Research graph
References from Diabetic cardiomyopathy as a disorder of proteostatic maladaptation: context-dependent ubiquitin-specific protease networks. Local targets link to admitted publications; unresolved targets remain external evidence.
Deubiquitylases in developmental ubiquitin signaling and congenital diseases
10.1038/s41418-020-00697-5 · 2021 · External reference
Mechanisms of diabetic cardiomyopathy: focus on inflammation
10.1111/dom.16242 · 2025 · External reference
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
10.1038/nature13418 · 2014 · External reference
Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control
10.3389/fphys.2018.01514 · 2018 · External reference
Molecular mechanisms of diabetic cardiomyopathy
10.1007/s00125-014-3171-6 · 2014 · External reference
Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies
10.7150/ijbs.75402 · 2022 · External reference
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
10.1016/j.freeradbiomed.2024.04.221 · 2024 · External reference
USP33 alleviates FIS1-dependent mitochondrial fission and cardiac microvascular injury in diabetic cardiomyopathy deubiquitinating and stabilizing ATG7
10.1038/s41419-026-08930-8 · 2026 · External reference
A related mechanism for USP18 regulating diabetic cardiomyopathy procession: promoting activity of AKT signaling pathway by improving Notch1 stability
10.1016/j.bbrc.2025.152626 · 2025 · External reference
Breaking the chains: deubiquitylating enzyme specificity begets function
10.1038/s41580-019-0099-1 · 2019 · External reference
Empagliflozin attenuates diabetic cardiomyopathy via inhibiting cardiomyocyte ferroptosis through the USP7/NRF2 signaling pathway
10.1177/15230864251377765 · 2026 · External reference
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
10.1038/nm.2536 · 2011 · External reference
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities
10.1038/s41418-020-00703-w · 2021 · External reference
Diabetic cardiomyopathy
10.1161/circresaha.118.314665 · 2019 · External reference
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
10.1172/jci14080 · 2002 · External reference
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
10.1093/cvr/cvx011 · 2017 · External reference
Molecular mechanisms of type 2 diabetes-related heart disease and therapeutic insights
10.3390/ijms26104548 · 2025 · External reference
Mitochondrial mechanisms in diabetic cardiomyopathy
10.4093/dmj.2019.0185 · 2020 · External reference
UBC9-Mediated sumoylation favorably impacts cardiac function in compromised hearts
10.1161/circresaha.115.308268 · 2016 · External reference
ATGL-Mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
10.1038/nm.2439 · 2011 · External reference
Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in Male mice
10.1038/s41467-025-61028-1 · 2025 · External reference
Lipotoxicity in diabetic cardiomyopathy: molecular basis and emerging therapeutic targets
10.3390/ijms27062740 · 2026 · External reference
Deubiquitylating enzymes and drug discovery: emerging opportunities
10.1038/nrd.2017.152 · 2018 · External reference
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
10.1186/s12933-023-01816-5 · 2023 · External reference
Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions
10.1038/s41420-023-01553-4 · 2023 · External reference
Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus
10.1186/s40842-025-00247-3 · 2025 · External reference
USP20 (Ubiquitin-Specific protease 20) inhibits TNF (tumor necrosis Factor)-Triggered smooth muscle cell inflammation and attenuates atherosclerosis
10.1161/atvbaha.118.311071 · 2018 · External reference
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
10.1161/circresaha.117.311586 · 2018 · External reference
Treatment with b-AP15 to inhibit UCHL5 and USP14 deubiquitinating activity and enhance p27 and cyclin E1 for tumors with p53 deficiency
10.1177/15330338221119745 · 2022 · External reference
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation
10.15252/embr.201744378 · 2018 · External reference
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
10.1038/s44161-022-00028-6 · 2022 · External reference
The ubiquitin code
10.1146/annurev-biochem-060310-170328 · 2012 · External reference
Deubiquitinases: from mechanisms to their inhibition by small molecules
10.1016/j.molcel.2021.10.027 · 2022 · External reference
Enhancement of proteasome activity by a small-molecule inhibitor of USP14
