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References from Milk-derived extracellular vesicles in cardiovascular therapy: emerging biological functions and therapeutic perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Exosomes with immune modulatory features are present in human breast milk
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Milk-derived exosomes for oral delivery of paclitaxel
10.1016/j.nano.2017.03.001 · 2017 · External reference
Characterization of extracellular vesicles from fresh vs. frozen human milk including the vesicular microRNA cargo
10.1002/jex2.70092 · 2025 · External reference
Inflammation in atherosclerosis: pathophysiology and mechanisms
10.1038/s41419-024-07166-8 · 2024 · External reference
Endothelial cell dysfunction in cardiac disease: driver or consequence?
10.3389/fcell.2023.1278166 · 2023 · External reference
Extracellular vesicle measurements with nanoparticle tracking analysis - an accuracy and repeatability comparison between NanoSight NS300 and ZetaView
10.1080/20013078.2019.1596016 · 2019 · External reference
Milk-Derived extracellular vesicles: a novel perspective on comparative therapeutics and targeted nanocarrier application
10.3390/vaccines12111282 · 2024 · External reference
The potential of exosomes from cow milk for oral delivery
10.1016/j.xphs.2018.11.022 · 2019 · External reference
Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography
10.1080/20013078.2017.1294340 · 2017 · External reference
Protein and lipid content of milk extracellular vesicles: a comparative overview
10.3390/life13020401 · 2023 · External reference
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications
10.1016/j.addr.2021.04.027 · 2021 · External reference
Which casein micelle removal method is suitable for studies of human milk extracellular vesicles? A systematic comparison of four different treatments for casein depletion before extracellular vesicle isolation from human milk
10.20517/evcna.2024.02 · 2024 · External reference
Human breast milk extracellular vesicles mitigate endothelial dysfunction
10.3390/nu17182953 · 2025 · External reference
Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences
10.1093/eurheartj/eht295 · 2013 · External reference
Current experimental and early investigational agents for cardiac fibrosis: where are we at?
10.1080/13543784.2024.2326024 · 2024 · External reference
Detection and characterization of extracellular vesicles by transmission and cryo-transmission electron microscopy
10.1007/978-1-4939-7253-1_18 · 2017 · External reference
A brief review on recent advances in diagnostic and therapeutic applications of extracellular vesicles in cardiovascular disease
10.1016/j.biocel.2024.106616 · 2024 · External reference
Fluorescent labeling of extracellular vesicles
10.1016/bs.mie.2020.09.002 · 2020 · External reference
Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-Based therapy
10.3390/ijms22031105 · 2021 · External reference
Advances in the isolation and characterization of milk-derived extracellular vesicles and their functions
10.3389/fnut.2024.1512939 · 2024 · External reference
Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles
10.1016/j.ijpx.2025.100428 · 2025 · External reference
Gut microbiome and cardiovascular health: mechanisms, therapeutic potential and future directions
10.17925/hi.2025.19.2.3 · 2025 · External reference
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease
10.1186/1755-1536-5-15 · 2012 · External reference
Antioxidant-Engineered milk-derived extracellular vesicles for accelerating wound healing via regulation of the PI3K-AKT signaling pathway
10.1002/adhm.202301865 · 2023 · External reference
Inflammation in myocardial Ischemia/Reperfusion Injury: underlying mechanisms and therapeutic potential
10.3390/antiox12111944 · 2023 · External reference
The extracellular matrix in ischemic and nonischemic heart failure
10.1161/circresaha.119.311148 · 2019 · External reference
Cardiac fibrosis
10.1093/cvr/cvaa324 · 2021 · External reference
Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease
10.3389/fcvm.2024.1503830 · 2024 · External reference
Endothelial cell dysfunction and the pathobiology of atherosclerosis
10.1161/circresaha.115.306301 · 2016 · External reference
Surface protein profiling of milk and serum extracellular vesicles unveils body fluid-specific signatures
10.1038/s41598-023-35799-w · 2023 · External reference
Milk-Derived exosomes as nanocarriers to deliver curcumin and resveratrol in breast tissue and enhance their anticancer activity
10.3390/ijms23052860 · 2022 · External reference
Dosing extracellular vesicles
10.1016/j.addr.2021.113961 · 2021 · External reference
Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease
10.1016/j.bioactmat.2023.12.010 · 2024 · External reference
Extracellular vesicle quantification and characterization: common methods and emerging approaches
10.3390/bioengineering6010007 · 2019 · External reference
Milk-Derived extracellular vesicles and microRNAs: potential modulators of intestinal homeostasis
