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References from Mitophagy in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
The STATus of STAT3 in lung cell senescence?
10.1165/rcmb.2019-0013ed · 2019 · External reference
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis
10.1172/jci.insight.158100 · 2023 · External reference
Miro1 regulates intercellular mitochondrial transport and enhances mesenchymal stem cell rescue efficacy
10.1002/embj.201386030 · 2014 · External reference
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease
10.1096/fj.14-268276 · 2015 · External reference
IPF lung fibroblasts have a senescent phenotype
10.1152/ajplung.00220.2017 · 2017 · External reference
Insufficient autophagy in idiopathic pulmonary fibrosis
10.1152/ajplung.00213.2012 · 2013 · External reference
PRKN-Regulated mitophagy and cellular senescence during COPD pathogenesis
10.1080/15548627.2018.1532259 · 2019 · External reference
The pathways of mitophagy for quality control and clearance of mitochondria
10.1038/cdd.2012.81 · 2013 · External reference
Tetrandrine--A molecule of wide bioactivity
10.1016/j.phytochem.2016.02.005 · 2016 · External reference
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
10.1016/j.jare.2023.02.012 · 2024 · External reference
Mechanisms of mitophagy: PINK1, parkin, USP30 and beyond
10.1016/j.freeradbiomed.2016.04.015 · 2016 · External reference
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
10.1038/nature13418 · 2014 · External reference
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
10.1038/cdd.2010.142 · 2011 · External reference
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
10.1172/jci74942 · 2015 · External reference
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis
10.1111/acel.12720 · 2018 · External reference
PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses
10.1371/journal.pone.0218003 · 2019 · External reference
Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis
10.1016/j.ecoenv.2025.117713 · 2025 · External reference
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
10.1016/j.xcrm.2023.100945 · 2023 · External reference
Berberine inhibits smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis
10.1007/s00109-015-1283-1 · 2015 · External reference
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy
10.1016/j.ejphar.2024.176459 · 2024 · External reference
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
10.1038/ncb3097 · 2015 · External reference
Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis
10.1165/rcmb.2011-0158oc · 2012 · External reference
Thymoquinone (Tq) protects necroptosis induced by autophagy/mitophagy-dependent oxidative stress in human bronchial epithelial cells exposed to cigarette smoke extract (CSE)
10.1111/jfbc.13366 · 2020 · External reference
Mechanism and medical implications of Mammalian autophagy
10.1038/s41580-018-0003-4 · 2018 · External reference
Effects of RNA interference-induced Smad3 gene silencing on pulmonary fibrosis caused by paraquat in mice
10.1258/ebm.2011.011280 · 2012 · External reference
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
10.4161/auto.7.6.15123 · 2011 · External reference
Heme oxygenase-1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction
10.1111/acel.12837 · 2018 · External reference
PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy
10.1016/j.redox.2022.102587 · 2023 · External reference
PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis
10.1007/s00018-019-03133-1 · 2019 · External reference
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
10.1038/ncb2012 · 2010 · External reference
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy
10.1016/j.molcel.2022.03.012 · 2022 · External reference
Number 2 feibi recipe inhibits H(2)O(2)-Mediated oxidative stress damage of alveolar epithelial cells by regulating the balance of mitophagy/apoptosis
10.3389/fphar.2022.830554 · 2022 · External reference
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice
10.1016/j.cellsig.2025.111868 · 2025 · External reference
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts
10.1183/13993003.02307-2021 · 2022 · External reference
mTOR overactivation and compromised autophagy in the pathogenesis of pulmonary fibrosis
10.1371/journal.pone.0138625 · 2015 · External reference
Molecular mechanisms responsible for the therapeutic potential of mesenchymal stem cell-derived exosomes in the treatment of lung fibrosis
10.3390/ijms25084378 · 2024 · External reference
Mitochondria in health, disease, and aging
10.1152/physrev.00058.2021 · 2023 · External reference
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
10.1038/nm.2005 · 2009 · External reference
A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
10.1016/j.cell.2013.07.030 · 2013 · External reference
Inflammation and immunity in IPF pathogenesis and treatment
10.1016/j.rmed.2018.12.015 · 2019 · External reference
Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis
10.1038/s41467-023-41529-7 · 2023 · External reference
PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
10.1080/15548627.2015.1017190 · 2015 · External reference
Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
10.1016/j.jmb.2019.07.016 · 2020 · External reference
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis
10.1172/jci139519 · 2020 · External reference
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis
10.1152/ajplung.00069.2019 · 2020 · External reference
Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
10.1016/j.bmcl.2018.05.013 · 2018 · External reference
Involvement of PARK2-Mediated mitophagy in idiopathic pulmonary fibrosis pathogenesis
