Research graph
References from Neuroinflammatory PET in Epilepsy: Prospects for Epileptogenic Zone Localization and Presurgical Planning. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1056/nejm200002033420503
10.1056/nejm200002033420503 · External reference
10.1111/epi.17194
10.1111/epi.17194 · External reference
10.1212/wnl.0000000000209304
10.1212/wnl.0000000000209304 · External reference
10.1227/neu.0b013e31827d1161
10.1227/neu.0b013e31827d1161 · External reference
10.1016/j.nbd.2023.106249
10.1016/j.nbd.2023.106249 · External reference
10.1038/s41582-022-00727-5
10.1038/s41582-022-00727-5 · External reference
10.3389/fnins.2023.1217451
10.3389/fnins.2023.1217451 · External reference
‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy
10.1093/brain/awac293 · 2023 · External reference
Neuroinflammation and epilepsy: from pathophysiology to therapies based on repurposing drugs
10.3390/ijms25084161 · 2024 · External reference
10.1016/j.bcp.2021.114786
10.1016/j.bcp.2021.114786 · External reference
10.1111/j.1552-6569.2010.00572.x
10.1111/j.1552-6569.2010.00572.x · External reference
10.1111/epi.15967
10.1111/epi.15967 · External reference
TSPO‐PET in pre‐surgical evaluations: correlation of neuroinflammation and SEEG epileptogenicity mapping in drug‐resistant focal epilepsy
10.1111/epi.18182 · 2025 · External reference
Exploring the role of TSPO-PET imaging among MRI-negative patients with temporal lobe epilepsy: from the perspective of heterogeneity
10.3390/brainsci16020246 · 2026 · External reference
10.1038/s41467-023-40937-z
10.1038/s41467-023-40937-z · External reference
10.2967/jnumed.110.079459
10.2967/jnumed.110.079459 · External reference
Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein
10.1001/jamaneurol.2015.0941 · 2015 · External reference
[18F]DPA-714 PET imaging in the presurgical evaluation of patients with drug-resistant focal epilepsy
10.1212/wnl.0000000000207811 · 2023 · External reference
Emerging translocator protein-positron emission tomographic imaging improves detection of focal cortical dysplasia
10.1111/epi.18351 · 2025 · External reference
10.1073/pnas.79.20.6385
10.1073/pnas.79.20.6385 · External reference
10.1371/journal.pone.0001616
10.1371/journal.pone.0001616 · External reference
TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy
10.1016/j.nicl.2021.102701 · 2021 · External reference
10.1038/jcbfm.2014.55
10.1038/jcbfm.2014.55 · External reference
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
10.1186/s12974-023-02749-2 · 2023 · External reference
Astrogliosis marker 11C-SL25.1188 PET in traumatic brain injury with persistent symptoms
10.1093/brain/awad279 · 2023 · External reference
10.2967/jnumed.120.244400
10.2967/jnumed.120.244400 · External reference
Characterization of the expression of the ATP-gated P2X7 receptor following status epilepticus and during epilepsy using a P2X7-EGFP reporter mouse
10.1007/s12264-020-00573-9 · 2020 · External reference
Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers
10.1186/s41181-025-00345-8 · 2025 · External reference
10.3389/fncel.2022.1047928
10.3389/fncel.2022.1047928 · External reference
10.1016/j.bmc.2010.05.058
10.1016/j.bmc.2010.05.058 · External reference
10.1177/0271678x16685105
10.1177/0271678x16685105 · External reference
Synthesis and preliminary biological evaluation of [11C]methyl (2-amino-5-(benzylthio)thiazolo[4,5-D]pyrimidin-7-yl)-D-leucinate for the fractalkine receptor (CX3CR1)
10.1016/j.bmcl.2017.04.052 · 2017 · External reference
10.1016/j.nbd.2014.11.009
10.1016/j.nbd.2014.11.009 · External reference
[18F]JHU16907 for PET imaging of MER tyrosine kinase (MERTK)
2017 · External reference
10.3390/molecules27051689
10.3390/molecules27051689 · External reference
Unresolved reference
External reference
40. Novel pet ligand [18F]PF974 can measure inflammatory activation of phosphodiesterase-4B (PDE4B) in rat brain [abstract]
10.1016/j.biopsych.2023.02.280 · 2023 · External reference
10.1021/cn2000525
10.1021/cn2000525 · External reference
Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020
10.1186/s41181-025-00338-7 · 2025 · External reference
10.1002/syn.21541
10.1002/syn.21541 · External reference
Synthesis and evaluation of [18F]RAGER: a first generation small-molecule PET radioligand targeting the receptor for advanced glycation endproducts
10.1021/acschemneuro.5b00319 · 2016 · External reference
Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE)
10.1016/j.jpha.2020.07.009 · 2020 · External reference
Radiolabeling of [11C]FPS-ZM1, a receptor for advanced glycation end products-targeting positron emission tomography radiotracer, using a [11C]CO2-to-[11C]CO chemical conversion
10.4155/fmc-2019-0329 · 2020 · External reference
Synthesis and evaluation of [11C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)
10.1016/j.nucmedbio.2014.03.025 · 2014 · External reference
In vivo imaging and kinetic modeling of novel glycogen synthase kinase-3 radiotracers [11C]OCM-44 and [18F]OCM-50 in non-human primates
10.3390/ph16020194 · 2023 · External reference
Discovery of [11C]PF-367 for neuroimaging of glycogen synthase kinase 3
2015 · External reference
Radiosynthesis and in vivo evaluation of [11C]A1070722, a high affinity GSK-3 PET tracer in primate brain
10.1021/acschemneuro.6b00376 · 2017 · External reference
10.2967/jnumed.112.116228
10.2967/jnumed.112.116228 · External reference
Monoamine oxidase B in astrocytic GABA synthesis: a central mechanism in neurodegeneration and neuroinflammation
10.33696/signaling.6.134 · 2025 · External reference
Positron emission tomography with [11C]deuterium-deprenyl in temporal lobe epilepsy
10.1111/j.1528-1157.1995.tb01051.x · 1995 · External reference
Ex vivo characterization of neuroinflammatory and neuroreceptor changes during epileptogenesis using candidate positron emission tomography biomarkers
10.1111/epi.16353 · 2019 · External reference
The Multifaceted role of P2X7R in microglia and astrocytes
10.1007/s11064-025-04502-y · 2025 · External reference
Increased expression of the P2X7 receptor in temporal lobe epilepsy: animal models and clinical evidence
2019 · External reference
More than a drug target: Purinergic signalling as a source for diagnostic tools in epilepsy
10.1016/j.neuropharm.2022.109303 · 2023 · External reference
Longitudinal positron emission tomography imaging with P2X7 receptor-specific radioligand 18F-FTTM in a kainic acid rat model of temporal lobe epilepsy
10.1021/acschemneuro.2c00557 · 2022 · External reference
Increased uptake of the P2X7 receptor radiotracer 18F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice
10.1111/epi.17484 · 2023 · External reference
10.1111/epi.16956
10.1111/epi.16956 · External reference
Spatiotemporal transcriptomic mapping reveals region-specific glial activation and astrocyte shifts in epileptogenesis beyond the hippocampus
10.1186/s40478-026-02224-y · 2026 · External reference
10.1073/pnas.1812155116
10.1073/pnas.1812155116 · External reference
First-in-human healthy volunteer dosimetry studies of the excitatory amino acid transporter 2 (EAAT2) PET imaging tracer methyl N4-(7-[18F]fluoro-9H-fluoren-2-yl)asparaginate, [18F]RP-115
10.1016/j.nucmedbio.2025.108992 · 2025 · External reference
Spotlight on P2X7 receptor PET imaging: a bright target or a failing star?
10.3390/ijms24021374 · 2023 · External reference
[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers
10.1007/s00259-019-04369-6 · 2019 · External reference
10.3390/ijms22010019
10.3390/ijms22010019 · External reference
Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer
10.1016/j.nucmedbio.2011.09.005 · 2012 · External reference
Synthesis, biodistribution and in vitro evaluation of brain permeable high affinity type 2 cannabinoid receptor agonists [11C]MA2 and [18F]MA3
10.3389/fnins.2016.00431 · 2016 · External reference
Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease
10.1016/j.ejmech.2021.113822 · 2021 · External reference
10.2967/jnumed.122.263838
10.2967/jnumed.122.263838 · External reference
