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References from Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential. Local targets link to admitted publications; unresolved targets remain external evidence.
IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
10.1016/j.diabres.2021.109119 · 2022 · External reference
Diabetes in China part 1: epidemiology and risk factors
10.1016/s2468-2667(24)00250-0 · 2024 · External reference
Inflammation, diabetic foot and related treatments
10.3389/fendo.2025.1676621 · 2025 · External reference
Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers: a systematic review and meta-analysis
10.3389/fendo.2024.1405301 · 2024 · External reference
Prevalence and risk factors of depression in patients with diabetes mellitus: a systematic review and meta-analysis
10.3389/fendo.2025.1660478 · 2025 · External reference
Guidelines for burn rehabilitation in China
10.1186/s41038-015-0019-3 · 2015 · External reference
The current burden of diabetic foot disease
10.1016/j.jcot.2021.01.017 · 2021 · External reference
IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023)
10.1093/cid/ciad527 · 2024 · External reference
Diabetic foot ulcer severity predicts mortality among veterans with type 2 diabetes
10.1016/j.jdiacomp.2016.11.020 · 2017 · External reference
Global mortality of diabetic foot ulcer: A systematic review and meta-analysis of observational studies
10.1111/dom.14840 · 2023 · External reference
Lower extremity amputations and long-term outcomes in diabetic foot ulcers: A systematic review
10.4239/wjd.v11.i9.391 · 2020 · External reference
Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers
10.2337/dci22-0043 · 2022 · External reference
Definitions and criteria for diabetes-related foot disease (IWGDF 2023 update)
10.1002/dmrr.3654 · 2024 · External reference
Risk of foot ulcer and lower-extremity amputation among participants in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
10.2337/dc21-1816 · 2022 · External reference
Risk factors for diabetic foot complications in type 2 diabetes-A systematic review
10.1002/edm2.175 · 2021 · External reference
Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis
10.1080/07853890.2016.1231932 · 2017 · External reference
Racial/ethnic disparities in diabetes quality of care: the role of healthcare access and socioeconomic status
10.1007/s40615-016-0335-8 · 2018 · External reference
Geographic and socioeconomic disparities in major lower extremity amputation rates in metropolitan areas
10.1161/jaha.121.021456 · 2021 · External reference
Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes
10.2337/diabetes.53.1.195 · 2004 · External reference
Immune mediators in patients with acute diabetic foot syndrome
10.2337/dc08-2318 · 2009 · External reference
Comprehensive Foot Examination and Risk Assessment: A report of the Task Force of the Foot Care Interest Group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists
10.1093/ptj/88.11.1436 · 2008 · External reference
Mechanisms involved in the development and healing of diabetic foot ulceration
10.2337/db12-0227 · 2012 · External reference
Macrophage polarization and diabetic wound healing
10.1016/j.trsl.2021.05.006 · 2021 · External reference
Endothelin 1, NF-κB, and ADAM-15 expression in diabetic foot wounds
10.4149/bll_2019_009 · 2019 · External reference
Targeting diabetic foot ulcer pathophysiology: altered signaling pathways and 3D scaffold as an emerging treatment strategy
10.1007/s13205-025-04440-0 · 2025 · External reference
Dysregulation of miR-146a is associated with exacerbated inflammation, oxidative and endoplasmic reticulum stress in the progression of diabetic foot ulcer
10.1111/wrr.13186 · 2024 · External reference
Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds
10.1016/j.diabres.2024.111605 · 2024 · External reference
SIRT6 overexpression enhances diabetic foot ulcer healing via nrf2 pathway activation
10.1007/s10753-025-02297-2 · 2025 · External reference
Integrated skin transcriptomics and serum multiplex assays reveal novel mechanisms of wound healing in diabetic foot ulcers
10.2337/db20-0188 · 2020 · External reference
Fibroblast growth factor in diabetic foot ulcer: progress and therapeutic prospects
10.3389/fendo.2021.744868 · 2021 · External reference
Molecular immunological mechanisms of impaired wound healing in diabetic foot ulcers (DFU), current therapeutic strategies and future directions
10.1016/j.intimp.2024.112713 · 2024 · External reference
Diabetic foot ulcers and their recurrence
10.1056/nejmra1615439 · 2017 · External reference
Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)
10.1002/dmrr.3280 · 2020 · External reference
Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing
10.1016/j.diabres.2021.109126 · 2022 · External reference
Comprehensive analyses of brain cell communications based on multiple scRNA-seq and snRNA-seq datasets for revealing novel mechanism in neurodegenerative diseases
10.1111/cns.14280 · 2023 · External reference
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
10.1186/s12967-023-04056-z · 2023 · External reference
Single-cell transcriptomic analysis of Alzheimer’s disease
10.1038/s41586-019-1195-2 · 2019 · External reference
The role of omics techniques in diabetic wound healing: recent insights into the application of single-cell RNA sequencing, bulk RNA sequencing, spatial transcriptomics, and proteomics
10.1007/s12325-025-03212-9 · 2025 · External reference
Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers
10.1093/burnst/tkad020 · 2023 · External reference
Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data
10.1186/s13062-025-00672-5 · 2025 · External reference
Combined analysis of single-cell sequencing and bulk transcriptome sequencing reveals new mechanisms for non-healing diabetic foot ulcers
