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References from Effects of gut microbiota-targeted interventions on pain, physical function, and inflammatory biomarkers in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Local targets link to admitted publications; unresolved targets remain external evidence.
Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial
10.1136/bjsports-2023-107793 · 2024 · External reference
Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines
10.1038/s41584-020-00523-9 · 2021 · External reference
Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritic human fluids
10.1002/art.1780100407 · 1967 · External reference
Gut microbiota and osteoarthritis management: an expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
10.1016/j.arr.2019.100946 · 2019 · External reference
Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
10.1152/ajpendo.00204.2014 · 2014 · External reference
Intestinal microbiome composition and its relation to joint pain and inflammation
10.1038/s41467-019-12873-4 · 2019 · External reference
A systematic review of microbiome composition in osteoarthritis subjects
10.1016/j.joca.2021.12.006 · 2022 · External reference
Human gut microbiome: hopes, threats and promises
10.1136/gutjnl-2018-316723 · 2018 · External reference
Metabolic endotoxemia initiates obesity and insulin resistance
10.2337/db06-1491 · 2007 · External reference
Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis
10.1155/2015/708152 · 2015 · External reference
Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
10.1016/s0140-6736(17)31744-0 · 2017 · External reference
The role of short-chain fatty acids in microbiota-gut-brain communication
10.1038/s41575-019-0157-3 · 2019 · External reference
The efficacy of a Mediterranean type diet on symptoms of osteoarthritis - a pilot study
10.1017/s0029665115001573 · 2015 · External reference
Gut-joint axis: the role of physical exercise on gut microbiota modulation in older people with osteoarthritis
10.3390/nu12020574 · 2020 · External reference
Saccharomyces boulardii improves clinical and paraclinical indices in overweight/obese knee osteoarthritis patients: a randomized triple-blind placebo-controlled trial
10.1007/s00394-024-03428-5 · 2024 · External reference
Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis
10.1007/s12603-016-0806-y · 2017 · External reference
Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial
10.1007/s00394-024-03415-w · 2024 · External reference
Global, regional, and national burden of osteoarthritis 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
10.22203/ecm.v021a16 · 2011 · External reference
Gut permeability and osteoarthritis, towards a mechanistic understanding of the pathogenesis: a systematic review
10.1080/07853890.2021.2014557 · 2021 · External reference
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
10.1136/bmj.39489.470347.ad · 2008 · External reference
The gut microbiota in osteoarthritis: where do we stand and what can we do
10.1186/s13075-021-02427-9 · 2021 · External reference
Modulation of Bone and Joint Biomarkers, Gut Microbiota, and Inflammation Status by Synbiotic Supplementation and Weight-Bearing Exercise: Human Study Protocol for a Randomized Controlled Trial
10.2196/30131 · 2021 · External reference
Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial
10.1007/s00394-025-03805-8 · 2025 · External reference
Probiotics’ supplementation alleviates disease severity and improves postural balance by repairing intestinal leak in patients suffering from osteoarthritis: a double-blinded clinical trial
10.1017/s0007114524002824 · 2024 · External reference
2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee
10.1002/acr.24131 · 2020 · External reference
The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial
10.3920/bm2016.0207 · 2017 · External reference
The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor alpha-stimulated endothelial cells via activation of GPR41/43 and inhibition of HDACs
10.3389/fphar.2018.00533 · 2018 · External reference
Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review
10.1002/j.1532-2149.2014.499.x · 2014 · External reference
Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019
10.1002/art.42089 · 2022 · External reference
Oral intake of Streptococcus thermophilus improves knee osteoarthritis degeneration: a randomized, double-blind, placebo-controlled clinical study
10.1016/j.heliyon.2020.e03668 · 2020 · External reference
Synovitis in osteoarthritis: current understanding with therapeutic implications
10.1186/s13075-017-1229-9 · 2017 · External reference
OARSI clinical trials recommendations: design, conduct and reporting of clinical trials for knee osteoarthritis
10.1016/j.joca.2015.03.005 · 2015 · External reference
The effect of probiotics on the management of pain and inflammation in osteoarthritis: a systematic review and meta-analysis of clinical studies
10.3390/nu16142243 · 2024 · External reference
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
10.1016/j.bbr.2014.07.027 · 2015 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases
10.3389/fimmu.2019.00277 · 2019 · External reference
A probiotic intervention on pain hypersensitivity and microbiota composition in patients with osteoarthritis pain: study protocol for a randomized controlled trial
10.46497/archrheumatol.2021.7719 · 2021 · External reference
C-reactive protein: a critical update
10.1172/jci18921 · 2003 · External reference
Knee replacement
10.1016/s0140-6736(18)32344-4 · 2018 · External reference
Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial
10.1016/j.joca.2010.02.012 · 2010 · External reference
Effects of a Mediterranean diet compared with the low-fat diet on patients with knee osteoarthritis: a randomized feeding trial
10.1155/2022/7275192 · 2022 · External reference
Nociceptive neurons detect cytokines in arthritis
10.1186/s13075-014-0470-8 · 2014 · External reference
Targeting the gut microbiome to treat the osteoarthritis of obesity
10.1172/jci.insight.95997 · 2018 · External reference
Efficacy and safety of Latilactobacillus sakei LB-P12 in patients with knee osteoarthritis: an exploratory randomized, double-blind, placebo-controlled clinical trial
10.1038/s41598-025-11250-0 · 2025 · External reference
Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease
10.1002/art.1780400419 · 1997 · External reference
Implication of intestinal barrier dysfunction in gut dysbiosis and diseases
10.3390/biomedicines10020289 · 2022 · External reference
Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study
10.1016/j.clnu.2018.11.032 · 2019 · External reference
A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the “Plants for Joints” randomized controlled trial
10.1016/j.joca.2023.05.014 · 2023 · External reference
Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis
10.1128/msystems.00862-25 · 2025 · External reference
Trial Sequential Analysis in systematic reviews with meta-analysis
10.1186/s12874-017-0315-7 · 2017 · External reference
The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis
10.1155/2014/561459 · 2014 · External reference
