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References from Role of Notch signaling pathway in joint homeostasis and osteoarthritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration
10.3390/jdb3040177 · 2015 · External reference
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
10.1074/jbc.m707000200 · 2008 · External reference
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
10.1016/j.cell.2009.03.025 · 2009 · External reference
Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice
10.1038/s41368-023-00240-5 · 2023 · External reference
Notch signalling in alveolar bone development and regeneration: a critical regulator for osteoblasts to osteocytes transitioning
10.1016/j.dtrs.2026.100025 · 2026 · External reference
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α
10.1016/j.jbc.2023.105372 · 2023 · External reference
NOTCH2 disrupts the synovial fibroblast identity and the inflammatory response of epiphyseal chondrocytes
10.1016/j.jbc.2025.110206 · 2025 · External reference
Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3beta) and NF-kappaB/p65 signalling
10.1371/journal.pone.0186764 · 2017 · External reference
MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
10.1038/s41467-023-41858-7 · 2023 · External reference
Osteoarthritis: a complicated joint disease requiring extensive studies with multiple approaches
10.1016/j.jot.2022.02.009 · 2022 · External reference
Mesenchymal stem cells in arthritic diseases
10.1186/ar2514 · 2008 · External reference
Notch signaling in skeletal stem cells
10.1007/s00223-013-9773-z · 2014 · External reference
HIF-1-VEGF-Notch mediates angiogenesis in temporomandibular joint osteoarthritis
2019 · External reference
Noncanonical NF-κB signaling pathway in liver diseases
10.14218/jcth.2020.00063 · 2021 · External reference
YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis
10.1016/j.intimp.2023.110438 · 2023 · External reference
Engineering of MSC-derived exosomes: a promising cell-free therapy for osteoarthritis
10.3390/membranes12080739 · 2022 · External reference
Fetal cartilage-derived cells have stem cell properties and are a highly potent cell source for cartilage regeneration
10.3727/096368915x688641 · 2016 · External reference
ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage
10.1177/002215540104900910 · 2001 · External reference
Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: from predictive fiction toward reality
10.3389/fmed.2022.992386 · 2022 · External reference
Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation
10.1242/dev.126.5.987 · 1999 · External reference
Engineering approaches for RNA-based and cell-based osteoarthritis therapies
10.1038/s41584-023-01067-4 · 2024 · External reference
Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1
10.1515/biol-2020-0058 · 2020 · External reference
WNT and NOTCH signaling in human trophoblast development and differentiation
10.1007/s00018-022-04285-3 · 2022 · External reference
Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development
10.1002/jcp.24045 · 2012 · External reference
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
10.1242/dev.042911 · 2010 · External reference
Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression
10.1186/s12964-019-0443-2 · 2019 · External reference
NOTCHing the bone: insights into multi-functionality
10.1016/j.bone.2009.05.027 · 2010 · External reference
Dimorphic effects of Notch signaling in bone homeostasis
10.1038/nm1712 · 2008 · External reference
Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway
10.1038/s41388-019-0704-y · 2019 · External reference
Signalling interaction between β-catenin and other signalling molecules during osteoarthritis development
10.1111/cpr.13600 · 2024 · External reference
Notch signaling in chondrogenesis
10.1016/s1937-6448(09)75003-8 · 2006 · External reference
Involvement of notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures
10.1007/s00774-005-0671-y · 2006 · External reference
Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
10.1136/annrheumdis-2012-201978 · 2013 · External reference
The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
10.1186/s13619-020-00072-2 · 2021 · External reference
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
10.1136/ard.2008.098764 · 2008 · External reference
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
10.1111/j.1749-6632.2009.05240.x · 2010 · External reference
Colocalization of β-catenin with notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation
10.1007/s11010-014-2163-7 · 2014 · External reference
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site
10.1002/art.23730 · 2008 · External reference
Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis
10.1186/ar2719 · 2009 · External reference
Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation
10.1038/cdd.2011.114 · 2012 · External reference
Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders
10.1186/s13287-024-04011-9 · 2024 · External reference
The distribution of Notch receptors and their ligands during articular cartilage development
10.1046/j.1469-7580.2003.00185.x · 2003 · External reference
Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models
10.3390/biology9080194 · 2020 · External reference
The role of the cartilage matrix in osteoarthritis
10.1038/nrrheum.2010.198 · 2011 · External reference
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
10.1038/nm1716 · 2008 · External reference
Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation
10.1002/jcp.21879 · 2009 · External reference
Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development
10.1073/pnas.1207458110 · 2013 · External reference
Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
10.1136/annrheumdis-2020-218089 · 2021 · External reference
Nanoparticle-Mediated inhibition of notch signaling promotes mitochondrial biogenesis and reduces subcutaneous adipose tissue expansion in pigs
10.1016/j.isci.2020.101167 · 2020 · External reference
