References

Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure the rotterdam study

10.1016/j.ehj.2004.06.038 · 2004 · External reference

Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review

10.1002/ejhf.483 · 2016 · External reference

Prevalence and incidence of heart failure among urban patients in China: a national population-based analysis

10.1161/circheartfailure.121.008406 · 2021 · External reference

Health-related quality of life and mortality in heart failure: the global congestive heart failure study of 23 000 patients from 40 countries

10.1161/circulationaha.120.050850 · 2021 · External reference

Metabolic remodeling and implicated calcium and signal transduction pathways in the pathogenesis of heart failure

10.3390/ijms221910579 · 2021 · External reference

Calcium signaling in cardiomyocyte function

10.1101/cshperspect.a035428 · 2020 · External reference

Calcium signaling in cardiac ventricular myocytes

10.1196/annals.1341.008 · 2005 · External reference

Cardiac excitation-contraction coupling

10.1038/415198a · 2002 · External reference

Altered myocardial calcium cycling and energetics in heart failure–a rational approach for disease treatment

10.1016/j.cmet.2015.01.005 · 2015 · External reference

Targeting calcium regulators as therapy for heart failure: focus on the sarcoplasmic reticulum ca-ATPase pump

10.3389/fcvm.2023.1185261 · 2023 · External reference

The role of the na+/ca2+ exchangers in ca2+ dynamics in ventricular myocytes

10.1016/j.pbiomolbio.2007.07.018 · 2008 · External reference

Physiological and pathological roles of the mitochondrial permeability transition pore in the heart

10.1016/j.cmet.2014.12.001 · 2015 · External reference

Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic m(2) and α7 nicotinic receptor expression

10.1016/j.trsl.2021.12.005 · 2022 · External reference

Altered cardiac myocyte ca regulation in heart failure

10.1152/physiol.00019.2006 · 2006 · External reference

Calcium cycling proteins and their association with heart failure

10.1038/clpt.2011.161 · 2011 · External reference

Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium

10.1172/jci114611 · 1990 · External reference

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport

10.1161/01.res.0000091871.54907.6b · 2003 · External reference

Calcium sparks

10.1152/physrev.00030.2007 · 2008 · External reference

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

10.1161/01.res.0000125626.33738.e2 · 2004 · External reference

Phosphorylation of RyR2 ser-2814 by CaMKII mediates β1-adrenergic stress induced ca(2+) -leak from the sarcoplasmic reticulum

10.1002/2211-5463.13274 · 2021 · External reference

Role of RyR2 phosphorylation at s2814 during heart failure progression

10.1161/circresaha.112.268094 · 2012 · External reference

Dual ablation of the RyR2-ser2808 and RyR2-ser2814 sites increases propensity for pro-arrhythmic spontaneous ca(2+) releases

10.1113/jp286453 · 2024 · External reference

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression

10.1126/scitranslmed.aan0724 · 2018 · External reference

PKA Phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

10.1016/s0092-8674(00)80847-8 · 2000 · External reference

Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart

10.1007/s10741-009-9146-x · 2009 · External reference

Regulation of sarco(endo)plasmic reticulum Ca2+-ATPase and calsequestrin gene expression in the heart

10.1139/y2012-057 · 2012 · External reference

The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA)

10.1139/cjpp-2014-0463 · 2015 · External reference

Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment

10.1586/14779072.4.3.417 · 2006 · External reference

Altering calcium sensitivity in heart failure: a crossroads of disease etiology and therapeutic innovation

10.3390/ijms242417577 · 2023 · External reference

Protein kinase a hyperphosphorylation increases basal current but decreases beta-adrenergic responsiveness of the sarcolemmal Na+-Ca2+ exchanger in failing pig myocytes

10.1161/01.res.0000069701.19660.14 · 2003 · External reference

Cyclophilin d controls mitochondrial pore-dependent ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

10.1172/jci43171 · 2010 · External reference

Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases

10.1111/bph.13010 · 2015 · External reference

Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex

10.1161/circulationaha.104.508796 · 2005 · External reference

Β1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27

10.1007/s00232-013-9571-6 · 2013 · External reference

Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration

10.1016/s0022-2828(03)00173-1 · 2003 · External reference

The role of β-adrenergic system remodeling in human heart failure: a mechanistic investigation

