Research graph
References from Scientific Opinion on waiving of the dog studies in the regulatory process of agrochemicals approval. Local targets link to admitted publications; unresolved targets remain external evidence.
Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi‐laboratory study
10.1016/j.tiv.2019.05.019 · 2019 · External reference
Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration
2023 · External reference
Is the 90‐day dog study necessary for pesticide toxicity testing?
10.1080/10408444.2023.2221987 · 2023 · External reference
Species variation in the response of the cytochrome P‐450‐dependent monooxygenase system to inducers and inhibitors
10.3109/00498259009046835 · 1990 · External reference
Gastric emptying rate is inversely related to body weight in dog breeds of different sizes
10.1093/jn/134.8.2039s · 2004 · External reference
The dog as a second species for toxicology testing provides value to drug development
10.1177/10915818221125670 · 2022 · External reference
Use of the dog as non‐rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): Present status
10.1007/s00204-005-0678-0 · 2005 · External reference
High‐throughput PBTK models for in vitro to in vivo extrapolation
10.1080/17425255.2021.1935867 · 2021 · External reference
Estimating body surface area from mass and height: Theory and the formula of Du Bois and Du Bois
10.1080/03014460801908439 · 2008 · External reference
Implementing new approach methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European food safety authority
10.1016/j.tifs.2023.02.006 · 2023 · External reference
10.2903/sp.efsa.2013.en-413
10.2903/sp.efsa.2013.en-413 · External reference
A big data approach to the concordance of the toxicity of pharmaceuticals in animals and humans
10.1016/j.yrtph.2018.04.018 · 2018 · External reference
Differentiating spontaneous from drug‐induced vascular injury in the dog
10.1080/01926230390174904 · 2003 · External reference
Species differences in drug plasma protein binding
10.1039/c4md00148f · 2014 · External reference
Comparison of canine and human gastrointestinal physiology
10.1023/a:1016353705970 · 1986 · External reference
Unresolved reference
2023 · External reference
10.2903/j.efsa.2023.7790
10.2903/j.efsa.2023.7790 · External reference
10.2903/j.efsa.2025.9409
10.2903/j.efsa.2025.9409 · External reference
10.2903/j.efsa.2025.9814
10.2903/j.efsa.2025.9814 · External reference
10.2903/j.efsa.2021.6970
10.2903/j.efsa.2021.6970 · External reference
10.2903/j.efsa.2012.2579
10.2903/j.efsa.2012.2579 · External reference
10.2903/j.efsa.2017.4971
10.2903/j.efsa.2017.4971 · External reference
10.2903/j.efsa.2023.8312
10.2903/j.efsa.2023.8312 · External reference
10.2903/j.efsa.2022.7584
10.2903/j.efsa.2022.7584 · External reference
Emesis in dogs: A review
10.1111/j.1748-5827.2009.00820.x · 2010 · External reference
Unresolved reference
2025 · External reference
Commission regulation (EU) No 283/2013 of 1 march 2013 setting out the data requirements for active substances, in accordance with regulation (EC) No 1107/2009 of the European Parliament and of the council concerning the placing of plant protection products on the market
2013 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2005 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2011 · External reference
Gastric emptying of nondigestible solids in the fasted dog
10.1002/jps.2600760207 · 1987 · External reference
10.1002/jbt.23588
10.1002/jbt.23588 · External reference
Benchmark dose (BMD) modeling: Current practice, issues, and challenges
10.1080/10408444.2018.1430121 · 2018 · External reference
Interleukin‐6 activity in dogs with juvenile polyarteritis syndrome: Effect of corticosteroids
10.1016/0090-1229(95)90143-4 · 1995 · External reference
The application of allometric scaling principles to predict pharmacokinetic parameters across species
10.1517/17425255.2014.934671 · 2014 · External reference
Development of a dynamic physiologically based mechanistic kidney model to predict renal clearance
2018 · External reference
A retrospective analysis of developmental toxicity studies in rat and rabbit: What is the added value of the rabbit as an additional test species?
