Research graph
References from When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
10.1038/s41419-023-05952-4 · 2023 · External reference
Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas
10.1126/scitranslmed.adw0834 · 2026 · External reference
Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise
1986 · External reference
The science and translation of lactate shuttle theory
10.1016/j.cmet.2018.03.008 · 2018 · External reference
Lactylation, a novel metabolic reprogramming code: current status and prospects
10.3389/fimmu.2021.688910 · 2021 · External reference
High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
10.1186/s12915-023-01698-9 · 2023 · External reference
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
10.1007/s00125-024-06156-x · External reference
Lactylated apolipoprotein C-II induces immunotherapy resistance by promoting extracellular lipolysis
10.1002/advs.202406333 · External reference
SIRT3 functions as an eraser of histone H3K9 lactylation to modulate transcription for inhibiting the progression of esophageal cancer
10.1016/j.mcpro.2025.100973 · External reference
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer
10.1016/j.celrep.2025.115774 · External reference
Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation
10.1096/fj.202402430rr · External reference
Proteomic analysis identifies PFKP lactylation in SW480 Colon cancer cells
10.1016/j.isci.2023.108645 · 2024 · External reference
Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the warburg effect
10.1038/s41419-023-06187-z · 2023 · External reference
Lactate dehydrogenase C4 accelerates triple-negative breast cancer progression by promoting Acetyl-CoA acyltransferase 2 lactylation to increase free fatty acid accumulation
10.1002/advs.202511849 · 2025 · External reference
YTHDC1 lactylation regulates its phase separation to enhance target mRNA stability and promote RCC progression
10.1016/j.molcel.2025.06.017 · 2025 · External reference
Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis
10.1038/s41419-025-07498-z · 2025 · External reference
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury
10.1038/s41418-025-01585-6 · 2026 · External reference
SLC2A3-Mediated lactate metabolism promotes lung cancer bone metastasis by modulating P53 lactylation and immune evasion
10.1002/advs.202516622 · 2026 · External reference
Histone lactylation-driven YTHDC1 promotes hepatocellular carcinoma progression via lipid metabolism remodeling
10.1016/j.canlet.2024.217426 · 2024 · External reference
Integrated lactylome characterization reveals the molecular dynamics of protein regulation in gastrointestinal cancers
10.1002/advs.202400227 · 2024 · External reference
Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells
10.1093/burnst/tkaf056 · 2025 · External reference
Lactylome analysis unveils Lactylation-Dependent mechanisms of stemness remodeling in the liver cancer stem cells
10.1002/advs.202405975 · 2024 · External reference
Non-enzymatic lysine lactoylation of glycolytic enzymes
10.1016/j.chembiol.2019.11.005 · 2020 · External reference
Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks
10.1073/pnas.1802901115 · 2018 · External reference
A tumor-derived lactate/ENO1 lactylation feedback loop facilitates osimertinib resistance of lung adenocarcinoma
10.1016/j.drup.2025.101346 · 2026 · External reference
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease
10.1097/hep.0000000000000279 · 2023 · External reference
Lactate metabolism: a new paradigm for the third millennium
10.1113/jphysiol.2003.058701 · 2004 · External reference
Exercise improves cognitive dysfunction and neuroinflammation in mice through histone H3 lactylation in microglia
10.1186/s12979-023-00390-4 · 2023 · External reference
HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma
10.1038/s41419-025-08113-x · External reference
HDAC2-Mediated METTL3 delactylation promotes DNA damage repair and chemotherapy resistance in triple-negative breast cancer
10.1002/advs.202413121 · External reference
Raising the iron curtain: lactate's secret role in oxidative stress defense
10.1016/j.redox.2025.103754 · 2025 · External reference
Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma
10.1002/pmic.202200432 · 2023 · External reference
ABCF1-K430-Lactylation promotes HCC malignant progression via transcriptional activation of HIF1 signaling pathway
10.1038/s41418-024-01436-w · External reference
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy
10.1038/s41418-025-01587-4 · External reference
Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader
10.1093/nar/gkae183 · External reference
Lactylation: the novel histone modification influence on gene expression, protein function, and disease
10.1186/s13148-024-01682-2 · External reference
Histone Lactylation-Driven GPD2 mediates M2 macrophage polarization to promote malignant transformation of cervical cancer progression
10.1089/dna.2024.0122 · External reference
YY1 lactylation aggravates autoimmune uveitis by enhancing microglial functions via inflammatory genes
10.1002/advs.202308031 · External reference
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
