Research graph
References from Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Homeostasis control in health and disease by the unfolded protein response
10.1038/s41580-024-00794-0 · 2025 · External reference
The structural biology of canonical wnt signalling
10.1042/bst20200243 · 2020 · External reference
Endoplasmic reticulum stress-mediated cell death in cardiovascular disease
10.1016/j.cstres.2023.12.003 · 2024 · External reference
CAF-induced physical constraints controlling T cell state and localization in solid tumours
10.1038/s41568-024-00740-4 · 2024 · External reference
Wnt/β-Catenin signaling regulates yap/taz activity during embryonic development in zebrafish
10.3390/ijms251810005 · 2024 · External reference
Wnt/β-catenin and notch signaling pathways in cardiovascular disease: mechanisms and therapeutics approaches
10.1016/j.phrs.2024.107565 · 2025 · External reference
The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases
10.1110/ps.8.8.1636 · 1999 · External reference
Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA
10.1161/01.cir.0000093186.22847.4c · 2003 · External reference
Designing novel therapies to mend broken hearts: ATF6 and cardiac proteostasis
10.3390/cells9030602 · 2020 · External reference
The wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
10.1210/me.2003-0498 · 2004 · External reference
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance
10.1186/s12967-024-05329-x · 2024 · External reference
Structural basis of frizzled 7 activation and allosteric regulation
10.1038/s41467-024-51664-4 · 2024 · External reference
Beyond wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
10.1242/jcs.026096 · 2008 · External reference
Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical wnt signaling from Fz7 to Ror2 during vertebrate gastrulation
10.1074/jbc.m116.733766 · 2016 · External reference
Inverse associations between circulating secreted frizzled related protein 2 (sFRP2) and cardiometabolic risk factors
10.3389/fcvm.2021.723205 · 2021 · External reference
The transformation of cancer-associated fibroblasts: current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance
10.1016/j.canlet.2021.08.002 · 2021 · External reference
SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars
10.1371/journal.pone.0050229 · 2012 · External reference
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring
10.1038/s41467-025-62248-1 · 2025 · External reference
Effect of SFRP5 (secreted frizzled-related protein 5) on the WNT5A (Wingless-Type family member 5A)-Induced endothelial dysfunction and its relevance with arterial stiffness in human subjects
10.1161/atvbaha.117.310649 · 2018 · External reference
A fibroblast-dependent TGF-β1/sFRP2 noncanonical wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis
10.1172/jci174598 · 2024 · External reference
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway
10.1158/0008-5472.can-08-3402 · 2009 · External reference
Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens
10.1016/j.devcel.2023.11.027 · 2024 · External reference
SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a
10.1634/stemcells.2007-0475 · 2008 · External reference
TGF-β signaling in health, disease, and therapeutics
10.1038/s41392-024-01764-w · 2024 · External reference
A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling
10.1242/jcs.112.21.3815 · 1999 · External reference
Skin fibrosis is accompanied by increased expression of secreted frizzled-related protein-2
10.1111/wrr.13211 · 2024 · External reference
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response
10.1074/jbc.m109.018036 · 2009 · External reference
FrzA, a secreted frizzled related protein, induced angiogenic response
10.1161/01.cir.0000039342.85015.5c · 2002 · External reference
Macrophage-derived GSDMD plays an essential role in atherosclerosis and cross talk between macrophages via the Mitochondria-STING-IRF3/NF-κB axis
10.1161/atvbaha.123.320612 · 2024 · External reference
sFRP2 supersedes VEGF as an age-related driver of angiogenesis in melanoma, affecting response to Anti-VEGF therapy in older patients
10.1158/1078-0432.ccr-20-0446 · 2020 · External reference
Signaling pathways in cancer-associated fibroblasts: recent advances and future perspectives
10.1002/cac2.12392 · 2023 · External reference
Purification and molecular cloning of a secreted, Frizzled-related antagonist of wnt action
10.1073/pnas.94.13.6770 · 1997 · External reference
A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth
10.1158/1535-7163.mct-12-1066 · 2013 · External reference
