Research graph
References from At the nucleus of neuronal health: Drosophila insights into LaminB-dependent homeostasis in aging and cell death. Local targets link to admitted publications; unresolved targets remain external evidence.
Karyoptosis: a novel type of cell death caused by chronic autophagy inhibition
10.1080/15548627.2018.1434372 · 2018 · External reference
Stall in canonical autophagy-lysosome pathways prompts nucleophagy-based nuclear breakdown in neurodegeneration
10.1016/j.cub.2017.10.054 · 2017 · External reference
Networking in the nucleus: a spotlight on LEM-Domain proteins
10.1016/j.ceb.2015.03.005 · 2015 · External reference
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
10.1038/s41467-019-09152-7 · 2019 · External reference
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity
10.1016/j.stem.2021.01.015 · 2021 · External reference
The LEM-ESCRT toolkit: repair and maintenance of the nucleus
10.3389/fcell.2022.989217/pdf · 2022 · External reference
Coaching from the sidelines: the nuclear periphery in genome regulation
10.1038/s41576-018-0063-5 · 2019 · External reference
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
10.1038/ncomms15772 · 2017 · External reference
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
10.1038/s41467-026-73802-w · 2026 · External reference
Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases
10.3389/fncel.2025.1549265/abstract · 2025 · External reference
Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia
10.1016/j.cell.2014.10.028 · 2014 · External reference
Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration
10.1016/j.neuron.2022.03.015 · 2022 · External reference
Nuclear and genome dynamics underlying DNA double-strand break repair
10.1038/s41580-025-00828-1 · 2025 · External reference
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
10.1073/pnas.0908790107 · 2010 · External reference
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons
10.1091/mbc.e11-06-0504 · 2011 · External reference
Cell competition and cancer from drosophila to mammals
10.1038/s41389-023-00505-y · 2024 · External reference
Fly immunity comes of age: the utility of drosophila as a model for studying variation in immunosenescence
10.3389/fragi.2022.1016962 · 2022 · External reference
Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in drosophila
10.1111/acel.12847 · 2019 · External reference
The integrated stress response: from mechanism to disease
10.1126/science.aat5314 · 2020 · External reference
Nuclear pore complexes — a doorway to neural injury in neurodegeneration
10.1038/s41582-022-00653-6 · 2022 · External reference
De novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity
10.1016/j.ajhg.2020.08.015/attachment/028f7c9c-64b8-4ef8-9b18-d978bdee88a0/mmc2 · 2020 · External reference
The functional organization of axonal mRNA transport and translation
10.1038/s41583-020-00407-7 · 2021 · External reference
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (charcot-marie-tooth disorder type 2) and mouse
10.1086/339274 · 2002 · External reference
DNA damage and its links to neuronal aging and degeneration
10.1016/j.neuron.2024.12.001 · 2025 · External reference
Reactivation of retrotransposable elements is associated with environmental stress and ageing
10.1038/s41576-025-00829-y · 2025 · External reference
Nuclear envelope rupture and repair during cancer cell migration
10.1126/science.aad7297 · 2016 · External reference
LMNA variants cause cytoplasmic distribution of nuclear pore proteins in drosophila and human muscle
10.1093/hmg/ddr592 · 2012 · External reference
Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation
10.1038/cdd.2012.100 · 2013 · External reference
Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival
10.1371/journal.pgen.1002833 · 2012 · External reference
Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
10.1038/s41467-021-25809-8 · 2021 · External reference
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species
10.3389/fgene.2026.1771707 · 2026 · External reference
The role of ferroptosis in neurodegenerative diseases
10.3389/fncel.2024.1475934/full · 2024 · External reference
RNA transport and local translation in neurodevelopmental and neurodegenerative disease
10.1038/s41593-020-00785-2 · 2021 · External reference
ER stress inhibits neuronal death by promoting autophagy
10.4161/auto.19716 · 2012 · External reference
Lamin dysfunction mediates neurodegeneration in tauopathies
