Research graph
References from Progress on hydrogel delivery systems targeting metabolism disorders in the treatment of diabetic foot ulcers. Local targets link to admitted publications; unresolved targets remain external evidence.
Ferroptosis in infected diabetic wounds and targeted therapeutic strategies: a narrative review
10.4103/jad.jad_147_25 · 2026 · External reference
Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds
10.3390/molecules26164917 · 2021 · External reference
Diabetic foot ulcers and their recurrence
10.1056/nejmra1615439 · 2017 · External reference
Diabetic foot ulcers: a review
10.1001/jama.2023.10578 · 2023 · External reference
Regulation and function of the Mammalian tricarboxylic acid cycle
10.1016/j.jbc.2022.102838 · 2023 · External reference
In search of differential inhibitors of aldose reductase
10.3390/biom12040485 · 2022 · External reference
The diabetic foot: pathophysiology, evaluation, and treatment
10.1053/j.semvascsurg.2019.02.001 · 2018 · External reference
Diabetes and branched-chain amino acids: what is the link?
10.1111/1753-0407.12645 · 2018 · External reference
Macrophage-mediated inflammation in normal and diabetic wound healing
10.4049/jimmunol.1700223 · 2017 · External reference
Thin copper hybrid structures by spray-assisted layer by layer chemical deposition on fabric surfaces for electromagnetic interference shielding
10.1016/j.colcom.2021.100365 · 2021 · External reference
Macrophage and neutrophil dysfunction in diabetic wounds
10.1089/wound.2023.0149 · 2024 · External reference
Branched-chain amino acids and insulin resistance, from protein supply to diet-induced obesity
10.3390/nu15010068 · 2023 · External reference
Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing
10.7150/thno.117949 · 2026 · External reference
New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism
10.1007/s00125-019-4959-1 · 2019 · External reference
Plasma amino acid levels and insulin secretion in obesity
10.1056/nejm196910092811503 · 1969 · External reference
Efficacy and safety of resina draconis for wound repair in the treatment of diabetic foot ulcer: a systematic review and meta-analysis of randomized controlled trials
10.1016/j.ctcp.2022.101707 · 2023 · External reference
Role of matrix metalloproteinases in diabetic foot ulcers: potential therapeutic targets
10.3389/fphar.2022.1050630 · 2022 · External reference
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
10.1056/nejmoa021778 · 2003 · External reference
Metal-polyphenol nanocomposite hybrid hydrogel: a multifunctional platform for treating diabetic foot ulcers through metabolic microenvironment reprogramming
10.1016/j.biomaterials.2025.123414 · 2025 · External reference
Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of l-lactate
10.1046/j.1524-475x.1998.60207.x · 1998 · External reference
Proresolving lipid mediators and diabetic wound healing
10.1097/med.0b013e3283514e00 · 2012 · External reference
Rational design and latest advances of polysaccharide-based hydrogels for wound healing
10.1039/d0bm00055h · 2020 · External reference
Multifunctional dual network hydrogel loaded with novel tea polyphenol magnesium nanoparticles accelerates wound repair of MRSA infected diabetes
10.1002/adfm.202312140 · 2024 · External reference
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
10.1038/ni.2956 · 2014 · External reference
Microenvironment-based diabetic foot ulcer nanomedicine
10.1002/advs.202203308 · 2023 · External reference
Silk-enriched hydrogels with ROS-Scavenging dendrimers for advanced wound care
10.1016/j.ijbiomac.2024.135567 · 2024 · External reference
Aldose reductase: an emerging target for development of interventions for diabetic cardiovascular complications
10.3389/fendo.2021.636267 · 2021 · External reference
ADSC-exo@MMP-PEG smart hydrogel promotes diabetic wound healing by optimizing cellular functions and relieving oxidative stress
10.1016/j.mtbio.2022.100365 · 2022 · External reference
Mitochondrial dysfunction and oxidative stress in diabetic wound
10.1002/jbt.23407 · 2023 · External reference
Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study
10.3389/fendo.2024.1412373 · 2024 · External reference
Application and development of stimulus-responsive hydrogel biomaterials for diabetic wound healing: a literature review
10.3389/fmed.2025.1740559 · 2025 · External reference
The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1
10.1007/s001250051224 · 1999 · External reference
Association of statin therapy with prevention of vision-threatening diabetic retinopathy
10.1001/jamaophthalmol.2018.6399 · 2019 · External reference
Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments
10.1016/j.bioactmat.2025.01.004 · 2025 · External reference
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
10.1016/j.bbamcr.2014.04.004 · 2014 · External reference
Macrophage related chronic inflammation in non-healing wounds
10.3389/fimmu.2021.681710 · 2021 · External reference