10.1038/nature09299 · 2010 · External reference
PPARs modulate cardiac metabolism and mitochondrial function in diabetes
10.1186/s12929-016-0309-5 · 2017 · External reference
Ubiquitin-specific protease: an emerging key player in cardiomyopathy
10.1186/s12964-025-02123-0 · 2025 · External reference
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy
10.1016/j.yjmcc.2016.11.013 · 2017 · External reference
Ufm1-Specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure
10.1161/circheartfailure.118.004917 · 2018 · External reference
Neddylation, an emerging mechanism regulating cardiac development and function
10.3389/fphys.2020.612927 · 2020 · External reference
USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradation
10.1126/sciadv.adx3827 · 2025 · External reference
Multi-omics profiling of the diabetic human heart reveals coupled dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling
10.1186/s13073-026-01668-0 · 2026 · External reference
Pharmacological inhibition of USP30 activates tissue-specific mitophagy
10.1111/apha.13666 · 2021 · External reference
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
10.1007/s00395-025-01144-7 · 2025 · External reference
Mechanisms of deubiquitinase specificity and regulation
10.1146/annurev-biochem-061516-044916 · 2017 · External reference
A guide to UFMylation, an emerging posttranslational modification
10.1111/febs.16730 · 2023 · External reference
Ubiquitin proteasome system role in diabetes-induced cardiomyopathy
10.3390/ijms242015376 · 2023 · External reference
ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation
10.1007/s00018-024-05397-8 · 2024 · External reference
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy
10.1016/j.biopha.2022.114200 · 2023 · External reference
Cellular quality control by the ubiquitin-proteasome system and autophagy
10.1126/science.aax3769 · 2019 · External reference
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
10.1016/j.molcel.2012.11.009 · 2013 · External reference
Deubiquitylating enzymes in cancer and immunity
10.1002/advs.202303807 · 2023 · External reference
SGLT2 inhibitors vs. GLP-1 agonists to treat the heart, the kidneys and the brain
10.3390/jcdd10080322 · 2023 · External reference
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates
10.1016/j.chembiol.2024.05.001 · 2024 · External reference
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
10.1126/scisignal.2000751 · 2010 · External reference
Deubiquitinating enzymes (DUBs): regulation, homeostasis, and oxidative stress response
10.1016/j.jbc.2021.101077 · 2021 · External reference
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
10.1038/ncomms13727 · 2016 · External reference
The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective
10.1093/cvr/cvp287 · 2010 · External reference
Mitochondrial quality control as a therapeutic target
10.1124/pr.115.011502 · 2016 · External reference
Exogenous H(2)S promoted USP8 sulfhydration to regulate mitophagy in the hearts of Db/Db mice
10.14336/ad.2019.0524 · 2020 · External reference
The structure and function of deubiquitinases: lessons from budding yeast
10.1098/rsob.200279 · 2020 · External reference
Mechanisms of generating polyubiquitin chains of different topology
10.3390/cells3030674 · 2014 · External reference
Ubiquitin modifications
10.1038/cr.2016.39 · 2016 · External reference
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence
10.1038/s41569-020-0339-2 · 2020 · External reference
Cardiometabolic benefits and risks of sodium-glucose Co-Transporter-2 (SGLT-2) inhibitor and glucagon-like Peptide-1 (GLP-1) receptor agonist combination therapy in type 2 diabetes: a systematic review
10.7759/cureus.96218 · 2025 · External reference
Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
10.1038/s41467-022-30376-7 · 2022 · External reference
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
10.1038/nature24451 · 2017 · External reference
Proteasome functional insufficiency in cardiac pathogenesis
10.1152/ajpheart.00714.2011 · 2011 · External reference
NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells
10.1002/1878-0261.13574 · 2024 · External reference
USP14 and ELAVL1-induced stabilization of VDAC1 aggravates myocardial cell injury in diabetic cardiomyopathy
10.1016/j.cellsig.2026.112410 · 2026 · External reference
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
10.1016/j.freeradbiomed.2023.11.032 · 2024 · External reference
