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Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

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Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 and inducing mitochondrial dysfunction

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Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

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Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and OPA1-mediated mitochondrial fusion

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Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy

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GULP1 protects against diabetic cardiomyopathy through IKIP/NF-κB-dependent improvement of mitochondrial function

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Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy

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RTA 408 ameliorates diabetic cardiomyopathy by activating Nrf2 to regulate mitochondrial fission and fusion and inhibiting NF-κB-mediated inflammation

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N6-Methyladenosine-mediated phase separation suppresses NOTCH1 expression and promotes mitochondrial fission in diabetic cardiac fibrosis

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Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics

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FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy, diabetes

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MARK4 aggravates cardiac dysfunction in mice with STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated myocardial lipid metabolism

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Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: role of the mitochondria-localized AMPK-parkin-ACSL4 signaling pathway

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Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis

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Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression

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Carnosic acid protects against mitochondrial dysfunction and ferroptosis in myocardial ischemia/reperfusion injury through mediating Mfn2

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SFRP2 improves mitochondrial dynamics and mitochondrial biogenesis, oxidative stress, and apoptosis in diabetic cardiomyopathy

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Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy

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Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and parkin-mediated mitophagy

10.1093/jmcb/mjad056 · 2023 · External reference

A ROCK1 inhibitior fasudil alleviates cardiomyocyte apoptosis in diabetic cardiomyopathy by inhibiting mitochondrial fission in a type 2 diabetes mouse model

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Mst1 knockout alleviates mitochondrial fission and mitigates left ventricular remodeling in the development of diabetic cardiomyopathy

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Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1alpha-PPARalpha pathway

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BNP protects against diabetic cardiomyopathy by promoting OPA1-mediated mitochondrial fusion via activating the PKG-STAT3 pathway

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FGF1ΔHBS Prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression

10.1038/s41392-021-00542-2 · 2021 · External reference

FGF21–Sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity

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Punicalagin protects against diabetic cardiomyopathy by promoting OPA1-mediated mitochondrial fusion via regulating PTP1B-Stat3 pathway

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Paeonol promotes OPA1-mediated mitochondrial fusion via activating the CK2alpha-Stat3 pathway in diabetic cardiomyopathy

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The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice

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A human engineered heart tissue-derived lipotoxic diabetic cardiomyopathy model revealed early benefits of empagliflozin

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