References

The Colorado thyroid disease prevalence study

10.1001/archinte.160.4.526 · ExternalCitation · doi-reference

Subclinical thyroid dysfunction as a risk factor for cardiovascular disease

10.1001/archinte.165.21.2467 · ExternalCitation · doi-reference

Subclinical hypothyroidism and the risk of coronary heart disease and mortality

10.1001/jama.2010.1361 · ExternalCitation · doi-reference

Executive summary of the third report of the national cholesterol education program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults

10.1001/jama.285.19.2486 · ExternalCitation · doi-reference

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

10.1001/jama.288.21.2709 · ExternalCitation · doi-reference

The role of serum C-reactive protein measured by high-sensitive method in thyroid disease

10.1007/s00005-014-0282-1 · ExternalCitation · doi-reference

The metabolic actions of thyroid hormone and leptin: A mandatory interplay or not

10.1007/s00125-005-1703-9 · ExternalCitation · doi-reference

Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression

10.1007/s11010-014-2067-6 · ExternalCitation · doi-reference

Hypothyroidism and dyslipidemia: modern concepts and approaches

10.1007/s11886-004-0054-3 · ExternalCitation · doi-reference

Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy

10.1007/s12020-007-9012-3 · ExternalCitation · doi-reference

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

10.1007/s12020-011-9446-5 · ExternalCitation · doi-reference

Metformin effect on TSH in subclinical hypothyroidism: Randomized, double-blind, placebo-controlled clinical trial

10.1007/s12020-017-1462-7 · ExternalCitation · doi-reference

A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases

10.1007/s12020-023-03503-7 · ExternalCitation · doi-reference

Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital

10.1007/s12291-010-0026-x · ExternalCitation · doi-reference

Thyroid hormone action in metabolic regulation

10.1007/s13238-011-1046-x · ExternalCitation · doi-reference

TSH lowering effects of metformin: a possible mechanism of action

10.1007/s40618-020-01445-9 · ExternalCitation · doi-reference

Thyroid functions and serum lipid profile in metabolic syndrome

10.1016/j.bj.2016.12.006 · ExternalCitation · doi-reference

Pharmacological activation of thyroid hormone receptors elicits a functional conversion of white to brown fat

10.1016/j.celrep.2015.10.022 · ExternalCitation · doi-reference

Leptin in inflammation and autoimmunity

10.1016/j.cyto.2016.10.011 · ExternalCitation · doi-reference

Dyslipidemia in South African patients with hypothyroidism

10.1016/j.jcte.2022.100302 · ExternalCitation · doi-reference

Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

10.1016/j.tem.2009.11.004 · ExternalCitation · doi-reference

Hypertriglyceridemia, insulin resistance, and the metabolic syndrome

10.1016/s0002-9149(99)00211-8 · ExternalCitation · doi-reference

The metabolic syndrome--a new worldwide definition

10.1016/s0140-6736(05)67402-8 · ExternalCitation · doi-reference

Prevention and management of type 2 diabetes: dietary components and nutritional strategies

10.1016/s0140-6736(14)60613-9 · ExternalCitation · doi-reference

Ectopic fat, insulin resistance and non-alcoholic fatty liver disease

10.1017/s0029665113001249 · ExternalCitation · doi-reference

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

10.1038/aps.2014.82 · ExternalCitation · doi-reference

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

10.1038/ijo.2009.140 · ExternalCitation · doi-reference

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

10.1038/srep26174 · ExternalCitation · doi-reference

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

10.1038/srep38124 · ExternalCitation · doi-reference

Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism

10.1042/cs1040007 · ExternalCitation · doi-reference

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice

10.1073/pnas.0504379102 · ExternalCitation · doi-reference

Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association

10.1089/thy.2012.0205 · ExternalCitation · doi-reference

Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association task force on thyroid hormone replacement

10.1089/thy.2014.0028 · ExternalCitation · doi-reference

2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum

10.1089/thy.2016.0457 · ExternalCitation · doi-reference

Familial risk of Hashimoto's thyroiditis among first-degree relatives: A population-based study in Korea

10.1089/thy.2020.0213 · ExternalCitation · doi-reference

Hypothyroidism: screening and subclinical disease

10.1136/bmj.314.7088.1175 · ExternalCitation · doi-reference

A comprehensive review on metabolic syndrome

10.1155/2014/943162 · ExternalCitation · doi-reference

Adipocyte DIO2 expression increases in human obesity but is not related to systemic insulin sensitivity

10.1155/2018/2464652 · ExternalCitation · doi-reference

Thyroid dysfunction in patients with metabolic syndrome: A cross-sectional, epidemiological, Pan-India study

10.1155/2018/2930251 · ExternalCitation · doi-reference

Palmitic acid downregulates thyroglobulin, sodium iodide symporter, and thyroperoxidase in human primary thyrocytes: a potential mechanism by which lipotoxicity affects thyroid

10.1155/2018/4215848 · ExternalCitation · doi-reference

Thyroid hormones and the metabolic syndrome

10.1159/000351249 · ExternalCitation · doi-reference

The effects of thyroid hormones on gene expression of acyl-coenzyme A thioesterases in adipose tissue and liver of mice