UBC9 ameliorates diabetic cardiomyopathy by modulating cardiomyocyte mitophagy through NEDD4/RUNX2/PSEN2 axis
10.1016/j.metabol.2025.156264 · 2025 · External reference
USP24 inhibits autophagy in diabetic myocardial disorder by regulating TRAF6-mediated ubiquitination of Beclin-1
10.1016/j.lfs.2026.124296 · 2026 · External reference
Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2
10.1016/j.freeradbiomed.2024.08.021 · 2024 · External reference
Ubiquitin-specific protease 38 exacerbates diabetic cardiomyopathy via post-translational modification of ACAD11
10.1016/j.redox.2025.103704 · 2025 · External reference
USP28 serves as a key suppressor of mitochondrial morphofunctional defects and cardiac dysfunction in the diabetic heart
10.1161/circulationaha.123.065603 · 2024 · External reference
USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes
10.1038/s41418-025-01612-6 · External reference
USP18 mediates high glucose-induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression
10.1111/jdi.70210 · External reference
Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta-analysis
10.1186/s12933-020-01197-z · 2021 · External reference
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β
10.1016/j.phrs.2024.107235 · 2024 · External reference
MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
10.1186/s12933-019-0811-7 · 2019 · External reference
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
10.1016/j.bcp.2018.08.039 · 2018 · External reference
USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy
10.1080/15548627.2024.2347103 · External reference
USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3
10.1016/j.freeradbiomed.2024.10.302 · External reference
Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3 deubiquitination
10.1002/advs.202416478 · 2025 · External reference
Cardiomyocyte-derived USP20 attenuates diabetic cardiomyopathy by facilitating the degradation of STING and mitigating STING-mediated inflammation
10.1096/fj.202503913r · 2026 · External reference
NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells
10.1002/1878-0261.13574 · ExternalCitation · doi-reference
Deubiquitylating enzymes in cancer and immunity
10.1002/advs.202303807 · ExternalCitation · doi-reference
Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3 deubiquitination
10.1002/advs.202416478 · ExternalCitation · doi-reference
ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation
10.1007/s00018-024-05397-8 · ExternalCitation · doi-reference
Molecular mechanisms of diabetic cardiomyopathy
10.1007/s00125-014-3171-6 · ExternalCitation · doi-reference
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
10.1007/s00395-025-01144-7 · ExternalCitation · doi-reference
A related mechanism for USP18 regulating diabetic cardiomyopathy procession: promoting activity of AKT signaling pathway by improving Notch1 stability
10.1016/j.bbrc.2025.152626 · ExternalCitation · doi-reference
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
10.1016/j.bcp.2018.08.039 · ExternalCitation · doi-reference
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy
10.1016/j.biopha.2022.114200 · ExternalCitation · doi-reference
USP14 and ELAVL1-induced stabilization of VDAC1 aggravates myocardial cell injury in diabetic cardiomyopathy
10.1016/j.cellsig.2026.112410 · ExternalCitation · doi-reference
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates
10.1016/j.chembiol.2024.05.001 · ExternalCitation · doi-reference
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
10.1016/j.freeradbiomed.2023.11.032 · ExternalCitation · doi-reference
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
10.1016/j.freeradbiomed.2024.04.221 · ExternalCitation · doi-reference
Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2
10.1016/j.freeradbiomed.2024.08.021 · ExternalCitation · doi-reference
USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3
10.1016/j.freeradbiomed.2024.10.302 · ExternalCitation · doi-reference
Deubiquitinating enzymes (DUBs): regulation, homeostasis, and oxidative stress response
10.1016/j.jbc.2021.101077 · ExternalCitation · doi-reference
USP24 inhibits autophagy in diabetic myocardial disorder by regulating TRAF6-mediated ubiquitination of Beclin-1
10.1016/j.lfs.2026.124296 · ExternalCitation · doi-reference
UBC9 ameliorates diabetic cardiomyopathy by modulating cardiomyocyte mitophagy through NEDD4/RUNX2/PSEN2 axis
10.1016/j.metabol.2025.156264 · ExternalCitation · doi-reference
