Research graph
References from Engineering osteoporosis-related bone organoids: a mechanism–module–functional readout framework for disease modelling and biomarker translation. Local targets link to admitted publications; unresolved targets remain external evidence.
A decade of organoid research: progress and challenges in the field of organoid technology
10.1021/acsomega.4c03683 · 2024 · External reference
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation
10.1038/s41598-017-07014-0 · 2017 · External reference
Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis
10.1096/fj.201802805rr · 2019 · External reference
Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from the european society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO), international osteoporosis foundation (IOF), and international Federation of clinical chemistry and laboratory medicine (IFCC)
10.1007/s00198-025-07422-3 · 2025 · External reference
Estrogen deficiency alters vascularization and mineralization dynamics: insight from a novel 3-D humanized and vascularized bone organoid model
10.1152/ajpcell.00738.2024 · 2025 · External reference
Organ-on-a-chip: current gaps and future directions
10.1042/bst20200661 · 2022 · External reference
Roles of Wnt/β-Catenin signaling in osteoporosis, disease pathogenesis, and natural compound intervention
10.4062/biomolther.2025.126 · 2026 · External reference
Mechanosignaling in osteoporosis: when cells feel the force
10.3390/ijms26094007 · 2025 · External reference
Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover
10.3390/ijms23031376 · 2022 · External reference
The epidemiology of osteoporosis
10.1093/bmb/ldaa005 · 2020 · External reference
Engineering osteoclast resorption units via sacrificial microgels in a bone-on-chip platform
10.1039/d5lc00682a · 2026 · External reference
Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024
10.1093/jbmr/zjae119 · 2024 · External reference
Loop between NLRP3 inflammasome and reactive oxygen species
10.1089/ars.2020.8257 · 2022 · External reference
Preservation of extracellular matrix in decellularized bone scaffolds: strategies, challenges, and future directions
10.1016/j.tice.2025.103047 · 2025 · External reference
A detailed methodology for a three-dimensional, self-structuring bone model that supports the differentiation of osteoblasts towards osteocytes and the production of a complex collagen-rich mineralised matrix
10.12688/f1000research.130779.3 · 2023 · External reference
Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of wnt-axis
10.1111/acel.14139 · 2024 · External reference
Osteochondral organoid biofabrication: construction strategies, applications and perspectives
10.1088/1758-5090/ade740 · 2025 · External reference
RANKL (receptor activator of NFκB ligand) produced by osteocytes is required for the increase in B cells and bone loss caused by estrogen deficiency in mice
10.1074/jbc.m116.742452 · 2016 · External reference
3D bioprinting bone/cartilage organoids: construction, applications, and challenges
10.1016/j.jot.2025.08.008 · 2025 · External reference
Toxic or not toxic? The specifications of the standard ISO 10993-5 are not explicit enough to yield comparable results in the cytotoxicity assessment of an identical medical device
10.3389/fmedt.2023.1195529 · 2023 · External reference
Dual 3D printing for vascularized bone tissue regeneration
10.1016/j.actbio.2021.01.012 · 2021 · External reference
Three-dimensionally cultured jaw periosteal cells attenuate macrophage activation of CD4(+) T cells and inhibit osteoclastogenesis
10.3390/ijms25042355 · 2024 · External reference
In-silico analysis predicts disruption of normal angiogenesis as a causative factor in osteoporosis pathogenesis
10.1186/s12863-024-01269-z · 2024 · External reference
Organoids are not organs: sources of variation and misinformation in organoid biology
10.1016/j.stemcr.2023.05.009 · 2023 · External reference
Bone-on-a-Chip: biomimetic models based on microfluidic technologies for biomedical applications
10.1021/acsbiomaterials.3c00066 · 2023 · External reference
Bone formation is coupled to resorption Via suppression of sclerostin expression by osteoclasts
10.1002/jbmr.3175 · 2017 · External reference
Advance in the application of organoids in bone diseases
10.3389/fcell.2024.1459891 · 2024 · External reference
Bone-on-a-chip simulating bone metastasis in osteoporosis
10.1088/1758-5090/ad6cf9 · 2024 · External reference
