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References from Sodium alginate-based dual-responsive nanoparticles co-loaded with baicalin and doxorubicin induce ferroptosis in hepatocellular carcinoma associated with the PI3K/AKT/FoxO3α axis regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
10.1038/s41586-019-1703-9 · 2019 · External reference
Construction and evaluation of BAL-PTX co-loaded lipid nanosystem for promoting the anti-lung cancer efficacy of paclitaxel and reducing the toxicity of chemotherapeutic drugs
10.2147/ijn.s460125 · 2024 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Baicalin inhibits cell viability, migration and invasion in breast cancer by regulating miR-338-3p and MORC4
10.2147/ott.s217624 · 2019 · External reference
YAP/TAZ and ATF4 drive resistance to sorafenib in hepatocellular carcinoma by preventing ferroptosis
10.15252/emmm.202014351 · 2021 · External reference
The role of epithelial-mesenchymal transformation in hepatocellular carcinoma and the progress of TCM intervention therapy
10.1016/j.joim.2021.06.003 · 2021 · External reference
Optimization and characterization of low-molecular-weight chitosan-coated baicalin mPEG-PLGA nanoparticles for the treatment of cataract
10.1021/acs.molpharmaceut.2c00321 · 2022 · External reference
Evaluation of efficacy, safety and underlying mechanism on traditional Chinese medicine as synergistic agents for cancer immunotherapy: a preclinical systematic review and meta-analysis
10.1016/j.jep.2024.119035 · 2025 · External reference
LncRNA GAS6-AS2 facilitates tumor growth and metastasis of hepatocellular carcinoma by activating the PI3K/AKT/FoxO3a signaling pathway
2019 · External reference
SYT7 promotes breast cancer cells growth through the PI3K/AKT pathway
10.21037/tcr-24-1218 · 2024 · External reference
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking
10.1038/s41598-023-51167-9 · 2024 · External reference
Akt in cancer: mediator and more
10.1016/j.semcancer.2019.05.002 · 2019 · External reference
Baicalin relieves LPS-induced lung inflammation via the NF-kB and MAPK pathways
10.3390/molecules28041873 · 2023 · External reference
AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc-activity
10.1016/j.cub.2018.06.010 · 2018 · External reference
Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling
10.1002/ptr.7964 · 2023 · External reference
Eco-friendly, pH-sensitive curcumin-loaded sodium alginate/hydroxyapatite/quaternary ammonium chitosan microspheres with enhanced antibacterial and antioxidant activities for fruit preservation
10.1016/j.ijbiomac.2024.135297 · 2024 · External reference
Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells
10.1155/2014/732516 · 2014 · External reference
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
10.1038/s41419-021-02690-9 · 2021 · External reference
AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
10.7150/ijbs.81145 · 2023 · External reference
Research progress of traditional Chinese medicine monomers in reversing multidrug resistance of breast cancer
10.1142/s0192415x23510024 · 2023 · External reference
Red ginseng polysaccharide promotes ferroptosis in gastric cancer cells by inhibiting PI3K/Akt pathway through down-regulation of AQP3
10.1080/15384047.2024.2284849 · 2024 · External reference
Baicalin induces ferroptosis in osteosarcomas through novel Nrf2/xCT/GPX4 regulatory axis
10.1016/j.phytomed.2023.154881 · 2023 · External reference
Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway
10.1016/j.intimp.2021.108097 · 2021 · External reference
Current status and prospect of treatments for recurrent hepatocellular carcinoma
10.4254/wjh.v15.i2.129 · 2023 · External reference
FA-PEG modified ZIF(Mn) nanoparticles loaded with baicalin for imaging-guided treatment of melanoma in mice
10.2147/ijn.s458761 · 2024 · External reference
Nanosized porphyrin-containing covalent organic polymer to enhance ferroptosis in photodynamic treatment of tumor cells via glutathione depletion
10.1021/acs.bioconjchem.4c00187 · 2024 · External reference
Ultrasmall iridium-encapsulated porphyrin metal-organic frameworks for enhanced photodynamic/catalytic therapy by producing reactive oxygen species storm
10.1016/j.jcis.2024.121022 · 2025 · External reference
A self-assembling cytotoxic nanotherapeutic strategy for high drug loading and synergistic delivery of molecularly targeted therapies
10.1016/j.actbio.2025.01.024 · 2025 · External reference