Research graph
References from Radiation-Induced Senescence in Radiopharmaceutical Therapy: Mechanisms and Therapeutic Implications. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1056/nejmoa1607427
10.1056/nejmoa1607427 · External reference
10.1056/nejmoa2107322
10.1056/nejmoa2107322 · External reference
177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial
10.1016/s0140-6736(24)01653-2 · 2024 · External reference
10.1016/0014-4827(61)90192-6
10.1016/0014-4827(61)90192-6 · External reference
The molecular mechanisms in senescent cells induced by natural aging and ionizing radiation
10.3390/cells13060550 · 2024 · External reference
10.1158/2159-8290.cd-22-0523
10.1158/2159-8290.cd-22-0523 · External reference
10.1186/s13014-022-02184-2
10.1186/s13014-022-02184-2 · External reference
10.3892/or.2019.7209
10.3892/or.2019.7209 · External reference
10.7554/elife.67190
10.7554/elife.67190 · External reference
Why senescent cells are resistant to apoptosis: an insight for senolytic development
10.3389/fcell.2022.822816 · 2022 · External reference
Harnessing senescence for antitumor immunity to advance cancer treatment
10.1667/rade-24-00098.1 · 2024 · External reference
10.1016/j.semradonc.2020.07.002
10.1016/j.semradonc.2020.07.002 · External reference
DNA damage by radiopharmaceuticals and mechanisms of cellular repair
10.3390/pharmaceutics15122761 · 2023 · External reference
Heterogeneity of dose distribution in normal tissues in case of radiopharmaceutical therapy with alpha-emitting radionuclides
10.1007/s00411-022-01000-5 · 2022 · External reference
10.2967/jnumed.123.265523
10.2967/jnumed.123.265523 · External reference
Dosimetric analysis of the short-ranged particle emitter 161Tb for radionuclide therapy of metastatic prostate cancer
10.3390/cancers13092011 · 2021 · External reference
10.1038/s41573-020-0073-9
10.1038/s41573-020-0073-9 · External reference
High and low LET radiation differentially induce normal tissue damage signals
10.1016/j.ijrobp.2011.09.057 · 2012 · External reference
Radionuclides for targeted therapy: physical properties
10.3390/molecules27175429 · 2022 · External reference
10.1007/s004110050135
10.1007/s004110050135 · External reference
In silico assessment of cellular damage from Lu-177, Ac-225, and Pb-212 therapeutic radionuclides
10.1002/mp.70089 · 2025 · External reference
10.1186/2041-9414-4-1
10.1186/2041-9414-4-1 · External reference
Comet assay analysis of DNA strand breaks after exposure to the DNA-incorporated Auger electron emitter iodine-125
10.1080/09553002.2020.1851059 · 2023 · External reference
10.1084/jem.20232136
10.1084/jem.20232136 · External reference
10.1016/b978-0-12-803309-8.00015-x
10.1016/b978-0-12-803309-8.00015-x · External reference
Relationship between p53 status and the bioeffect of ionizing radiation
10.3892/ol.2021.12922 · 2021 · External reference
Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
10.1186/s13578-022-00941-0 · 2022 · External reference
Cell senescence and the DNA single-strand break damage repair pathway
2024 · External reference
10.1038/ncomms10399
10.1038/ncomms10399 · External reference
The combination of radiation with PARP inhibition enhances senescence and sensitivity to the senolytic, navitoclax, in triple negative breast tumor cells
10.3390/biomedicines11113066 · 2023 · External reference
10.1158/1535-7163.mct-11-0061
10.1158/1535-7163.mct-11-0061 · External reference
10.1158/0008-5472.can-09-4224
10.1158/0008-5472.can-09-4224 · External reference
Comparable senescence induction in three-dimensional human cartilage model by exposure to therapeutic doses of x-rays or C-ions
10.1016/j.ijrobp.2016.02.014 · 2016 · External reference
10.1136/jitc-2024-sitc2024.1009
10.1136/jitc-2024-sitc2024.1009 · External reference
Chronic low dose rate ionizing radiation exposure induces premature senescence in human fibroblasts that correlates with up regulation of proteins involved in protection against oxidative stress
10.3390/proteomes2030341 · 2014 · External reference
10.1038/sj.bjc.6603775
10.1038/sj.bjc.6603775 · External reference
10.1002/pmic.201200463
10.1002/pmic.201200463 · External reference
10.1158/1078-0432.ccr-19-1440
10.1158/1078-0432.ccr-19-1440 · External reference
10.1038/s41418-024-01417-z
10.1038/s41418-024-01417-z · External reference
Multiple facets of p53 in senescence induction and maintenance
10.1111/cas.13060 · 2016 · External reference
Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
10.3389/fcell.2021.645593 · 2021 · External reference
10.1126/science.abb3420
10.1126/science.abb3420 · External reference
Immunosenescence: molecular mechanisms, diseases, and therapeutic innovations
10.1002/mco2.70515 · 2025 · External reference
10.1111/febs.16350
10.1111/febs.16350 · External reference
10.1093/jnci/djab064
10.1093/jnci/djab064 · External reference
Senolytic cocktail dasatinib plus quercetin enhances the antitumor effect of senescence-inducing radiotherapy in a preclinical model of melanoma
10.1016/j.ijrobp.2021.07.146 · 2021 · External reference
10.1038/s41598-021-94259-5
10.1038/s41598-021-94259-5 · External reference
Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax
2021 · External reference
Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc638N/+ mice
10.18632/aging.206183 · 2025 · External reference
Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice
10.7554/elife.75492 · 2022 · External reference
10.1667/rr2727.1
10.1667/rr2727.1 · External reference
Imaging DNA damage response by gammaH2AX in vivo predicts treatment response to lutetium-177 radioligand therapy and suggests senescence as a therapeutically desirable outcome
10.7150/thno.82101 · 2023 · External reference
A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy
10.1016/j.xcrm.2023.100960 · 2023 · External reference
10.1126/scitranslmed.abb3631
10.1126/scitranslmed.abb3631 · External reference
Immunomodulatory effects of alpha vs beta radiopharmaceutical therapy in murine prostate cancer
10.3389/fimmu.2025.1563387 · 2025 · External reference
Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice
10.1038/s41467-026-68834-1 · 2026 · External reference
Salivary gland toxicity of PSMA-targeted radioligand therapy with 177Lu-PSMA and combined 225Ac- and 177Lu-Labeled PSMA ligands (TANDEM-PRLT) in advanced prostate cancer: a single-center systematic investigation
10.3390/diagnostics12081926 · 2022 · External reference
Targeted alpha therapy in mCRPC (metastatic castration-resistant prostate cancer) patients: predictive dosimetry and toxicity modeling of 225Ac-PSMA (prostate-specific membrane antigen)
10.3389/fonc.2020.531660 · 2020 · External reference
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
10.1038/s41419-020-03074-9 · 2020 · External reference
10.2967/jnumed.120.261016
10.2967/jnumed.120.261016 · External reference
Targeting senescence with radioactive 223Ra/Ba SAzymes enables senolytics-unlocked one-two punch strategy to boost anti-tumor immunotherapy
10.1016/j.biomaterials.2024.122915 · 2025 · External reference
Radiation induced senescence limits radiopharmaceutical therapy efficacy in murine models of GU cancers
2025 · External reference
10.1016/j.cell.2024.05.059
10.1016/j.cell.2024.05.059 · External reference