Sclerostin binds to LRP5/6 and antagonizes canonical wnt signaling
10.1074/jbc.m413274200 · 2005 · External reference
Dkk1-mediated inhibition of wnt signaling in bone results in osteopenia
10.1016/j.bone.2006.03.017 · 2006 · External reference
Vascularization of a bone organoid using dental pulp stem cells
10.1155/2023/5367887 · 2023 · External reference
Bone organoids as advanced models for osteoporosis: development, application, and future prospects
10.3390/ijms27073118 · 2026 · External reference
Innovative strategies for bone organoid: synergistic application and exploration of advanced technologies
10.1016/j.jot.2025.07.010 · 2025 · External reference
Osteoimmunology: crosstalk between T cells and osteoclasts in osteoporosis
10.1007/s12016-025-09046-1 · 2025 · External reference
ISSCR standards for the use of human stem cells in basic research
10.1016/j.stemcr.2023.08.003 · 2023 · External reference
Printability and cell viability in extrusion-based bioprinting from experimental, computational, and machine learning views
10.3390/jfb13020040 · 2022 · External reference
Role of wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders
10.1007/s00198-022-06523-7 · 2023 · External reference
The role of reactive oxygen species in bone cell physiology and pathophysiology
10.1016/j.bonr.2023.101664 · 2023 · External reference
A novel 3D osteoblast and osteocyte model revealing changes in mineralization and pro-osteoclastogenic paracrine signaling during estrogen deficiency
10.3389/fbioe.2020.00601 · 2020 · External reference
3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate
10.1021/acs.biomac.0c00045 · 2020 · External reference
Collagen/hydroxyapatite hydrogels promote intercellular interactions and osteogenic differentiation
10.1002/jbm.b.35632 · 2025 · External reference
Effect of T cells on bone
10.1016/j.bone.2023.116675 · 2023 · External reference
Biomarker discovery and validation: statistical considerations
10.1016/j.jtho.2021.01.1616 · 2021 · External reference
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
10.1016/j.stemcr.2024.03.009 · 2024 · External reference
Revolutionizing immune research with organoid-based co-culture and chip systems
10.1093/cei/uxae004 · 2024 · External reference
Trabecular bone organoid model for studying the regulation of localized bone remodeling
10.1126/sciadv.abd6495 · 2021 · External reference
Pathophysiology of bone remodelling cycle: role of immune system and lipids
10.1016/j.bcp.2025.116844 · 2025 · External reference
Type H blood vessels in bone modeling and remodeling
10.7150/thno.34126 · 2020 · External reference
Modelling osteoporosis in pre-clinical research-challenges, trends and new approaches
10.3390/cells14211649 · 2025 · External reference
Functional roles of immune cells in osteoporosis
10.3389/fimmu.2025.1698283 · 2025 · External reference
Molecular mechanosensors in osteocytes
10.1038/s41413-020-0099-y · 2020 · External reference
Structure and functions of blood vessels and vascular niches in bone
10.1155/2017/5046953 · 2017 · External reference
Blood flow controls bone vascular function and osteogenesis
10.1038/ncomms13601 · 2016 · External reference
Principles of indirect Co-culture method using transwell
10.1007/7651_2024_537 · 2025 · External reference
Microengineered bone models: advances and applications of bone-on-a-chip technology
10.1186/s13036-026-00703-3 · 2026 · External reference
Measuring mineralised tissue formation and resorption in a human 3D osteoblast-osteoclast co-culture model
10.22203/ecm.v040a12 · 2020 · External reference
Development of a microfluidic vascularized osteochondral model as a drug testing platform for osteoarthritis
10.1002/adhm.202402350 · 2024 · External reference
3D in vitro models of the bone marrow niche
10.1021/acsbiomaterials.5c01421 · 2026 · External reference
The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990-2019
10.3389/fendo.2022.882241 · 2022 · External reference
MicroRNAs in serum exosomes as circulating biomarkers for postmenopausal osteoporosis
10.3389/fendo.2022.819056 · 2022 · External reference
A comparison of osteoblast and osteoclast in vitro Co-Culture models and their translation for preclinical drug testing applications
10.3390/ijms21030912 · 2020 · External reference
Advances in pathogenesis and therapeutic strategies for osteoporosis
10.1016/j.pharmthera.2022.108168 · 2022 · External reference
