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References from Apolipoprotein E ε3/ε4 and coronary artery disease: lipid and non-lipid mechanisms in personalized prevention — narrative review. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cardiovascular diseases death rate prediction
10.1016/j.cpcardiol.2023.101622 · 2023 · External reference
Fundamental pathobiology of coronary atherosclerosis and clinical implications for chronic ischemic heart disease management—the plaque hypothesis: a narrative review
10.1001/jamacardio.2022.3926 · 2023 · External reference
Coronary heart disease risk: low-density lipoprotein and beyond
10.1016/j.tcm.2021.04.002 · 2022 · External reference
70-year Legacy of the framingham heart study
10.1038/s41569-019-0202-5 · 2019 · External reference
A brief review of cardiovascular diseases, associated risk factors and current treatment regimes
10.2174/1381612825666190925163827 · 2019 · External reference
Coronary artery disease incidence, risk factors, awareness, and medication utilization in a 10-year cohort study
10.1186/s12872-024-03769-3 · 2024 · External reference
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · 1988 · External reference
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
10.1016/j.pathol.2018.11.002 · 2019 · External reference
Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis
10.1172/jci113849 · 1989 · External reference
Extrahepatic synthesis of apolipoprotein E
10.1016/s0022-2275(20)34454-0 · 1984 · External reference
Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content
10.1016/s0021-9258(18)99263-x · 1991 · External reference
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
10.1016/s0022-2275(20)38094-9 · 1982 · External reference
The genetics of the human APOE polymorphism
10.1089/rej.2011.1169 · 2011 · External reference
APOE gene variants in primary dyslipidemia
10.1016/j.atherosclerosis.2021.05.007 · 2021 · External reference
Association of different combinations of ALDH2 rs671, APOE rs429358, rs7412 polymorphisms with hypertension in middle-aged and elderly people: a case-control study
10.2147/ijgm.s402437 · 2023 · External reference
Apolipoprotein E isoforms and lipoprotein metabolism
10.1002/iub.1314 · 2014 · External reference
LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease
10.1016/j.gene.2016.05.032 · 2016 · External reference
Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis
10.1515/cclm-2016-0145 · 2017 · External reference
Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease
10.14712/fb2000046050181 · 2000 · External reference
Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma
10.1016/j.arcmed.2018.08.008 · 2018 · External reference
Apolipoprotein E polymorphism and atherosclerosis
10.1161/01.atv.8.1.1 · 1988 · External reference
Time to challenge the spurious hierarchy of systematic over narrative reviews?
10.1111/eci.12931 · 2018 · External reference
SANRA—a scale for the quality assessment of narrative review articles
10.1186/s41073-019-0064-8 · 2019 · External reference
Apolipoprotein E polymorphism in a Romanian population
10.2478/rjc-2022-0031 · 2023 · External reference
Apolipoprotein E: far more than a lipid transport protein
10.1146/annurev.genom.1.1.507 · 2000 · External reference
Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease
10.1186/1475-2840-11-36 · 2012 · External reference
Allele?