10.4049/jimmunol.1600265 · 2016 · External reference
Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
10.1186/s12931-017-0600-3 · 2017 · External reference
The phosphodiesterase 4 inhibitor roflumilast protects against cigarette smoke extract-induced mitophagy-dependent cell death in epithelial cells
10.4046/trd.2017.0115 · 2018 · External reference
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
10.1002/art.33482 · 2012 · External reference
Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis
10.1016/j.immuni.2016.01.001 · 2016 · External reference
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
10.1073/pnas.1107559108 · 2011 · External reference
Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD)
10.1038/s41598-018-33471-2 · 2018 · External reference
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α
10.1128/mcb.00839-13 · 2014 · External reference
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
10.1089/rej.2005.8.3 · 2005 · External reference
Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword
10.1042/bsr20182417 · 2019 · External reference
Mitochondrial dysfunction in fibrotic diseases
10.1038/s41420-020-00316-9 · 2020 · External reference
Metformin attenuates silica-induced pulmonary fibrosis by activating autophagy via the AMPK-mTOR signaling pathway
10.3389/fphar.2021.719589 · 2021 · External reference
PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy
10.1016/j.tox.2022.153251 · 2022 · External reference
Effective-component compatibility of bufei yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway
10.1186/s12890-022-02191-9 · 2022 · External reference
A novel therapeutic approach for IPF: based on the Autophagy - apoptosis balance regulation of zukamu granules in alveolar macrophages
10.1016/j.jep.2022.115568 · 2022 · External reference
USP30 deubiquitylates mitochondrial parkin substrates and restricts apoptotic cell death
10.15252/embr.201439820 · 2015 · External reference
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis
10.1172/jci157338 · 2022 · External reference
Involvement of NEAT1/PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM(2.5)
10.21037/atm-22-542 · 2022 · External reference
ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy
10.1038/s41598-024-78136-5 · 2024 · External reference
Deciphering the power of resveratrol in mitophagy: from molecular mechanisms to therapeutic applications
10.1002/ptr.8433 · 2025 · External reference
Essential role for autophagy in life span extension
10.1172/jci73946 · 2015 · External reference
Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice
10.1016/j.fct.2020.111588 · 2020 · External reference
The mitochondria in lung fibrosis: friend or foe?
10.1016/j.trsl.2018.05.005 · 2018 · External reference
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation
10.1016/j.freeradbiomed.2016.10.001 · 2016 · External reference
Mitochondrial dysfunction in lung resident mesenchymal stem cells from idiopathic pulmonary fibrosis patients
10.3390/cells12162084 · 2023 · External reference
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
10.1172/jci74985 · 2014 · External reference
Autophagy fights disease through cellular self-digestion
10.1038/nature06639 · 2008 · External reference
Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis
10.1172/jci87440 · 2017 · External reference
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
10.1146/annurev-pathol-042320-030240 · 2022 · External reference
Autophagy in pulmonary diseases
10.1164/rccm.201512-2468so · 2016 · External reference
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane
10.1091/mbc.e07-11-1103 · 2008 · External reference
The mitochondria-targeted antioxidant MitoQ attenuated PM(2.5)-induced vascular fibrosis via regulating mitophagy
10.1016/j.redox.2021.102113 · 2021 · External reference
Molecular mechanisms and physiological functions of mitophagy
10.15252/embj.2020104705 · 2021 · External reference
Complex interplay between autophagy and oxidative stress in the development of pulmonary disease
10.1016/j.redox.2020.101679 · 2020 · External reference
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
10.1038/s41556-018-0176-2 · 2018 · External reference
Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis
10.1371/journal.pone.0121246 · 2015 · External reference
Mitochondrial network dynamics in pulmonary disease: bridging the gap between inflammation, oxidative stress, and bioenergetics
10.1016/j.redox.2024.103049 · 2024 · External reference
Metformin reverses established lung fibrosis in a bleomycin model
10.1038/s41591-018-0087-6 · 2018 · External reference
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
10.1164/rccm.201712-2410oc · 2019 · External reference
Idiopathic pulmonary fibrosis
10.1016/s0140-6736(17)30866-8 · 2017 · External reference
Structure and function of parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
10.1038/ncomms2982 · 2013 · External reference
Mitochondrial quality control in age-related pulmonary fibrosis
10.3390/ijms21020643 · 2020 · External reference
Effects of the cytoplasm and mitochondrial specific hydroxyl radical scavengers TA293 and mitoTA293 in bleomycin-induced pulmonary fibrosis model mice
10.3390/antiox10091398 · 2021 · External reference
Mesenchymal stromal cells and their secretome: new therapeutic perspectives for skeletal muscle regeneration
10.3389/fbioe.2021.652970 · 2021 · External reference
Cellular senescence mediates fibrotic pulmonary disease
10.1038/ncomms14532 · 2017 · External reference
A model of the aged lung epithelium in idiopathic pulmonary fibrosis
10.18632/aging.203291 · 2021 · External reference
