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References from Mitochondria–immunometabolism in sepsis-induced liver injury: mechanisms, biomarkers, and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation
10.1016/j.celrep.2019.06.018 · 2019 · External reference
Metabolic coordination of cell fate by α-ketoglutarate-dependent dioxygenases
10.1016/j.tcb.2020.09.010 · 2021 · External reference
Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate
10.1016/j.tox.2004.11.035 · 2005 · External reference
Hepatic glucocorticoid receptor plays a greater role than adipose GR in metabolic syndrome despite renal compensation
10.1210/en.2016-1615 · 2016 · External reference
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
10.1126/science.aam9949 · 2017 · External reference
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension
10.1038/sj.ki.5002394 · 2007 · External reference
Assessment of S100A8/A9 and resistin as predictive biomarkers for mortality in critically ill patients with sepsis
10.3389/fcimb.2025.1555307 · 2025 · External reference
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
10.1038/nature13909 · 2014 · External reference
Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection
10.1093/eurheartj/ehab605 · 2021 · External reference
Cytosolic proteostasis networks of the mitochondrial stress response
10.1016/j.tibs.2017.05.002 · 2017 · External reference
Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases
10.1016/j.mito.2017.12.001 · 2018 · External reference
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
10.4049/jimmunol.204.supp.69.1 · 2020 · External reference
Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase
10.1126/science.1207861 · 2011 · External reference
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2
10.1016/s1074-7613(02)00471-5 · 2002 · External reference
Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9
10.1074/jbc.m114.579474 · 2015 · External reference
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
10.1182/blood-2012-03-419747 · 2012 · External reference
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
10.1038/s41467-017-01919-0 · 2017 · External reference
Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes
10.3389/fimmu.2024.1352789 · 2024 · External reference
An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance
10.1016/j.cmet.2020.01.009 · 2020 · External reference
Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR
10.1093/nar/gnf067 · 2002 · External reference
Metabolic reprogramming in liver fibrosis
10.1016/j.cmet.2024.05.003 · 2024 · External reference
13C-pyruvate imaging reveals alterations in glycolysis that precede c-myc-induced tumor formation and regression
10.1016/j.cmet.2011.04.012 · 2011 · External reference
Hepatocyte nuclear factor 4 alpha activation is essential for termination of liver regeneration in mice
10.1002/hep.30405 · 2019 · External reference
Fluctuations of spleen cytokine and blood lactate, importance of cellular immunity in host defense against blood stage malaria Plasmodium yoelii
10.3389/fimmu.2019.02207 · 2019 · External reference
Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models
10.1016/j.biomaterials.2022.121973 · 2023 · External reference
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
10.1016/j.immuni.2015.02.005 · 2015 · External reference
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas
10.1158/0008-5472.can-12-3461 · 2013 · External reference
SLC25A33-mediated mitochondrial DNA synthesis plays a critical role in the inflammatory response of M1 macrophages by contributing to mitochondrial ROS and VDAC oligomerization
10.7150/ijbs.96563 · 2025 · External reference
The effects of mitochondrial transplantation on sepsis depend on the type of cell from which they are isolated
10.3390/ijms241210113 · 2023 · External reference
Sepsis-associated liver injury: incidence, classification and the clinical significance
10.1111/j.1872-034x.2012.01069.x · 2013 · External reference
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
10.1074/jbc.m610415200 · 2007 · External reference
Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure
10.1186/2110-5820-1-41 · 2011 · External reference
Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
10.1016/j.cmet.2016.06.004 · 2016 · External reference
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
10.1038/s41590-019-0453-7 · 2019 · External reference
The microbiome and gut homeostasis
10.1126/science.abp9960 · 2022 · External reference
Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆
10.1016/j.jhep.2020.04.025 · 2020 · External reference
Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
10.1371/journal.pone.0286525 · 2023 · External reference
Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction
10.1038/cdd.2010.93 · 2011 · External reference
Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury
10.1016/j.freeradbiomed.2020.08.009 · 2020 · External reference
The acute effect of different NAD+ precursors included in the combined metabolic activators
10.1016/j.freeradbiomed.2023.05.032 · 2023 · External reference
Regulation of ubiquitination in sepsis: from PAMP versus DAMP to peripheral inflammation and cell death
10.3389/fimmu.2024.1513206 · 2024 · External reference
Sepsis toxicity network reconstruction—dynamic signaling and multi-organ injury: a review
10.17305/bb.2025.12931 · 2025 · External reference
Deubiquitinase OTUD5 as a novel protector against 4-HNE-triggered ferroptosis in myocardial ischemia/reperfusion injury
10.1002/advs.202301852 · 2023 · External reference
SUCNR1-driven microglial polarization: jiawei xionggui decoction as a therapeutic strategy for alzheimer’s-related neuroinflammation
10.1016/j.phymed.2026.157978 · 2026 · External reference
Metabolic reprogramming consequences of sepsis: adaptations and contradictions
10.1007/s00018-022-04490-0 · 2022 · External reference
Single-cell omics in tracing cellular heterogeneity of drug-induced liver injury: Technological landscape and prospective application
10.1016/j.hlife.2024.01.004 · 2024 · External reference
Efficacy and safety of pyridoxal 5’-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial
10.1001/jama.299.15.joc80027 · 2008 · External reference
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
10.1073/pnas.1111247108 · 2011 · External reference
Monocyte iron load correlates with immune suppression and sepsis severity: a longitudinal analysis
10.1016/j.jinf.2025.106660 · 2025 · External reference
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