10.1159/000437304 · ExternalCitation · doi-reference

2018 European Thyroid Association Guidelines on the diagnosis and management of central hypothyroidism

10.1159/000491388 · ExternalCitation · doi-reference

Evidence-based use of levothyroxine/liothyronine combinations in treating hypothyroidism: a consensus document

10.1159/000512970 · ExternalCitation · doi-reference

Thyroid function in adult Nigerians with metabolic syndrome

10.11604/pamj.2014.18.352.4551 · ExternalCitation · doi-reference

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

10.1172/jci10741 · ExternalCitation · doi-reference

Deiodinases: implications of the local control of thyroid hormone action

10.1172/jci29812 · ExternalCitation · doi-reference

The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin

10.1172/jci8857 · ExternalCitation · doi-reference

2025 American Thyroid Association management guidelines for adult patients with differentiated thyroid cancer

10.1177/10507256251363120 · ExternalCitation · doi-reference

The role of thyroid hormone in metabolism and metabolic syndrome

10.1177/2042018820917869 · ExternalCitation · doi-reference

Assessment of the relationship between subclinical hypothyroidism and blood lipid profile: reliable or not

10.1186/s12944-022-01749-0 · ExternalCitation · doi-reference

Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism

10.1186/s13104-023-06516-7 · ExternalCitation · doi-reference

Exploring the association between triglyceride-glucose index and thyroid function

10.1186/s40001-023-01501-z · ExternalCitation · doi-reference

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

10.1194/jlr.m047654 · ExternalCitation · doi-reference

Lipid management in patients with endocrine disorders: an endocrine society clinical practice guideline

10.1210/clinem/dgaa674 · ExternalCitation · doi-reference

CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential

10.1210/endocr/bqz046 · ExternalCitation · doi-reference

Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population

10.1210/jc.2004-2225 · ExternalCitation · doi-reference

Investigations of thyroid hormones and antibodies in obesity: Leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants

10.1210/jc.2009-2798 · ExternalCitation · doi-reference

Weight loss after therapy of hypothyroidism is mainly caused by excretion of excess body water associated with myxoedema

10.1210/jc.2010-1521 · ExternalCitation · doi-reference

Lipotoxicity, a potential risk factor for the increasing prevalence of subclinical hypothyroidism

10.1210/jc.2014-3987 · ExternalCitation · doi-reference

Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature

10.1210/jc.85.9.2993 · ExternalCitation · doi-reference

TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study)

10.1210/jcem.86.10.7973 · ExternalCitation · doi-reference

Association between TSH levels within the reference range and adiposity markers at the baseline of the ELSA-Brasil study

10.1371/journal.pone.0228801 · ExternalCitation · doi-reference

Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention, National Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, and International Association for the Study of Obesity

10.14341/2071-8713-5281 · ExternalCitation · doi-reference

Subclinical hypothyroidism may be associated with elevated high-sensitive C-reactive protein and fasting hyperinsulinemia

10.1507/endocrj.52.89 · ExternalCitation · doi-reference

Levothyroxine in the treatment of overt or subclinical hypothyroidism: a systematic review and meta-analysis

10.1507/endocrj.ej19-0583 · ExternalCitation · doi-reference

Thyroid hormones in the regulation of brown adipose tissue thermogenesis

10.1530/ec-20-0562 · ExternalCitation · doi-reference

Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism

10.1530/ec-21-0002 · ExternalCitation · doi-reference

Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism

10.1530/ec-23-0314 · ExternalCitation · doi-reference

Endoplasmic reticulum stress contributes to insulin resistance in Hashimoto's thyroiditis

10.1530/ec-25-0158 · ExternalCitation · doi-reference

Raised serum TSH levels in patients with morbid obesity: Is it enough to diagnose subclinical hypothyroidism

10.1530/eje-08-0734 · ExternalCitation · doi-reference

Studies of insulin resistance in patients with clinical and subclinical hypothyroidism

10.1530/eje-08-0797 · ExternalCitation · doi-reference

Association of thyroid function with insulin resistance: data from two population-based studies

10.1530/etj-21-0063 · ExternalCitation · doi-reference

Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin

10.1530/joe-12-0498 · ExternalCitation · doi-reference

Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells

10.1590/s0100-879x2011007500121 · ExternalCitation · doi-reference

Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors

10.1677/jme-09-0107 · ExternalCitation · doi-reference

Insight into the physiological actions of thyroid hormone receptors from genetically modified mice

10.1677/joe.0.1750553 · ExternalCitation · doi-reference

Frequency of insulin resistance in people with thyroid dysfunction

10.18502/sjms.v16i4.9950 · ExternalCitation · doi-reference

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

10.18632/oncotarget.10045 · ExternalCitation · doi-reference

The incidence of metabolic syndrome in subclinical hypothyroid patients

10.19127/mbsjohs.561137 · ExternalCitation · doi-reference

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome

10.2139/ssrn.4689131 · ExternalCitation · doi-reference

Is there an association between thyroid disease and metabolic syndrome

10.21608/zumj.2023.249581.3008 · ExternalCitation · doi-reference

8. Obesity and weight management for the prevention and treatment of diabetes: Standards of care in diabetes-2026

10.2337/dc24-s008 · ExternalCitation · doi-reference

The relation of thyroid function to components of the metabolic syndrome in Korean men and women

