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References from Pharmacological strategies for myocardial protection in cardiac surgery: current science and the emerging role of multi-omics and artificial intelligence. Local targets link to admitted publications; unresolved targets remain external evidence.
The value of biomarkers in major cardiovascular surgery necessitating cardiopulmonary bypass
10.31083/j.rcm2510355 · 2024 · External reference
ESC Joint working groups on cardiovascular surgery and the cellular biology of the heart position paper: perioperative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery
10.1093/eurheartj/ehx383 · 2017 · External reference
The use of controlled reperfusion strategies in cardiac surgery to minimize ischaemia/reperfusion damage
10.1093/cvr/cvp110 · 2009 · External reference
Cell biology of ischemia/reperfusion injury
10.1016/b978-0-12-394309-5.00006-7 · 2012 · External reference
Myocardial ischemia reperfusion injury: from basic science to clinical bedside
10.1177/1089253211436350 · 2012 · External reference
Custodiol for myocardial protection and preservation: a systematic review
10.3978/j.issn.2225-319x.2013.11.10 · 2013 · External reference
History and use of del nido cardioplegia solution at Boston children’s hospital
10.1051/ject/201244098 · 2012 · External reference
Genomics and multiomics in the age of precision medicine
10.1038/s41390-025-04021-0 · 2025 · External reference
Systems biology in cardiovascular disease: a multiomics approach
10.1038/s41569-020-00477-1 · 2021 · External reference
Network pharmacology approaches to myocardial infarction reperfusion injury: exploring mechanisms, pathophysiology, and novel therapies
10.3390/biomedicines13071532 · 2025 · External reference
Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning
10.1161/circresaha.116.305348 · 2017 · External reference
Redox signalling and cardioprotection: translatability and mechanism
10.1111/bph.12975 · 2015 · External reference
Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K+ channel and protein kinase C activation
10.1007/s00395-006-0584-5 · 2006 · External reference
Myocardial no-reflow in humans
10.1016/j.jacc.2009.03.054 · 2009 · External reference
Considerations on the management of acute postoperative ischaemia after cardiac surgery: a scientific statement from the American Heart Association
10.1161/cir.0000000000001154 · 2023 · External reference
Myocardial stunning: mechanisms, molecular insights, and gaps in knowledge
10.1042/bsr20253410 · 2025 · External reference
Atrial fibrillation occurring during acute hospitalization: a scientific statement from the American Heart Association
10.1161/cir.0000000000001133 · 2023 · External reference
Long-term continuous monitoring of new-onset atrial fibrillation after coronary artery bypass grafting
10.1001/jama.2025.14891 · 2025 · External reference
Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
10.1016/j.amjcard.2010.03.032 · 2010 · External reference
Cyclosporine protects the heart during aortic valve surgery
10.1097/aln.0000000000000331 · 2014 · External reference
Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent
10.1111/j.1476-5381.2011.01700.x · 2012 · External reference
The effect of cyclosporin-A on peri-operative myocardial injury in adult patients undergoing coronary artery bypass graft surgery: a randomised controlled clinical trial
10.1136/heartjnl-2013-304845 · 2014 · External reference
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin
10.1681/asn.2012121216 · 2013 · External reference
Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects
10.3390/cells8070728 · 2019 · External reference
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
10.1038/s42003-020-1101-3 · 2020 · External reference
Phase 2a clinical trial of mitochondrial protection (elamipretide) during stent revascularization in patients with atherosclerotic renal artery stenosis
10.1161/circinterventions.117.005487 · 2017 · External reference
Novel mitochondria-targeting peptide in heart failure treatment: a randomized, placebo-controlled trial of elamipretide
10.1161/circheartfailure.117.004389 · 2017 · External reference
Elamipretide improves mitochondrial function in the failing human heart
10.1016/j.jacbts.2018.12.005 · 2019 · External reference
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with coenzyme Q10 protect cardiac grafts against cold ischaemia-reperfusion injury in heart transplantation
10.1186/s12967-023-04763-7 · 2023 · External reference
Mitochondrial ROS in myocardial ischemia reperfusion and remodeling
10.1016/j.bbadis.2020.165768 · 2020 · External reference
The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model
10.1016/j.healun.2015.05.007 · 2015 · External reference
The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia-reperfusion injury by enhancing PINK1/parkin-mediated mitophagy in type 2 diabetic rats
10.1007/s12192-022-01273-1 · 2022 · External reference
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
10.1096/fj.05-3718com · 2005 · External reference
Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
10.1016/j.jtcvs.2004.03.034 · 2005 · External reference
The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery
10.1053/j.jvca.2008.03.007 · 2008 · External reference
Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
