Research graph
References from Programmed cell death in degenerative skeletal diseases: molecular crosstalk and combinatorial therapeutic strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension
10.1038/s41598-024-54944-7 · 2024 · External reference
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells
10.18632/aging.103109 · 2020 · External reference
Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis
10.3390/life12040582 · 2022 · External reference
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
10.1074/jbc.ra120.015924 · 2020 · External reference
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
10.1038/s41413-024-00341-9 · 2024 · External reference
Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage–dependent miR-150-FNDC5/pyroptosis axis
10.2337/db21-0573 · 2022 · External reference
Pyroptosis: molecular mechanisms and roles in disease
10.1038/s41422-025-01107-6 · 2025 · External reference
Epigenetic regulation in knee osteoarthritis
10.3389/fgene.2022.942982 · 2022 · External reference
Inflammatory stimulation mediates nucleus pulposus cell necroptosis through mitochondrial function disfunction and oxidative stress pathway
10.31083/j.fbl2704111 · 2022 · External reference
Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment
10.1186/s12951-024-02538-w · 2024 · External reference
Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression
10.1016/j.jot.2024.10.005 · 2025 · External reference
Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling
10.1016/j.phymed.2024.155516 · 2024 · External reference
TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis
10.7150/ijbs.108832 · 2025 · External reference
Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation
10.1038/s12276-022-00753-9 · 2022 · External reference
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression
10.18632/aging.205373 · External reference
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death
10.3892/mmr.2023.13089 · External reference
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells
10.1016/j.intimp.2024.111661 · External reference
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1
10.1016/j.freeradbiomed.2024.05.007 · External reference
EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis
10.1097/cm9.0000000000003186 · External reference
Amelioration of intervertebral disc degeneration using engineered extracellular vesicle-delivered ZDHHC5 via inhibiting PANoptosis
10.1177/20417314251351011 · External reference
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis
10.4252/wjsc.v17.i4.103919 · External reference
Exosomes inhibit ferroptosis to alleviate intervertebral disc degeneration via the p62-KEAP1-NRF2 pathway
10.1016/j.freeradbiomed.2025.02.027 · External reference
Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis
10.1007/s10863-023-09991-6 · 2024 · External reference
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
10.1038/s41413-025-00441-0 · 2025 · External reference
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway
10.18632/aging.204612 · 2023 · External reference
Regulation of endoplasmic reticulum stress on autophagy and apoptosis of nucleus pulposus cells in intervertebral disc degeneration and its related mechanisms
10.7717/peerj.17212 · 2024 · External reference
Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway
10.1016/j.phymed.2023.155282 · 2024 · External reference
Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction
10.3389/fphys.2025.1633618 · 2025 · External reference
miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay
10.1126/science.1215691 · 2012 · External reference
Exosomes derived from quercetin-treated bone marrow derived mesenchymal stem cells inhibit the progression of osteoarthritis through delivering miR-124-3p to chondrocytes
10.1089/dna.2023.0341 · 2024 · External reference
Extracellular vesicles derived from LPS-Preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model
10.1186/s13287-021-02507-2 · 2021 · External reference
Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling
10.3389/fendo.2022.994307 · 2022 · External reference
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis
10.1016/j.ymthe.2023.10.016 · 2023 · External reference
General control non-derepressible 2 alleviates cartilage degeneration and inhibits NLRP3 inflammasome activation in osteoarthritis
10.1369/00221554231225514 · 2024 · External reference
Lumbar disc nomenclature: version 2.0: recommendations of the combined task forces of the north American spine society, the American society of spine radiology and the American society of neuroradiology
10.1016/j.spinee.2014.04.022 · 2014 · External reference
Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages
10.1016/j.redox.2024.103255 · External reference
Intra-articular injection of platinum nanozyme-loaded silk fibroin/pullulan hydrogels relieves osteoarthritis through ROS scavenging and ferroptosis suppression
10.1016/j.ijbiomac.2024.135863 · External reference
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
10.1186/s10020-024-00819-6 · External reference
PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis
10.1007/s13577-024-01067-w · External reference
ROS‐Responsive injectable hydrogel loaded with SLC7A11‐modRNA inhibits ferroptosis and mitigates intervertebral disc degeneration in rats
10.1002/adhm.202401103 · External reference
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
10.1042/cs20243438 · 2025 · External reference
Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis
10.1007/s10787-022-01098-5 · 2023 · External reference
Chronic ethanol consumption induces osteopenia via activation of osteoblast necroptosis
10.1155/2021/3027954 · 2021 · External reference
Injectable nanocomposite hydrogels for intervertebral disc degeneration: combating oxidative stress, mitochondrial dysfunction, and ferroptosis
10.1002/adhm.202403892 · 2025 · External reference
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β‐catenin axis
10.1111/acel.13677 · 2022 · External reference
Comparison of necroptosis with apoptosis for OVX-induced osteoporosis
10.3389/fmolb.2021.790613 · 2021 · External reference
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway
10.1186/s11658-024-00605-6 · External reference
Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4’s dual functions
10.1016/j.biopha.2024.116697 · External reference
Epigenetic crossroads in intervertebral disc degeneration: unlocking novel therapeutic avenues
10.3892/mmr.2026.13823 · 2026 · External reference
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis
10.1097/js9.0000000000002783 · 2025 · External reference
Identifying potential ferroptosis key genes for diagnosis and treatment of postmenopausal osteoporosis through competitive endogenous RNA network analysis
10.1016/j.heliyon.2023.e23672 · 2024 · External reference
Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: an in vitro and in vivo study
10.1002/iub.2656 · 2022 · External reference
Circular RNAs as microRNA sponges: evidence and controversies
10.1042/ebc20200060 · 2021 · External reference
Injectable hydrogel encapsulating siMMP13 with anti-ROS and anti-apoptotic functions for osteoarthritis treatment
10.1186/s12951-024-02740-w · 2024 · External reference
Inhibition of EGFR pathway suppresses M1 macrophage polarization and osteoclastogenesis, mitigating titanium particle-induced bone resorption
10.2147/jir.s484529 · 2024 · External reference
Pharmacological activation of the Nrf2 pathway by taxifolin remodels articular cartilage microenvironment for the therapy of osteoarthritis
10.1016/j.intimp.2023.110587 · 2023 · External reference
Ferroptosis in osteocytes as a target for protection against postmenopausal osteoporosis
10.1002/advs.202307388 · External reference
Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival
10.1186/s13020-024-00909-x · External reference
Morin improves the bone histomorphology and biochemical markers in an animal model of ovariectomy‐induced osteoporosis by suppressing autophagy and apoptosis
10.1002/fsn3.4554 · External reference
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance
10.1016/j.immuni.2013.02.003 · 2013 · External reference
Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts
10.1084/jem.186.4.489 · 1997 · External reference
Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in osteoarthritis
10.3389/fimmu.2023.1181156 · 2023 · External reference
Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy
10.1016/j.biopha.2024.116273 · 2024 · External reference
C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis
10.1096/fj.202100896r · 2022 · External reference
Suppression of IRF9 promotes osteoclast differentiation by decreased ferroptosis via STAT3 activation
10.1007/s10753-023-01896-1 · 2024 · External reference
OARSI-FDA initiative: defining the disease state of osteoarthritis
10.1016/j.joca.2010.09.013 · 2011 · External reference
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
10.1038/s41586-021-03875-8 · 2021 · External reference
Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration
10.1186/s11658-023-00517-x · 2023 · External reference
The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis
10.1038/s41598-022-13791-0 · External reference
miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway
10.1186/s13018-021-02886-5 · External reference
PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products
10.1038/s41419-023-05595-5 · External reference
Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
10.1186/s13020-023-00748-2 · External reference
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression
10.1016/j.intimp.2022.109489 · External reference
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis: nrf2/HMGB1 affects osteoarthritis
10.3724/abbs.2023078 · External reference
Tetrahedral framework nucleic acids-based delivery of microRNA-155 alleviates intervertebral disc degeneration through targeting Bcl-2/Bax apoptosis pathway
10.1111/cpr.13689 · External reference
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis
10.1016/j.mtbio.2024.101202 · External reference
Analysis of PANoptosis-related ceRNA network reveals lncRNA MIR17HG involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α
10.1007/s11033-024-09810-0 · External reference
Reprogramming macrophage polarization, depleting ROS by astaxanthin and thioketal‐containing polymers delivering rapamycin for osteoarthritis treatment
10.1002/advs.202305363 · External reference
Near infrared responsive gold nanorods attenuate osteoarthritis progression by targeting TRPV1
10.1002/advs.202307683 · External reference
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
10.1038/s41413-024-00319-7 · External reference
Gut microbiota metabolite urolithin B inhibits chondrocyte ferroptosis by rewriting iron homeostasis via FGFR3/NCOA4/FTH1 axis, alleviating osteoarthritis
10.1016/j.phymed.2025.157292 · External reference
MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent mechanism
10.1016/j.freeradbiomed.2025.09.056 · External reference
Functionalized biomimetic nanoparticles targeting the IL‐10/IL‐10Rα/glycolytic axis in synovial macrophages alleviate cartilage degeneration in osteoarthritis
10.1002/advs.202504768 · External reference
Mechanism of the enterobacterial metabolite sodium butyrate mediating ferroptosis to affect osteogenic ability of BMSCs in mice with estrogen deficiency-caused osteoporosis via the PTEN/PI3K/AKT pathway
10.1007/s10495-025-02179-w · External reference
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis
10.1186/s12951-025-03990-y · 2026 · External reference
IRE1 signaling affects cell fate during the unfolded protein response
10.1126/science.1146361 · 2007 · External reference
Eicosapentaenoic acid-induced autophagy attenuates intervertebral disc degeneration by suppressing endoplasmic reticulum stress, extracellular matrix degradation, and apoptosis
10.3389/fcell.2021.745621 · 2021 · External reference
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy
10.1038/s12276-024-01196-0 · External reference
Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1
10.1038/s41420-024-01986-5 · External reference
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission
10.1186/s12951-024-02517-1 · External reference
Autosis is a na+, K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia
10.1073/pnas.1319661110 · 2013 · External reference
Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro
10.1080/21655979.2021.2024685 · 2022 · External reference
Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling
10.1016/j.biopha.2022.114118 · External reference
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation
10.1186/s13075-023-03214-4 · External reference
Sirtuins in osteoarthritis: current understanding
10.3389/fimmu.2023.1140653 · External reference
Vitamin D plays a protective role in osteoarthritis by regulating AMPK/mTOR signalling pathway to activate chondrocyte autophagy
10.55563/clinexprheumatol/chmuts · 2024 · External reference
Impacts of nonenzymatic glycation crosslinks in bone matrix on the mechanosensitivity of osteocyte
10.1007/s00223-025-01411-8 · 2025 · External reference
Ferroportin‐dependent iron homeostasis protects against oxidative stress‐induced nucleus pulposus cell ferroptosis and ameliorates intervertebral disc degeneration in vivo
10.1155/2021/6670497 · 2021 · External reference
Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis
10.7717/peerj.20701 · 2026 · External reference
Glucocorticoids regulate the expression of Srsf1 through Hdac4/Foxc1 axis to induce apoptosis of osteoblasts
10.1038/s42003-025-07989-x · 2025 · External reference
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
10.1038/s41420-022-01002-8 · 2022 · External reference
GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development
10.1016/j.jare.2024.05.033 · 2025 · External reference
Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses
10.1074/jbc.r116.760884 · 2017 · External reference
