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References from cCLT1-decorated nanodisk as a novel cancer-associated fibroblast-targeted curcumin delivery system for enhanced breast tumor metastasis treatment by TME remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Overall survival with pembrolizumab in early-stage triple-negative breast cancer
10.1056/nejmoa2409932 · 2024 · External reference
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: A randomized phase 3 trial
10.1038/s41591-023-02677-x · 2024 · External reference
Breast cancer metastasis: Markers and models
10.1038/nrc1670 · 2005 · External reference
Breast cancer statistics, 2013
10.3322/caac.21203 · 2014 · External reference
Breast cancer survivorship, quality of life, and late toxicities
10.3389/fonc.2020.00864 · 2020 · External reference
Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets
10.1016/j.semcancer.2019.08.012 · 2020 · External reference
Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery
10.1016/j.mtbio.2025.102180 · 2025 · External reference
Engineering precision nanoparticles for drug delivery
10.1038/s41573-020-0090-8 · 2021 · External reference
Form follows function: Nanoparticle shape and its implications for nanomedicine
10.1021/acs.chemrev.7b00194 · 2017 · External reference
Nanodiscs: A versatile nanocarrier platform for cancer diagnosis and treatment
10.1039/d1cs01074c · 2022 · External reference
Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions
10.1016/j.jconrel.2021.04.016 · 2021 · External reference
Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutes
10.1016/j.biomaterials.2004.09.015 · 2005 · External reference
Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers
10.1016/j.jconrel.2010.10.025 · 2011 · External reference
Recent advances in nanotechnology-based drug delivery systems for the diagnosis and treatment of reproductive disorders
10.1021/acsabm.3c01064 · 2024 · External reference
Designer vaccine nanodiscs for personalized cancer immunotherapy
10.1038/nmat4822 · 2017 · External reference
Melittin: A lytic peptide with anticancer properties
10.1016/j.etap.2013.06.009 · 2013 · External reference
RGD-modified lipid disks as drug carriers for tumor targeted drug delivery
10.1039/c5nr05577f · 2016 · External reference
Deformable discoidal polymeric nanoconstructs for the precise delivery of therapeutic and imaging agents
10.1016/j.ymthe.2017.02.012 · 2017 · External reference
Cancer-associated fibroblasts: How do they contribute to metastasis
10.1007/s10585-019-09959-0 · 2019 · External reference
A dual chemodrug-loaded hyaluronan nanogel for differentiation induction therapy of refractory AML via disrupting lysosomal homeostasis
10.1126/sciadv.ado3923 · 2025 · External reference
Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis
10.1158/0008-5472.can-13-1791 · 2013 · External reference
Role of the tumor microenvironment in cancer hallmarks and targeted therapy (review)
10.3892/ijo.2022.5471 · 2023 · External reference
Tumor microenvironment complexity and therapeutic implications at a glance
10.1186/s12964-020-0530-4 · 2020 · External reference
Tumor microenvironment pathways: Cross regulation in breast cancer metastasis
10.1016/j.gendis.2020.11.015 · 2022 · External reference
The biology and function of fibroblasts in cancer
10.1038/nrc.2016.73 · 2016 · External reference
Cancer-associated fibroblasts in the single-cell era
10.1038/s43018-022-00411-z · 2022 · External reference
Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy
10.1016/j.ebiom.2017.02.019 · 2017 · External reference
Cancer-associated fibroblasts: The chief architect in the tumor microenvironment
10.3389/fcell.2023.1089068 · 2023 · External reference
Cancer-associated fibroblasts: Tumorigenicity and targeting for cancer therapy
10.3390/cancers14163906 · 2022 · External reference
The implications of angiogenesis for the biology and therapy of cancer metastasis
10.1016/0092-8674(94)90187-2 · 1994 · External reference
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
10.1016/j.cell.2005.02.034 · 2005 · External reference
Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma
1993 · External reference
Revisiting the mystery of fibronectin multimers: The fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds
10.1016/j.matbio.2009.03.002 · 2009 · External reference
Plasma fibronectin as a marker for cancer and other diseases
10.1016/0002-9343(84)90366-8 · 1984 · External reference
