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References from Non-invasive assessment of embryo development and ploidy: morphokinetics predict blastulation, and exploratory metabolomics identifies candidate metabolic signatures for euploidy. Local targets link to admitted publications; unresolved targets remain external evidence.
Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis
10.1093/humupd/dmac022 · 2022 · External reference
A comparison of 12 machine learning models developed to predict ploidy, using a morphokinetic meta-dataset of 8147 embryos
10.1093/humrep/dead034 · 2023 · External reference
The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection
10.1093/humrep/deu331 · 2015 · External reference
Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics
10.1016/j.rbmo.2013.02.006 · 2013 · External reference
Selecting embryos with the highest implantation potential using data mining and decision tree based on classical embryo morphology and morphokinetics
10.1007/s10815-017-0955-x · 2017 · External reference
Morphokinetic analysis of cleavage stage embryos and its relationship to aneuploidy in a retrospective time-lapse imaging study
10.1007/s10815-014-0372-3 · 2015 · External reference
Analysis of metabolic differences in day5 culture media of embryos with varying developmental potential by high performance liquid chromatography-tandem mass spectrometry
10.3969/j.issn.1004-3845.2025.09.010 · External reference
Preliminary study on predicting early embryonic developmental potential by metabolomics analysis of day 3 embryo culture medium
10.3760/cma.j.cn101441-20240914-00342 · External reference
Type of chromosome abnormality affects embryo morphology dynamics
10.1016/j.fertnstert.2016.09.019 · 2017 · External reference
Are cleavage anomalies, multinucleation, or specific cell cycle kinetics observed with time-lapse imaging predictive of embryo developmental capacity or ploidy?
10.1016/j.fertnstert.2017.12.025 · 2018 · External reference
Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health
10.1371/journal.pone.0052791 · 2012 · External reference
LC-MS analysis revealed the significantly different metabolic profiles in spent culture media of human embryos with distinct morphology, karyotype and implantation outcomes
10.3390/ijms23052706 · 2022 · External reference
Good practice recommendations for the use of time-lapse technology
10.1093/hropen/hoaa008 · 2020 · External reference
Why do we study sphingolipids?
10.1007/s00424-024-03020-0 · 2024 · External reference
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
10.1128/mcb.24.21.9508-9516.2004 · 2004 · External reference
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
10.1016/s0015-0282(00)00518-5 · 2000 · External reference
Time-lapse imaging: morphokinetic analysis of in vitro fertilization outcomes
10.1016/j.fertnstert.2023.06.015 · 2023 · External reference
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
10.1016/j.devcel.2006.10.007 · 2006 · External reference
Roles of sphingosine-1-phosphate in reproduction
10.1177/1933719113512534 · 2014 · External reference
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
10.1172/jci.insight.175462 · 2024 · External reference
A time to look back: analysis of morphokinetic characteristics of human embryo development
10.1016/j.fertnstert.2013.08.033 · 2013 · External reference
An artificial intelligence model (euploid prediction algorithm) can predict embryo ploidy status based on time-lapse data
10.1186/s12958-021-00864-4 · 2021 · External reference
mTOR activity paces human blastocyst stage developmental progression
10.1016/j.cell.2024.08.048 · 2024 · External reference
Does conventional morphological evaluation still play a role in predicting blastocyst formation?
10.1186/s12958-022-00945-y · 2022 · External reference
A deep learning model for predicting blastocyst formation from cleavage-stage human embryos using time-lapse images
10.1038/s41598-024-79175-8 · 2024 · External reference
Assessing morphokinetic parameters via time lapse microscopy (TLM) to predict euploidy: are aneuploidy risk classification models universal?
10.1007/s10815-014-0285-1 · 2014 · External reference
How many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors?