10.1096/fj.202501630r · 2025 · External reference
Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages
10.3168/jds.2014-9076 · 2015 · External reference
Potential of milk-derived extracellular vesicles as carriers for oral delivery of active phytoconstituents
10.1146/annurev-food-072023-034354 · 2024 · External reference
Targeted oral delivery of Paclitaxel using colostrum-derived exosomes
10.3390/cancers13153700 · 2021 · External reference
Validation of a particle tracking analysis method for the size determination of nano- and microparticles
10.1007/s11051-017-3966-8 · 2017 · External reference
Protective effects of human breast milk-derived exosomes on inflammatory bowel disease through modulation of immune cells
10.1038/s41538-025-00400-3 · 2025 · External reference
Regular industrial processing of bovine milk impacts the integrity and molecular composition of extracellular vesicles
10.1093/jn/nxab031 · 2021 · External reference
Nanoparticle tracking analysis: an effective tool to characterize extracellular vesicles
10.3390/molecules29194672 · 2024 · External reference
Extracellular vesicles in cardiovascular diseases: pathogenic mediators, diagnostic tools, and therapeutic vectors
10.3389/fcvm.2025.1666589 · External reference
Exploring regulatory frameworks for exosome therapy: insights and perspectives
10.1002/hcs2.70028 · External reference
Better medications adherence lowers cardiovascular events, stroke, and all-cause mortality risk: a dose-response meta-analysis
10.3390/jcdd8110146 · 2021 · External reference
Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression
10.1007/s00394-021-02720-y · 2022 · External reference
Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
10.1038/s41598-018-29780-1 · 2018 · External reference
Orally delivered milk-derived nanovesicles loaded with connexin 43 peptides for targeted cardiac ischemia-reperfusion therapy
10.1101/2025.01.01.630994 · 2025 · External reference
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper
10.1080/20013078.2017.1286095 · 2017 · External reference
Isolation and characterization of milk exosomes for use in advanced therapies
10.3390/biom14070810 · 2024 · External reference
Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
10.1186/s12951-024-02631-0 · 2024 · External reference
Global burden of cardiovascular diseases and risks, 1990-2022
10.1016/j.jacc.2023.11.007 · 2023 · External reference
Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability
10.1021/acsomega.0c01582 · 2020 · External reference
Comparison of isolation methods using commercially available kits for obtaining extracellular vesicles from cow milk
10.3168/jds.2020-19849 · 2021 · External reference
Bovine milk-derived exosomes for drug delivery
10.1016/j.canlet.2015.10.020 · 2016 · External reference
MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response
10.1186/s41544-019-0041-x · 2020 · External reference
Mechanisms of physiological and pathological cardiac hypertrophy
10.1038/s41569-018-0007-y · 2018 · External reference
Bioengineered milk-derived extracellular vesicles implementing high drug loading and membrane integrity for efficient oral drug delivery
10.1016/j.ajps.2025.101093 · 2025 · External reference
Improved characterization of EV preparations based on protein to lipid ratio and lipid properties
10.1371/journal.pone.0121184 · 2015 · External reference
Advances in extracellular vesicle research over the past decade: source and isolation method are connected with cargo and function
10.1002/adhm.202303941 · 2024 · External reference
PKH26 labeling of extracellular vesicles: characterization and cellular internalization of contaminating PKH26 nanoparticles
10.1016/j.bbamem.2018.03.013 · 2018 · External reference
Comprehensive proteomic analysis revealed a large number of newly identified proteins in the small extracellular vesicles of milk from late-stage lactating cows
10.3390/ani11092506 · 2021 · External reference
Cow and human milk-derived exosomes ameliorate colitis in DSS Murine model
10.3390/nu12092589 · 2020 · External reference
Bovine milk exosome proteome
10.1016/j.jprot.2011.11.017 · 2012 · External reference
Antiinflammatory therapy with canakinumab for atherosclerotic disease
10.1056/nejmoa1707914 · 2017 · External reference
Milk-derived exosomes as functional nanocarriers in wound healing: mechanisms, applications, and future directions
10.1016/j.mtbio.2025.101715 · 2025 · External reference
Evolocumab and clinical outcomes in patients with cardiovascular disease
10.1056/nejmoa1615664 · 2017 · External reference
Milk-Derived extracellular vesicles: biomedical applications, Current challenges, and future perspectives
10.1021/acs.jafc.3c07899 · 2024 · External reference
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
10.1038/s41467-021-24273-8 · 2021 · External reference
Targeting inflammation in atherosclerosis — from experimental insights to the clinic
10.1038/s41573-021-00198-1 · 2021 · External reference
