Research graph
References from PFKP in malignant tumors: bridging metabolic reprogramming, post-translational modifications, and the immunosuppressive microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Gene expression levels of the glycolytic enzymes lactate dehydrogenase A (LDHA) and phosphofructokinase platelet (PFKP) are good predictors of survival time, recurrence and risk of death in cervical
10.1101/2022.08.02.22277946 · 2022 · External reference
The mRNA and protein levels of the glycolytic enzymes lactate dehydrogenase A (LDHA) and phosphofructokinase platelet (PFKP) are good predictors of survival time, recurrence, and risk of death in cervical cancer patients
10.1002/cam4.6123 · 2023 · External reference
All in for nuclear PFKP-induced CXCR4 metastasis: a T cell acute lymphoblastic leukemia prognostic marker
10.1172/jci151295 · 2021 · External reference
PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism
10.1016/j.cmet.2017.03.011 · 2017 · External reference
Hitting the sweet spot: how glucose metabolism is orchestrated in space and time by Phosphofructokinase-1
10.3390/cancers16010016 · 2023 · External reference
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells
10.15252/embr.202255683 · 2023 · External reference
Targeting phosphofructokinase in cancer: integrating natural products for metabolic reprogramming and therapeutic innovation
10.3389/fphar.2026.1844992 · 2026 · External reference
The importance of PFK-P and PEA-15 (Phosphoprotein enriched in astrocytes-15kDa) expression in cases of endometrioid endometrial carcinoma and endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia
2024 · External reference
Unresolved reference
2024 · External reference
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth
10.1007/s12094-023-03096-7 · 2023 · External reference
Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase
10.1016/j.thromres.2013.11.009 · 2014 · External reference
Silencing PFKP inhibits starvation-induced autophagy, glycolysis, and epithelial mesenchymal transition in oral squamous cell carcinoma
10.1016/j.yexcr.2018.06.007 · 2018 · External reference
HOTAIRM1 knockdown enhances Cytarabine-Induced cytotoxicity by suppression of glycolysis through the Wnt/β-catenin/PFKP pathway in acute myeloid
10.1016/j.abb.2019.108244 · 2020 · External reference
PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation
10.1038/s41421-022-00406-1 · 2022 · External reference
HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer
10.1126/sciadv.adk3663 · 2024 · External reference
Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration
10.17305/bb.2024.10530 · External reference
RNF123 inhibits cell viability, cell cycle and colony formation of breast cancer by inhibiting glycolysis via ubiquitination of PFKP
10.1007/s00210-024-03723-2 · External reference
Hypoxia-inducible Factor-1α mediates hyperglycemia-induced pancreatic cancer glycolysis
10.2174/1871520619666190626120359 · 2019 · External reference
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells
10.1016/j.isci.2023.108645 · 2024 · External reference
Breast cancer subtypes underlying EMT-Mediated catabolic metabolism
10.3390/cells9092064 · 2020 · External reference
Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells
10.1016/j.bbamcr.2022.119252 · 2022 · External reference
PFKP is upregulated in 5-fluorouracil-resistant patients and suppresses the antitumor activity of 5-fluorouracil in colorectal cancer in vitro and in vivo
10.1080/1120009x.2023.2288742 · 2023 · External reference
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet
10.1006/bbrc.1994.1141 · 1994 · External reference
Anti-Warburg effect by targeting HRD1-PFKP pathway May inhibit breast cancer progression
10.1186/s12964-020-00679-7 · 2021 · External reference
PFKP is required for chemoresistant phenotype of breast cancer through modulating the formation of CD133+ cancer stem like cells
10.1186/s43556-026-00454-z · 2026 · External reference
Targeting metabolic plasticity and flexibility dynamics for cancer therapy
10.1158/2159-8290.cd-20-0844 · 2020 · External reference
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches
10.1042/bcj20200656 · 2020 · External reference
Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation
10.1038/s41598-019-55211-w · 2019 · External reference
Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells
10.3390/ijms231710037 · 2022 · External reference
PFKP phenotype in lung cancer: prognostic potential and beyond
10.1007/s11033-020-05805-9 · 2020 · External reference
SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure
10.3389/fimmu.2022.1079962 · 2023 · External reference
Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia
10.1172/jci143119 · 2021 · External reference
Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis
10.3389/fphar.2025.1578877 · 2025 · External reference
IL-6-Driven autocrine lactate promotes immune escape of uveal melanoma
10.1167/iovs.65.3.37 · 2024 · External reference
MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration
10.1007/s12032-023-01974-2 · 2023 · External reference
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer
10.1038/s41568-025-00800-3 · 2025 · External reference
Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)
10.1200/jco.2021.39.15_suppl.3115 · 2021 · External reference
A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer
10.1158/1078-0432.ccr-22-2263 · 2023 · External reference
Pan-cell death-related signature reveals tumor immune microenvironment and optimizes personalized therapy alternations in lung adenocarcinoma
10.1038/s41598-024-66662-1 · 2024 · External reference
Cancer drug resistance: an evolving paradigm
10.1038/nrc3599 · 2013 · External reference
P53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
10.1016/j.celrep.2023.113426 · 2023 · External reference
Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer
10.3892/or.2021.8220 · 2022 · External reference
Phosphofructokinase-1 in cancer: a promising target for diagnosis and therapy
10.2174/0115748928321372240813080131 · 2024 · External reference
Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation
10.3892/or.2021.8185 · 2021 · External reference
Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes
10.23876/j.krcp.23.005 · 2024 · External reference
Effect of lncRNA XIST on acute myeloid leukemia cells via miR-142-5p-PFKP axis
10.1080/16078454.2024.2306444 · 2024 · External reference
Phosphofructokinase 1 platelet isoform enhances VEGF expression in part through HIF-la Up-regulation in breast cancer
10.21873/anticanres.16136 · 2023 · External reference
Phosphofructokinase (PFK) isozymes in man: I. Studies of adult human tissues
10.1007/bf00273280 · 1979 · External reference
Phosphofructokinase-1 subunit composition and activity in the skeletal muscle
10.1292/jvms.19-0049 · 2019 · External reference
Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation
10.1042/bj20150251 · 2015 · External reference
Molecular mechanisms of impaired antigenic presentation as a cause of tumor escape from immune surveillance
10.17116/patol20238506176 · 2023 · External reference
PFKP signaling at a glance: an emerging mediator of cancer cell metabolism
10.1007/978-3-030-12668-1_13 · 2019 · External reference
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
10.1038/s41467-017-00906-9 · 2017 · External reference
EGFR-phosphorylated platelet isoform of phosphofructokinase 1 promotes PI3K activation
10.1016/j.molcel.2018.03.018 · 2018 · External reference
Phosphofructokinase 1 platelet isoform promotes beta-Catenin transactivation for tumor development
10.3389/fonc.2020.00211 · 2020 · External reference
Understanding and targeting resistance mechanisms in cancer
10.1002/mco2.265 · 2023 · External reference
PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy
10.1016/j.cellsig.2021.109956 · 2021 · External reference
The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining
10.1016/j.bioactmat.2022.03.036 · 2022 · External reference
Controlling the confounding effect of metabolic gene expression to identify actual metabolite targets
10.1186/s40246-023-00465-9 · 2023 · External reference
The lncRNA XIST/miR-29b-3p/COL3A1 axis regulates central carbon metabolism in head and neck squamous cell carcinoma and is associated with poor tumor prognosis
10.21037/atm-23-30 · 2023 · External reference
TRIM25 potentiates innate immune response to senecavirus A by enhancing K63-linked ubiquitination of RIG-I and K48-linked ubiquitin-facilitated degradation of PFKP
10.1016/j.vetmic.2025.110634 · 2025 · External reference