10.1083/jcb.202308099 · External reference
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation
10.1016/j.redox.2025.103553 · 2025 · External reference
GCN5-ERK lactylation-phosphorylation loop amplifies lactate-driven cancer progression
10.1038/s41589-025-02107-8 · 2026 · External reference
Glucose feeds the TCA cycle via circulating lactate
10.1038/nature24057 · 2017 · External reference
ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
10.1126/sciadv.adg4993 · 2023 · External reference
Lactate modulates cellular metabolism through histone Lactylation-Mediated gene expression in non-small cell lung cancer
10.3389/fonc.2021.647559 · 2021 · External reference
Lactylation-related gene signature for prognostic prediction and immune infiltration analysis in breast cancer
10.1016/j.heliyon.2024.e24777 · 2024 · External reference
Positive feedback between histone H4K16 lactylation and glycolysis promotes MAFLD progression
10.1007/s12072-025-10978-1 · 2025 · External reference
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer
10.1172/jci174587 · 2024 · External reference
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development
10.3389/fimmu.2025.1531246 · 2025 · External reference
Global profiling of lysine lactylation in prostate cancer cells
10.21873/cgp.20547 · 2025 · External reference
The first demonstration of lactic acid in human blood in shock by johann joseph scherer (1814-1869) in January 1843
10.1007/s00134-007-0788-7 · 2007 · External reference
UGDH lactylation aggravates osteoarthritis by suppressing glycosaminoglycan synthesis and orchestrating nucleocytoplasmic transport to activate MAPK signaling
10.1002/advs.202413709 · 2025 · External reference
The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice
10.1016/j.heliyon.2024.e24421 · 2024 · External reference
Lactate metabolism in human health and disease
10.1038/s41392-022-01151-3 · 2022 · External reference
AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases
10.1038/s41586-024-07992-y · 2024 · External reference
Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth
10.1007/s13402-025-01058-5 · External reference
PDHA1-mediated H3K18 lactylation is involved in arsenic-induced nonalcoholic fatty liver disease by activating the CD36-NLRP3 inflammasome axis
10.1016/j.jhazmat.2025.139852 · External reference
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD
10.1016/j.celrep.2025.115465 · External reference
Altered lactylation myocardial tissue may contribute to a more severe energy-deprived state of the tissue and left ventricular outflow tract obstruction in HOCM
10.3390/bioengineering12040379 · External reference
Lactylation enhances the activity of lactate dehydrogenase A and promotes the chemoresistance to cisplatin through facilitating DNA nonhomologous end junction in lung adenocarcinoma
10.1002/advs.202510733 · External reference
JOSD1 drives hepatocellular carcinoma malignancy by modulating the ubiquitination-lactylation switch on PGAM1
10.1136/gutjnl-2025-337331 · External reference
PKM2 lactylation promotes colorectal cancer vasculogenic mimicry and bevacizumab resistance by facilitating FOSL1 super-enhancer formation
10.1158/0008-5472.can-25-3520 · External reference
Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity
10.1016/j.celrep.2025.116854 · External reference
EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma
10.1016/j.tranon.2026.102750 · 2026 · External reference
Augmentation of scleral glycolysis promotes myopia through histone lactylation
10.1016/j.cmet.2023.12.023 · 2024 · External reference
Lactylation, an emerging hallmark of metabolic reprogramming: current progress and open challenges
10.3389/fcell.2022.972020 · 2022 · External reference
H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer
10.1186/s13046-025-03512-6 · External reference
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
10.1016/j.cmet.2024.11.005 · External reference
ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of nanog to impact cell stemness and cholesterol uptake
10.1007/s10565-025-10068-w · External reference
Lactate and lactylation in intervertebral disc degeneration
10.3389/fmolb.2025.1685975 · External reference
Lactate: a key regulator of the immune response
10.1016/j.immuni.2025.02.008 · 2025 · External reference
Lactylation-driven IGF2BP3-Mediated serine metabolism reprogramming and RNA m6A-Modification promotes lenvatinib resistance in HCC
10.1002/advs.202401399 · 2024 · External reference
PSMD14-Mediated LDHA deubiquitination upregulates ACLY expression via H3K18 lactylation to promote lipid synthesis and pancreatic cancer progression
10.1002/advs.202505762 · 2025 · External reference
Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation
10.3389/fcvm.2025.1567310 · 2025 · External reference
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
10.1038/s41422-023-00864-6 · 2024 · External reference
Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression
10.1186/s13046-024-02943-x · External reference
Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation
10.1016/j.redox.2024.103108 · External reference
PFKP lactylation promotes the ovarian cancer progression through targeting PTEN