10.1016/j.cub.2015.11.039 · 2016 · External reference
Proteostatic regulation in neuronal compartments
10.1016/j.tins.2021.08.002 · 2022 · External reference
A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
10.1093/hmg/ddv065 · 2014 · External reference
A Pin1/Mutant p53 axis promotes aggressiveness in breast cancer
10.1016/j.ccr.2011.06.004 · 2011 · External reference
Repair of nuclear ruptures requires barrier-to-autointegration factor
10.1083/jcb.201901116 · 2019 · External reference
Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
10.1172/jci66737 · 2013 · External reference
Mechanisms, regulation and functions of the unfolded protein response
10.1038/s41580-020-0250-z · 2020 · External reference
Transposable element DNA and RNA: drivers of gene expression, evolution, and disease
10.1016/j.cell.2026.05.003 · 2026 · External reference
The integrated stress response in the brain: cell type-specific functions in health and neurological disorders
10.1016/j.tins.2025.08.002 · 2025 · External reference
New roles of bZIP-Containing membrane-bound transcription factors in chromatin tethering and karyoptosis
10.3390/ijms262210896 · 2025 · External reference
Neuronal glycolysis meets mitophagy to govern organismal wellbeing
10.1016/j.tem.2025.05.005 · 2026 · External reference
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
10.1073/pnas.1111780109/-/dcsupplemental · 2012 · External reference
Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration
10.1073/pnas.1303916110 · 2013 · External reference
Mechanics and functional consequences of nuclear deformations
10.1038/s41580-022-00480-z · 2022 · External reference
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
10.1038/s41583-024-00806-0 · 2024 · External reference
Functional mechanisms and abnormalities of the nuclear lamina
10.1038/s41556-020-00630-5 · 2021 · External reference
Using drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer
10.1016/j.trecan.2024.01.007 · 2024 · External reference
Control of lifespan and survival by drosophila NF-KB signaling through neuroendocrine cells and neuroblasts
10.18632/aging.104196 · 2020 · External reference
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells
10.1126/science.1211222 · 2011 · External reference
Proliferation and differentiation of mouse embryonic stem cells lacking all lamins
10.1038/cr.2013.118 · 2013 · External reference
Dysregulation of organelle membrane contact sites in neurological diseases
10.1016/j.neuron.2022.04.020 · 2022 · External reference
Emerging views of the nucleus as a cellular mechanosensor
10.1038/s41556-018-0038-y · 2018 · External reference
The role of DNA damage in neural plasticity in physiology and neurodegeneration
10.3389/fncel.2022.836885/full · 2022 · External reference
Lamin B1 as a key modulator of the developing and aging brain
10.3389/fncel.2023.1263310/full · 2023 · External reference
Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2
10.1091/mbc.e14-01-0683 · 2014 · External reference
The kingdom of the prolyl-isomerase Pin1: the structural and functional convergence and divergence of Pin1
10.3389/fcell.2022.956071/full · 2022 · External reference
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death
10.1038/s12276-024-01195-1 · 2024 · External reference
Neuroferroptosis in health and diseases
10.1038/s41583-025-00930-5 · 2025 · External reference
Insertional mutation of the drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae
10.1083/jcb.137.5.1001 · 1997 · External reference
Lamin mutations accelerate aging via defective export of mitochondrial mRNAs through nuclear envelope budding
10.1016/j.cub.2016.06.007 · 2016 · External reference
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
10.1038/nature01832 · 2003 · External reference
Nuclear pore complex maintenance and implications for age-related diseases
10.1016/j.tcb.2021.10.001 · 2022 · External reference
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
10.1080/19491034.2020.1832734 · 2020 · External reference
Hallmarks of health
10.1016/j.cell.2020.11.034 · 2021 · External reference
Pin1-catalyzed conformational regulation after phosphorylation: a distinct checkpoint in cell signaling and drug discovery
10.1126/scisignal.adi8743 · 2024 · External reference
Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors
10.1038/s41420-024-02045-9 · 2024 · External reference
Regulation of lamin properties and functions: does phosphorylation do it all?