10.1016/j.yrtph.2007.11.007 · 2008 · External reference
Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development
2013 · External reference
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
10.1002/bdd.2510160502 · 1995 · External reference
Characterization of the GI transit conditions in beagle dogs with a telemetric motility capsule
10.1016/j.ejpb.2019.01.026 · 2019 · External reference
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogens
10.1289/ehp.98106633 · 1998 · External reference
A retrospective analysis of the added value of 1‐year dog studies in pesticide human health risk assessments
10.1080/10408444.2017.1290044 · 2017 · External reference
Species differences between mouse, rat, dog, monkey and human CYP‐mediated drug metabolism, inhibition and induction
10.1517/17425255.2.6.875 · 2006 · External reference
Factors influencing the gastric residence of dosage forms in dogs
10.1002/jps.21499 · 2009 · External reference
Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of P‐glycoprotein in dogs and cats
10.1016/j.cvsm.2011.12.005 · 2012 · External reference
Effect of size and density on canine gastric emptying of nondigestible solids
10.1016/0016-5085(85)90576-1 · 1985 · External reference
Importance of species selection in drug toxicity testing
10.1016/s0378-4274(98)00263-x · 1998 · External reference
10.1016/j.yrtph.2021.105029
10.1016/j.yrtph.2021.105029 · External reference
10.1016/j.cofs.2023.101091
10.1016/j.cofs.2023.101091 · External reference
Unresolved reference
1981 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
1998 · External reference
Unresolved reference
2006 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2018 · External reference
Unresolved reference
2020 · External reference
Unresolved reference
2021 · External reference
Unresolved reference
2025 · External reference
Evaluation of necessity of 1‐year toxicity study in dogs: Development of the new tiered approach for toxicity studies of pesticide considering species difference in toxicity profile and toxicity dose‐response
10.14252/foodsafetyfscj.2017023 · 2018 · External reference
Canine gastrointestinal physiology: Breed variations that can influence drug absorption
10.1016/j.ejpb.2015.09.009 · 2015 · External reference
Next generation physiologically based kinetic (NG‐PBK) models in support of regulatory decision making
10.1016/j.comtox.2018.11.002 · 2019 · External reference
10.2903/j.efsa.2022.e200923
10.2903/j.efsa.2022.e200923 · External reference
10.1016/j.yrtph.2020.104624
10.1016/j.yrtph.2020.104624 · External reference
Dose translation from animal to human studies revisited
10.1096/fj.07-9574lsf · 2008 · External reference
Unresolved reference
2004 · External reference
Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
10.1038/nrd2173 · 2007 · External reference
10.1016/j.envint.2023.108082
10.1016/j.envint.2023.108082 · External reference
Unresolved reference
1960 · External reference
Unresolved reference
1964 · External reference
To scale or not to scale: The principles of dose extrapolation
10.1111/j.1476-5381.2009.00267.x · 2009 · External reference
A review of the physiology of the canine digestive tract related to the development of in vitro systems
10.1079/nrr19980005 · 1998 · External reference
The seminiferous epithelium cycle and its duration in different breeds of dog (Canis familiaris)
10.1111/j.1469-7580.2009.01122.x · 2009 · External reference
Idiopathic canine polyarteritis in control beagle dogs from toxicity studies
10.4142/jvs.2004.5.2.147 · 2004 · External reference
Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in Swiss mice and beagle dogs erythrocytes
10.1023/a:1014853421871 · 2002 · External reference
Unresolved reference
1803 · External reference
Predictive value of animal models for human cytochrome P450 (CYP)‐mediated metabolism: A comparative study in vitro
10.1080/00498250701658312 · 2007 · External reference
All you need to know about allometric scaling: An integrative review on the theoretical basis, empirical evidence, and application in human pharmacology
10.1007/s40262-024-01444-6 · 2025 · External reference
Assessing toxicokinetic uncertainty and variability in risk prioritization
10.1093/toxsci/kfz205 · 2019 · External reference
Population PBPK modeling using parametric and nonparametric methods of the Simcyp simulator, and Bayesian samplers
2022 · External reference
International harmonization of nomenclature and diagnostic criteria (INHAND): Nonproliferative and proliferative lesions of the dog
10.1177/0192623320968181 · 2021 · External reference
10.1016/j.yrtph.2025.105863
10.1016/j.yrtph.2025.105863 · External reference
