therapy through multidimensional regulation in rheumatoid arthritis management
10.1016/j.biomaterials.2025.123560 · 2026 · External reference
Electric pulse regulated MXene based nanozymes for integrative bioelectricity immuno-cancer therapy
10.1002/adfm.202420870 · 2025 · External reference
A plant-inspired long-lasting adhesive bilayer nanocomposite hydrogel based on redox-active Ag/tannic acid-cellulose nanofibers
10.1016/j.carbpol.2020.117508 · 2021 · External reference
Molecular design of heterogeneous electrocatalysts using tannic acid-derived metal-phenolic networks
10.1039/d1nr05901g · 2021 · External reference
Metal-phenolic network composites: From fundamentals to applications
10.1039/d3cs00273j · 2024 · External reference
Onion-mitochondria inhibit lipopolysaccharide-induced acute lung injury by shaping lung macrophage mitochondrial function
10.1002/advs.202506107 · 2025 · External reference
A NADH oxidase nanozyme restores redox homeostasis to ameliorate multi-organ aging and ischemic cardiomyopathy
10.34133/research.0973 · 2025 · External reference
Wisdom across interfaces: Adhesion mechanism and application potential of wet-adhesive hydrogel in periodontal tissue
10.1016/j.bioactmat.2025.09.047 · 2026 · External reference
Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review
10.1016/j.jconrel.2021.03.041 · 2021 · External reference
Hitchhiking delivery systems: Therapeutic hydrogels as advanced tools for immunomodulatory applications
10.1021/acs.chemrev.4c00923 · 2025 · External reference
Injectable responsive hydrogel with synergistic antibacterial and anti-inflammatory properties for enhanced periodontitis treatment
10.1186/s12951-025-03698-z · 2025 · External reference
NIR-driven GOx-like nanozyme-modified injectable thermoresponsive hydrogel for antibacterial therapy and bone regeneration in periodontitis
10.1016/j.cej.2025.160108 · 2025 · External reference
Photodynamic therapy combined with quaternized chitosan antibacterial strategy for instant and prolonged bacterial infection treatment
10.1016/j.carbpol.2024.123147 · 2025 · External reference
Engineered magneto-piezoelectric nanoparticles-enhanced scaffolds disrupt biofilms and activate oxidative phosphorylation in icam1+ macrophages for infectious bone defect regeneration
10.1021/acsnano.4c13562 · 2024 · External reference
Muscle-inspired MXene conductive hydrogels with anisotropy and low-temperature tolerance for wearable flexible sensors and arrays
10.1002/adfm.202105264 · 2021 · External reference
Nanoparticle-based drug delivery systems for non-surgical periodontal therapy: Innovations and clinical applications
10.1007/s13205-025-04443-x · 2025 · External reference
Advanced biomaterials for targeting mature biofilms in periodontitis therapy
10.1016/j.bioactmat.2025.02.026 · 2025 · External reference
The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering
10.1016/j.bioactmat.2025.03.009 · 2025 · External reference
Advances in local drug delivery for periodontal treatment: Present strategies and future directions
10.3390/biom15060903 · 2025 · External reference
Periodontal diseases
10.1038/nrdp.2017.38 · 2017 · External reference
Fusobacterium nucleatum: Ecology, pathogenesis and clinical implications
10.1038/s41579-025-01237-z · 2026 · External reference
Antibiotic resistance in human chronic periodontitis microbiota
10.1902/jop.2013.130142 · 2014 · External reference
Macrophages in immunoregulation and therapeutics
10.1038/s41392-023-01452-1 · 2023 · External reference
Pyruvate kinase M2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the Warburg effect in LPS-activated macrophages
10.1016/j.cmet.2014.12.005 · 2015 · External reference
Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment
10.1016/j.bioactmat.2025.09.030 · 2026 · External reference