10.1016/j.yjmcc.2020.12.004 · 2021 · External reference

New insights in cardiac β-adrenergic signaling during heart failure and aging

10.3389/fphar.2018.00904 · 2018 · External reference

Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation

10.1016/j.yjmcc.2017.05.011 · 2017 · External reference

Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis

10.1007/s00395-015-0461-1 · 2015 · External reference

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor

10.1172/jci29576 · 2007 · External reference

{Beta}1-adrenergic receptor activation induces mouse cardiac myocyte death through both l-type calcium channel-dependent and -independent pathways

10.1152/ajpheart.00392.2010 · 2010 · External reference

The role of g protein coupled receptor kinases in neurocardiovascular pathophysiology

10.5114/aoms.2012.29996 · 2012 · External reference

Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin i, and c-protein in ventricular myocardium from patients with terminal heart failure

10.1161/01.cir.99.1.65 · 1999 · External reference

Modulation of human cardiac function through 4 beta-adrenoceptor populations

10.1007/pl00004999 · 1997 · External reference

Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure

10.1111/febs.15706 · 2021 · External reference

CAMP Imaging at ryanodine receptors reveals β(2)-adrenoceptor driven arrhythmias

10.1161/circresaha.120.318234 · 2021 · External reference

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

10.1172/jci31060 · 2007 · External reference

Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart

10.1161/circep.114.002065 · 2015 · External reference

Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum ca load

10.1161/circresaha.107.169011 · 2008 · External reference

Beta-adrenergic receptor blockade modulates bcl-x(s) expression and reduces apoptosis in failing myocardium

10.1016/s0022-2828(03)00052-x · 2003 · External reference

Β-adrenergic receptor antagonism in mice: a model for pediatric heart disease

10.1152/japplphysiol.00627.2013 · 2013 · External reference

Association between dose and plasma concentration of bisoprolol in patients with heart failure (CVI ARO 6)

10.1536/ihj.20-052 · 2020 · External reference

Five-year outcomes and prognostic value of feature-tracking cardiovascular magnetic resonance in patients receiving early prereperfusion metoprolol in acute myocardial infarction

10.1016/j.amjcard.2020.07.037 · 2020 · External reference

Distribution and function of the muscarinic receptor subtypes in the cardiovascular system

10.1152/physiolgenomics.00062.2017 · 2018 · External reference

Quantitation of mRNAs for m(1) to m(5) subtypes of muscarinic receptors in rat heart and brain cortex

10.1124/mol.61.6.1267 · 2002 · External reference

The detection of the non-m2 muscarinic receptor subtype in the rat heart atria and ventricles

10.1007/s00210-008-0285-8 · 2008 · External reference

Muscarinic receptors in the failing human heart

10.1016/s0014-2999(99)00261-7 · 1999 · External reference

Adrenergic and cholinergic plasticity in heart failure

10.1161/circresaha.115.306439 · 2015 · External reference

Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart

10.1007/s003950170003 · 2001 · External reference

Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking m2 or m3 muscarinic acetylcholine receptors

10.1096/fj.03-0648fje · 2004 · External reference

Deficiency of m2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress

10.1152/ajpheart.00724.2007 · 2008 · External reference

Loss of m2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (danio rerio)

10.1152/ajpregu.00036.2009 · 2009 · External reference

Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation

10.1111/j.1750-3639.2009.00016.x · 2009 · External reference

Carbachol exhibited positive inotropic effect on rat ventricular myocytes via m2 muscarinic receptors

2007 · External reference

Role of muscarinic acetylcholine receptor-2 in the cerebellar cortex in cardiovascular modulation in anaesthetized rats

10.1007/s11064-015-1755-2 · 2016 · External reference

Vagus nerve stimulation for the treatment of heart failure: the INOVATE-HF trial

10.1016/j.jacc.2016.03.525 · 2016 · External reference

L-type ca(2+) current in ventricular cardiomyocytes

10.1016/j.yjmcc.2009.07.026 · 2010 · External reference

Physiological modulation of inactivation in l-type Ca2+ channels: one switch

10.1113/jphysiol.2003.047902 · 2004 · External reference

Regulation of cardiac l-type Ca2+ channel CaV1.2 via the β-adrenergic-cAMP-protein kinase a pathway: old dogmas, advances, and new uncertainties

10.1161/circresaha.113.301781 · 2013 · External reference

10.1080/19336950.2018.1499368 · 2018 · Admitted local publication

Microdomain-specific modulation of l-type calcium channels leads to triggered ventricular arrhythmia in heart failure