Milk exosomes prevent intestinal inflammation in a genetic mouse model of ulcerative colitis: a pilot experiment
10.1159/000507626 · 2020 · External reference
The absorption of bovine milk small extracellular vesicles largely depends on galectin 3 and galactose ligands in human intestinal cells and C57BL/6J mice
10.1152/ajpcell.00282.2023 · 2023 · External reference
Quality and safety considerations for therapeutic products based on extracellular vesicles
10.1007/s11095-024-03757-4 · 2024 · External reference
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
10.1056/nejmoa1109400 · 2013 · External reference
Gut Microbiota in cardiovascular health and disease
10.1161/circresaha.117.309715 · 2017 · External reference
Global requirements for manufacturing and validation of clinical grade extracellular vesicles
10.1016/j.jlb.2024.100278 · 2024 · External reference
Unlocking the secrets of human milk: isolation and characterization of extracellular vesicles
10.1016/j.advnut.2025.100430 · 2025 · External reference
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota
10.7150/thno.62046 · 2021 · External reference
Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
10.1126/sciadv.ade5041 · 2023 · External reference
Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure
10.1016/j.biomaterials.2024.122976 · 2025 · External reference
Plasma lipopolysaccharide is closely associated with glycemic control and abdominal obesity: evidence from bariatric surgery
10.2337/dc13-0451 · 2013 · External reference
Extracellular vesicles for drug delivery
10.1016/j.addr.2016.02.006 · 2016 · External reference
A systematic review and meta-analysis of clinical trials assessing safety and efficacy of human extracellular vesicle-based therapy
10.1002/jev2.12458 · 2024 · External reference
Comprehensive proteomic analysis of human milk-derived extracellular vesicles unveils a novel functional proteome distinct from other milk components
10.1074/mcp.m116.060426 · 2016 · External reference
Abundantly present miRNAs in milk-derived extracellular vesicles are conserved between mammals
10.3389/fnut.2018.00081 · 2018 · External reference
A method for the isolation and enrichment of purified bovine milk exosomes
10.1016/j.repbio.2017.09.007 · 2017 · External reference
A complete proteomic profile of human and bovine milk exosomes by liquid chromatography mass spectrometry
10.1080/14789450.2021.1980389 · 2021 · External reference
Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study
10.1080/20013078.2017.1344087 · 2017 · External reference
2024 ESC Guidelines for the management of chronic coronary syndromes
10.1093/eurheartj/ehae177 · 2024 · External reference
Endothelial dysfunction: molecular mechanisms and clinical implications
10.1002/mco2.651 · 2020 · External reference
Assessment of isolation strategies to remove caseins for high-quality milk-derived extracellular vesicles
10.3168/jds.2024-25162 · 2024 · External reference
Milk-derived exosome nanovesicles: recent progress and daunting hurdles
10.1080/10408398.2024.2338831 · 2025 · External reference
Isolation of bovine and human milk extracellular vesicles
10.3390/biomedicines11102715 · 2023 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement
10.1016/j.jacc.2024.02.056 · 2024 · External reference
Comparison of methods for pre-processing, exosome isolation, and RNA extraction in unpasteurized bovine and human milk
10.1371/journal.pone.0257633 · 2021 · External reference
Gut Microbiota and cardiovascular disease
10.1161/circresaha.120.316242 · 2020 · External reference
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
10.1016/j.apsb.2021.12.015 · 2022 · External reference
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress
10.1007/s13346-023-01306-x · 2023 · External reference
Research progress of connexin 43 in cardiovascular diseases
10.3389/fcvm.2025.1650548 · 2025 · External reference
Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies
10.1038/s41392-025-02312-w · 2025 · External reference
Lipidomic analysis of extracellular vesicles in human breast milk and comparison with milk polar lipids using ultraperformance supercritical fluid chromatography-mass spectrometry
10.1021/acs.jafc.5c01263 · 2025 · External reference
Bovine milk exosomes alleviate cardiac fibrosis via enhancing angiogenesis in vivo and in vitro
10.1007/s12265-021-10174-0 · 2022 · External reference
Probing milk extracellular vesicles for intestinal delivery of RNA therapies
10.1186/s12951-023-02173-x · 2023 · External reference
Milk-derived extracellular vehicles alleviate heart failure with preserved ejection fraction by modulating gut microbiota
10.1093/eurheartj/ehae666.3748 · External reference
Hybrid milk extracellular vesicles as potential systems for oral delivery of siRNA
10.1002/adtp.202300335 · External reference
Oral delivery of semaglutide and tirzepatide using milk-derived small extracellular vesicles
10.1002/jex2.70099 · 2025 · External reference
Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures
10.3402/jev.v3.24215 · 2014 · External reference