10.1098/rsob.150094 · 2015 · External reference
Hallmarks of brain aging: adaptive and pathological modification by metabolic states
10.1016/j.cmet.2018.05.011 · 2018 · External reference
Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster
10.1242/dev.205125/3697377/dev205125.pdf · 2026 · External reference
Duplication and deletion upstream of LMNB1 in autosomal dominant adult-onset leukodystrophy
10.1212/nxg.0000000000000292 · 2018 · External reference
Getting the better of ER stress
10.1007/s12079-014-0251-9 · 2014 · External reference
Lamin post-translational modifications: emerging toggles of nuclear organization and function
10.1016/j.tibs.2021.05.007 · 2021 · External reference
Axonal transport and local translation of mRNA in neurodegenerative diseases
10.3389/fnmol.2021.697973/pdf · 2021 · External reference
Polyglutamine atrophin provokes neurodegeneration in drosophila by repressing fat
10.1038/emboj.2011.1 · 2011 · External reference
p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
10.1371/journal.pgen.1007024 · 2017 · External reference
Intersections between regulated cell death and autophagy
10.1016/j.tcb.2018.12.007 · 2019 · External reference
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
10.1016/j.celrep.2021.109694 · 2021 · External reference
Neurodegeneration by polyglutamine atrophin is not rescued by induction of autophagy
10.1038/cdd.2010.31 · 2010 · External reference
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
10.1038/s41580-024-00757-5 · 2024 · External reference
Genomic deletions upstream of lamin B1 lead to atypical autosomal dominant leukodystrophy
10.1212/nxg.0000000000000305 · 2019 · External reference
Lamins as structural nuclear elements through evolution
10.1016/j.ceb.2023.102267 · 2023 · External reference
Plasma proteomics links brain and immune system aging with healthspan and longevity
10.1038/s41591-025-03798-1 · 2025 · External reference
Null mutants of drosophila B-type lamin Dm0 show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation
10.1016/j.ydbio.2005.05.022 · 2005 · External reference
Neuronal lamin regulates motor circuit integrity and controls motor function and lifespan
10.15698/cst2018.09.152 · 2018 · External reference
Lamin B1 duplications cause autosomal dominant leukodystrophy
10.1038/ng1872 · 2006 · External reference
Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy
10.1038/s41436-020-00980-3 · 2021 · External reference
Molecular mechanisms and physiological importance of circadian rhythms
10.1038/s41580-019-0179-2 · 2020 · External reference
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
10.1126/science.aad7611 · 2016 · External reference
Lysosomal membrane homeostasis and its importance in physiology and disease
10.1038/s41580-025-00873-w · 2026 · External reference
Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress
10.1080/15548627.2018.1558001 · 2019 · External reference
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
10.1038/ncb1822 · 2009 · External reference
Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast
10.1002/emmm.201302909 · 2014 · External reference
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
10.1016/j.cmet.2013.07.013 · 2013 · External reference
Expression of two histone H4 epigenetic modifications (lysine 12 acetylation and lysine 20 trimethylation), and the senescence marker lamin B1 in the postnatal, adult, and old mouse brain
10.3389/fceld.2025.1632653 · 2025 · External reference
Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in drosophila
10.1038/s43587-022-00214-y · 2022 · External reference
Accumulation of F-actin drives brain aging and limits healthspan in drosophila
10.1038/s41467-024-53389-w · 2024 · External reference
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
10.1038/s41586-022-04924-6 · 2022 · External reference
AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis
10.1038/s42255-025-01442-3 · 2026 · External reference
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins
10.1016/j.cell.2012.03.046 · 2012 · External reference
Thirty years of reaper: lessons learned from programmed cell death in drosophila
10.3389/fceld.2026.1770008 · 2026 · External reference
The role of lamins in the nucleoplasmic reticulum, a pleiomorphic organelle that enhances nucleo-cytoplasmic interplay
10.3389/fcell.2022.914286/full · 2022 · External reference
Inter-organ communication is a critical machinery to regulate metabolism and aging
10.1016/j.tem.2024.11.013 · 2025 · External reference
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication
10.1016/j.cmet.2023.12.011 · 2024 · External reference
Phosphorylation of lamins determine their structural properties and signaling functions
10.1080/19491034.2015.1017167 · 2015 · External reference
Dysregulated proteostasis network in neuronal diseases
10.3389/fcell.2023.1075215/pdf · 2023 · External reference
Nuclear lamina integrity is required for proper spatial organization of chromatin in drosophila
10.1038/s41467-019-09185-y · 2019 · External reference
Unresolved reference
External reference
The power of drosophila in modeling human disease mechanisms
10.1242/dmm.049549 · 2022 · External reference
The nuclear lamina
10.1101/cshperspect.a040113 · 2022 · External reference
The nuclear envelope and nuclear pore complexes in neurodegenerative diseases
10.3389/fcell.2025.1550859/abstract · 2025 · External reference
Alternative germ cell death pathway in drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart
10.1016/j.devcel.2013.02.002 · 2013 · External reference
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target
10.1038/s41580-026-00958-0 · 2026 · External reference
Oncogenic hijacking of the PIN1 signaling network
10.3389/fonc.2019.00094 · 2019 · External reference
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
10.1038/nature12143 · 2013 · External reference
Post-translational modification of lamins: mechanisms and functions
10.3389/fcell.2022.864191/full · 2022 · External reference
Regulation of the proteostasis network by the neuronal system
10.3389/fmolb.2023.1290118/full · 2023 · External reference
Regulation of lifespan by neural excitation and REST
10.1038/s41586-019-1647-8 · 2019 · External reference