10.3389/fgene.2022.1058261 · 2022 · External reference
Raman profiling of embryo culture medium to identify aneuploid and euploid embryos
10.1016/j.fertnstert.2018.11.036 · 2019 · External reference
Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth
10.1016/j.fertnstert.2015.11.003 · 2016 · External reference
Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway
10.1006/dbio.2001.0461 · 2001 · External reference
Elective transfer of one embryo is associated with a higher cumulative live birth rate and improved perinatal outcomes compared to the transfer of two embryos with in vitro fertilization
10.1016/j.xfre.2020.10.011 · 2020 · External reference
A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development
10.1007/s10815-015-0440-3 · 2015 · External reference
Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence
10.1111/j.1582-4934.2008.00326.x · 2009 · External reference
The association of kinetic variables with blastocyst development and ploidy status
10.18502/jri.v22i3.6716 · 2021 · External reference
Quality assurance committee of the society for assisted reproductive technology, and the practice committee of the American society for reproductive medicine. Electronic address: asrm@asrm.org. Multiple gestation associated with infertility therapy: a committee opinion
10.1016/j.fertnstert.2021.12.016 · 2022 · External reference
Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging
10.1038/s41467-024-51823-7 · 2024 · External reference
Can time-lapse parameters predict embryo ploidy? A systematic review
10.1016/j.rbmo.2018.01.001 · 2018 · External reference
No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study
10.1016/j.rbmo.2014.09.012 · 2015 · External reference
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis
10.1038/s41467-022-34931-0 · 2022 · External reference
Phytosphingosine alleviates DSS-Induced colitis by regulating the gut microbiota and inflammatory responses
10.1016/j.intimp.2025.115610 · 2025 · External reference
The influence of in vitro fertilization and embryo culture on the embryo epigenetic constituents and the possible consequences in the bovine model
10.1017/s2040174417000125 · 2017 · External reference
Birth after the reimplantation of a human embryo
10.1016/s0140-6736(78)92957-4 · 1978 · External reference
Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study
10.1093/humrep/dev159 · 2015 · External reference
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic chagas disease cardiomyopathy
10.1038/s41598-017-06275-z · 2017 · External reference
Absolute risk of adverse obstetric outcomes among twin pregnancies after in vitro fertilization by maternal age
10.1001/jamanetworkopen.2021.23634 · 2021 · External reference
The biological functions and metabolic pathways of valine in swine
10.1186/s40104-023-00927-z · 2023 · External reference
High frequency of imprinted methylation errors in human preimplantation embryos
10.1038/srep17311 · 2015 · External reference
Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
10.1038/nbt.1686 · 2010 · External reference
Converging roles of the aryl hydrocarbon receptor in early embryonic development, maintenance of stemness, and tissue repair
10.1093/toxsci/kfab050 · 2021 · External reference
Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos
10.1007/s10815-017-0965-8 · External reference
Novel metabolic and physiological functions of branched chain amino acids: a review
10.1186/s40104-016-0139-z · External reference
The pregnancy outcome of mosaic embryo transfer: a prospective multicenter study and meta-analysis
10.3390/genes11090973 · 2020 · External reference
Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis
10.1093/humupd/dmab027 · 2021 · External reference
Absolute risk of adverse obstetric outcomes among twin pregnancies after in vitro fertilization by maternal age
10.1001/jamanetworkopen.2021.23634 · ExternalCitation · doi-reference
Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway
10.1006/dbio.2001.0461 · ExternalCitation · doi-reference
Why do we study sphingolipids?
10.1007/s00424-024-03020-0 · ExternalCitation · doi-reference
Assessing morphokinetic parameters via time lapse microscopy (TLM) to predict euploidy: are aneuploidy risk classification models universal?
10.1007/s10815-014-0285-1 · ExternalCitation · doi-reference
Morphokinetic analysis of cleavage stage embryos and its relationship to aneuploidy in a retrospective time-lapse imaging study
10.1007/s10815-014-0372-3 · ExternalCitation · doi-reference
A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development
10.1007/s10815-015-0440-3 · ExternalCitation · doi-reference
Selecting embryos with the highest implantation potential using data mining and decision tree based on classical embryo morphology and morphokinetics
10.1007/s10815-017-0955-x · ExternalCitation · doi-reference
Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos
10.1007/s10815-017-0965-8 · ExternalCitation · doi-reference
mTOR activity paces human blastocyst stage developmental progression
10.1016/j.cell.2024.08.048 · ExternalCitation · doi-reference
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
10.1016/j.devcel.2006.10.007 · ExternalCitation · doi-reference
A time to look back: analysis of morphokinetic characteristics of human embryo development
10.1016/j.fertnstert.2013.08.033 · ExternalCitation · doi-reference
Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth
10.1016/j.fertnstert.2015.11.003 · ExternalCitation · doi-reference
Type of chromosome abnormality affects embryo morphology dynamics
10.1016/j.fertnstert.2016.09.019 · ExternalCitation · doi-reference
Are cleavage anomalies, multinucleation, or specific cell cycle kinetics observed with time-lapse imaging predictive of embryo developmental capacity or ploidy?