Collagen II enrichment through scAAV6-RNAi-mediated inhibition of matrix-metalloproteinases 3 and 13 in degenerative nucleus-pulposus cells degenerative disc disease and biological treatment strategies
10.3389/ebm.2024.10048 · 2024 · External reference
Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
10.1016/j.ebiom.2022.103847 · 2022 · External reference
Bcl2l1 deficiency in osteoblasts reduces the trabecular bone due to enhanced osteoclastogenesis likely through osteoblast apoptosis
10.3390/ijms242417319 · 2023 · External reference
Necroptosis and its involvement in various diseases
10.1007/978-981-99-9781-7_9 · 2024 · External reference
Hypoxia inhibits RANKL-Induced ferritinophagy and protects osteoclasts from ferroptosis
10.1016/j.freeradbiomed.2021.04.027 · 2021 · External reference
Osteoporosis prevention, diagnosis, and therapy
10.1001/jama.285.6.785 · 2001 · External reference
Temsirolimus, a water-soluble mTOR inhibitor, alleviates osteoarthritic changes in human chondrocytes and mouse osteoarthritis models
10.1080/03008207.2025.2521404 · 2025 · External reference
Circular RNAs act as miRNA sponges
10.1007/978-981-13-1426-1_6 · 2018 · External reference
Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression
10.1186/s13075-025-03589-6 · 2025 · External reference
The bcr-abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases
10.1016/j.biopha.2023.114528 · 2023 · External reference
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles
10.1016/j.actbio.2024.05.014 · 2024 · External reference
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
10.1007/s10565-025-10071-1 · 2025 · External reference
MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells
10.1016/j.cellsig.2023.110678 · 2023 · External reference
The muscle–intervertebral disc interaction mediated by L-BAIBA modulates extracellular matrix homeostasis and PANoptosis in nucleus pulposus cells
10.1038/s12276-024-01345-5 · 2024 · External reference
Protein kinase C and matrix metalloproteinases expression using phorbol myristate acetate in degenerative intervertebral disc cells
10.4055/cios23365 · 2024 · External reference
Gsmtx4 alleviated osteoarthritis through Piezo1/Calcineurin/NFAT1 signaling axis under excessive mechanical strain
10.3390/ijms24044022 · 2023 · External reference
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
10.1038/ncomms14128 · 2017 · External reference
miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis
10.1186/s13018-022-03334-8 · 2022 · External reference
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
10.1038/s41413-024-00365-1 · 2024 · External reference
Metal–organic framework-integrated nanoplatform orchestrates osteochondral-synovial homeostasis for osteoarthritis therapy
10.1021/acsnano.5c10692 · 2025 · External reference
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
10.1172/jci.insight.93612 · 2017 · External reference
The role of ferroptosis in osteoarthritis: progress and prospects
10.1016/j.bbrc.2024.150683 · 2024 · External reference
Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-κb pathway and the reactive oxygen species-related Nrf2 signaling pathway: X. Shi et al
10.1007/s10787-024-01552-6 · 2024 · External reference
Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1α pathway mediated mitophagy
10.1016/j.intimp.2024.113895 · External reference
Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells
10.1016/j.jot.2025.01.013 · External reference
Mitophagy in degenerative joint diseases
10.1080/15548627.2020.1822097 · 2021 · External reference
JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy
10.1016/j.freeradbiomed.2023.03.008 · External reference
Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy
10.1038/s41420-023-01406-0 · External reference
Glycolysis‐derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration
10.1002/advs.202416149 · External reference
PPARγ-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis
10.1186/s11658-025-00802-x · External reference
Effect of autophagy gene DRAM on proliferation, cell cycle, apoptosis, and autophagy of osteoblast in osteoporosis rats
10.1002/jcp.27304 · 2019 · External reference
The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis
10.1016/j.jot.2023.11.005 · 2024 · External reference
Urolithin A suppresses RANKL-Induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways
10.1016/j.phrs.2021.105967 · 2021 · External reference
NOX1-mediated oxidative stress induces chondrocyte ferroptosis by inhibiting the Nrf2/HO-1 pathway
10.1038/s41598-024-70991-6 · 2024 · External reference
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
10.1155/2014/970607 · 2014 · External reference