Inhibitors of the wnt pathway in osteoporosis: a review of mechanisms of action and potential as therapeutic targets
10.17305/bb.2024.11200 · 2025 · External reference
A 3D human bone and bone Marrow-on-a-Chip model for in vitro bone remodeling and immune cell maintenance
10.1002/advs.202518224 · 2026 · External reference
Vascularized tissue organoids
10.3390/bioengineering10020124 · 2023 · External reference
Synergistic promotion of bone regeneration through co-culture of endothelial cells with mesenchymal stem cells in endochondral ossification organoids
10.1186/s13287-025-04733-4 · 2025 · External reference
Inflammatory processes affecting bone health and repair
10.1007/s11914-023-00824-4 · 2023 · External reference
Molecular mechanisms involved in hypoxia-induced alterations in bone remodeling
10.3390/ijms23063233 · 2022 · External reference
A protocol for modeling human bone inflammation: co-culture of osteoblasts and osteoclasts exposed to different inflammatory microenvironments
10.3390/mps8050097 · 2025 · External reference
Practical considerations for the clinical application of bone turnover markers in osteoporosis
10.1007/s00223-021-00930-4 · 2023 · External reference
Osteoclasts, master sculptors of bone
10.1146/annurev-pathmechdis-031521-040919 · 2023 · External reference
Discovery of potential biomarkers for osteoporosis using LC-MS/MS metabolomic methods
10.1007/s00198-019-04892-0 · 2019 · External reference
Mechanical regulation of bone remodeling
10.1038/s41413-022-00190-4 · External reference
Insights into the role of macrophage polarization in the pathogenesis of osteoporosis
10.1155/2022/2485959 · External reference
Engineering large-scale self-mineralizing bone organoids with bone matrix-inspired hydroxyapatite hybrid bioinks
10.1002/adma.202309875 · 2024 · External reference
Integrated single-cell RNA-Seq and bulk RNA-Seq identify diagnostic biomarkers for postmenopausal osteoporosis
10.2174/0109298673343344240930054414 · External reference
Standardization and consensus in the development and application of bone organoids
10.7150/thno.105840 · External reference
Emerging applications of feature selection in osteoporosis research: from biomarker discovery to clinical decision support
10.1093/jbmr/zjaf105 · External reference
Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-Dependent pathway
10.1371/journal.pone.0025900 · 2011 · External reference
Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis
10.3389/fcell.2025.1670716 · 2025 · External reference
A review on cell damage, viability, and functionality during 3D bioprinting
10.1186/s40779-022-00429-5 · 2022 · External reference
From niche to organoid: engineering bone tissues through microenvironmental insights
10.1177/20417314251358567 · 2025 · External reference
Contribution of macrophage polarization in bone metabolism: a literature review
10.1016/j.cyto.2024.156768 · 2024 · External reference
Single-cell RNA sequencing reveals multiple immune cell subpopulations promote the formation of abnormal bone microenvironment in osteoporosis
10.1038/s41598-024-80993-z · 2024 · External reference
Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
10.1002/mco2.735 · 2024 · External reference
Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis
10.1002/med.22081 · 2025 · External reference
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes
10.1038/s41421-024-00652-5 · 2024 · External reference
Gene expression profiles for in vitro human stem cell differentiation into osteoblasts and osteoclasts: a systematic review
10.7717/peerj.14174 · 2022 · External reference
Motivating role of type H vessels in bone regeneration
10.1111/cpr.12874 · 2020 · External reference
Long-term mechanical loading is required for the formation of 3D bioprinted functional osteocyte bone organoids
10.1088/1758-5090/ac73b9 · 2022 · External reference
Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases
10.1111/nyas.14348 · 2020 · External reference
Organoids
10.1038/s43586-022-00174-y · 2022 · External reference
Bone organoids: recent advances and future challenges
10.1002/adhm.202302088 · 2024 · External reference
Beyond bone loss: a biology perspective on osteoporosis pathogenesis, multi-omics approaches, and interconnected mechanisms
10.3390/biomedicines13061443 · 2025 · External reference
Advances in the construction and application of Bone-on-a-Chip based on microfluidic technologies
10.1002/jbm.b.35502 · 2024 · External reference