10.1007/s10528-024-10990-4 · 2025 · External reference
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
10.1091/mbc.e05-01-0033 · 2005 · External reference
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases
10.1126/sciadv.abi6696 · 2022 · External reference
HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
10.1038/s41467-024-47900-6 · 2024 · External reference
The TRIM33 bromodomain recognizes histone lysine lactylation
10.1021/acschembio.4c00248 · 2024 · External reference
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in alzheimer's disease
10.1016/j.cmet.2022.02.013 · 2022 · External reference
Cox10-mediated mitochondrial respiration in brown adipocytes regulates adaptive thermogenesis and systemic metabolism
10.1016/j.isci.2026.116442 · 2026 · External reference
Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets
10.1186/s43556-025-00275-6 · 2025 · External reference
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
10.1038/nature10350 · 2011 · External reference
Histone H3K18 and ezrin lactylation promote renal dysfunction in sepsis-associated acute kidney injury
10.1002/advs.202307216 · 2024 · External reference
Lactylation reprogramming in the bone infection microenvironment identifies PGK1 K361 as a potential therapeutic target for osteogenic dysfunction
10.1002/advs.202523583 · 2026 · External reference
PRMT5 K240lac confers ferroptosis resistance via ALKBH5/SLC7A11 axis in colorectal cancer
10.1038/s41388-025-03457-2 · 2025 · External reference
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth
10.1016/j.celrep.2025.115441 · 2025 · External reference
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma
10.1038/s41421-025-00829-6 · 2025 · External reference
Dexmedetomidine ameliorates myocardial ischemia-reperfusion injury by inhibiting MDH2 lactylation via regulating metabolic reprogramming
10.1002/advs.202409499 · 2024 · External reference
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
10.1038/s41392-025-02255-2 · 2025 · External reference
PFKM promotes the progression of gastric cancer by Up-regulating CNTN1 expression through H3K18la modification
10.1007/s12010-025-05319-9 · 2025 · External reference
Biochemistry and regulation of histone lysine L-lactylation
10.1038/s41580-025-00876-7 · 2026 · External reference
Non-histone lactylation: unveiling its functional significance
10.3389/fcell.2025.1535611 · 2025 · External reference
Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1
10.1038/s41419-025-07914-4 · 2025 · External reference
Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer
10.1038/s41467-023-42025-8 · 2023 · External reference
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed alpha-tubulin lactylation
10.1038/s41467-024-52729-0 · 2024 · External reference
Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
10.7150/thno.104858 · External reference
Glycolysis-derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration
10.1002/advs.202416149 · External reference
MeCP2 lactylation protects against ischemic brain injury by transcriptionally regulating neuronal apoptosis
10.1002/advs.202415309 · External reference
Global profiling of lysine acetylation and lactylation in kupffer cells
10.1021/acs.jproteome.3c00156 · 2023 · External reference
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI
10.1038/s41598-025-10928-9 · 2025 · External reference
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance
10.1016/j.ijbiomac.2025.146571 · 2025 · External reference
Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation
10.1096/fj.05-4682rev · 2006 · External reference
Glyoxalase 2 Coordinates de novo Serine Metabolism
10.1002/cbic.202401086 · 2025 · External reference
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
10.1038/s41388-024-03243-6 · 2025 · External reference
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
10.1038/s41592-022-01523-1 · 2022 · External reference
Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages
10.7150/ijbs.75434 · 2022 · External reference
Effects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis
10.1038/s41598-024-82150-y · External reference
The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation
10.1186/s12894-024-01444-5 · External reference
A positive feedback inhibition of isocitrate dehydrogenase 3beta on paired-box gene 6 promotes alzheimer-like pathology
10.1038/s41392-024-01812-5 · External reference
Gut microbiota-derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation
10.1002/imt2.70048 · External reference
Serpina3k lactylation protects from cardiac ischemia reperfusion injury
10.1038/s41467-024-55589-w · External reference
PD-L1 delactylation-promoted nuclear translocation accelerates liver cancer growth through elevating SQLE transcription activity
10.1016/j.canlet.2025.217901 · External reference
Hypoxia/Reoxygenation-Induced glycolysis mediates myocardial ischemia-reperfusion injury through promoting the lactylation of GPX4
10.1007/s12265-025-10628-9 · External reference
Histone lactylation-mediated overexpression of RASD2 promotes endometriosis progression via upregulating the SUMOylation of CTPS1
10.1152/ajpcell.00493.2024 · External reference
