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References from Single-cell RNA sequencing reveals a pro-fibrotic epithelial subpopulation contributing to endometrial dysfunction in polycystic ovary syndrome. Local targets link to admitted publications; unresolved targets remain external evidence.
Polycystic ovary syndrome
10.1126/science.adq0328 · 2024 · External reference
Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis
10.7554/elife.85338 · 2023 · External reference
Polycystic ovary syndrome (PCOS): Symptoms, causes, and treatment
10.31083/j.ceog5105126 · 2024 · External reference
American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and Pcos Society Disease State Clinical Review: Guide to the best practices in the evaluation and treatment of polycystic ovary syndrome--part 1
10.4158/ep15748.dsc · 2015 · External reference
American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and Pcos Society Disease State Clinical Review: Guide to the best practices in the evaluation and treatment of polycystic ovary syndrome - part 2
10.4158/ep15748.dscpt2 · 2015 · External reference
Recommendations from the 2023 International Evidence-based Guideline for the assessment and management of polycystic ovary syndrome
10.2139/ssrn.4689131 · 2023 · External reference
Endometrial function in women with polycystic ovary syndrome: A comprehensive review
10.1093/humupd/dmaa051 · 2021 · External reference
Implantation and decidualization in PCOS: Unraveling the complexities of pregnancy
10.3390/ijms25021203 · 2024 · External reference
Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
10.1038/s41467-024-49749-1 · 2024 · External reference
Polycystic ovary syndrome increases the rate of early spontaneous miscarriage in women who have undergone single vitrified euploid blastocyst transfer
10.1016/j.rbmo.2023.04.014 · 2023 · External reference
Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization
10.1016/j.jare.2020.09.002 · 2021 · External reference
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential
10.1210/jc.2013-1923 · 2013 · External reference
The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review
10.1016/j.critrevonc.2022.103852 · 2022 · External reference
Obesity and reproduction: A committee opinion
10.1016/s0029-7844(02)01986-5 · 2021 · External reference
The impact of obesity on reproductive health and metabolism in reproductive-age females
10.1016/j.fertnstert.2024.04.036 · 2024 · External reference
Obesity and female infertility: Potential mediators of obesity's impact
10.1016/j.fertnstert.2017.01.017 · 2017 · External reference
Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics
10.1016/j.metabol.2018.11.002 · 2019 · External reference
Female obesity and infertility: Outcomes and regulatory guidance
10.23750/abm.v93i4.13466 · 2022 · External reference
PCOS endometrium-derived epithelial organoids as a novel model to study endometrial dysfunction
10.1093/humrep/deaf113 · 2025 · External reference
Decorin the antifibrotic proteoglycan and its progression in therapy
10.1152/ajpcell.01075.2024 · 2025 · External reference
Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis
10.1369/0022155412438104 · 2012 · External reference
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-beta1 activation
10.1136/gutjnl-2024-333213 · 2025 · External reference
Endometrial expression of estrogen receptors and the androgen receptor in women with polycystic ovary syndrome: A lifestyle intervention study
10.1210/jc.2015-3803 · 2016 · External reference
Single-cell profiling of the human endometrium in polycystic ovary syndrome
10.1038/s41591-025-03592-z · 2025 · External reference
Fibrosis: From mechanisms to medicines
10.1038/s41586-020-2938-9 · 2020 · External reference
Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice
10.1038/labinvest.2010.172 · 2011 · External reference
The human extracellular matrix gene 1 (ECM1): Genomic structure, cDNA cloning, expression pattern, and chromosomal localization
10.1006/geno.1997.4918 · 1997 · External reference
ECM1 prevents activation of transforming growth factor beta, hepatic stellate cells, and fibrogenesis in mice
10.1053/j.gastro.2019.07.036 · 2019 · External reference
Myofibroblast markers and microscopy detection methods in cell culture and histology
10.1007/978-1-0716-1382-5_3 · 2021 · External reference
TGF-beta-induced alpha-SMA expression is mediated by C/EBPbeta acetylation in human alveolar epithelial cells
10.1186/s10020-021-00283-6 · 2021 · External reference
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice
10.1016/j.scitotenv.2020.141049 · 2020 · External reference
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia
10.1016/j.intimp.2023.111141 · 2023 · External reference
GPX4 deficiency-induced ferroptosis drives endometrial epithelial fibrosis in polycystic ovary syndrome
10.1016/j.redox.2025.103615 · 2025 · External reference
The interactions between autophagy and immune in the liver-adipose-ovary circuit of polycystic ovary syndrome
10.3389/fimmu.2025.1733950 · 2025 · External reference
TGF-beta-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies
10.1016/j.ejphar.2021.174510 · 2021 · External reference
TGF-beta and the TGF-beta family: Context-dependent roles in cell and tissue physiology
10.1101/cshperspect.a021873 · 2016 · External reference
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
10.1016/s0021-9258(17)35666-1 · 1986 · External reference
Role of transforming growth factor beta in human disease
10.1056/nejm200005043421807 · 2000 · External reference
TGF-beta: The master regulator of fibrosis
10.1038/nrneph.2016.48 · 2016 · External reference
Central role of dysregulation of TGF-beta/Smad in CKD progression and potential targets of its treatment
10.1016/j.biopha.2018.02.090 · 2018 · External reference
TGF-beta/Smad and renal fibrosis
10.1093/ndt/gfx161.mp049 · 2019 · External reference
Novel regulators of bone formation: Molecular clones and activities
10.1126/science.3201241 · 1988 · External reference
Bone morphogenetic protein
10.1177/00220345710500060601 · 1971 · External reference
The interactivity between TGFbeta and BMP signaling in organogenesis, fibrosis, and cancer
10.3390/cells8101130 · 2019 · External reference
Role of the TGF-beta/BMP-7/Smad pathways in renal diseases
10.1042/cs20120252 · 2013 · External reference
Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis in Schistosoma japonicum-infected mice via transforming growth factor-beta/Smad signaling
10.3748/wjg.v19.i9.1405 · 2013 · External reference
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis
10.1038/s41467-021-23571-5 · 2021 · External reference
Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis
10.21203/rs.3.rs-3471243/v1 · 2024 · External reference