10.18632/aging.103742 · 2020 · External reference
Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis
10.1093/icvts/ivu334 · 2015 · External reference
No-reflow phenomenon: a contemporary review
10.3390/jcm11082233 · 2022 · External reference
Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass
10.1111/anae.14577 · 2019 · External reference
Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review
10.1186/s13054-020-02948-w · 2020 · External reference
Microcirculatory perfusion is preserved during off-pump but not on-pump cardiac surgery
10.1053/j.jvca.2013.05.026 · 2014 · External reference
The crucial triad: endothelial glycocalyx, oxidative stress, and inflammation in cardiac surgery: exploring the molecular connections
10.3390/ijms252010891 · 2024 · External reference
Correlation between acute degradation of the endothelial glycocalyx and microcirculation dysfunction during cardiopulmonary bypass in cardiac surgery
10.1016/j.mvr.2019.02.004 · 2019 · External reference
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
10.2337/diabetes.55.02.06.db05-1103 · 2006 · External reference
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
10.1038/nm.2022 · 2009 · External reference
Capillary pericytes regulate cerebral blood flow in health and disease
10.1038/nature13165 · 2014 · External reference
Capillary pericytes mediate coronary no-reflow after myocardial ischaemia
10.7554/elife.29280 · 2017 · External reference
Prolonged cardiopulmonary bypass time-induced endothelial dysfunction via glypican-1 shedding, inflammation, and matrix metalloproteinase 9 in patients undergoing cardiac surgery
10.3390/biomedicines13010033 · 2024 · External reference
Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: a randomised controlled trial
10.1016/j.mvr.2022.104381 · 2022 · External reference
Effect of dexmedetomidine on endothelial glycocalyx in patients undergoing cardiac surgery with cardiopulmonary bypass
10.1053/j.jvca.2025.09.232 · 2026 · External reference
Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction
10.3389/fmed.2023.1110532 · 2023 · External reference
Total complement inhibition: an effective strategy to limit ischemic injury during coronary revascularization on cardiopulmonary bypass
10.1161/01.cir.100.13.1438 · 1999 · External reference
Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass
10.1161/01.cir.0000138315.99788.eb · 2004 · External reference
Elevated circulating levels of neutrophil extracellular traps after cardiopulmonary bypass surgery as risk factors of postoperative atrial fibrillation and mortality
10.21037/jtd-24-295 · 2024 · External reference
Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass
10.1038/s41598-019-55863-8 · 2019 · External reference
The low-dose colchicine in patients after non-CABG cardiac surgery: a randomized controlled trial
10.1186/s13054-023-04341-9 · 2023 · External reference
Colchicine reduces postoperative atrial fibrillation: results of the colchicine for the prevention of the postpericardiotomy syndrome (COPPS) atrial fibrillation substudy
10.1161/circulationaha.111.026153 · 2011 · External reference
Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the COPPS-2 randomized clinical trial
10.1001/jama.2014.11026 · 2014 · External reference
Safety and efficacy of colchicine for the prevention of post-operative atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials
10.1093/europace/euad169 · 2023 · External reference
Colchicine in patients with coronary disease who underwent coronary artery bypass surgery: a meta-analysis of randomized controlled trials
10.1016/j.amjcard.2024.09.003 · 2024 · External reference
Effects of N-acetylcysteine on myocardial ischemia-reperfusion injury in bypass surgery
10.1007/s00380-005-0873-1 · 2006 · External reference
Effect of N-acetylcysteine in attenuating ischemic reperfusion injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
10.1016/j.avsg.2008.12.005 · 2009 · External reference
N-acetylcysteine use among patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized trials
10.1371/journal.pone.0213862 · 2019 · External reference
Efficacy of N-acetylcysteine in preventing acute kidney injury and major adverse cardiac events after cardiac surgery: a meta-analysis and trial sequential analysis
10.3389/fmed.2022.795839 · 2022 · External reference
N-acetylcysteine to reduce mortality for patients requiring cardiac catheterization or cardiac surgery: a systematic review and meta-analysis
10.1097/fjc.0000000000001551 · 2024 · External reference
Cardiopulmonary and systemic effects of methylprednisolone in patients undergoing cardiac surgery
10.1016/j.athoracsur.2007.01.003 · 2007 · External reference
The efficacy and safety of prophylactic corticosteroids for the prevention of adverse outcomes in patients undergoing heart surgery using cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials
10.1093/ejcts/ezz325 · 2020 · External reference
Corticosteroids in patients undergoing cardiac surgery: a meta-analysis of 12,559 patients
10.1177/02676591221106324 · 2023 · External reference
Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
10.1016/s0140-6736(15)00273-1 · 2015 · External reference
The effects of corticosteroids on survival in pediatric and nonelderly adult patients undergoing cardiac surgery: a meta-analysis of randomized studies