10.1016/j.cell.2016.08.064 · 2016 · External reference
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
10.1038/ni.2550 · 2013 · External reference
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
10.1038/s41467-021-27766-8 · 2022 · External reference
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
10.1038/s41467-021-27766-8 · 2022 · External reference
Periportal macrophages protect against commensal-driven liver inflammation
10.1038/s41586-024-07372-6 · 2024 · External reference
Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis
10.3389/fimmu.2023.1224335 · 2023 · External reference
Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis
10.1016/j.celrep.2025.116032 · 2025 · External reference
Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches
10.1038/s44321-024-00155-6 · 2024 · External reference
Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
10.1038/s42255-024-01145-1 · 2024 · External reference
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
10.1038/nm873 · 2003 · External reference
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis
10.1172/jci.insight.153944 · 2022 · External reference
Defective mitochondrial fission augments NLRP3 inflammasome activation
10.1038/srep15489 · 2015 · External reference
The reduced concentration of citrate in cancer cells: an indicator of cancer aggressiveness and a possible therapeutic target
10.1016/j.drup.2016.09.003 · 2016 · External reference
Acetyl coenzyme A: a central metabolite and second messenger
10.1016/j.cmet.2015.05.014 · 2015 · External reference
Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer
10.3748/wjg.v22.i8.2441 · 2016 · External reference
NAD+ deficiency in age-related mitochondrial dysfunction
10.1016/j.cmet.2014.01.005 · 2014 · External reference
NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension
10.1038/s41392-023-01577-3 · 2023 · External reference
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
10.1172/jci1325 · 1998 · External reference
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
10.1007/bf03401914 · 1998 · External reference
Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver
10.1002/hep.20304 · 2004 · External reference
Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
10.1016/s0140-6736(19)32989-7 · 2020 · External reference
Protecting the mitochondrial powerhouse
10.1016/j.tcb.2014.11.002 · 2015 · External reference
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
10.1038/nri2294 · 2008 · External reference
Real-time hyperpolarized 13C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers
10.1038/s41598-019-52952-6 · 2019 · External reference
Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition
10.1124/pr.56.3.3 · 2004 · External reference
The third international consensus definitions for sepsis and septic shock (sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation
10.1016/j.cmet.2016.04.001 · 2016 · External reference
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
10.1091/mbc.e19-05-0291 · 2019 · External reference
Liver — guardian, modifier and target of sepsis
10.1038/nrgastro.2016.168 · 2017 · External reference
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · 2013 · External reference
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
10.1172/jci25790 · 2006 · External reference
Sepsis: bile acids promote inflammation in cholestasis-associated sepsis
10.1038/nrgastro.2017.55 · 2017 · External reference
Interleukin-12 and the regulation of innate resistance and adaptive immunity
10.1038/nri1001 · 2003 · External reference
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
10.1038/s41467-022-28718-6 · 2022 · External reference
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
10.6019/s-biad1239 · 2024 · External reference
Balancing metabolism and regeneration in liver diseases through HNF4α targeting
10.1016/j.tem.2025.04.003 · 2026 · External reference
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
10.1038/s41573-023-00822-2 · 2024 · External reference
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
10.15252/emmm.201911319 · 2020 · External reference
Mitochondrial metabolism regulates macrophage biology
10.1016/j.jbc.2021.100904 · 2021 · External reference
Metabolic adaptation establishes disease tolerance to sepsis
10.1016/j.cell.2017.05.031 · 2017 · External reference
Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies
10.3389/fimmu.2025.1575554 · 2025 · External reference
Pleiotropic activities of succinate: the interplay between gut microbiota and cardiovascular diseases
10.1002/imt2.124 · 2023 · External reference
A dual-responsive antibiotic-loaded nanoparticle specifically binds pathogens and overcomes antimicrobial-resistant infections
10.1002/adma.202006772 · 2021 · External reference
The role of the liver in sepsis
10.3109/08830185.2014.889129 · 2014 · External reference
Tricarboxylic acid cycle metabolites: new players in macrophage
10.1007/s00011-024-01853-0 · 2024 · External reference
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis
10.1038/s41565-022-01137-w · 2022 · External reference
Interleukins‐27 aggravates liver injury by impairing the antimicrobial response of macrophages via the promotion of mitochondrial dysfunction in the context of sepsis
10.1155/mi/6608718 · 2025 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis
10.1016/j.redox.2025.103877 · 2025 · External reference
Circulating mitochondrial DAMPs cause inflammatory responses to injury
10.1038/nature08780 · 2010 · External reference
Circulating mitochondrial DAMPs cause inflammatory responses to injury
10.1038/nature08780 · 2010 · External reference
Metabolic regulation of gene expression by histone lactylation
10.1038/s41586-019-1678-1 · 2019 · External reference
STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice
10.1016/j.redox.2022.102367 · 2022 · External reference
Deficiency of S100A9 alleviates sepsis-induced acute liver injury through regulating AKT-AMPK-dependent mitochondrial energy metabolism
10.3390/ijms24032112 · 2023 · External reference
Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy
10.1186/s12967-023-04367-1 · 2023 · External reference
Serum mitochondrial-encoded NADH dehydrogenase 6 and Annexin A1 as novel biomarkers for mortality prediction in critically ill patients with sepsis
10.3389/fimmu.2024.1486322 · 2024 · External reference
Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway
10.1016/j.scitotenv.2024.175332 · 2024 · External reference
Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
10.1186/s12974-024-03161-0 · 2024 · External reference