10.1016/j.fertnstert.2017.12.025 · ExternalCitation · doi-reference
Raman profiling of embryo culture medium to identify aneuploid and euploid embryos
10.1016/j.fertnstert.2018.11.036 · ExternalCitation · doi-reference
Quality assurance committee of the society for assisted reproductive technology, and the practice committee of the American society for reproductive medicine. Electronic address: asrm@asrm.org. Multiple gestation associated with infertility therapy: a committee opinion
10.1016/j.fertnstert.2021.12.016 · ExternalCitation · doi-reference
Time-lapse imaging: morphokinetic analysis of in vitro fertilization outcomes
10.1016/j.fertnstert.2023.06.015 · ExternalCitation · doi-reference
Phytosphingosine alleviates DSS-Induced colitis by regulating the gut microbiota and inflammatory responses
10.1016/j.intimp.2025.115610 · ExternalCitation · doi-reference
Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics
10.1016/j.rbmo.2013.02.006 · ExternalCitation · doi-reference
No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study
10.1016/j.rbmo.2014.09.012 · ExternalCitation · doi-reference
Can time-lapse parameters predict embryo ploidy? A systematic review
10.1016/j.rbmo.2018.01.001 · ExternalCitation · doi-reference
Elective transfer of one embryo is associated with a higher cumulative live birth rate and improved perinatal outcomes compared to the transfer of two embryos with in vitro fertilization
10.1016/j.xfre.2020.10.011 · ExternalCitation · doi-reference
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
10.1016/s0015-0282(00)00518-5 · ExternalCitation · doi-reference
Birth after the reimplantation of a human embryo
10.1016/s0140-6736(78)92957-4 · ExternalCitation · doi-reference
The influence of in vitro fertilization and embryo culture on the embryo epigenetic constituents and the possible consequences in the bovine model
10.1017/s2040174417000125 · ExternalCitation · doi-reference
Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
10.1038/nbt.1686 · ExternalCitation · doi-reference
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis
10.1038/s41467-022-34931-0 · ExternalCitation · doi-reference
Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging
10.1038/s41467-024-51823-7 · ExternalCitation · doi-reference
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic chagas disease cardiomyopathy
10.1038/s41598-017-06275-z · ExternalCitation · doi-reference
A deep learning model for predicting blastocyst formation from cleavage-stage human embryos using time-lapse images
10.1038/s41598-024-79175-8 · ExternalCitation · doi-reference
High frequency of imprinted methylation errors in human preimplantation embryos
10.1038/srep17311 · ExternalCitation · doi-reference
Good practice recommendations for the use of time-lapse technology
10.1093/hropen/hoaa008 · ExternalCitation · doi-reference
A comparison of 12 machine learning models developed to predict ploidy, using a morphokinetic meta-dataset of 8147 embryos
10.1093/humrep/dead034 · ExternalCitation · doi-reference
The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection
10.1093/humrep/deu331 · ExternalCitation · doi-reference
Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study
10.1093/humrep/dev159 · ExternalCitation · doi-reference
Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis
10.1093/humupd/dmab027 · ExternalCitation · doi-reference
Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis
10.1093/humupd/dmac022 · ExternalCitation · doi-reference
Converging roles of the aryl hydrocarbon receptor in early embryonic development, maintenance of stemness, and tissue repair
10.1093/toxsci/kfab050 · ExternalCitation · doi-reference
Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence
10.1111/j.1582-4934.2008.00326.x · ExternalCitation · doi-reference
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
10.1128/mcb.24.21.9508-9516.2004 · ExternalCitation · doi-reference
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
10.1172/jci.insight.175462 · ExternalCitation · doi-reference
Roles of sphingosine-1-phosphate in reproduction
10.1177/1933719113512534 · ExternalCitation · doi-reference
An artificial intelligence model (euploid prediction algorithm) can predict embryo ploidy status based on time-lapse data
10.1186/s12958-021-00864-4 · ExternalCitation · doi-reference
Does conventional morphological evaluation still play a role in predicting blastocyst formation?
10.1186/s12958-022-00945-y · ExternalCitation · doi-reference
Novel metabolic and physiological functions of branched chain amino acids: a review
10.1186/s40104-016-0139-z · ExternalCitation · doi-reference
The biological functions and metabolic pathways of valine in swine
10.1186/s40104-023-00927-z · ExternalCitation · doi-reference
Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health
10.1371/journal.pone.0052791 · ExternalCitation · doi-reference
The association of kinetic variables with blastocyst development and ploidy status
10.18502/jri.v22i3.6716 · ExternalCitation · doi-reference
How many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors?
10.3389/fgene.2022.1058261 · ExternalCitation · doi-reference
The pregnancy outcome of mosaic embryo transfer: a prospective multicenter study and meta-analysis
10.3390/genes11090973 · ExternalCitation · doi-reference
LC-MS analysis revealed the significantly different metabolic profiles in spent culture media of human embryos with distinct morphology, karyotype and implantation outcomes
10.3390/ijms23052706 · ExternalCitation · doi-reference
Preliminary study on predicting early embryonic developmental potential by metabolomics analysis of day 3 embryo culture medium
10.3760/cma.j.cn101441-20240914-00342 · ExternalCitation · doi-reference
Analysis of metabolic differences in day5 culture media of embryos with varying developmental potential by high performance liquid chromatography-tandem mass spectrometry
10.3969/j.issn.1004-3845.2025.09.010 · ExternalCitation · doi-reference