HSF1 increases EOGT-mediated glycosylation of Notch1 to promote IL-1β-Induced inflammatory injury of chondrocytes
10.1177/19476035241229211 · 2025 · External reference
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors
10.1126/science.1242366 · 2013 · External reference
Subchondral bone and cartilage disease: a rediscovered functional unit
10.1097/00004424-200010000-00004 · 2000 · External reference
ADAM-10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis
10.1002/art.37755 · 2013 · External reference
Molecular mechanisms of chondrocyte hypertrophy mediated by physical cues and therapeutic strategies in osteoarthritis
10.3390/ijms27020624 · 2026 · External reference
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
10.1038/nrrheum.2010.196 · 2011 · External reference
Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis
10.1159/000121610 · 2008 · External reference
HES1 and HES5 are dispensable for cartilage and endochondral bone formation
10.1159/000280416 · 2010 · External reference
Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway
10.1002/term.3149 · 2021 · External reference
Cartilage-specific RBPjκ-dependent and -independent notch signals regulate cartilage and bone development
10.1242/dev.070649 · 2012 · External reference
Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9
10.1038/boneres.2015.21 · 2015 · External reference
Notch signaling regulates the chondrogenic potential of both articular chondrocytes and their progenitors during expansion
10.1093/stmcls/sxad031 · 2023 · External reference
Notch post-translationally regulates β-catenin protein in stem and progenitor cells
10.1038/ncb2313 · 2011 · External reference
Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes
10.1016/0167-4889(90)90145-4 · 1990 · External reference
Acute synovitis after trauma precedes and is associated with osteoarthritis onset and progression
10.7150/ijbs.39015 · 2020 · External reference
A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6
10.1016/j.jaut.2016.10.008 · 2017 · External reference
A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis
10.1126/scisignal.aaa3792 · 2015 · External reference
Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance
10.1016/j.joca.2015.10.015 · 2016 · External reference
Suppressing mesenchymal stem cell hypertrophy and endochondral ossification in 3D cartilage regeneration with nanofibrous poly(l-lactic acid) scaffold and matrilin-3
10.1016/j.actbio.2018.06.027 · 2018 · External reference
Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: mechanisms and perspectives
10.1016/j.biopha.2023.115884 · 2023 · External reference
Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: a new paradigm in cartilage repair
10.1002/jor.24136 · 2019 · External reference
Maintenance of bone homeostasis by DLL1-Mediated notch signaling
10.1002/jcp.25647 · 2017 · External reference
The roles of signaling pathways in bone repair and regeneration
10.1002/jcp.26042 · 2018 · External reference
Mesenchymal stem cells for cartilage regeneration: insights into molecular mechanism and therapeutic strategies
10.1016/j.tice.2024.102380 · 2024 · External reference
Hippo signaling is required for notch-dependent smooth muscle differentiation of neural crest
10.1242/dev.125807 · 2015 · External reference
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
10.1038/nrrheum.2012.80 · 2012 · External reference
Recent advances in intra-articular drug delivery systems for osteoarthritis therapy
10.1016/j.drudis.2018.05.023 · 2018 · External reference
Gene expression and chondrogenic potential of cartilage cells: osteoarthritis grade differences
10.3390/ijms231810610 · 2022 · External reference
Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development
10.1073/pnas.0902306106 · 2009 · External reference
RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance
10.1002/art.38076 · 2013 · External reference
Notch1 upregulates LPS‐induced macrophage activation by increasing NF‐κB activity
10.1002/eji.200838722 · 2009 · External reference
Exploring the full spectrum of macrophage activation
10.1038/nri2448 · 2008 · External reference
Dynamic ligand discrimination in the notch signaling pathway
10.1016/j.cell.2018.01.002 · 2018 · External reference
Learn, simplify and implement: developmental re-engineering strategies for cartilage repai
10.4414/smw.2016.14346 · 2016 · External reference
Notch signaling during chondrogenesis of human bone marrow stem cells
10.1016/j.bone.2009.04.242 · 2010 · External reference
Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis
10.1634/stemcells.2007-0806 · 2008 · External reference
Matrix remodeling during endochondral ossification
10.1016/j.tcb.2003.12.003 · 2004 · External reference
Off the beaten pathway: the complex cross talk between Notch and NF-kappaB
10.1038/labinvest.3700700 · 2008 · External reference
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
10.1128/mcb.18.4.2077 · 1998 · External reference
Notch signaling: its essential roles in bone and craniofacial development
10.1016/j.gendis.2020.04.006 · 2021 · External reference
Notch signaling is activated by TLR stimulation and regulates macrophage functions
10.1002/eji.200636999 · 2007 · External reference
Type H blood vessels in bone modeling and remodeling
10.7150/thno.34126 · External reference
The NF-κB signaling pathway, the Microbiota, and gastrointestinal tumorigenesis: recent advances
10.3389/fimmu.2020.01387 · External reference
Unresolved reference
2026 · External reference
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments
10.4049/jimmunol.174.9.5781 · 2005 · External reference
The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression
10.3390/ijms21072358 · 2020 · External reference
The notch intracellular domain can function as a coactivator for LEF-1
10.1128/mcb.21.22.7537-7544.2001 · 2001 · External reference
Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage
10.1038/nmat2116 · 2008 · External reference
Notch regulates fibrocartilage stem cell fate and is upregulated in inflammatory TMJ arthritis