10.1046/j.1469-1809.1999.6340301.x · 1999 · External reference
Apolipoprotein E gene polymorphism effects on lipid metabolism and risk of cerebral infarction in northwest Han Chinese population
10.2147/pgpm.s404663 · 2023 · External reference
Frequencies and distribution of APOE gene polymorphisms and its association with lipid parameters in the Senegalese population
10.7759/cureus.24063 · 2022 · External reference
Association of apolipoprotein E gene polymorphisms with risk of coronary artery disease in a Han Chinese population at middle and high altitude in China
10.3389/fendo.2026.1765770 · 2026 · External reference
Association of apo E polymorphism with plasma lipid levels in a multiethnic elderly population
10.1161/01.atv.17.12.3534 · 1997 · External reference
Apolipoprotein B particles and cardiovascular disease: a narrative review
10.1001/jamacardio.2019.3780 · 2019 · External reference
Apolipoprotein variations across APOE genotypes in young and elderly patients with coronary heart disease
10.1042/bsr20260258 · 2026 · External reference
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European atherosclerosis society consensus statement
10.1093/eurheartj/ehac361 · 2022 · External reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of type 2 diabetes mellitus complicated with coronary artery disease
10.1186/s12872-024-03831-0 · 2024 · External reference
APOE gene ε4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population
10.1002/jcla.23925 · 2021 · External reference
Relation between apolipoprotein E gene polymorphism and severity of coronary artery disease in acute myocardial infarction
10.1155/2015/363458 · 2015 · External reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease
10.1186/s12872-024-04021-8 · 2024 · External reference
ε3/ε4 genotype is associated with premature myocardial infarction: a hospital based retrospective study
10.1186/s12872-026-05513-5 · 2026 · External reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension
10.1186/s12872-024-04169-3 · 2024 · External reference
New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults
10.1194/jlr.m092809 · 2019 · External reference
Apoe gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population
10.1007/s10238-015-0389-7 · 2016 · External reference
Apolipoprotein E gene polymorphism and coronary artery disease risk among patients in northwest China
10.2147/pgpm.s338285 · 2021 · External reference
Synergistic effects of apolipoprotein E gene epsilon polymorphism and some conventional risk factors on premature ischaemic heart disease development
2007 · External reference
The associations between apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphisms and the risk of coronary artery disease in patients with type 2 diabetes mellitus
10.3389/fphys.2017.01031 · 2017 · External reference
A case-control study of the association of the polymorphisms of MTHFR and APOE with risk factors and the severity of coronary artery disease
10.1159/000499866 · 2019 · External reference
Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography
10.1161/01.atv.15.8.1030 · 1995 · External reference
Apolipoprotein E polymorphism is not associated with lipid levels and coronary artery disease in Greek patients with familial hypercholesterolaemia
10.1007/s10238-005-0086-z · 2005 · External reference
Apolipoprotein E genotype, lifestyle and coronary artery disease: gene-environment interaction analyses in the UK biobank population
10.1016/j.atherosclerosis.2021.05.014 · 2021 · External reference
Risk factors of premature coronary artery disease in Iran: a systematic review and meta-analysis
10.1111/eci.13124 · 2019 · External reference
Modifiable and non-modifiable risk factors for premature coronary heart disease: systematic review and meta-analysis
10.1016/j.hlc.2023.12.012 · 2024 · External reference
Premature coronary artery disease, risk factors, clinical presentation, angiography and interventions: hospital-based registry
10.1016/j.ihj.2022.08.003 · 2022 · External reference
What causes premature coronary artery disease?
10.1007/s11883-024-01200-y · 2024 · External reference
Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the aachen study
10.1111/j.1365-2362.2007.01764.x · 2007 · External reference
Meta-analysis of the association between apolipoprotein E polymorphism and risks of myocardial infarction
10.1186/s12872-022-02566-0 · 2022 · External reference
Apolipoprotein E and atherosclerosis: from lipoprotein metabolism to microRNA control of inflammation
10.3390/jcdd5020030 · 2018 · External reference
Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion
10.1016/j.jbc.2021.101106 · 2021 · External reference
Apolipoprotein E in cardiometabolic and neurological health and diseases
10.3390/ijms23179892 · 2022 · External reference
Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype
10.1080/00365510802172145 · 2008 · External reference
Regulation of apolipoprotein E production in macrophages
10.3892/ijmm.6.3.253 · 2000 · External reference
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses
10.1161/atvbaha.108.179283 · 2010 · External reference
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
10.1074/jbc.m409324200 · 2004 · External reference
Impact of ApoE genotype on oxidative stress, inflammation and disease risk
10.1002/mnfr.200700322 · 2008 · External reference
Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation
10.1002/jcb.240540306 · 1994 · External reference
The role of efferocytosis in atherosclerosis
10.1161/circulationaha.116.025684 · 2017 · External reference
Apolipoprotein E polymorphisms contribute to statin response in Chinese ASCVD patients with dyslipidemia
10.1186/s12944-019-1069-5 · 2019 · External reference
Apolipoprotein E polymorphisms and outcome in patients with coronary artery disease treated with statins: the GISSI-prevenzione study
10.1093/eurheartj/ehm196 · 2007 · External reference
Association of stage 1 hypertension defined by the ACC/AHA 2017 guideline with asymptomatic coronary atherosclerosis
10.1093/ajh/hpab051 · 2021 · External reference
Differential impact of degree of hypertension on subclinical coronary atherosclerosis in asymptomatic subjects with and without diabetes mellitus
10.1016/j.amjcard.2023.07.036 · 2023 · External reference
Endothelial dysfunction in hypertension: current concepts and clinical implications
10.3389/fmed.2021.798958 · 2022 · External reference
Effects of tobacco smoking on cardiovascular disease
10.1253/circj.cj-19-0323 · 2019 · External reference
Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study
10.1016/s0140-6736(06)69249-0 · 2006 · External reference
Mechanisms of coronary thrombosis in cigarette smoke exposure
10.1161/atvbaha.112.300154 · 2013 · External reference
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
10.1161/cir.0000000000000973 · 2021 · External reference
Coronary artery disease and body mass index: what is the relationship?