The metabolic characteristics of patients at the risk for diabetic foot ulcer: a comparative study of diabetic patients with and without diabetic foot
10.2147/dmso.s430426 · 2023 · External reference
Role of microRNA-21 and its underlying mechanisms in inflammatory responses in diabetic wounds
10.3390/ijms21093328 · 2020 · External reference
Skin wounds, the healing process, and hydrogel-based wound dressings: a short review
10.1080/09205063.2021.1946461 · 2021 · External reference
MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells
10.1016/j.bioactmat.2024.09.006 · 2025 · External reference
Synthetic polymeric antibacterial hydrogel for methicillin-resistant staphylococcus aureus-infected wound healing: Nanoantimicrobial self-assembly, Drug- and cytokine-free strategy
10.1021/acsnano.0c03855 · 2020 · External reference
Efficacy and safety of ultrasound-assisted wound debridement in the treatment of diabetic foot ulcers: a systematic review and meta-analysis of 11 randomized controlled trials
10.3389/fendo.2024.1393251 · 2024 · External reference
Macrophage polarization and diabetic wound healing
10.1016/j.trsl.2021.05.006 · 2021 · External reference
Kinsenoside-loaded microneedle accelerates diabetic wound healing by reprogramming macrophage metabolism via inhibiting IRE1α/XBP1 signaling axis
10.1002/advs.202502293 · 2025 · External reference
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
10.1038/s41420-023-01725-2 · External reference
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression
10.1096/fj.202300874rr · External reference
Progressive hydrogel applications in diabetic foot ulcer management: phase-dependent healing strategies
10.3390/polym17172303 · 2025 · External reference
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
10.1016/j.cell.2016.08.064 · 2016 · External reference
Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies
10.2337/dc21-1705 · 2022 · External reference
Macrophage activation and polarization: nomenclature and experimental guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
Cytokine signaling in diabetic neuropathy: a key player in peripheral nerve damage
10.3390/biomedicines13030589 · 2025 · External reference
Itaconate: the poster child of metabolic reprogramming in macrophage function
10.1038/s41577-019-0128-5 · 2019 · External reference
Immunometabolism governs dendritic cell and macrophage function
10.1084/jem.20151570 · 2016 · External reference
Diabetes and wound angiogenesis
10.3390/ijms18071419 · 2017 · External reference
Controlled superficial assembly of DNA-Amorphous calcium phosphate nanocomposite spheres for surface-mediated gene delivery
10.1016/j.colsurfb.2016.02.010 · 2016 · External reference
Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies
10.3389/fcell.2025.1625474 · 2025 · External reference
ADA clinical compendia series. Diagnosis and Treatment of Painful Diabetic Peripheral Neuropathy. Arlington (VA): American Diabetes Association © 2022 by American Diabetes Association. All rights reserved. None of the contents may be reproduced without the written permission of the American Diabetes Association
2022 · External reference
Vascular actions of insulin with implications for endothelial dysfunction
10.1152/ajpendo.00297.2009 · 2009 · External reference
Glucose-responsive Cascade nanozyme for controlled ROS release and bacterial carbon metabolic reprogramming in infected diabetic wounds
10.1016/j.jconrel.2025.114590 · 2026 · External reference
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing
10.1038/s41420-024-02030-2 · 2024 · External reference
The electrical response to injury: molecular mechanisms and wound healing
10.1089/wound.2013.0442 · 2014 · External reference
Endothelial cell metabolism in health and disease
10.1016/j.tcb.2017.10.010 · 2018 · External reference
Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons
10.1096/fj.201700206r · 2018 · External reference
Prevalence of factors predisposing to foot complication and their relation to other risks
2012 · External reference
Injectable DMM/GelMA hydrogel for diabetic wound healing via regulating mitochondrial metabolism and macrophage repolarization
10.1016/j.colsurfb.2024.114488 · 2025 · External reference
Recent progress in design and preparation of glucose-responsive insulin delivery systems
10.1016/j.jconrel.2020.02.014 · 2020 · External reference
Suppression the glucose-induced ferroptosis in endothelial cells by 4OI-loading exosomes hydrogel for the treatment of diabetic foot ulcer
10.1016/j.cej.2024.154696 · 2024 · External reference
Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: part I. Effect of process variables on the mean size
10.3109/02652048.2013.814729 · 2014 · External reference
Protein, amino acids and obesity treatment
10.1007/s11154-020-09574-5 · 2020 · External reference
Preventing foot ulcers in patients with diabetes
10.1001/jama.293.2.217 · 2005 · External reference
Physiological and pathological roles of aldose reductase
10.3390/metabo11100655 · 2021 · External reference