Unresolved reference
2025 · External reference
QS418. anti-human protein S antibody induces tissue factor expression through direct interaction with platelet phosphofructokinase in human coronary artery endothelial cells
10.1016/j.jss.2008.11.730 · 2009 · External reference
Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth
10.1038/s41419-022-05449-6 · 2022 · External reference
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
10.1038/onc.2014.320 · 2014 · External reference
A comprehensive prognostic and immunological implications of PFKP in pan-cancer
10.1186/s12935-024-03497-w · 2024 · External reference
MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
10.1038/oncsis.2016.35 · 2016 · External reference
Prognostic roles of phosphofructokinase platelet in clear cell renal cell carcinoma and correlation with immune infiltration
10.2147/ijgm.s321337 · 2021 · External reference
Extracellular vesicle PD-L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies
10.1186/s12964-021-00816-w · 2022 · External reference
A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
10.1186/s12943-024-02051-6 · 2024 · External reference
Lactylation of PFKP-K688 enhances glycolytic flux and confers cardioprotection in myocardial ischemia
10.3389/fphar.2026.1717779 · External reference
ATM promotes PFKP nuclear translocation to balance glycolysis and homologous recombination repair
10.1093/nar/gkag336 · 2026 · External reference
Isoliquiritigenin impedes breast cancer progression through PITX1-PFKP-Mediated glycolysis reprogramming
10.32604/or.2026.077059 · External reference
Overexpression accelerated colorectal cancer cell growth and motility
10.7150/jca.82738 · 2023 · External reference
Phosphofructokinase platelet overexpression accelerated colorectal cancer cell growth and motility
10.7150/jca.82738 · 2023 · External reference
The platelet isoform of phosphofructokinase in acute myeloid leukemia: clinical relevance and prognostic implication
10.1182/blood-2018-99-113786 · 2018 · External reference
Structural basis for allosteric regulation of human phosphofructokinase-1
10.1038/s41467-024-51808-6 · 2024 · External reference
Unresolved reference
2024 · External reference
Identification of a hypoxia-associated signature for lung adenocarcinoma
10.3389/fgene.2020.00647 · 2020 · External reference
Single-cell transcriptomics reveals the role of macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma
10.1186/s12967-022-03675-2 · 2022 · External reference
Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas
10.1186/1471-2407-11-198 · 2011 · External reference
Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer
10.1074/jbc.m111.236737 · 2011 · External reference
Who controls the Atp supply in cancer cells?
10.1016/j.biocel.2014.01.025 · 2014 · External reference
Partial purification and some properties of brain phosphofructokinase
10.1016/0003-9861(53)90371-3 · 1953 · External reference
Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15
10.1007/bf00207053 · 1992 · External reference
Moonlighting functions of metabolic enzymes and metabolites in cancer
10.1016/j.molcel.2021.08.031 · 2021 · External reference
Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis
10.1093/jimmun/vkaf078 · 2025 · External reference
Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520
10.1002/hep.26310 · 2013 · External reference
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer
10.1038/s41598-023-43982-2 · 2023 · External reference
PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression
10.1186/s13058-024-01767-z · 2024 · External reference
Phosphofructokinase-P modulates P44/42 MAPK levels in HeLa cells
10.1002/jcb.25774 · 2017 · External reference
Salvia Miltiorrhiza-Derived Sal-miR-58 induces autophagy and attenuates inflammation in vascular smooth muscle
10.1016/j.omtn.2020.06.015 · 2020 · External reference
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis
10.1016/j.molcel.2020.12.026 · 2021 · External reference
2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine
10.3389/fneur.2023.1115318 · 2023 · External reference
Cancer models in preclinical research: a chronicle review of advancement in effective cancer research
10.1002/ame2.12165 · 2021 · External reference
Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity
10.1126/sciadv.adc9657 · 2022 · External reference
Silencing PFKP restrains the stemness of hepatocellular carcinoma cells
10.1016/j.yexcr.2021.112789 · 2021 · External reference
Positive feedback in Cav‐1‐ROS signalling in PSCs mediates metabolic coupling between PSCs and tumour
10.1111/jcmm.15596 · 2020 · External reference
PFKP is highly expressed in lung cancer and regulates glucose metabolism
10.1007/s13402-020-00508-6 · 2020 · External reference
Integrative analysis of single-cell and bulk transcriptomes reveals metabolic heterogeneity and identifies PFKP as a therapeutic target in cervical cancer
10.1016/j.bbadis.2025.168146 · 2026 · External reference
Isolation and sequence of a cDNA encoding human platelet phosphofructokinase
10.1016/s0006-291x(05)81276-8 · 1991 · External reference
Overexpressed WDR3 induces the activation of hippo pathway by interacting with GATA4 in pancreatic cancer
10.1186/s13046-021-01879-w · 2021 · External reference
Xueshuantong injection alleviates ischemic heart failure via targeting PFKP-mediated endothelial-to-mesenchymal transition
10.1016/j.phymed.2026.158085 · 2026 · External reference
FOXK1 and FOXK2 regulate aerobic glycolysis
10.1038/s41586-019-0900-5 · 2019 · External reference
Genetic alteration in phosphofructokinase family promotes growth of muscle-invasive bladder
10.5301/jbm.5000189 · 2016 · External reference
10.1101/2024.03.03.583230
10.1101/2024.03.03.583230 · 2024 · External reference
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis
10.1007/s13105-025-01114-6 · 2025 · External reference
Isozymes of rabbit phosphofructokinase
10.1016/s0021-9258(19)44336-6 · 1973 · External reference
Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer
10.1016/j.yexcr.2020.112282 · 2020 · External reference
Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling
10.1093/cvr/cvaa233 · 2021 · External reference
Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system
10.1073/pnas.77.1.62 · 1980 · External reference
Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy
1985 · External reference
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity
10.1042/bcj20230207 · 2023 · External reference
The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma
10.18632/oncotarget.8382 · 2016 · External reference
Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non-small cell lung cancer
10.3892/mmr.2020.11712 · 2021 · External reference
Meldonium ameliorates hypoxia-induced lung injury and oxidative stress by regulating platelet-type phosphofructokinase-mediated glycolysis
10.3389/fphar.2022.863451 · 2022 · External reference
Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion
10.1007/s13258-022-01291-4 · 2022 · External reference
PFKP confers chemoresistance by upregulating ABCC2 transporter in non-small cell lung cancer
10.21037/tlcr-23-567 · 2023 · External reference
RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac4C modification
10.1038/s41368-023-00276-7 · 2024 · External reference
PFKP binding AMOTL1 promotes tumor aerobic glycolysis and epithelial-mesenchymal transition by modulating hippo pathway in head and neck cancer
10.1515/jtim-2026-0006 · 2026 · External reference
The c-Myc-USP14-PFKP axis sustains chemoresistance in pancreatic ductal adenocarcinoma
10.1016/j.drup.2026.101385 · 2026 · External reference
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
10.1038/nature14405 · 2015 · External reference
The glycolytic enzyme phosphofructokinase-1 assembles into filaments
10.1083/jcb.201701084 · 2017 · External reference
Trim21 mediates metabolic reprogramming in renal tubular cells via PFKP ubiquitination to alleviate renal fibrosis
10.1002/jcp.31439 · 2024 · External reference
PFKP inhibition protects against pathological cardiac hypertrophy by regulating protein synthesis
10.1016/j.bbadis.2024.167542 · 2024 · External reference
Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors
10.2147/dddt.s71061 · 2014 · External reference
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming
10.1038/s41556-024-01349-3 · 2024 · External reference
The role of MCT1 in tumor progression and targeted therapy: a comprehensive review
10.3389/fimmu.2025.1610466 · 2025 · External reference
Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis
10.1038/s41419-023-06347-1 · 2023 · External reference
Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis
10.1038/s41435-024-00252-z · 2024 · External reference
Bioinformatics identification of prognostic genes and potential interaction analysis in renal cell carcinoma
10.21037/tcr-22-2242 · 2023 · External reference
Phosphofructokinase-1 redefined: a metabolic hub orchestrating cancer hallmarks through multi-dimensional control networks
10.1186/s12967-025-06897-2 · 2025 · External reference
Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells
10.1016/j.ymgme.2010.04.006 · 2010 · External reference
Hyperbaric oxygen therapy represses the warburg effect and epithelial–mesenchymal transition in hypoxic NSCLC cells via the HIF-1α/PFKP axis
10.3389/fonc.2021.691762 · 2021 · External reference
Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse sertoli cells
10.1016/j.taap.2021.115606 · 2021 · External reference
PFKP activation ameliorates foot process fusion in podocytes in diabetic kidney disease
10.3389/fendo.2021.797025 · 2022 · External reference
Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation
10.1002/ctm2.1369 · 2023 · External reference
Abstract 5023: PFKP contributes to ovarian cancer metastasis, stemness and anchorage-independent growth via α5 integrin and ERK/MMP9 signaling
10.1158/1538-7445.am2023-5023 · 2023 · External reference
10.1101/2024.01.07.24300871
10.1101/2024.01.07.24300871 · 2024 · External reference
Warburg effect and lactylation in cancer: mechanisms for chemoresistance
10.1186/s10020-025-01205-6 · 2025 · External reference
PFKP silencing suppresses tumor growth via the AXL-MET axis
10.7150/ijbs.100525 · 2024 · External reference
Integrating bioinformatics and machine learning to identify glucose metabolism-related biomarkers with diagnostic and prognostic value for patients with kidney renal clear cell carcinoma
10.56434/j.arch.esp.urol.20257803.48 · 2025 · External reference
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
10.1186/s13045-022-01358-5 · 2022 · External reference
VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells
10.1038/s41419-018-1015-x · 2018 · External reference
ZNF148/PFKP/PD-L1 axis promotes non-small cell lung cancer proliferation, migration and glycolysis
10.20517/2394-4722.2023.111 · 2023 · External reference
Cancer models in preclinical research: a chronicle review of advancement in effective cancer research
10.1002/ame2.12165 · ExternalCitation · doi-reference
The mRNA and protein levels of the glycolytic enzymes lactate dehydrogenase A (LDHA) and phosphofructokinase platelet (PFKP) are good predictors of survival time, recurrence, and risk of death in cervical cancer patients
10.1002/cam4.6123 · ExternalCitation · doi-reference
Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation
10.1002/ctm2.1369 · ExternalCitation · doi-reference
Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520
10.1002/hep.26310 · ExternalCitation · doi-reference
Phosphofructokinase-P modulates P44/42 MAPK levels in HeLa cells
10.1002/jcb.25774 · ExternalCitation · doi-reference
Trim21 mediates metabolic reprogramming in renal tubular cells via PFKP ubiquitination to alleviate renal fibrosis
10.1002/jcp.31439 · ExternalCitation · doi-reference
Understanding and targeting resistance mechanisms in cancer
10.1002/mco2.265 · ExternalCitation · doi-reference
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet
10.1006/bbrc.1994.1141 · ExternalCitation · doi-reference
PFKP signaling at a glance: an emerging mediator of cancer cell metabolism
10.1007/978-3-030-12668-1_13 · ExternalCitation · doi-reference
Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15
10.1007/bf00207053 · ExternalCitation · doi-reference
Phosphofructokinase (PFK) isozymes in man: I. Studies of adult human tissues
10.1007/bf00273280 · ExternalCitation · doi-reference
RNF123 inhibits cell viability, cell cycle and colony formation of breast cancer by inhibiting glycolysis via ubiquitination of PFKP
10.1007/s00210-024-03723-2 · ExternalCitation · doi-reference
PFKP phenotype in lung cancer: prognostic potential and beyond
10.1007/s11033-020-05805-9 · ExternalCitation · doi-reference
MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration
10.1007/s12032-023-01974-2 · ExternalCitation · doi-reference