10.1016/j.clnesp.2019.08.008 · 2019 · External reference
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in east Asian and European populations
10.1186/s13073-022-01067-1 · 2022 · External reference
Metabolic syndrome and the risk of adverse cardiovascular events after an acute coronary syndrome
10.1177/2047487318763897 · 2018 · External reference
Heart function assessment during aging in apolipoprotein E knock-out mice
10.15190/d.2021.15 · 2021 · External reference
Apolipoprotein E4 is associated with right ventricular dysfunction in dilated cardiomyopathy—an animal and in-human comparative study
10.3390/ijms22189688 · 2021 · External reference
Apolipoprotein B particles and cardiovascular disease: a narrative review
10.1001/jamacardio.2019.3780 · ExternalCitation · doi-reference
Fundamental pathobiology of coronary atherosclerosis and clinical implications for chronic ischemic heart disease management—the plaque hypothesis: a narrative review
10.1001/jamacardio.2022.3926 · ExternalCitation · doi-reference
Apolipoprotein E isoforms and lipoprotein metabolism
10.1002/iub.1314 · ExternalCitation · doi-reference
Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation
10.1002/jcb.240540306 · ExternalCitation · doi-reference
APOE gene ε4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population
10.1002/jcla.23925 · ExternalCitation · doi-reference
Impact of ApoE genotype on oxidative stress, inflammation and disease risk
10.1002/mnfr.200700322 · ExternalCitation · doi-reference
Apolipoprotein E polymorphism is not associated with lipid levels and coronary artery disease in Greek patients with familial hypercholesterolaemia
10.1007/s10238-005-0086-z · ExternalCitation · doi-reference
Apoe gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population
10.1007/s10238-015-0389-7 · ExternalCitation · doi-reference
What causes premature coronary artery disease?
10.1007/s11883-024-01200-y · ExternalCitation · doi-reference
Differential impact of degree of hypertension on subclinical coronary atherosclerosis in asymptomatic subjects with and without diabetes mellitus
10.1016/j.amjcard.2023.07.036 · ExternalCitation · doi-reference
Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma
10.1016/j.arcmed.2018.08.008 · ExternalCitation · doi-reference
APOE gene variants in primary dyslipidemia
10.1016/j.atherosclerosis.2021.05.007 · ExternalCitation · doi-reference
Apolipoprotein E genotype, lifestyle and coronary artery disease: gene-environment interaction analyses in the UK biobank population
10.1016/j.atherosclerosis.2021.05.014 · ExternalCitation · doi-reference
Coronary artery disease and body mass index: what is the relationship?