Diabetes and peripheral artery disease: a review
10.4239/wjd.v12.i6.827 · 2021 · External reference
Lipid-lowering therapy in patients with type 2 diabetes: the case for early intervention
10.1002/dmrr.806 · 2008 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
10.1016/j.diabres.2021.109119 · 2022 · External reference
Immunomodulation in diabetic wounds healing: the intersection of macrophage reprogramming and immunotherapeutic hydrogels
10.1177/20417314241265202 · 2024 · External reference
Arginase signalling as a key player in chronic wound pathophysiology and healing
10.3389/fmolb.2021.773866 · 2021 · External reference
Wireless thermoelectric hydrogel recreates biomimetic electric field and angiogenic signal accelerating diabetic ulcer repair
10.1002/adfm.202425610 · 2025 · External reference
4-Octyl itaconate promotes diabetic wound healing by enhancing pro-resolving macrophages via the Efferocytosis-MCT1-Lactate-GPR132 pathway and macrophage-independent synergistic effects
10.4093/dmj.2024.0579 · 2025 · External reference
Cellular death, reactive oxygen species (ROS) and diabetic complications
10.1038/s41419-017-0135-z · 2018 · External reference
Diabetic wound healing: the impact of diabetes on myofibroblast activity and its potential therapeutic treatments
10.1111/wrr.12954 · 2021 · External reference
An injectable hyaluronic acid-silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing
10.1016/j.bioactmat.2025.08.040 · 2025 · External reference
Targeted energy metabolomics study on wound tissue of diabetic rats
10.3760/cma.j.cn501225-20241014-00385 · 2025 · External reference
Metabolite profiles and the risk of developing diabetes
10.1038/nm.2307 · 2011 · External reference
Natural carrier-free binary small molecule self-assembled hydrogel synergize antibacterial effects and promote wound healing by inhibiting virulence factors and alleviating the inflammatory response
10.1002/smll.202205528 · 2023 · External reference
Diagnosis and treatment of diabetic foot ulcer complicated with lower extremity vasculopathy: consensus recommendation from the chinese medical association (CMA), chinese medical doctor association (CMDA)
10.1002/dmrr.3776 · External reference
Metabolic reprogramming in skin wound healing
10.1093/burnst/tkad047 · External reference
L-arginine-loaded microneedle patch enhances diabetic wound healing by regulating macrophage polarisation and mitochondrial homeostasis
10.1093/rb/rbaf092 · 2025 · External reference
Organization of glucose-responsive systems and their properties
10.1021/cr200027j · 2011 · External reference
Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes
10.3389/fnut.2025.1746827 · 2025 · External reference
Quantitative assessment of macrophage functions in repair and fibrosis
10.1002/0471142735.im1422s93 · 2011 · External reference
Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair
10.1016/j.actbio.2022.05.047 · 2022 · External reference
pH-responsive printable conductive hydrogels loaded with ApoVs promote diabetic wound repair through oxidative stress scavenging and macrophage reprogramming
10.1016/j.mtbio.2026.102882 · 2026 · External reference
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications
10.3389/fendo.2024.1359255 · 2024 · External reference
Crosstalk between glucose metabolism, lactate production and immune response modulation
10.1016/j.cytogfr.2022.11.001 · 2022 · External reference
Engineering synthetic artificial pancreas using chitosan hydrogels integrated with glucose-responsive microspheres for insulin delivery
10.1016/j.msec.2018.11.032 · 2019 · External reference
Amino acid-induced impairment of insulin signaling and involvement of G-Protein coupling receptor
10.3390/nu13072229 · 2021 · External reference
Global disability burdens of diabetes-related lower-extremity complications in 1990 and 2016
10.2337/dc19-1614 · 2020 · External reference
Extracellular mitochondrial-derived vesicles affect the progression of diabetic foot ulcer by regulating oxidative stress and mitochondrial dysfunction
10.1002/advs.202407574 · 2025 · External reference
Tissue-conforming organoselenium hydrogel with microphase-controlled acylhydrazone crosslinking kinetics expedites diabetic wound healing by inhibiting AGE-RAGE pathways
10.1002/adma.72776 · External reference
Self-regulating hydrogel for diabetic wound healing: from animal models to a pilot clinical study
10.1126/sciadv.aed4981 · External reference
Dermal fibroblast senescence: the central hub of skin aging-from intrinsic dysfunction to microenvironmental remodeling
10.3390/ijms27041653 · 2026 · External reference
Targeting BCAA catabolism to treat obesity-associated insulin resistance
10.2337/db18-0927 · 2019 · External reference
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
10.1038/s41467-022-32000-0 · 2022 · External reference
Mitochondrial mGPDH modulates fibroblast function in diabetic wound healing via the SIRT1-c-Myc-TGF-β1 axis
10.2337/db25-0539 · 2026 · External reference