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References from Second-generation N,N′-disubstituted aliphatic diamines: discovery of potent hits for multi-species leishmaniasis treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
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DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1
10.1126/scitranslmed.adh9902 · 2023 · External reference
Synthesis and antikinetoplastid activity of a series of N,N′-Substituted diamines
10.1016/j.bmcl.2011.12.101 · 2012 · External reference
Susceptibility to paromomycin in clinical isolates and reference strains of leishmania species responsible for tegumentary leishmaniasis in Brazil
10.1016/j.actatropica.2020.105806 · 2021 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
Unresolved reference
2026 · External reference
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
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10.1038/nrd.2016.175 · 2016 · External reference
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Drug screening for kinetoplastids diseases
2009 · External reference
Stable transfection of the human parasite Leishmania major delineates a 30-Kilobase region sufficient for extrachromosomal replication and expression
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Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases
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Heterocyclic diamines with leishmanicidal activity
10.1021/acsinfecdis.1c00215 · 2021 · External reference
Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi
10.1016/j.dnarep.2023.103485 · 2023 · External reference
A simple colorimetric method to screen drug cytotoxicity against leishmania using the dye alamar blue®
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Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives
10.1016/j.bioorg.2024.108083 · 2025 · External reference
DNDI-6148: a novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis
10.1021/acs.jmedchem.1c01437 · 2021 · External reference
Effects of bis(benzyl)polyamine analogs on Leishmania donovani promastigotes
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Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases
10.1021/acs.jmedchem.0c00499 · 2020 · External reference
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10.3390/microorganisms9122500 · 2021 · External reference
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Polyamines in protozoan pathogens
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10.1021/acsinfecdis.8b00298 · 2019 · External reference
Advancing N,N′-Disubstituted diamines in antimalarial drug development: structure-Activity relationships and mechanistic studies
10.1016/j.ejmech.2025.117630 · 2025 · External reference
Mechanistic exploration of N,N′-Disubstituted diamines as promising chagas disease treatments
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Antileishmanial effect of 3-Aminooxy-1-Aminopropane is due to polyamine depletion
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Unresolved reference
2021 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Activation of bicyclic nitro-Drugs by a novel nitroreductase (NTR2) in leishmania
10.1371/journal.ppat.1005971 · 2016 · External reference
Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages
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In vitro sensitivity of leishmania (viannia) braziliensis and leishmania (leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B
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