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
10.1016/j.molcel.2012.11.009 · ExternalCitation · doi-reference
Deubiquitinases: from mechanisms to their inhibition by small molecules
10.1016/j.molcel.2021.10.027 · ExternalCitation · doi-reference
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β
10.1016/j.phrs.2024.107235 · ExternalCitation · doi-reference
Ubiquitin-specific protease 38 exacerbates diabetic cardiomyopathy via post-translational modification of ACAD11
10.1016/j.redox.2025.103704 · ExternalCitation · doi-reference
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy
10.1016/j.yjmcc.2016.11.013 · ExternalCitation · doi-reference
Ubiquitin modifications
10.1038/cr.2016.39 · ExternalCitation · doi-reference
Enhancement of proteasome activity by a small-molecule inhibitor of USP14
10.1038/nature09299 · ExternalCitation · doi-reference
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
10.1038/nature13418 · ExternalCitation · doi-reference
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
10.1038/nature24451 · ExternalCitation · doi-reference
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
10.1038/ncomms13727 · ExternalCitation · doi-reference
ATGL-Mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
10.1038/nm.2439 · ExternalCitation · doi-reference
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
10.1038/nm.2536 · ExternalCitation · doi-reference
Deubiquitylating enzymes and drug discovery: emerging opportunities
10.1038/nrd.2017.152 · ExternalCitation · doi-reference
Deubiquitylases in developmental ubiquitin signaling and congenital diseases
10.1038/s41418-020-00697-5 · ExternalCitation · doi-reference
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities
10.1038/s41418-020-00703-w · ExternalCitation · doi-reference
USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes
10.1038/s41418-025-01612-6 · ExternalCitation · doi-reference
USP33 alleviates FIS1-dependent mitochondrial fission and cardiac microvascular injury in diabetic cardiomyopathy deubiquitinating and stabilizing ATG7
10.1038/s41419-026-08930-8 · ExternalCitation · doi-reference
Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions
10.1038/s41420-023-01553-4 · ExternalCitation · doi-reference
Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
10.1038/s41467-022-30376-7 · ExternalCitation · doi-reference
Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in Male mice
10.1038/s41467-025-61028-1 · ExternalCitation · doi-reference
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence
10.1038/s41569-020-0339-2 · ExternalCitation · doi-reference
Breaking the chains: deubiquitylating enzyme specificity begets function
10.1038/s41580-019-0099-1 · ExternalCitation · doi-reference
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
10.1038/s44161-022-00028-6 · ExternalCitation · doi-reference
USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy
10.1080/15548627.2024.2347103 · ExternalCitation · doi-reference
The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective
10.1093/cvr/cvp287 · ExternalCitation · doi-reference
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
10.1093/cvr/cvx011 · ExternalCitation · doi-reference
Cardiomyocyte-derived USP20 attenuates diabetic cardiomyopathy by facilitating the degradation of STING and mitigating STING-mediated inflammation
10.1096/fj.202503913r · ExternalCitation · doi-reference
The structure and function of deubiquitinases: lessons from budding yeast
10.1098/rsob.200279 · ExternalCitation · doi-reference
Pharmacological inhibition of USP30 activates tissue-specific mitophagy
10.1111/apha.13666 · ExternalCitation · doi-reference
Mechanisms of diabetic cardiomyopathy: focus on inflammation
10.1111/dom.16242 · ExternalCitation · doi-reference
A guide to UFMylation, an emerging posttranslational modification
10.1111/febs.16730 · ExternalCitation · doi-reference
USP18 mediates high glucose-induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression
10.1111/jdi.70210 · ExternalCitation · doi-reference
Mitochondrial quality control as a therapeutic target
10.1124/pr.115.011502 · ExternalCitation · doi-reference
USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradation
10.1126/sciadv.adx3827 · ExternalCitation · doi-reference
Cellular quality control by the ubiquitin-proteasome system and autophagy
10.1126/science.aax3769 · ExternalCitation · doi-reference