10.1016/j.clnesp.2019.08.008 · ExternalCitation · doi-reference
Global cardiovascular diseases death rate prediction
10.1016/j.cpcardiol.2023.101622 · ExternalCitation · doi-reference
LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease
10.1016/j.gene.2016.05.032 · ExternalCitation · doi-reference
Modifiable and non-modifiable risk factors for premature coronary heart disease: systematic review and meta-analysis
10.1016/j.hlc.2023.12.012 · ExternalCitation · doi-reference
Premature coronary artery disease, risk factors, clinical presentation, angiography and interventions: hospital-based registry
10.1016/j.ihj.2022.08.003 · ExternalCitation · doi-reference
Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion
10.1016/j.jbc.2021.101106 · ExternalCitation · doi-reference
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
10.1016/j.pathol.2018.11.002 · ExternalCitation · doi-reference
Coronary heart disease risk: low-density lipoprotein and beyond
10.1016/j.tcm.2021.04.002 · ExternalCitation · doi-reference
Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content
10.1016/s0021-9258(18)99263-x · ExternalCitation · doi-reference
Extrahepatic synthesis of apolipoprotein E
10.1016/s0022-2275(20)34454-0 · ExternalCitation · doi-reference
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
10.1016/s0022-2275(20)38094-9 · ExternalCitation · doi-reference
Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study
10.1016/s0140-6736(06)69249-0 · ExternalCitation · doi-reference
70-year Legacy of the framingham heart study
10.1038/s41569-019-0202-5 · ExternalCitation · doi-reference
Apolipoprotein variations across APOE genotypes in young and elderly patients with coronary heart disease
10.1042/bsr20260258 · ExternalCitation · doi-reference
Allele?
10.1046/j.1469-1809.1999.6340301.x · ExternalCitation · doi-reference
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
10.1074/jbc.m409324200 · ExternalCitation · doi-reference
Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype
10.1080/00365510802172145 · ExternalCitation · doi-reference
The genetics of the human APOE polymorphism
10.1089/rej.2011.1169 · ExternalCitation · doi-reference
Association of stage 1 hypertension defined by the ACC/AHA 2017 guideline with asymptomatic coronary atherosclerosis
10.1093/ajh/hpab051 · ExternalCitation · doi-reference
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European atherosclerosis society consensus statement
10.1093/eurheartj/ehac361 · ExternalCitation · doi-reference
Apolipoprotein E polymorphisms and outcome in patients with coronary artery disease treated with statins: the GISSI-prevenzione study
10.1093/eurheartj/ehm196 · ExternalCitation · doi-reference
Time to challenge the spurious hierarchy of systematic over narrative reviews?
10.1111/eci.12931 · ExternalCitation · doi-reference
Risk factors of premature coronary artery disease in Iran: a systematic review and meta-analysis
10.1111/eci.13124 · ExternalCitation · doi-reference
Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the aachen study
10.1111/j.1365-2362.2007.01764.x · ExternalCitation · doi-reference
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · ExternalCitation · doi-reference
Apolipoprotein E: far more than a lipid transport protein
10.1146/annurev.genom.1.1.507 · ExternalCitation · doi-reference
Relation between apolipoprotein E gene polymorphism and severity of coronary artery disease in acute myocardial infarction
10.1155/2015/363458 · ExternalCitation · doi-reference
A case-control study of the association of the polymorphisms of MTHFR and APOE with risk factors and the severity of coronary artery disease
10.1159/000499866 · ExternalCitation · doi-reference
Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography
10.1161/01.atv.15.8.1030 · ExternalCitation · doi-reference
Association of apo E polymorphism with plasma lipid levels in a multiethnic elderly population
10.1161/01.atv.17.12.3534 · ExternalCitation · doi-reference
Apolipoprotein E polymorphism and atherosclerosis
10.1161/01.atv.8.1.1 · ExternalCitation · doi-reference
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses
10.1161/atvbaha.108.179283 · ExternalCitation · doi-reference
Mechanisms of coronary thrombosis in cigarette smoke exposure
10.1161/atvbaha.112.300154 · ExternalCitation · doi-reference
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
10.1161/cir.0000000000000973 · ExternalCitation · doi-reference
The role of efferocytosis in atherosclerosis
10.1161/circulationaha.116.025684 · ExternalCitation · doi-reference
Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis
10.1172/jci113849 · ExternalCitation · doi-reference
Metabolic syndrome and the risk of adverse cardiovascular events after an acute coronary syndrome
10.1177/2047487318763897 · ExternalCitation · doi-reference
Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease
10.1186/1475-2840-11-36 · ExternalCitation · doi-reference
Meta-analysis of the association between apolipoprotein E polymorphism and risks of myocardial infarction
10.1186/s12872-022-02566-0 · ExternalCitation · doi-reference
Coronary artery disease incidence, risk factors, awareness, and medication utilization in a 10-year cohort study
10.1186/s12872-024-03769-3 · ExternalCitation · doi-reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of type 2 diabetes mellitus complicated with coronary artery disease
10.1186/s12872-024-03831-0 · ExternalCitation · doi-reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease
10.1186/s12872-024-04021-8 · ExternalCitation · doi-reference
Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension
10.1186/s12872-024-04169-3 · ExternalCitation · doi-reference
ε3/ε4 genotype is associated with premature myocardial infarction: a hospital based retrospective study
10.1186/s12872-026-05513-5 · ExternalCitation · doi-reference
Apolipoprotein E polymorphisms contribute to statin response in Chinese ASCVD patients with dyslipidemia
10.1186/s12944-019-1069-5 · ExternalCitation · doi-reference
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in east Asian and European populations
10.1186/s13073-022-01067-1 · ExternalCitation · doi-reference
SANRA—a scale for the quality assessment of narrative review articles
10.1186/s41073-019-0064-8 · ExternalCitation · doi-reference
New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults
10.1194/jlr.m092809 · ExternalCitation · doi-reference
Effects of tobacco smoking on cardiovascular disease
10.1253/circj.cj-19-0323 · ExternalCitation · doi-reference
Effect of apolipoprotein E polymorphism and apolipoprotein A-1 gene promoter polymorphism on lipid parameters and premature coronary artery disease
10.14712/fb2000046050181 · ExternalCitation · doi-reference
Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis
10.1515/cclm-2016-0145 · ExternalCitation · doi-reference
Heart function assessment during aging in apolipoprotein E knock-out mice
10.15190/d.2021.15 · ExternalCitation · doi-reference
Association of different combinations of ALDH2 rs671, APOE rs429358, rs7412 polymorphisms with hypertension in middle-aged and elderly people: a case-control study
10.2147/ijgm.s402437 · ExternalCitation · doi-reference
Apolipoprotein E gene polymorphism and coronary artery disease risk among patients in northwest China
10.2147/pgpm.s338285 · ExternalCitation · doi-reference
Apolipoprotein E gene polymorphism effects on lipid metabolism and risk of cerebral infarction in northwest Han Chinese population
10.2147/pgpm.s404663 · ExternalCitation · doi-reference
A brief review of cardiovascular diseases, associated risk factors and current treatment regimes
10.2174/1381612825666190925163827 · ExternalCitation · doi-reference
Apolipoprotein E polymorphism in a Romanian population
10.2478/rjc-2022-0031 · ExternalCitation · doi-reference
Association of apolipoprotein E gene polymorphisms with risk of coronary artery disease in a Han Chinese population at middle and high altitude in China
10.3389/fendo.2026.1765770 · ExternalCitation · doi-reference
Endothelial dysfunction in hypertension: current concepts and clinical implications
10.3389/fmed.2021.798958 · ExternalCitation · doi-reference
The associations between apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphisms and the risk of coronary artery disease in patients with type 2 diabetes mellitus
10.3389/fphys.2017.01031 · ExternalCitation · doi-reference
Apolipoprotein E4 is associated with right ventricular dysfunction in dilated cardiomyopathy—an animal and in-human comparative study
10.3390/ijms22189688 · ExternalCitation · doi-reference
Apolipoprotein E in cardiometabolic and neurological health and diseases
10.3390/ijms23179892 · ExternalCitation · doi-reference
Apolipoprotein E and atherosclerosis: from lipoprotein metabolism to microRNA control of inflammation
10.3390/jcdd5020030 · ExternalCitation · doi-reference
Regulation of apolipoprotein E production in macrophages
10.3892/ijmm.6.3.253 · ExternalCitation · doi-reference
Frequencies and distribution of APOE gene polymorphisms and its association with lipid parameters in the Senegalese population
10.7759/cureus.24063 · ExternalCitation · doi-reference
