Research graph
References from The gut-bone marrow axis in acute leukemia: an evidence-graded review of microbiota-immune crosstalk and therapeutic implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Human gut microbiota in health and disease: Unveiling the relationship
10.3389/fmicb.2022.999001 · 2022 · External reference
Next-generation probiotics: the upcoming biotherapeutics
10.1007/s11033-024-09398-5 · 2024 · External reference
Gut microbiota and acute myeloid leukemia: State of the art, clinical signals, and translational opportunities
10.3390/antibiotics15040417 · 2026 · External reference
Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia
10.3389/fmicb.2025.1559033 · 2025 · External reference
A fructo-oligosaccharide prebiotic is well tolerated in adults undergoing allogeneic hematopoietic stem cell transplantation: A phase I dose-escalation trial
10.1016/j.jtct.2021.07.009 · 2021 · External reference
Prebiotic fiber enteral supplementation after allogeneic transplantation: Feasibility and impact on the microbiome
10.1182/bloodadvances.2024015703 · 2025 · External reference
Tumor-associated macrophages: An effective player of the tumor microenvironment
10.3389/fimmu.2023.1295257 · 2023 · External reference
Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant
10.1182/blood.2021013972 · 2022 · External reference
Role of maternal diet in the risk of childhood acute leukemia: A systematic review and meta-analysis
10.3390/ijerph20075428 · 2023 · External reference
Macrophage polarization states in the tumor microenvironment
10.3390/ijms22136995 · 2021 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Natural polyreactive IgA antibodies coat the intestinal microbiota
10.1126/science.aan6619 · 2017 · External reference
Progress of research on PD-1/PD-L1 in leukemia
10.3389/fimmu.2023.1265299 · 2023 · External reference
Gut microbiota-butyrate-PPARγ axis modulates adipose regulatory T cell population
10.1002/advs.202411086 · 2025 · External reference
Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy
10.1186/s12885-020-6654-5 · 2020 · External reference
Third-party fecal microbiota transplantation for high-risk treatment-naïve acute GVHD of the lower GI tract
10.1182/bloodadvances.2024012556 · 2024 · External reference
Probiotic-associated aspiration pneumonia due to Lactobacillus rhamnosus
10.1128/jcm.01065-14 · 2014 · External reference
The effects of LactoCare synbiotic administration on chemotherapy-induced nausea, vomiting, diarrhea, and constipation in children with ALL: A double-blind randomized clinical trial
10.1002/pbc.30328 · 2023 · External reference
Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
10.1038/s41598-021-90888-y · 2021 · External reference
Short-chain fatty acids and human health: from metabolic pathways to current therapeutic implications
10.3390/life14050559 · 2024 · External reference
The intestinal microenvironment shapes macrophage and dendritic cell identity and function
10.1016/j.imlet.2023.01.003 · 2023 · External reference
An enterococcal phage-derived enzyme suppresses graft-versus-host disease
10.1038/s41586-024-07667-8 · 2024 · External reference
Gut microbiome signatures are predictive of infectious risk following induction therapy for acute myeloid leukemia
10.1093/cid/ciz777 · 2020 · External reference
A new insight into acute lymphoblastic leukemia in children: Influences of changed intestinal microfloras
10.1186/s12887-020-02192-9 · 2020 · External reference
Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases
10.3390/ijms22063061 · 2021 · External reference
Butyrates, as a single drug, induce histone acetylation and granulocytic maturation: possible selectivity on core-binding-factor acute myeloid leukemia blasts
2003 · External reference
Probiotic potential of Clostridium spp.-advantages and doubts
10.3390/cimb44070215 · 2022 · External reference
Sever sepsis after probiotic treatment with Escherichia coli NISSLE 1917
10.1097/inf.0b013e3181c36eb9 · 2010 · External reference
Gut microbiota disruption in hematologic cancer therapy: Molecular insights and implications for treatment efficacy
10.3390/ijms251910255 · 2024 · External reference
Gut microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia
10.1093/cid/ciy153 · 2018 · External reference
The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease
10.1080/19490976.2024.2393270 · 2024 · External reference
High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells
10.1038/s41598-020-73020-4 · 2020 · External reference
The microbiota in adaptive immune homeostasis and disease
10.1038/nature18848 · 2016 · External reference
PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion
10.1016/j.celrep.2023.112436 · 2023 · External reference
Short-chain fatty acids stimulate dendrite elongation in dendritic cells by inhibiting histone deacetylase
10.1111/febs.16945 · 2023 · External reference
Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation
10.1186/s40168-019-0745-z · 2019 · External reference
Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
10.3389/fcell.2023.1228283 · 2023 · External reference
NK cell exhaustion in the tumor microenvironment
10.3389/fimmu.2023.1303605 · 2023 · External reference
Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut
10.1016/j.tcb.2023.12.004 · 2024 · External reference
Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota
10.1038/s41556-023-01145-5 · 2023 · External reference
Gut microbiota promote hematopoiesis to control bacterial infection
10.1016/j.chom.2014.02.006 · 2014 · External reference
Gut microbiota-derived metabolites tune host homeostasis fate
10.1007/s00281-024-01012-x · 2024 · External reference
Obesity accelerates acute promyelocytic leukemia in mice and reduces sex differences in latency and penetrance
10.1002/oby.23435 · 2022 · External reference
PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity
10.1136/jitc-2022-006619 · 2023 · External reference
Recent advances in research on the relationship between gut microbiota, its metabolites, and acute myeloid leukemia--review
10.19746/j.cnki.issn.1009-2137.2025.03.044 · 2025 · External reference
Probiotic supplements might not be universally-effective and safe: A review
10.1016/j.biopha.2018.12.104 · 2019 · External reference
The safety and feasibility of probiotics in children and adolescents undergoing hematopoietic cell transplantation
10.1038/bmt.2015.275 · 2016 · External reference
How bile acids and the microbiota interact to shape host immunity
10.1038/s41577-024-01057-x · 2024 · External reference
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor-positive niche cells
10.1038/s12276-021-00667-y · 2021 · External reference
Benefits and harm of probiotics and synbiotics in adult critically ill patients. A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
10.1016/j.clnu.2023.01.019 · 2023 · External reference
Pediatric acute lymphoblastic leukemia patients exhibit distinctive alterations in the gut microbiota
10.3389/fcimb.2020.558799 · 2020 · External reference
Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
10.1186/s12885-021-08917-y · 2021 · External reference
Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease
10.1186/s40364-024-00612-x · 2024 · External reference
Exploring the dynamics of gut microbiota, antibiotic resistance, and chemotherapy impact in acute leukemia patients: A comprehensive metagenomic analysis
10.1080/21505594.2024.2428843 · 2024 · External reference
Immunotherapy: reshape the tumor immune microenvironment
10.3389/fimmu.2022.844142 · 2022 · External reference
Role of gut microbiota in infectious and inflammatory diseases
10.3389/fmicb.2023.1098386 · 2023 · External reference
Gut microbiota restoration with oral pooled fecal microbiotherapy after intensive chemotherapy: the phase 1b CIMON trial
10.1182/bloodadvances.2024015571 · 2025 · External reference
Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients
10.1038/s41467-021-23376-6 · 2021 · External reference
Short-chain fatty acids: linking diet, the microbiome and immunity
10.1038/s41577-024-01014-8 · 2024 · External reference
Novel therapeutic approaches in pediatric acute lymphoblastic leukemia
10.3390/ijms262311362 · 2025 · External reference
Fecal microbiota transplantation for decolonization from multidrug-resistant bacteria in pediatric allogeneic hematopoietic stem cell transplantation recipients: a retrospective real-world data study
10.3324/haematol.2025.288067 · 2025 · External reference
Macrophages and gut barrier function: guardians of gastrointestinal health in post-inflammatory and post-infection responses
10.3390/ijms25179422 · 2024 · External reference
Emerging issues in probiotic safety: 2023 perspectives
10.1080/19490976.2023.2185034 · 2023 · External reference
Maternal dietary patterns and acute leukemia in infants: results from a case control study in Mexico
10.3389/fnut.2023.1278255 · 2023 · External reference
The effect of short-chain fatty acids on human monocyte-derived dendritic cells
10.1038/srep16148 · 2015 · External reference
Infectious complications are associated with alterations in the gut microbiome in pediatric patients with acute lymphoblastic leukemia
10.3389/fcimb.2019.00028 · 2019 · External reference