10.3346/jkms.2011.26.4.540 · ExternalCitation · doi-reference

Hypothyroidism: cardiovascular endpoints of thyroid hormone replacement

10.3389/fendo.2019.00888 · ExternalCitation · doi-reference

The relationship between thyroid function and metabolic syndrome and its components: A cross-sectional study in a Chinese population

10.3389/fendo.2021.661160 · ExternalCitation · doi-reference

Levothyroxine treatment and cardiovascular outcomes in older people with subclinical hypothyroidism: Pooled individual results of two randomised controlled trials

10.3389/fendo.2021.674841 · ExternalCitation · doi-reference

Subclinical hypothyroidism increases insulin resistance in normoglycemic people

10.3389/fendo.2023.1106968 · ExternalCitation · doi-reference

Metabolic syndrome and risk of subclinical hypothyroidism: A systematic review and meta-analysis

10.3389/fendo.2024.1399236 · ExternalCitation · doi-reference

The effects of obesity on thyroid function in a metabolically healthy high-fat, high-carbohydrate diet-induced obese rat model

10.3389/fendo.2025.1538627 · ExternalCitation · doi-reference

The impact of obesity on thyroid autoimmunity and dysfunction: A systematic review and meta-analysis

10.3389/fimmu.2019.02349 · ExternalCitation · doi-reference

ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets

10.3389/fimmu.2025.1639196 · ExternalCitation · doi-reference

Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: A metabolic perspective

10.3389/fmolb.2024.1379124 · ExternalCitation · doi-reference

Implications of GLP-1 receptor agonist on thyroid function: A literature review of its effects on thyroid volume, risk of cancer, functionality and TSH levels

10.3390/biom14060687 · ExternalCitation · doi-reference

Obesity and thyroid axis

10.3390/ijerph18189434 · ExternalCitation · doi-reference

Metabolic syndrome, thyroid dysfunction, and cardiovascular risk: the triptych of evil

10.3390/ijms251910628 · ExternalCitation · doi-reference

The IDF definition is better suited for screening metabolic syndrome and estimating risks of diabetes in Asian American adults: Evidence from NHANES 2011-2016

10.3390/jcm9123871 · ExternalCitation · doi-reference

Subclinical hypothyroidism in patients with obesity and metabolic syndrome: A narrative review

10.3390/nu16010087 · ExternalCitation · doi-reference

Why can insulin resistance be a natural consequence of thyroid dysfunction

10.4061/2011/152850 · ExternalCitation · doi-reference

Pattern of thyroid dysfunction in patients with metabolic syndrome and its relationship with components of metabolic syndrome

10.4093/dmj.2015.39.1.66 · ExternalCitation · doi-reference

Association between altered thyroid state and insulin resistance

10.4103/0976-500x.95517 · ExternalCitation · doi-reference

Hypothyroidism and obesity: An intriguing link

10.4103/2230-8210.183454 · ExternalCitation · doi-reference

Subclinical hypothyroidism: summary of evidence in 2014

10.4414/smw.2014.14058 · ExternalCitation · doi-reference

Study of the relationship between thyroid autoimmunity, obesity and serum leptin level in a sample of Egyptian individuals

10.55133/eji.310413 · ExternalCitation · doi-reference

The metabolic syndrome: A global public health problem and a new definition

10.5551/jat.12.295 · ExternalCitation · doi-reference

Insulin resistance and thyroid disorders

10.5603/ep.2014.0010 · ExternalCitation · doi-reference

The effect of hypothyroidism occurring in patients with metabolic syndrome

10.5603/ep.2015.0036 · ExternalCitation · doi-reference

Associations between metabolic syndrome, serum thyrotropin, and thyroid antibodies status in postmenopausal women, and the role of interleukin-6

10.5603/ep.2015.0049 · ExternalCitation · doi-reference

Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study

10.7326/0003-4819-132-4-200002150-00004 · ExternalCitation · doi-reference

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

10.7555/jbr.30.20150103 · ExternalCitation · doi-reference

Association of thyroid function with lipid profile in patients with metabolic syndrome: a prospective cross-sectional study in the Indian population

10.7759/cureus.44745 · ExternalCitation · doi-reference

A comprehensive review of pathophysiological link between non-alcoholic fatty liver disease, insulin resistance, and metabolic syndrome

10.7759/cureus.75677 · ExternalCitation · doi-reference

Thyroid disorders and their impact on metabolic syndrome and cardiovascular risk: A narrative review

10.7759/cureus.93669 · ExternalCitation · doi-reference

Variations of adipokines and insulin resistance in primary hypothyroidism

10.7860/jcdr/2017/26666.10345 · ExternalCitation · doi-reference