Development of a novel humanized monoclonal antibody to secreted frizzled-related Protein-2 that inhibits triple-negative breast cancer and angiosarcoma growth in vivo
10.1245/s10434-019-07800-2 · 2019 · External reference
The mechanism and promising therapeutic strategy of diabetic cardiomyopathy dysfunctions: focus on pyroptosis
10.1016/j.jdiacomp.2024.108848 · 2024 · External reference
TGF-β signaling: critical nexus of fibrogenesis and cancer
10.1186/s12967-024-05411-4 · 2024 · External reference
Cancer-associated fibroblasts: tumorigenicity and targeting for cancer therapy
10.3390/cancers14163906 · 2022 · External reference
Pathway selectivity in frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations
10.1038/s41467-023-40213-0 · 2023 · External reference
ROR2/Wnt5a signaling regulates directional cell migration and early tumor cell invasion in ovarian cancer
10.1158/1541-7786.mcr-23-0616 · 2024 · External reference
Extracellular WNTs: trafficking, exosomes, and ligand-receptor interaction
10.1007/164_2021_531 · 2021 · External reference
Secreted frizzled related proteins in cardiovascular and metabolic diseases
10.3389/fendo.2021.712217 · 2021 · External reference
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
10.1007/s10555-024-10186-7 · 2024 · External reference
Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
10.1073/pnas.1004708107 · 2010 · External reference
Fibrosis: from mechanisms to medicines
10.1038/s41586-020-2938-9 · 2020 · External reference
ATF6 protects against protein misfolding during cardiac hypertrophy
10.1016/j.yjmcc.2024.02.001 · 2024 · External reference
Wnt signaling in cardiac development and heart diseases
10.1007/s11626-024-00917-z · 2024 · External reference
Role of TGFβ-activated cancer-associated fibroblasts in the resistance to checkpoint blockade immunotherapy
10.3389/fonc.2025.1602452 · 2025 · External reference
Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer
10.1186/s13058-025-02176-6 · 2025 · External reference
Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2
10.1038/s41598-023-31144-3 · 2023 · External reference
Gasdermin D-Mediated pyroptosis promotes the development of atherosclerosis
10.1016/j.labinv.2024.100337 · 2024 · External reference
Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
10.1016/j.celrep.2023.112103 · 2023 · External reference
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies
10.1038/s41392-023-01559-5 · 2023 · External reference
Bone morphogenetic protein-1: the type I procollagen C-proteinase
10.1126/science.271.5247.360 · 1996 · External reference
Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism
10.1073/pnas.1814044115 · 2018 · External reference
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
10.1038/ncb1811 · 2009 · External reference
SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt/β-catenin pathway
10.3892/mmr.2024.13190 · 2024 · External reference
Unlocking the wnt pathway: therapeutic potential of selective targeting FZD(7) in cancer
10.1016/j.drudis.2021.12.008 · 2022 · External reference
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases
10.1016/j.cell.2005.12.018 · 2006 · External reference
Molecular mechanism of ATF6 in unfolded protein response and its role in disease
10.1016/j.heliyon.2024.e25937 · 2024 · External reference
Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study
10.3389/fonc.2026.1748759 · 2026 · External reference
SFRPs are biphasic modulators of wnt-signaling-elicited cancer stem cell properties beyond extracellular control
10.1016/j.celrep.2019.07.023 · 2019 · External reference
sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling
10.1152/ajpcell.00137.2016 · 2016 · External reference
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-Dependent sFRP2-ATF6-NF-κB pathway
10.1016/j.trsl.2025.05.006 · 2025 · External reference
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
10.1038/s41392-021-00762-6 · 2022 · External reference
SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β
10.1186/s13046-024-03255-w · External reference
Frizzled receptors (FZDs) in wnt signaling: potential therapeutic targets for human cancers
10.1038/s41401-024-01270-3 · External reference
Articular cartilage and biomechanical properties of the long bones in Frzb‐knockout mice
10.1002/art.23137 · 2007 · External reference
Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and caMKII/mek/erk pathway in mesangial cells
10.1016/j.bbadis.2023.166933 · 2024 · External reference
Evolutionary and structural assessment of the human secreted frizzled-related protein (SFRP) family
10.1007/s00239-025-10249-5 · 2025 · External reference
TGF-β signaling in health and disease
10.1016/j.cell.2023.07.036 · 2023 · External reference
Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
10.1152/ajpcell.00238.2013 · 2014 · External reference
Endoplasmic reticulum stress and unfolded protein response in immune cell function
10.3389/fimmu.2025.1694102 · 2025 · External reference
Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction
10.1038/s41580-024-00823-y · 2025 · External reference
Heparan sulfate proteoglycan clustering in wnt signaling and dispersal
10.3389/fcell.2020.00631 · 2020 · External reference
Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
10.1073/pnas.0610024104 · 2007 · External reference
Overcoming PD-1 inhibitor resistance with a monoclonal antibody to secreted frizzled-related protein 2 in metastatic osteosarcoma
10.3390/cancers13112696 · 2021 · External reference
CXADR-mediated formation of an AKT inhibitory signalosome at tight junctions controls epithelial-mesenchymal plasticity in breast cancer
10.1158/0008-5472.can-18-1742 · 2019 · External reference
Structural basis of WLS/Evi-Mediated wnt transport and secretion
10.1016/j.cell.2020.11.038 · 2021 · External reference
A new molecular target for blunting organ fibrosis. Focus on secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
10.1152/ajpcell.00020.2014 · 2014 · External reference
Contributions of coxsackievirus adenovirus receptor to tumorigenesis
10.1042/bst20221203 · 2023 · External reference
Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis
10.1007/s10456-017-9574-5 · 2017 · External reference
Molecular basis of wnt biogenesis, secretion, and Wnt7-specific signaling
10.1016/j.cell.2023.09.021 · 2023 · External reference
Structural basis of frizzled 4 in recognition of dishevelled 2 unveils mechanism of WNT signaling activation
10.1038/s41467-024-52174-z · 2024 · External reference
Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review
10.1186/s13148-020-00904-7 · 2020 · External reference
ROR2 homodimerization is sufficient to activate a neuronal wnt/Calcium signaling pathway
10.1016/j.jbc.2023.105350 · 2023 · External reference
Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
10.1038/sj.onc.1203783 · 2000 · External reference
Secreted Frizzled-related proteins in animal development
10.1007/s00418-025-02415-z · 2025 · External reference
sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium
10.1016/j.niox.2017.02.012 · 2017 · External reference
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
10.1242/dev.02274 · 2006 · External reference
Sfrp1, Sfrp2, and Sfrp5 regulate the wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
10.1002/dvg.20369 · 2008 · External reference
Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of wnt pathways
10.1016/j.yjmcc.2015.06.003 · 2015 · External reference
Identification of unique gene expression patterns within different lesional sites of keloids
10.1111/j.1524-475x.2007.00343.x · 2008 · External reference
Pax6 is essential for lens fiber cell differentiation
10.1242/dev.032888 · 2009 · External reference
Transforming growth Factor-β signaling in fibrotic diseases and cancer-associated fibroblasts
10.3390/biom10121666 · 2020 · External reference
The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus
10.1371/journal.pone.0020412 · 2011 · External reference
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
10.1186/s13045-024-01563-4 · 2024 · External reference
The variation trends of SFRP2 methylation of tissue, feces, and blood detection in colorectal cancer development
10.1097/cej.0000000000000185 · 2016 · External reference
shRNA targeting SFRP2 promotes the apoptosis of hypertrophic scar fibroblast
10.1007/s11010-011-0736-2 · 2011 · External reference
A novel panel of stool-based DNA biomarkers for early screening of colorectal neoplasms in a Chinese population
10.1007/s00432-019-02992-2 · 2019 · External reference
Secreted frizzled related proteins: implications in cancers
10.1016/j.bbcan.2013.11.004 · 2014 · External reference
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
10.1038/ng1330 · 2004 · External reference
Myofibroblast transcriptome indicates SFRP2(hi) fibroblast progenitors in systemic sclerosis skin
10.1038/s41467-021-24607-6 · 2021 · External reference
Stromal barriers to the abscopal effect
10.1016/j.ccell.2025.04.008 · 2025 · External reference
Soluble Frizzled-related proteins promote exosome-mediated wnt re-secretion
10.1038/s42003-024-05881-8 · 2024 · External reference
Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis
10.1172/jci159884 · 2024 · External reference
Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma
10.1371/journal.pone.0086642 · 2014 · External reference
Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma
10.1371/journal.pone.0174281 · 2017 · External reference
Secreted frizzled-related protein 2: a key player in noncanonical wnt signaling and tumor angiogenesis
10.1007/s10555-020-09941-3 · 2021 · External reference
Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis
10.1007/s00395-020-0808-0 · 2020 · External reference
A pan-cancer analysis of secreted Frizzled-related proteins: re-examining their proposed tumour suppressive function
10.1038/srep42719 · 2017 · External reference
Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling
10.1016/j.bbrc.2010.08.043 · 2010 · External reference
Concurrent hypermethylation of SFRP2 and DKK2 activates the Wnt/β-Catenin pathway and is associated with poor prognosis in patients with gastric cancer
10.14348/molcells.2017.2245 · 2017 · External reference
Crosstalk between MST1‐Hippo and Wnt/β‐Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology
10.1007/s13105-025-01099-2 · 2025 · External reference
TLR4/NF-κB signaling induces GSDMD-related pyroptosis in tubular cells in diabetic kidney disease
10.3389/fendo.2019.00603 · 2019 · External reference
Role of pyroptosis in diabetic cardiomyopathy: an updated review
10.3389/fendo.2023.1322907 · 2023 · External reference
Single cell analysis revealed SFRP2 cancer associated fibroblasts drive tumorigenesis in head and neck squamous cell carcinoma
10.1038/s41698-024-00716-5 · 2024 · External reference
Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway
10.1007/s11010-020-03802-x · 2020 · External reference
Multiple roles of sFRP2 in cardiac development and cardiovascular disease
10.7150/ijbs.40923 · 2020 · External reference
Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications
10.1007/s10456-025-10024-6 · 2025 · External reference
Promoting roles of the secreted frizzled-related protein 2 as a wnt agonist in lung cancer cells
10.3892/or.2015.4221 · 2015 · External reference
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances
10.1038/s41392-025-02142-w · 2025 · External reference
Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis
10.1038/srep33339 · 2016 · External reference
Secreted frizzled-related protein 2 and extracellular volume fraction in patients with heart failure
10.1155/2020/2563508 · 2020 · External reference
The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
10.1186/s12860-023-00470-9 · 2023 · External reference
SFRP2 modulates functional phenotype transition and energy metabolism of macrophages during diabetic wound healing
10.3389/fimmu.2024.1432402 · 2024 · External reference
Post-myocardial infarction fibrosis: pathophysiology, examination, and intervention
10.3389/fphar.2023.1070973 · 2023 · External reference
The evolving roles of wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
10.1016/j.gendis.2023.04.042 · 2024 · External reference
The prognostic value of secreted frizzled-related protein 2 in elderly patients with heart failure: a single-center retrospective study
10.1038/s41598-025-11765-6 · 2025 · External reference
Secreted frizzled-related proteins: a promising therapeutic target for cancer therapy through wnt signaling inhibition
10.1016/j.biopha.2023.115344 · 2023 · External reference
Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution
10.1186/s13045-024-01600-2 · External reference
A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
10.1016/j.stem.2024.07.006 · External reference
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways
10.1038/s41421-023-00627-y · External reference
Hippo/YAP signaling's multifaceted crosstalk in cancer
10.3389/fcell.2025.1595362 · External reference
Polydopamine-modified hydrogel nanofibers for sustained SFRP2 release: synergistic promotion of angiogenesis and nerve regeneration
10.1038/s41427-025-00610-x · External reference
PAI-1-driven SFRP2(high) cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
10.1016/j.ccell.2025.02.024 · External reference
A novel plasma based early colorectal cancer screening assay base on methylated SDC2 and SFRP2
10.1016/j.cca.2020.01.010 · 2020 · External reference
Methylated SFRP2 and SDC2 in stool specimens for colorectal cancer early detection: a cost-effective strategy for Chinese population
10.7150/jca.52478 · 2021 · External reference
Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy
10.1016/j.bbadis.2023.166989 · 2024 · External reference
Synergistic effect of PCPE1 and sFRP2 on the processing of procollagens via BMP1
10.1002/1873-3468.13291 · 2019 · External reference
Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and barrett's esophagus
10.1002/ijc.21045 · 2005 · External reference