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
10.1126/scisignal.2000751 · ExternalCitation · doi-reference
The ubiquitin code
10.1146/annurev-biochem-060310-170328 · ExternalCitation · doi-reference
Mechanisms of deubiquitinase specificity and regulation
10.1146/annurev-biochem-061516-044916 · ExternalCitation · doi-reference
Proteasome functional insufficiency in cardiac pathogenesis
10.1152/ajpheart.00714.2011 · ExternalCitation · doi-reference
USP20 (Ubiquitin-Specific protease 20) inhibits TNF (tumor necrosis Factor)-Triggered smooth muscle cell inflammation and attenuates atherosclerosis
10.1161/atvbaha.118.311071 · ExternalCitation · doi-reference
Ufm1-Specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure
10.1161/circheartfailure.118.004917 · ExternalCitation · doi-reference
UBC9-Mediated sumoylation favorably impacts cardiac function in compromised hearts
10.1161/circresaha.115.308268 · ExternalCitation · doi-reference
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
10.1161/circresaha.117.311586 · ExternalCitation · doi-reference
Diabetic cardiomyopathy
10.1161/circresaha.118.314665 · ExternalCitation · doi-reference
USP28 serves as a key suppressor of mitochondrial morphofunctional defects and cardiac dysfunction in the diabetic heart
10.1161/circulationaha.123.065603 · ExternalCitation · doi-reference
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
10.1172/jci14080 · ExternalCitation · doi-reference
Empagliflozin attenuates diabetic cardiomyopathy via inhibiting cardiomyocyte ferroptosis through the USP7/NRF2 signaling pathway
10.1177/15230864251377765 · ExternalCitation · doi-reference
Treatment with b-AP15 to inhibit UCHL5 and USP14 deubiquitinating activity and enhance p27 and cyclin E1 for tumors with p53 deficiency
10.1177/15330338221119745 · ExternalCitation · doi-reference
PPARs modulate cardiac metabolism and mitochondrial function in diabetes
10.1186/s12929-016-0309-5 · ExternalCitation · doi-reference
MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
10.1186/s12933-019-0811-7 · ExternalCitation · doi-reference
Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta-analysis
10.1186/s12933-020-01197-z · ExternalCitation · doi-reference
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
10.1186/s12933-023-01816-5 · ExternalCitation · doi-reference
Ubiquitin-specific protease: an emerging key player in cardiomyopathy
10.1186/s12964-025-02123-0 · ExternalCitation · doi-reference
Multi-omics profiling of the diabetic human heart reveals coupled dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling
10.1186/s13073-026-01668-0 · ExternalCitation · doi-reference
Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus
10.1186/s40842-025-00247-3 · ExternalCitation · doi-reference
Exogenous H(2)S promoted USP8 sulfhydration to regulate mitophagy in the hearts of Db/Db mice
10.14336/ad.2019.0524 · ExternalCitation · doi-reference
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation
10.15252/embr.201744378 · ExternalCitation · doi-reference
Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control
10.3389/fphys.2018.01514 · ExternalCitation · doi-reference
Neddylation, an emerging mechanism regulating cardiac development and function
10.3389/fphys.2020.612927 · ExternalCitation · doi-reference
Mechanisms of generating polyubiquitin chains of different topology
10.3390/cells3030674 · ExternalCitation · doi-reference
Ubiquitin proteasome system role in diabetes-induced cardiomyopathy
10.3390/ijms242015376 · ExternalCitation · doi-reference
Molecular mechanisms of type 2 diabetes-related heart disease and therapeutic insights
10.3390/ijms26104548 · ExternalCitation · doi-reference
Lipotoxicity in diabetic cardiomyopathy: molecular basis and emerging therapeutic targets
10.3390/ijms27062740 · ExternalCitation · doi-reference
SGLT2 inhibitors vs. GLP-1 agonists to treat the heart, the kidneys and the brain
10.3390/jcdd10080322 · ExternalCitation · doi-reference
Mitochondrial mechanisms in diabetic cardiomyopathy
10.4093/dmj.2019.0185 · ExternalCitation · doi-reference
Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies
10.7150/ijbs.75402 · ExternalCitation · doi-reference
Cardiometabolic benefits and risks of sodium-glucose Co-Transporter-2 (SGLT-2) inhibitor and glucagon-like Peptide-1 (GLP-1) receptor agonist combination therapy in type 2 diabetes: a systematic review
10.7759/cureus.96218 · ExternalCitation · doi-reference