Fibronectin at a glance
10.1242/jcs.00059 · 2002 · External reference
Cancer-associated fibroblasts in digestive tumors
10.3748/wjg.v20.i47.17804 · 2014 · External reference
In search of definitions: Cancer-associated fibroblasts and their markers
10.1002/ijc.32193 · 2020 · External reference
Cancer-associated fibroblast mimetic AIE probe for precision imaging-guided full-cycle management of ovarian cancer surgery
10.1021/acs.analchem.3c03164 · 2023 · External reference
CLT1 targets angiogenic endothelium through CLIC1 and fibronectin
10.1007/s10456-011-9247-8 · 2012 · External reference
Evaluation of CLT1-(Gd-DTPA) for MR molecular imaging in a mouse breast cancer model
2011 · External reference
A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI
10.1021/bc800211r · 2008 · External reference
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds
10.1073/pnas.0511219103 · 2006 · External reference
Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles
10.1016/j.biomaterials.2014.01.046 · 2014 · External reference
Cascade drug delivery through tumor barriers of pancreatic cancer via ultrasound in combination with functional microbubbles
10.1021/acsbiomaterials.2c00069 · 2022 · External reference
Cancer-associated fibroblast-targeted delivery of captopril to overcome penetration obstacles for enhanced pancreatic cancer therapy
10.1021/acsabm.2c00486 · 2022 · External reference
Luteolin and glycyrrhetinic exert cooperative effect on liver cancer by selfassembling into carrier-free nanostructures
10.1016/j.cclet.2025.111325 · 2025 · External reference
Reshaping prostate tumor microenvironment to suppress metastasis via cancer-associated fibroblast inactivation with peptide-assembly-based nanosystem
10.1021/acsnano.9b04857 · 2019 · External reference
Precision targeted cancer-associated fibroblast nano-regulator enhanced chemo-immunotherapy for triple-negative breast cancer
10.1016/j.biomaterials.2025.123679 · 2026 · External reference
Targeted reprogramming of vitamin B3 metabolism as a nanotherapeutic strategy towards chemoresistant cancers
10.1002/adma.202301257 · 2023 · External reference
Breaking physical barrier of fibrotic breast cancer for photodynamic immunotherapy by remodeling tumor extracellular matrix and reprogramming cancer-associated fibroblasts
10.1021/acsnano.4c01499 · 2024 · External reference
Androgen deprivation therapy for prostate cancer
10.1001/jama.294.2.238 · 2005 · External reference
Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines
10.1158/2326-6066.cir-14-0076 · 2014 · External reference
Nitric oxide-loaded bioinspired lipoprotein normalizes tumor vessels to improve intratumor delivery and chemotherapy of albumin-bound paclitaxel nanoparticles
10.1021/acs.nanolett.2c04312 · 2023 · External reference
Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
10.1007/s10456-011-9213-5 · 2011 · External reference
Vasculogenic mimicry formation in EBV-associated epithelial malignancies
10.1038/s41467-018-07308-5 · 2018 · External reference
Extracellular matrix in the tumor microenvironment and its impact on cancer therapy
10.3389/fmolb.2019.00160 · 2020 · External reference
10.1038/s41388-020-01499-2
10.1038/s41388-020-01499-2 · External reference
TGF-β1-activated cancer-associated fibroblasts promote breast cancer invasion, metastasis and epithelial-mesenchymal transition by autophagy or overexpression of FAP-α
10.1016/j.bcp.2021.114527 · 2021 · External reference
Nanomedicines for renal disease: Current status and future applications
10.1038/nrneph.2016.156 · 2016 · External reference
Disturbed flow-facilitated margination and targeting of nanodisks protect against atherosclerosis
10.1002/smll.202204694 · 2023 · External reference
Recent advances in nanotechnology-based drug delivery systems for the kidney
10.1016/j.jconrel.2020.02.027 · 2020 · External reference
Pre-metastatic niches: Organ-specific homes for metastases
10.1038/nrc.2017.6 · 2017 · External reference
A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived
10.1074/jbc.m611315200 · 2007 · External reference
Dynamic structure of plasma fibronectin
10.1080/10409238.2016.1184224 · 2016 · External reference
Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites
10.1073/pnas.0907518106 · 2009 · External reference
A DNA aptamer targeting cellular fibronectin rather than plasma fibronectin for bioimaging and targeted chemotherapy of tumors
10.1002/adfm.202205002 · 2022 · External reference