Epigenetic modifications of MiRNAs in osteoarthritis: a systematic review on their methylation levels and effects on chondrocytes, extracellular matrix and joint inflammation
10.3390/cells12141821 · 2023 · External reference
Apoptotic cell death in disease—Current understanding of the NCCD 2023
10.1038/s41418-023-01153-w · 2023 · External reference
Role of macrophage CD44 in the disposal of inflammatory cell corpses
10.1042/cs1030441 · 2002 · External reference
Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NFκB signaling pathway
10.1016/j.freeradbiomed.2021.05.014 · 2021 · External reference
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
10.1038/nature22393 · 2017 · External reference
PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy
10.1016/j.bbrc.2018.06.031 · 2018 · External reference
miR-222 induces apoptosis in human intervertebral disc nucleus pulposus cells by targeting Bcl-2
10.3892/mmr.2019.10732 · 2019 · External reference
Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx
10.1016/j.jare.2022.01.004 · External reference
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes
10.1016/j.freeradbiomed.2022.08.018 · External reference
Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis
10.1007/s12011-021-02627-z · External reference
Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
10.1186/s12891-023-07003-7 · 2023 · External reference
MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis
10.1016/j.jare.2025.09.060 · 2026 · External reference
Injectable ECM-Mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
10.1038/s41467-025-58447-5 · 2025 · External reference
Human amniotic epithelial stem cell exosomes regulate chondrocyte ferroptosis through ACTA2-AS1-targeted binding to ACSL4 for osteoarthritis intervention
10.34133/research.0814 · 2025 · External reference
GelMA@ APPA microspheres promote chondrocyte regeneration and alleviate osteoarthritis via Fgfr2 activation
10.1016/j.phymed.2024.156176 · 2025 · External reference
Multimodal analysis investigating the shared pathogenic mechanisms of osteoporosis and osteoarthritis with an initial exploration of the role of ferroptosis
10.1371/journal.pone.0332769 · 2025 · External reference
DDIT3 drives nucleus pulposus cell PANoptosis and intervertebral disc degeneration progression
10.1007/s10495-025-02231-9 · 2026 · External reference
Apoptosis activation and autophagy inhibition of chondrocytes by leptin by the upregulation of LOXL3 in osteoarthritis pathogenesis
10.1155/2022/4026128 · 2022 · External reference
Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis
10.1038/s41420-023-01331-2 · 2023 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
LDHA‐mediated glycolytic metabolism in nucleus pulposus cells is a potential therapeutic target for intervertebral disc degeneration
10.1155/2021/9914417 · 2021 · External reference
Ajugol's upregulation of TFEB-Mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model
10.1186/s13020-023-00824-7 · 2023 · External reference
Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2
10.1089/ars.2023.0384 · 2024 · External reference
UCHL1 alleviates nucleus pulposus cell senescence by promoting chaperone-mediated autophagy antagonizing autophagy-dependent ferroptosis through deubiquitination of HSPA8
10.1080/15548627.2025.2544287 · 2025 · External reference
ELP2-NLRP3-GSDMD/GSDME-mediated pyroptosis is induced by TNF-α in MC3T3-E1 cells during osteogenic differentiation
10.1111/jcmm.17994 · External reference
Retuning mitochondrial apoptosis/mitophagy balance via SIRT3‐Energized and microenvironment‐modulated hydrogel microspheres to impede osteoarthritis
10.1002/adhm.202302475 · External reference
REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis
10.1038/s41419-023-06160-w · External reference
Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α
10.1186/s40001-025-02702-4 · External reference
Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies
10.3389/fimmu.2025.1604652 · External reference
USP7 inhibits osteoclastogenesis via dual effects of attenuating TRAF6/TAK1 axis and stimulating STING signaling
10.14336/ad.2023.0325-1 · External reference
ITGB1 alleviates osteoarthritis by inhibiting cartilage inflammation and apoptosis via activating cAMP pathway
10.1186/s13018-023-04342-y · External reference
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration
10.1186/s12951-021-00991-5 · 2021 · External reference
Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis
10.1186/s13018-023-04010-1 · 2023 · External reference
miRNA-141 induced pyroptosis in intervertebral disk degeneration by targeting ROS generation and activating TXNIP/NLRP3 signaling in nucleus pulpous cells
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