Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome. Local targets link to admitted publications; unresolved targets remain external evidence.
Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus
10.1074/jbc.m111.302174 · External reference
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
10.1074/jbc.m111.333120 · External reference
Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability
10.1016/j.ajhg.2008.10.020 · 2008 · External reference
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
10.1073/pnas.1815365116 · 2019 · External reference
Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of fragile X syndrome‐linked mutations
10.1111/febs.70564 · 2026 · External reference
The emerging role of amino acids of the brain microenvironment in the process of metastasis formation
10.3390/cancers13122891 · 2021 · External reference
Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase
2022 · External reference
Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
2023 · External reference
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
10.1073/pnas.1706617114 · 2017 · External reference
Features and development of coot
10.1107/s0907444910007493 · 2010 · External reference
The role of evolutionarily conserved hydrophobic contacts in the Quaternary structure stability of Escherichia coli serine hydroxymethyltransferase
10.1111/j.1742-4658.2008.06761.x · 2009 · External reference
Location of the pteroylpolyglutamate-binding site on rabbit cytosolic serine hydroxymethyltransferase
10.1074/jbc.m210649200 · 2003 · External reference
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome
10.1007/s00401-020-02223-w · 2020 · External reference
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein
10.1073/pnas.1405233111 · 2014 · External reference
Fuzziness and frustration in the energy landscape of protein folding, function, and assembly
10.1021/acs.accounts.0c00813 · 2021 · External reference
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to group II decarboxylases
10.1073/pnas.1111456108 · 2011 · External reference
How pyridoxal 5’-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
10.1111/febs.13211 · 2015 · External reference
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis
10.1038/s41598-017-11948-w · 2017 · External reference
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells
10.1111/febs.14610 · 2018 · External reference
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene
10.1016/s0378-1119(98)00085-7 · 1998 · External reference
The moonlighting RNA-Binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism
10.1093/nar/gkz129 · 2019 · External reference
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis
10.1073/pnas.1403182111 · 2014 · External reference
“RNA-Mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation”, cell death discovery
10.1038/s41420-025-02646-y · 2025 · External reference
Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment
10.1371/journal.pone.0123106 · 2015 · External reference
“Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA”, Journal of Biological Chemistry
10.1074/jbc.m111.307629 · 2011 · External reference
The mechanism of addition of pyridoxal 5’-phosphate to Escherichia coli apo-serine hydroxymethyltransferase
10.1042/bj20061681 · 2007 · External reference
10.1016/j.csbj.2021.05.019 · 2021 · Admitted local publication
REFMAC5 for the refinement of macromolecular crystal structures
10.1107/s0907444911001314 · 2011 · External reference
Unresolved reference
2013 · External reference
Structural insights into binding of polyglutamylated tetrahydrofolate by serine hydroxymethyltransferase 8 from soybean
10.3389/fpls.2024.1451839 · 2024 · External reference
New insights emerging from recent investigations on human group II pyridoxal 5’-Phosphate decarboxylases
10.2174/0929867324666161123093339 · 2017 · External reference
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
10.1038/cddis.2014.482 · 2014 · External reference
Oligomeric defects in soybean serine hydroxymethyltransferase 8: tetramer destabilization by A149T and other variants associated with soybean cyst nematode resistance
10.1111/febs.70528 · 2026 · External reference
Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling
10.1016/s0006-3495(00)76713-0 · 2000 · External reference
The dynameomics rotamer library: amino acid side chain conformations and dynamics from comprehensive molecular dynamics simulations in water
10.1002/pro.565 · 2011 · External reference
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex
10.1111/febs.16248 · External reference
Crystal structure of Aspergillus fumigatus AroH, an aromatic amino acid aminotransferase
10.1002/prot.26234 · External reference
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
10.1016/j.molcel.2024.06.016 · 2024 · External reference
Kirrel3-Mediated synapse formation is attenuated by disease-associated missense variants
10.1523/jneurosci.3058-19.2020 · 2020 · External reference
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison: full kinetic characterization and substrate inhibition properties
10.1021/acs.biochem.8b01074 · 2018 · External reference
“structural basis for allostery in PLP-Dependent enzymes”, frontiers in molecular biosciences
10.3389/fmolb.2022.884281 · 2022 · External reference
The elusive folding mechanism of KH1 domain of fragile X messenger ribonucleoprotein 1
2026 · External reference
Molecular replacement with MOLREP
10.1107/s0907444909042589 · 2010 · External reference
Metabolic control of BRISC–SHMT2 assembly regulates immune signalling
2019 · External reference
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis
2018 · External reference
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
10.1016/j.celrep.2013.08.025 · 2013 · External reference