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth
10.1007/s12094-023-03096-7 · ExternalCitation · doi-reference
P4HA2 promotes the progression of thyroid cancer by regulating PFKP-mediated glycolysis
10.1007/s13105-025-01114-6 · ExternalCitation · doi-reference
Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion
10.1007/s13258-022-01291-4 · ExternalCitation · doi-reference
PFKP is highly expressed in lung cancer and regulates glucose metabolism
10.1007/s13402-020-00508-6 · ExternalCitation · doi-reference
Partial purification and some properties of brain phosphofructokinase
10.1016/0003-9861(53)90371-3 · ExternalCitation · doi-reference
HOTAIRM1 knockdown enhances Cytarabine-Induced cytotoxicity by suppression of glycolysis through the Wnt/β-catenin/PFKP pathway in acute myeloid
10.1016/j.abb.2019.108244 · ExternalCitation · doi-reference
PFKP inhibition protects against pathological cardiac hypertrophy by regulating protein synthesis
10.1016/j.bbadis.2024.167542 · ExternalCitation · doi-reference
Integrative analysis of single-cell and bulk transcriptomes reveals metabolic heterogeneity and identifies PFKP as a therapeutic target in cervical cancer
10.1016/j.bbadis.2025.168146 · ExternalCitation · doi-reference
Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells
10.1016/j.bbamcr.2022.119252 · ExternalCitation · doi-reference
The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining
10.1016/j.bioactmat.2022.03.036 · ExternalCitation · doi-reference
Who controls the Atp supply in cancer cells?
10.1016/j.biocel.2014.01.025 · ExternalCitation · doi-reference
PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy
10.1016/j.cellsig.2021.109956 · ExternalCitation · doi-reference
P53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
10.1016/j.celrep.2023.113426 · ExternalCitation · doi-reference
PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism
10.1016/j.cmet.2017.03.011 · ExternalCitation · doi-reference
The c-Myc-USP14-PFKP axis sustains chemoresistance in pancreatic ductal adenocarcinoma
10.1016/j.drup.2026.101385 · ExternalCitation · doi-reference
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells
10.1016/j.isci.2023.108645 · ExternalCitation · doi-reference
QS418. anti-human protein S antibody induces tissue factor expression through direct interaction with platelet phosphofructokinase in human coronary artery endothelial cells
10.1016/j.jss.2008.11.730 · ExternalCitation · doi-reference
EGFR-phosphorylated platelet isoform of phosphofructokinase 1 promotes PI3K activation
10.1016/j.molcel.2018.03.018 · ExternalCitation · doi-reference
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis
10.1016/j.molcel.2020.12.026 · ExternalCitation · doi-reference
Moonlighting functions of metabolic enzymes and metabolites in cancer
10.1016/j.molcel.2021.08.031 · ExternalCitation · doi-reference
Salvia Miltiorrhiza-Derived Sal-miR-58 induces autophagy and attenuates inflammation in vascular smooth muscle
10.1016/j.omtn.2020.06.015 · ExternalCitation · doi-reference
Xueshuantong injection alleviates ischemic heart failure via targeting PFKP-mediated endothelial-to-mesenchymal transition
10.1016/j.phymed.2026.158085 · ExternalCitation · doi-reference
Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse sertoli cells
10.1016/j.taap.2021.115606 · ExternalCitation · doi-reference
Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase
10.1016/j.thromres.2013.11.009 · ExternalCitation · doi-reference
TRIM25 potentiates innate immune response to senecavirus A by enhancing K63-linked ubiquitination of RIG-I and K48-linked ubiquitin-facilitated degradation of PFKP
10.1016/j.vetmic.2025.110634 · ExternalCitation · doi-reference
Silencing PFKP inhibits starvation-induced autophagy, glycolysis, and epithelial mesenchymal transition in oral squamous cell carcinoma
10.1016/j.yexcr.2018.06.007 · ExternalCitation · doi-reference
Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer
10.1016/j.yexcr.2020.112282 · ExternalCitation · doi-reference
Silencing PFKP restrains the stemness of hepatocellular carcinoma cells
10.1016/j.yexcr.2021.112789 · ExternalCitation · doi-reference
Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells
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