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1alpha signal pathway in endometrial carcinoma
10.1038/s41420-024-01898-4 · 2024 · External reference
BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma
10.1038/s41418-026-01698-6 · 2026 · External reference
Lactylation drives hCG-triggered luteinization in hypoxic granulosa cells
10.1016/j.ijbiomac.2024.135580 · 2024 · External reference
Wogonoside inhibits fibroblast activation and pulmonary fibrosis by dual regulation of Snail1 lactylation and PGC1alpha/PINK1-mediated mitophagy
10.1016/j.phymed.2025.157240 · External reference
Lactylation-driven transcriptional activation of FBXO33 promotes gallbladder cancer metastasis by regulating p53 polyubiquitination
10.1038/s41419-025-07372-y · External reference
TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis
10.1038/s41467-026-70263-z · 2026 · External reference
Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis
10.1002/ctm2.70597 · 2026 · External reference
Metabolic interplay in acute lung injury: PARK7 integrates FADS1/2-Dependent PUFA metabolism and H3K14 lactylation to attenuate endothelial ferroptosis and dysfunction
10.1002/advs.202508725 · External reference
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis
10.1038/s41420-025-02334-x · External reference
Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience
10.1016/j.cmet.2024.07.018 · 2024 · External reference
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
10.1038/nrm2346 · 2008 · External reference
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis
10.1038/s41418-021-00841-9 · 2022 · External reference
Global profiling of lysine lactylation in human lungs
10.1002/pmic.202200437 · External reference
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
10.1038/s42255-022-00710-w · External reference
Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer
10.1136/gutjnl-2024-334361 · External reference
Function and mechanism of lactylation in health and diseases: a comprehensive review
10.1097/js9.0000000000002623 · External reference
Extracellular CD44 lactylation impairs CD8(+) T cell function in KRAS-Mutant colorectal cancer
10.1038/s42255-026-01482-3 · 2026 · External reference
Chemical and structural biology of protein lysine deacetylases
10.2183/pjab.93.019 · 2017 · External reference
Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome
10.1016/j.celrep.2025.116084 · 2025 · External reference
The lactate-primed KAT8‒PCK2 axis exacerbates hepatic ferroptosis during ischemia/reperfusion injury by reprogramming OXSM-dependent mitochondrial fatty acid synthesis
10.1002/advs.202414141 · 2025 · External reference
IDH2 lactylation promotes angiogenesis in murine diabetic myocardial infarction via blocking Cav1-eNOS interaction
10.1038/s41467-025-67877-0 · 2025 · External reference
Effects of the acetyltransferase p300 on tumour regulation from the novel perspective of posttranslational protein modification
10.3390/biom13030417 · 2023 · External reference
Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk
10.1016/j.mtbio.2025.102101 · 2025 · External reference
DPF2 reads histone lactylation to drive transcription and tumorigenesis
10.1073/pnas.2421496121 · 2024 · External reference
Metabolic regulation of gene expression by histone lactylation
10.1038/s41586-019-1678-1 · 2019 · External reference
alpha-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
10.1038/s41422-023-00844-w · 2023 · External reference
Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage
10.1186/s12974-024-03185-6 · External reference
The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts
10.1016/j.jgg.2024.02.009 · External reference
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring
10.1038/s41423-024-01212-3 · External reference
Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis
10.1038/s41589-024-01680-8 · External reference
Lactylation of HADHA promotes sepsis-induced myocardial depression
10.1161/circresaha.124.325708 · External reference
The lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines
10.1007/s11033-025-10960-y · External reference
Lactylation of PLBD1 facilitates brain injury induced by ischemic stroke
10.31083/jin25949 · External reference
Hypoxia-induced PRMT1 lactylation drives vimentin arginine asymmetric dimethylation in tumor metastasis
10.1002/advs.202509861 · External reference
Lactate and lactylation in cardiovascular diseases: current progress and future perspectives
10.1016/j.metabol.2024.155957 · 2024 · External reference
TEC-Mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis
10.1186/s13148-025-01813-3 · External reference
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-Hyperactivated intrahepatic cholangiocarcinoma
10.1002/cac2.70036 · External reference
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
10.1016/j.cmet.2024.10.015 · External reference
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
10.1016/j.cell.2024.04.002 · 2024 · External reference
Emerging roles of lysine lactyltransferases and lactylation
10.1038/s41556-025-01635-8 · 2025 · External reference
SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells
10.1038/s41421-022-00398-y · 2022 · External reference