Novel therapeutic strategies and drugs for idiopathic pulmonary fibrosis
10.1002/ardp.202400192 · 2024 · External reference
Quercetogetin protects against cigarette smoke extract-induced apoptosis in epithelial cells by inhibiting mitophagy
10.1016/j.tiv.2018.01.011 · 2018 · External reference
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages
10.1038/s41401-021-00693-6 · 2022 · External reference
Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
10.1111/acel.12357 · 2015 · External reference
Idiopathic pulmonary fibrosis: disease mechanisms and drug development
10.1016/j.pharmthera.2020.107798 · 2021 · External reference
Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells
10.18632/aging.205994 · 2024 · External reference
The mitochondrial basis of aging
10.1016/j.molcel.2016.01.028 · 2016 · External reference
MUTYH deficiency is associated with attenuated pulmonary fibrosis in a bleomycin-induced model
10.1155/2020/4828256 · 2020 · External reference
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
10.1038/s41467-023-36314-5 · 2023 · External reference
Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis
10.1186/s12931-022-02001-0 · 2022 · External reference
Thymosin β4 suppresses LPS-induced murine lung fibrosis by attenuating oxidative injury and alleviating inflammation
10.1007/s10753-021-01528-6 · 2022 · External reference
Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF
10.1186/s12931-019-1196-6 · 2019 · External reference
Redox imbalance in idiopathic pulmonary fibrosis: a role for oxidant cross-talk between NADPH oxidase enzymes and mitochondria
10.1089/ars.2019.7742 · 2019 · External reference
Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts
10.1016/j.yexcr.2018.01.019 · 2018 · External reference
Role of mitophagy in cigarette smoke-induced lung epithelial cell injury in vitro
10.2174/1566524023666221025100002 · 2023 · External reference
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy
10.1186/s12967-022-03837-2 · 2023 · External reference
A new perspective for improving COPD: ginsenoside Rg3 links SIRT1 to inhibit mitochondrial autophagy
10.24976/discov.med.202436191.220 · External reference
Mitophagy-enhanced nanoparticle-engineered mitochondria restore homeostasis of mitochondrial pool for alleviating pulmonary fibrosis
10.1021/acsnano.4c10328 · External reference
ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis
10.1016/j.bbadis.2023.166960 · 2024 · External reference
Pulmonary fibrosis: pathogenesis and therapeutic strategies
10.1002/mco2.744 · 2024 · External reference
Hydrogen sulfide attenuates PM2.5-induced COPD by inhibiting cellular senescence via the Klotho/parkin-Mediated mitophagy signaling pathway
10.1016/j.ecoenv.2025.117987 · 2025 · External reference
Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis
10.1007/s00210-023-02390-z · 2023 · External reference
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3/PINK 1-Parkin/EMT
10.1016/j.freeradbiomed.2024.08.036 · 2024 · External reference
Mesenchymal stem cell-derived exosomes: a promising therapeutic strategy for age-related diseases
10.1111/cpr.13795 · 2025 · External reference
Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment
10.1002/jcb.29028 · 2019 · External reference
Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy
10.1186/s10020-024-00843-6 · 2024 · External reference
IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells
10.1111/jcmm.17600 · 2022 · External reference
Emerging views of mitophagy in immunity and autoimmune diseases
10.1080/15548627.2019.1603547 · 2020 · External reference
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM(2) (.5) in mice
10.1002/tox.23140 · 2021 · External reference
Tissue-resident Klebsiella quasipneumoniae contributes to progression of idiopathic pulmonary fibrosis by triggering macrophages mitophagy in mice
10.1038/s41420-025-02444-6 · 2025 · External reference
How autophagy eats large mitochondria: autophagosome formation coupled with mitochondrial fragmentation
10.1080/15548627.2017.1291113 · 2017 · External reference
Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
10.1515/med-2023-0798 · 2023 · External reference
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
10.1038/nm.4447 · 2018 · External reference
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
10.1038/cr.2014.20 · 2014 · External reference
Mitochondrial dynamics in basal and stressful conditions
10.3390/ijms19020564 · 2018 · External reference
Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke
10.1002/jcp.28117 · 2019 · External reference
MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease
10.1016/j.freeradbiomed.2021.07.004 · 2021 · External reference
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis
10.1016/j.freeradbiomed.2021.02.013 · 2021 · External reference
Senescent AECII and the implication for idiopathic pulmonary fibrosis treatment
10.3389/fphar.2022.1059434 · 2022 · External reference
Curcumin analogue EF24 prevents alveolar epithelial cell senescence to ameliorate idiopathic pulmonary fibrosis via activation of PTEN
10.1016/j.phymed.2024.155882 · 2024 · External reference
Glycolysis to lactylation: unraveling the metabolic and epigenetic landscape in tissue fibrosis
10.3892/mmr.2025.13655 · 2025 · External reference
TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression
10.1016/j.exger.2024.112441 · 2024 · External reference
Role of autophagy in tumorigenesis and drug resistance: molecular mechanisms and therapeutic targets
10.1186/s43556-026-00430-7 · 2026 · External reference
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
10.1111/acel.12287 · 2015 · External reference