10.1161/circresaha.116.308698 · 2016 · External reference

Ras reduces l-type calcium channel current in cardiac myocytes. Corrective effects of l-channels and SERCA2 on [ca(2+)](i) regulation and cell morphology

10.1161/01.res.88.1.63 · 2001 · External reference

L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices

10.1161/01.res.0000033988.13062.7c · 2002 · External reference

Reduction in density of transverse tubules and l-type ca(2+) channels in canine tachycardia-induced heart failure

10.1016/s0008-6363(00)00256-x · 2001 · External reference

Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces i(ca,l) and i(to) in rapid atrial pacing in rabbits

10.1016/s0735-1097(02)02922-4 · 2003 · External reference

Expression of the l-type calcium channel in human heart failure

10.1007/s003950200022 · 2002 · External reference

The l-type calcium channel in the heart: the beat goes on

10.1172/jci27167 · 2005 · External reference

New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)

10.1161/circulationaha.112.124990 · 2012 · External reference

Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction

10.1016/j.jacc.2020.11.044 · 2021 · External reference

The physiology and pathophysiology of t-tubules in the heart

10.3389/fphys.2021.718404 · 2021 · External reference

2022 AHA/ACC/HFSA guideline for the management of heart failure

10.1016/j.cardfail.2022.02.010 · 2022 · External reference

Suppression of ventricular arrhythmias by targeting late l-type Ca2+ current

10.1085/jgp.202012584 · 2021 · External reference

The l-type ca(2+) channel as a therapeutic target in heart disease

10.2174/092986709789057671 · 2009 · External reference

The structural basis of ryanodine receptor ion channel function

10.1085/jgp.201711878 · 2017 · External reference

Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure

10.1080/14728222.2020.1708326 · 2020 · External reference

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target

10.1038/s41569-020-0394-8 · 2020 · External reference

FK506-binding Proteins 12 and 12.6 (FKBPs) as regulators of cardiac ryanodine receptors: insights from new functional and structural knowledge

10.1080/19336950.2017.1344799 · 2017 · External reference

Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor

10.1074/jbc.274.22.15315 · 1999 · External reference

Functional role of calstabin2 in age-related cardiac alterations

10.1038/srep07425 · 2014 · External reference

Mechanisms of disease: ryanodine receptor defects in heart failure and fatal arrhythmia

10.1038/ncpcardio0419 · 2006 · External reference

Abnormal ryanodine receptor function in heart failure

10.1016/j.pharmthera.2005.04.003 · 2005 · External reference

Intracellular calcium release and cardiac disease

10.1146/annurev.physiol.67.040403.114521 · 2005 · External reference

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium

10.1161/circresaha.110.220418 · 2010 · External reference

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene

10.1111/1440-1681.12669 · 2017 · External reference

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-s2808 or RyR2-s2814

10.1016/j.yjmcc.2019.03.018 · 2019 · External reference

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure

10.1161/circulationaha.104.507921 · 2005 · External reference

Defective cardiac ryanodine receptor regulation during atrial fibrillation

10.1161/01.cir.0000162461.67140.4c · 2005 · External reference

Cardiac ryanodine receptor function and regulation in heart disease

10.1196/annals.1302.012 · 2004 · External reference

FKBP12.6-mediated Stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

10.1161/01.cir.0000044917.74408.be · 2003 · External reference

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2

10.1126/science.1094301 · 2004 · External reference

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

10.1073/pnas.0500353102 · 2005 · External reference

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor

10.1016/j.jacc.2009.01.065 · 2009 · External reference

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias

10.1093/europace/euaa079 · 2020 · External reference

Dantrolene: from better bacon to a treatment for ventricular fibrillation

10.1161/circulationaha.113.007657 · 2014 · External reference

How does flecainide impact RyR2 channel function?