10.1053/j.jvca.2024.07.001 · 2024 · External reference
Cardioprotection: chances and challenges of its translation to the clinic
10.1016/s0140-6736(12)60916-7 · 2013 · External reference
Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological treatments and ischemic conditioning
10.1124/pharmrev.121.000348 · 2023 · External reference
Multitarget strategies to reduce myocardial ischaemia/reperfusion injury
10.1016/j.jacc.2018.09.086 · 2019 · External reference
From “omics” to multi-omics technologies: the discovery of novel causal mediators
10.1007/s11883-022-01078-8 · 2023 · External reference
Multiomics network medicine approaches to precision medicine and therapeutics in cardiovascular diseases
10.1161/atvbaha.122.318731 · 2023 · External reference
Integrative omics for health and disease
10.1038/nrg.2018.4 · 2018 · External reference
Network medicine: a network-based approach to human disease
10.1038/nrg2918 · 2011 · External reference
Multi-omics profiling for health
10.1016/j.mcpro.2023.100561 · 2023 · External reference
Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
10.1161/circulationaha.105.001032 · 2006 · External reference
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery—a sub-analysis of the RIPHeart-study
10.1186/s12872-019-1002-x · 2019 · External reference
Gene polymorphisms and cytokine plasma levels as predictive factors of complications after cardiopulmonary bypass
10.1016/j.jtcvs.2011.12.022 · 2012 · External reference
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation
10.1186/s13148-022-01414-4 · 2022 · External reference
Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
10.1093/cvr/cvq082 · 2010 · External reference
Plasma levels of microRNA-499 provide an early indication of perioperative myocardial infarction in coronary artery bypass graft patients
10.1371/journal.pone.0104618 · 2014 · External reference
Using next-generation RNA sequencing to examine ischemic changes induced by cold blood cardioplegia on the human left ventricular myocardium transcriptome
10.1097/aln.0000000000000582 · 2015 · External reference
Preoperative soluble VCAM-1 contributes to predict late mortality after coronary artery surgery
10.1002/clc.23443 · 2020 · External reference
Prognostic role of serum high mobility group box 1 concentration in cardiac surgery
10.1038/s41598-020-63051-2 · 2020 · External reference
The association between novel biomarkers and 1-year readmission or mortality after cardiac surgery
10.1016/j.athoracsur.2018.04.084 · 2018 · External reference
Soluble urokinase plasminogen activator receptor and survival in elective cardiac surgery
10.1111/eci.13953 · 2023 · External reference
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
10.1038/nature13909 · 2014 · External reference
A longitudinal serum NMR-based metabolomics dataset of ischemia-reperfusion injury in adult cardiac surgery
10.1038/s41597-020-0545-0 · 2020 · External reference
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion
10.1161/circulationaha.108.816116 · 2009 · External reference
New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation
10.1093/cvr/cvab073 · 2021 · External reference
Artificial intelligence in precision cardiovascular medicine
10.1016/j.jacc.2017.03.571 · 2017 · External reference
High-performance medicine: the convergence of human and artificial intelligence
10.1038/s41591-018-0300-7 · 2019 · External reference
Machine learning improves mortality risk prediction after cardiac surgery: systematic review and meta-analysis
10.1016/j.jtcvs.2020.07.105 · 2022 · External reference
Transforming cardiovascular care with artificial intelligence: from discovery to practice: JACC state-of-the-art review
10.1016/j.jacc.2024.05.003 · 2024 · External reference
Use of artificial intelligence in improving outcomes in heart disease: a scientific statement from the American Heart Association
10.1161/cir.0000000000001201 · 2024 · External reference
AI-driven drug-target interaction prediction: current progress, challenges, and future roadmap for precision medicine
10.1007/s10822-026-00798-2 · 2026 · External reference
Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors
10.3389/fmed.2024.1365524 · 2024 · External reference
Integrated multi-omics for rapid rare disease diagnosis on a national scale
10.1038/s41591-023-02401-9 · 2023 · External reference
Challenges and opportunities in multi-omics data acquisition and analysis: toward integrative solutions
10.3390/biom16020271 · 2026 · External reference
Explainability for artificial intelligence in healthcare: a multidisciplinary perspective
10.1186/s12911-020-01332-6 · 2020 · External reference
The role of explainability in creating trustworthy artificial intelligence for health care: a comprehensive survey of the terminology, design choices, and evaluation strategies
10.1016/j.jbi.2020.103655 · 2021 · External reference
Ensuring fairness in machine learning to advance health equity
10.7326/m18-1990 · 2018 · External reference
Sociodemographic bias in clinical machine learning models: a scoping review of algorithmic bias instances and mechanisms
10.1016/j.jclinepi.2024.111606 · 2025 · External reference
Effects of elamipretide on left ventricular function in patients with heart failure with reduced ejection fraction: the PROGRESS-HF phase 2 trial
10.1016/j.cardfail.2020.02.001 · 2020 · External reference