10.1371/journal.pone.0306248 · 2024 · External reference
Single-cell RNA-seq in diabetic foot ulcer wound healing
10.1111/wrr.13218 · 2024 · External reference
Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing
10.1016/j.cell.2017.05.035 · 2017 · External reference
Single-cell and spatial transcriptomics analysis of non-small cell lung cancer
10.1038/s41467-024-48700-8 · 2024 · External reference
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · 2020 · External reference
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
10.1038/s41556-020-00613-6 · 2021 · External reference
Spatiotemporal single-cell roadmap of human skin wound healing
10.1016/j.jid.2024.10.551 · 2025 · External reference
Single-cell RNA sequencing reveals cellular and transcriptional changes associated with M1 macrophage polarization in hidradenitis suppurativa
10.3389/fmed.2021.665873 · 2021 · External reference
Loureirin B accelerates diabetic wound healing by promoting TGFβ/smad-dependent macrophage M2 polarization: A concerted analytical approach through single-cell RNA sequencing and experimental verification
10.1002/ptr.8373 · 2025 · External reference
Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws
10.1007/s00018-024-05128-z · 2024 · External reference
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway
10.1016/j.phymed.2023.154931 · 2023 · External reference
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair
10.1038/s41423-022-00919-5 · 2022 · External reference
IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3
10.1038/s41467-025-67456-3 · 2025 · External reference
Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling
10.2337/figshare.25979548.v1 · 2024 · External reference
The lysine demethylase KDM5B regulates islet function and glucose homeostasis
10.1155/2019/5451038 · 2019 · External reference
Single cell transcriptomic landscape of diabetic foot ulcers
10.1038/s41467-021-27801-8 · 2022 · External reference
Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair
10.1172/jci.insight.138443 · 2020 · External reference
Tracing immunological interaction in trimethylamine N-oxide hydrogel-derived zwitterionic microenvironment during promoted diabetic wound regeneration
10.1002/adma.202402738 · 2024 · External reference
Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
10.7554/elife.95113 · 2024 · External reference
Apoptosis recognition receptors regulate skin tissue repair in mice
10.7554/elife.86269 · 2023 · External reference
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
10.21203/rs.3.rs-1100779/v1 · 2023 · External reference
Single-cell transcriptomic analysis reveals immune dysregulation and macrophage reprogramming in diabetic foot ulcers
10.3724/zdxbyxb-2025-0464 · 2025 · External reference
Candidate biomarkers for hard-to-heal wounds revealed by single-cell RNA sequencing of wound fluid in murine wound models
10.1111/wrr.70038 · 2025 · External reference
Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell
10.1186/s40001-024-02179-7 · 2024 · External reference
Single-cell analysis reveals distinct functional heterogeneity of CD34(+) cells in anagen wound and diabetic wound
10.1016/j.bbrc.2022.11.080 · 2023 · External reference
Identification of potential immunologic resilience in the healing process of diabetic foot ulcers
10.1111/iwj.14465 · 2024 · External reference
Single-cell RNA sequencing reveals the impaired epidermal differentiation and pathological microenvironment in diabetic foot ulcer
10.1093/burnst/tkae065 · 2025 · External reference
Development of novel lysosome-related signatures and their potential target drugs based on bulk RNA-seq and scRNA-seq for diabetic foot ulcers
10.1186/s40246-024-00629-1 · 2024 · External reference
Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds
10.1038/s41565-024-01660-y · 2024 · External reference
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers
10.15252/embr.202154558 · 2022 · External reference
Skin wound healing: Normal macrophage function and macrophage dysfunction in diabetic wounds
10.3390/molecules26164917 · 2021 · External reference
Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study
10.4239/wjd.v16.i1.99755 · 2025 · External reference
Macrophage and neutrophil dysfunction in diabetic wounds
10.1089/wound.2023.0149 · 2024 · External reference
Cross-tissue organization of the fibroblast lineage
10.1038/s41586-021-03549-5 · 2021 · External reference
Characterization of diabetic and non-diabetic foot ulcers using single-cell RNA-sequencing
10.3390/mi11090815 · 2020 · External reference
Deciphering the dysregulating IGF-1-SP1-CD248 pathway in fibroblast functionality during diabetic wound healing
10.1016/j.jid.2024.07.035 · 2025 · External reference
Immune microenvironment and fibroblast subpopulation in diabetic wound healing
10.1016/j.isci.2025.113440 · 2025 · External reference
Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers
10.3389/fendo.2023.1275612 · 2023 · External reference
Hydroxytyrosol from olive oil mitigates endothelial dysfunction in diabetic foot ulcers via redox, inflammatory, and survival pathways
10.1016/j.tjnut.2025.09.038 · 2025 · External reference
An essential role of NRF2 in diabetic wound healing
10.2337/db15-0564 · 2016 · External reference
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
10.1038/s41586-024-07237-y · 2024 · External reference
Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides
10.1016/j.autneu.2019.102610 · 2020 · External reference
Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions
10.1111/wrr.12470 · 2016 · External reference
Characterization of the microenvironment of diabetic foot ulcers and potential drug identification based on scRNA-seq
10.3389/fendo.2022.997880 · 2022 · External reference