10.1177/0022034520924656 · 2020 · External reference
Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage
10.1038/322547a0 · 1986 · External reference
Effects of an experimental arthritis on the sensory properties of fine articular afferent units
10.1152/jn.1985.54.5.1109 · 1985 · External reference
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
10.1074/jbc.m307757200 · 2003 · External reference
Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis
10.1002/art.38743 · 2014 · External reference
Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest
10.1038/srep25594 · 2016 · External reference
Notch1 augments NF-kappaB activity by facilitating its nuclear retention
10.1038/sj.emboj.7600902 · 2006 · External reference
Effects of cartilage progenitor cells and microRNA-140 on repair of osteoarthritic cartilage injury
10.7507/1002-1892.201806060 · 2019 · External reference
Notch signaling in development, tissue homeostasis, and disease
10.1152/physrev.00005.2017 · 2017 · External reference
The basic science of articular cartilage: structure, composition, and function
10.1177/1941738109350438 · 2009 · External reference
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage
10.1002/art.24857 · 2009 · External reference
Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells
10.1016/s0945-053x(02)00003-3 · 2002 · External reference
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases
10.1186/1471-2474-15-93 · 2014 · External reference
Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair
10.1038/s12276-018-0151-9 · 2018 · External reference
Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis
10.1136/ard.2006.063354 · 2007 · External reference
Degradome expression profiling in human articular cartilage
10.1186/ar2741 · 2009 · External reference
MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression
10.1016/j.lfs.2016.02.031 · 2016 · External reference
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
10.1016/j.semcdb.2016.11.008 · 2017 · External reference
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
10.1053/joca.2001.0427 · 2001 · External reference
Crosstalk between YAP/TAZ and notch signaling
10.1016/j.tcb.2018.03.001 · 2018 · External reference
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma
10.1053/j.gastro.2013.02.009 · 2013 · External reference
Physiological notch signaling maintains bone homeostasis via RBPjk and hey upstream of NFATc1
10.1371/journal.pgen.1002577 · 2012 · External reference
NOTCH signaling is essential for maturation, self‐renewal, and tri‐differentiation of in vitro derived human neural stem cells
10.1089/cell.2017.0009 · 2017 · External reference
Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint
10.1016/j.archoralbio.2008.04.004 · 2008 · External reference
Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis
10.1093/rheumatology/keq188 · 2010 · External reference
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
10.1016/j.joca.2024.12.002 · 2025 · External reference
Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis
10.3389/fimmu.2022.967193 · 2022 · External reference
Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj
10.1016/j.bbrc.2010.07.133 · 2010 · External reference
Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating notch signaling pathway in osteoarthritis
10.1177/1535370215587918 · 2015 · External reference
MiR-145 targeting BNIP3 reduces apoptosis of chondrocytes in osteoarthritis through notch signaling pathway
10.26355/eurrev_202008_22622 · 2020 · External reference
The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis
10.1186/s12964-025-02584-3 · 2025 · External reference
Suppression of differentiation and proliferation of early chondrogenic cells by Notch
10.1007/s00774-003-0428-4 · 2003 · External reference
Notch signalling drives synovial fibroblast identity and arthritis pathology
10.1038/s41586-020-2222-z · 2020 · External reference
The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis
10.1155/2014/561459 · 2014 · External reference
Notch signaling regulates MMP-13 expression via Runx2 in chondrocytes
10.1038/s41598-019-52125-5 · 2019 · External reference
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
10.1038/ni.2304 · 2012 · External reference
Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes
10.1016/j.yexcr.2009.03.008 · 2009 · External reference
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
10.1083/jcb.153.1.35 · 2001 · External reference
Down-regulation of microRNA-23b aggravates LPS-induced inflammatory injury in chondrogenic ATDC5 cells by targeting PDCD4
10.22038/ijbms.2018.25856.6364 · 2018 · External reference
MiR-9 facilitates cartilage regeneration of osteoarthritis in rabbits through regulating Notch signaling pathway
10.26355/eurrev_201906_18168 · 2019 · External reference
Another notch in the Belt of rheumatoid arthritis
10.1002/art.42937 · 2024 · External reference
Notch signaling and the skeleton
10.1210/er.2016-1002 · 2016 · External reference
NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB
10.1172/jci68901 · 2014 · External reference
Progress in the use of mesenchymal stromal cells for osteoarthritis treatment
10.1016/j.jcyt.2021.01.008 · 2021 · External reference
Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
10.1038/nm.3143 · 2013 · External reference
DAPT mitigates osteoarthritic cartilage degeneration and enhances articular repair through targeted modulation of the Gucy1a3 and notch signaling axis
10.2147/dddt.s599941 · 2026 · External reference
Correlation between gene expression and osteoarthritis progression in human
10.3390/ijms17071126 · 2016 · External reference
Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis
10.1016/j.jot.2021.11.002 · External reference
Notch signaling pathway: architecture, disease, and therapeutics
10.1038/s41392-022-00934-y · External reference
Notch signaling in skeletal development, homeostasis and pathogenesis
10.3390/biom10020332 · 2020 · External reference