10.1085/jgp.202213089 · 2022 · External reference

RYR2 Channel inhibition is the principal mechanism of flecainide action in CPVT

10.1161/circresaha.120.316819 · 2021 · External reference

Phenytoin reduces activity of cardiac ryanodine receptor 2; A potential mechanism for its cardioprotective action

10.1124/mol.119.117721 · 2020 · External reference

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

10.1172/jci37649 · 2010 · External reference

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure

10.1161/01.cir.0000068316.53218.49 · 2003 · External reference

Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor

10.1161/hc1102.105270 · 2002 · External reference

Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated ca(2+) leak from the sarcoplasmic reticulum and increases contractility

10.1161/01.res.88.2.188 · 2001 · External reference

Effects of FKBP12.6 gene transfection on cardiac function and myocardial pathological changes in heart failure dogs

10.16016/j.1000-5404.2008.05.022 · 2008 · External reference

Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome

10.1161/circresaha.111.259754 · 2012 · External reference

Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis

10.1016/j.bbamcr.2014.08.002 · 2014 · External reference

Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation

10.1093/cvr/cvad037 · 2023 · External reference

SERCA2a: a key protein in the ca(2+) cycle of the heart failure

10.1007/s10741-019-09873-3 · 2020 · External reference

Structures of the heart specific SERCA2a ca(2+)-ATPase

10.15252/embj.2018100020 · 2019 · External reference

Sites on the cytoplasmic region of phospholamban involved in interaction with the calcium-activated ATPase of the sarcoplasmic reticulum

10.1046/j.1432-1327.1999.00688.x · 1999 · External reference

Understanding the role of SERCA2a microdomain remodeling in heart failure induced by obesity and type 2 diabetes

10.3390/jcdd9050163 · 2022 · External reference

Phospholamban: a crucial regulator of cardiac contractility

10.1038/nrm1151 · 2003 · External reference

Factors controlling the activity of the SERCA2a pump in the normal and failing heart

10.1002/biof.63 · 2009 · External reference

Acetylation of SERCA2a, another target for heart failure treatment?

10.1161/circresaha.119.315017 · 2019 · External reference

Effects of MiR-214-3p regulation of SERCA2a expression on contractility of cardiomyocytes in heart failure model

10.14715/cmb/2022.68.4.25 · 2022 · External reference

Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure

10.1002/ehf2.12271 · 2018 · External reference

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span

10.1016/j.yjmcc.2006.05.014 · 2006 · External reference

Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase

10.1016/j.yjmcc.2007.03.738 · 2007 · External reference

SERCA2a Dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established

10.1007/s10741-025-10487-1 · 2025 · External reference

Correcting calcium dysregulation in chronic heart failure using SERCA2a gene therapy

10.3390/ijms19041086 · 2018 · External reference

Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

10.1111/bph.12278 · 2013 · External reference

Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure

10.1016/j.phrs.2021.105843 · 2021 · External reference

SERCA2a Overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes

10.1006/jmcc.2001.1368 · 2001 · External reference

SERCA2a Gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure

10.1161/circep.110.961615 · 2011 · External reference

SERCA2a Gene therapy in heart failure: an anti-arrhythmic positive inotrope

10.1111/bph.12472 · 2014 · External reference

Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

10.1161/circulationaha.111.022889 · 2011 · External reference

Gene therapy in heart failure. SERCA2a as a therapeutic target

10.1253/circj.cj-14-1053 · 2014 · External reference

Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

10.1002/ejhf.826 · 2017 · External reference

Focus on cardiac troponin complex: from gene expression to cardiomyopathy

10.1016/j.gendis.2024.101263 · 2024 · External reference

Structure and function of cardiac troponin c (TNNC1): implications for heart failure, cardiomyopathies, and troponin modulating drugs

10.1016/j.gene.2015.07.074 · 2015 · External reference

The unique functions of cardiac troponin i in the control of cardiac muscle contraction and relaxation

10.1016/j.bbrc.2007.12.114 · 2008 · External reference

Troponin t isoforms and posttranscriptional modifications: evolution, regulation and function

10.1016/j.abb.2010.10.013 · 2011 · External reference

Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics

10.1007/s12551-014-0143-5 · 2014 · External reference

Human cardiac troponin complex. Structure and functions

10.1134/s0006297913130063 · 2013 · External reference

Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan

10.1016/j.ijcard.2011.07.022 · 2012 · External reference

Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport

10.1042/bj20070619 · 2007 · External reference

Triple threat: the na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure

10.2174/138945011795378559 · 2011 · External reference

Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

10.1038/s41467-024-47850-z · 2024 · External reference

Mapping the in vitro interactome of cardiac sodium (na(+) )-calcium (ca(2+) ) exchanger 1 (NCX1)

10.1002/pmic.201600417 · 2017 · External reference

The na+/Ca2+ exchanger in cardiac ischemia/reperfusion injury

10.12659/msm.883533 · 2012 · External reference

Altered na+/ca2+-exchanger activity due to downregulation of na+/k+-ATPase alpha2-isoform in heart failure