Analysis of global, regional, and national burden and attributable risk factors of acute lymphoblastic leukemia and acute myeloid leukemia from 1990 to 2021
10.1371/journal.pone.0330479 · 2025 · External reference
Roseburia intestinalis: A beneficial gut organism from the discoveries in genus and species
10.3389/fcimb.2021.757718 · 2021 · External reference
Microbial metabolomics in acute myeloid leukemia: from pathogenesis to treatment
10.17219/acem/191559 · 2025 · External reference
The gut microbiota-immune-brain axis: Therapeutic implications
10.1016/j.xcrm.2025.101982 · 2025 · External reference
Dendritic cells as a therapeutic strategy in acute myeloid leukemia: Vaccines
10.3390/vaccines12020165 · 2024 · External reference
The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorγt(+)Treg and PD-1 blockade efficacy
10.1080/19490976.2024.2315631 · 2024 · External reference
Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation
10.1056/nejmoa1900623 · 2020 · External reference
Microbiota-derived short-chain fatty acids boost antitumoral natural killer cell activity
10.3390/jcm13133885 · 2024 · External reference
Targeting the innate immune system in pediatric and adult AML
10.1038/s41375-024-02217-7 · 2024 · External reference
Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia
10.3324/haematol.2023.284138 · 2024 · External reference
Gut microbiota alterations induced by intensive chemotherapy in acute myeloid leukaemia patients are associated with gut barrier dysfunction and body weight loss
10.1016/j.clnu.2023.09.021 · 2023 · External reference
Recent developments and challenges in the treatment of acute leukemia and myelodysplastic syndromes: A systematic review
10.7759/cureus.72599 · 2024 · External reference
Persistent gut microbial dysbiosis in children with acute lymphoblastic leukemia (ALL) during chemotherapy
10.1007/s00248-019-01448-x · 2020 · External reference
Lasting shift in the gut microbiota in patients with acute myeloid leukemia
10.1182/bloodadvances.2021006783 · 2022 · External reference
Randomized double-blind phase II trial of fecal microbiota transplantation versus placebo in allogeneic hematopoietic cell transplantation and AML
10.1200/jco.22.02366 · 2023 · External reference
Gut microbiota profiles of treatment-naïve adult acute myeloid leukemia patients with neutropenic fever during intensive chemotherapy
10.1371/journal.pone.0236460 · 2020 · External reference
Probiotic supplementation decreases chemotherapy-induced gastrointestinal side effects in patients with acute leukemia
10.1097/mph.0000000000001497 · 2019 · External reference
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
10.1016/j.immuni.2024.12.012 · 2025 · External reference
Gut microbiota functions: metabolism of nutrients and other food components
10.1007/s00394-017-1445-8 · 2018 · External reference
Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis
10.1126/scitranslmed.aao4755 · 2018 · External reference
Redirecting the immune microenvironment in acute myeloid leukemia
10.3390/cancers13061423 · 2021 · External reference
Targeting natural killer cells: from basic biology to clinical application in hematologic Malignancies
10.1186/s40164-024-00481-y · 2024 · External reference
Bacteroides fragilis restricts colitis-associated cancer via negative regulation of the NLRP3 axis
10.1016/j.canlet.2021.10.002 · 2021 · External reference
The pros and cons of probiotic use in pediatric oncology patients following treatment for acute lymphoblastic leukemia
10.3389/fped.2024.1427185 · 2024 · External reference
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
10.1038/s41591-022-01702-9 · 2022 · External reference
The gut microbiota and mucosal T cells
10.3389/fmicb.2011.00111 · 2011 · External reference
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD
10.1172/jci.insight.136841 · 2021 · External reference
Changes in gut microbiota predict neutropenia after induction treatment in childhood acute lymphoblastic leukemia
10.1182/bloodadvances.2024013986 · 2025 · External reference
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
10.3389/fimmu.2023.1127743 · 2023 · External reference
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
10.1038/s41467-018-05901-2 · 2018 · External reference
Microbial metabolites and gut immunology
10.1146/annurev-immunol-090222-102035 · 2024 · External reference
Catch me if you can: How AML and its niche escape immunotherapy
10.1038/s41375-021-01350-x · 2022 · External reference
Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)
10.1038/s41522-025-00891-8 · 2025 · External reference
Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis
10.1038/s41467-023-37419-7 · 2023 · External reference
Pharma[e]cology: How the gut microbiome contributes to variations in drug response
10.1146/annurev-pharmtox-022724-100847 · 2025 · External reference
Provocateurs of autoimmunity within the gut microbiota
10.1126/scitranslmed.add3901 · 2022 · External reference
Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases
10.3389/fimmu.2025.1637191 · 2025 · External reference
Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy
10.1016/j.ymthe.2023.01.012 · 2023 · External reference
Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
10.1038/s41467-021-23460-x · 2021 · External reference
Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease
10.1080/19490976.2023.2178805 · 2023 · External reference
Study of the intestinal microbiota composition and the effect of treatment with intensive chemotherapy in patients recovered from acute leukemia
10.1038/s41598-024-56054-w · 2024 · External reference
Microbial sensing in the intestine
10.1093/procel/pwad028 · 2023 · External reference
Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis
10.1016/j.heliyon.2024.e39731 · 2024 · External reference
Microbial metagenomic shifts in children with acute lymphoblastic leukaemia during induction therapy and predictive biomarkers for infection
10.1186/s12941-024-00717-z · 2024 · External reference
Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
10.1038/s41467-022-30240-8 · 2022 · External reference
How to think about acute leukemia of ambiguous lineage
10.1182/hematology.2024000554 · 2024 · External reference
The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies
10.3390/nu13030886 · 2021 · External reference
Gut microbiota in colorectal cancer development and therapy
10.1038/s41571-023-00766-x · 2023 · External reference
A metabolome and microbiome analysis of acute myeloid leukemia: Insights into the carnosine-histidine metabolic pathway
10.3390/toxics12010014 · 2023 · External reference
Interplay between hypertriglyceridemia and acute promyelocytic leukemia mediated by the cooperation of peroxisome proliferator-activated receptor-α with the PML/RAR α fusion protein on super-enhancers
10.3324/haematol.2021.280147 · 2022 · External reference
A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC
10.1186/s13045-024-01571-4 · 2024 · External reference
Alteration of gut microbiome and correlated amino acid metabolism are associated with acute myelocytic leukemia carcinogenesis
10.1002/cam4.6283 · 2023 · External reference
Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells
10.1038/leu.2016.349 · 2017 · External reference
Causal relationship between gut microbiota and leukemia: future perspectives
10.1007/s40487-024-00300-8 · 2024 · External reference
The role of short-chain fatty acids in immunity, inflammation and metabolism
10.1080/10408398.2020.1854675 · 2022 · External reference
Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation
10.1182/bloodadvances.2020002604 · 2020 · External reference
Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study
10.1038/s41409-024-02198-2 · 2024 · External reference
Gut microbiota modulate CD8(+) T cell immunity in gastric cancer through butyrate/GPR109A/HOPX
10.1080/19490976.2024.2307542 · 2024 · External reference
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF-positive T cells and Th17 cells
10.1172/jci143137 · 2021 · External reference
Profiling of gut microbial dysbiosis in adults with myeloid leukemia
10.1002/2211-5463.13193 · 2021 · External reference
Butyrate limits human natural killer cell effector function
10.1038/s41598-023-29731-5 · 2023 · External reference
Thymic development of gut-microbiota-specific T cells
10.1038/s41586-021-03531-1 · 2021 · External reference
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow
10.1016/j.stem.2021.12.009 · 2022 · External reference
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
10.1186/s13046-021-01987-7 · 2021 · External reference
Characteristics of gut microbiota changes and their relationship with infectious complications during induction chemotherapy in AML patients
10.19746/j.cnki.issn.1009-2137.2025.03.017 · 2025 · External reference
Regulatory role of short-chain fatty acids in inflammatory bowel disease
10.1186/s12964-022-00869-5 · 2022 · External reference
Interaction between microbiota and immunity in health and disease
10.1038/s41422-020-0332-7 · 2020 · External reference
Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment
10.1080/19490976.2023.2276314 · 2023 · External reference
Gut microbiota in acute leukemia: Current evidence and future directions
10.3389/fmicb.2022.1045497 · 2022 · External reference