10.1093/cvr/cvn013 · 2008 · External reference

Na(+)–Ca2+ exchange in the regulation of cardiac excitation-contraction coupling

10.1016/j.cardiores.2005.04.031 · 2005 · External reference

Acute inhibition of the na(+)/ca(2+) exchanger reduces proarrhythmia in an experimental model of chronic heart failure

10.1016/j.hrthm.2011.11.004 · 2012 · External reference

Alternative strategies in arrhythmia therapy: evaluation of na/ca exchange as an anti-arrhythmic target

10.1016/j.pharmthera.2011.12.001 · 2012 · External reference

Ca2+ entry mode of na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction

10.1093/eurheartj/ehr106 · 2012 · External reference

Cardiac contractility modulation electrical signals normalize activity, expression, and phosphorylation of the na+-Ca2+ exchanger in heart failure

10.1016/j.cardfail.2008.08.011 · 2009 · External reference

Individual cardiac mitochondria undergo rare transient permeability transition pore openings

10.1161/circresaha.115.308093 · 2016 · External reference

A calcium guard in the outer membrane: is VDAC a regulated gatekeeper of mitochondrial calcium uptake?

10.3390/ijms22020946 · 2021 · External reference

How the mitochondrial calcium uniporter complex (MCU(cx)) works

10.1073/pnas.2015886117 · 2020 · External reference

MICU1 And MICU2 control mitochondrial calcium signaling in the mammalian heart

10.1073/pnas.2402491121 · 2024 · External reference

Physiological and pathophysiological roles of mitochondrial na(+)-ca(2+) exchanger, NCLX, in hearts

10.3390/biom11121876 · 2021 · External reference

Spatial and functional crosstalk between the mitochondrial na(+)-ca(2+) exchanger NCLX and the sarcoplasmic reticulum ca(2+) pump SERCA in cardiomyocytes

10.3390/ijms23147948 · 2022 · External reference

Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease

10.3389/fmmed.2023.1235188 · 2023 · External reference

Mitochondrial calcium regulation of cardiac metabolism in health and disease

10.1152/physiol.00014.2024 · 2024 · External reference

Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

10.1038/s41418-023-01187-0 · 2023 · External reference

What is the mitochondrial permeability transition pore?

10.1016/j.yjmcc.2009.02.021 · 2009 · External reference

Dimers of mitochondrial ATP synthase form the permeability transition pore

10.1073/pnas.1217823110 · 2013 · External reference

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

10.1073/pnas.1711201114 · 2017 · External reference

Mitochondrial dysfunction in pathophysiology of heart failure

10.1172/jci120849 · 2018 · External reference

The permeability transition pore as a ca(2+) release channel: new answers to an old question

10.1016/j.ceca.2012.03.004 · 2012 · External reference

What is the nature of the mitochondrial permeability transition pore and what is it not?

10.1002/iub.1130 · 2013 · External reference

Pharmacology of mitochondrial permeability transition pore inhibitors

10.1002/ddr.21593 · 2019 · External reference

Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection

10.1159/000103747 · 2007 · External reference

Effect of cyclosporine on reperfusion injury in acute myocardial infarction

10.1056/nejmoa071142 · 2008 · External reference

Cyclosporine before PCI in patients with acute myocardial infarction

10.1056/nejmoa1505489 · 2015 · External reference

NIM811, A cyclophilin inhibitor without immunosuppressive activity, is beneficial in collagen VI congenital muscular dystrophy models

10.1093/hmg/ddu254 · 2014 · External reference

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

10.1016/j.livres.2024.02.002 · 2024 · External reference

Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy

10.1016/j.antiviral.2011.01.003 · 2011 · External reference

Small and large animal models in cardiac contraction research: advantages and disadvantages

10.1016/j.pharmthera.2013.10.007 · 2014 · External reference

Bridging the translational gap in heart failure research: using human iPSC-derived cardiomyocytes to accelerate therapeutic insights

10.14797/mdcvj.1295 · 2023 · External reference

From the laboratory to the clinic: differentiation, disease modeling and transplantation of cardiac organoids

10.1002/adhm.202502698 · 2026 · External reference

Targeting calcium regulation for heart failure and arrhythmia therapeutics: a critical review

10.1161/circulationaha.125.075150 · 2025 · External reference