References

Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

10.3322/caac.21834 · 2024 · External reference

Clinical and translational advances in ovarian cancer therapy

10.1038/s43018-023-00617-9 · 2023 · External reference

Cancer statistics, 2026

10.3322/caac.70043 · 2026 · External reference

Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO)

10.1002/cncr.24149 · 2009 · External reference

NCCN guidelines(R) insights: ovarian cancer, version 3.2022

10.6004/jnccn.2022.0047 · 2022 · External reference

High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints

10.3390/ijms20040952 · 2019 · External reference

Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

10.1186/s13048-022-01004-1 · 2022 · External reference

Deciphering ovarian cancer heterogeneity through spatial transcriptomics, single-cell profiling, and copy number variations

10.1371/journal.pone.0317115 · 2025 · External reference

Ovarian tumor microenvironment contributes to tumor progression and chemoresistance

10.20517/cdr.2024.111 · 2024 · External reference

The complex tumor microenvironment in ovarian cancer: therapeutic challenges and opportunities

10.3390/curroncol31070283 · 2024 · External reference

The role of tumor-associated macrophages in the progression and chemoresistance of ovarian cancer

10.3390/cells9051299 · 2020 · External reference

Rho GTPases in gynecologic cancers: in-depth analysis toward the paradigm change from reactive to predictive, preventive, and personalized medical approach benefiting the patient and healthcare

10.3390/cancers12051292 · 2020 · External reference

Digital biomarkers: 3PM approach revolutionizing chronic disease management - EPMA 2024 position

10.1007/s13167-024-00364-6 · 2024 · External reference

diaPASEF: parallel accumulation-serial fragmentation combined with data-independent acquisition

10.1038/s41592-020-00998-0 · 2020 · External reference

Determinants and clinical implications of chromosomal instability in cancer

10.1038/nrclinonc.2017.198 · 2018 · External reference

The role of chromosomal instability in cancer and therapeutic responses

10.3390/cancers10010004 · 2017 · External reference

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms

10.1016/j.cca.2024.119992 · 2025 · External reference

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

10.1186/s12885-024-11895-6 · 2024 · External reference

Online parallel accumulation-serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

10.1074/mcp.tir118.000900 · 2018 · External reference

Thin-diaPASEF: diaPASEF for maximizing proteome coverage in single-shot proteomics

10.1093/dnares/dsaf019 · 2025 · External reference

Enhanced identifications and quantification through retention time down-sampling in fast-cycling diagonal-PASEF methods

10.1016/j.mcpro.2025.101480 · 2026 · External reference

DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput

10.1038/s41592-019-0638-x · 2020 · External reference

UniProt: the universal protein knowledgebase in 2021

10.1093/nar/gkaa1100 · 2021 · External reference

Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set

10.1038/s41467-025-64501-z · 2025 · External reference

Data-independent acquisition: A milestone and prospect in clinical mass spectrometry-based proteomics

10.1016/j.mcpro.2024.100800 · 2024 · External reference

Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ

10.1074/mcp.m113.031591 · 2014 · External reference

The gene ontology knowledgebase in 2023

10.1093/genetics/iyad031 · 2023 · External reference

KEGG: biological systems database as a model of the real world

10.1093/nar/gkae909 · 2025 · External reference

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets

10.1093/nar/gkaa1074 · 2021 · External reference

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

10.1093/nar/gkx247 · 2017 · External reference

Apoptosis induction by ceramide derivatives and its potential mechanisms through domain formation

10.1016/j.bmc.2025.118222 · 2025 · External reference

Cell cycle control in cancer

10.1038/s41580-021-00404-3 · 2022 · External reference

DNA repair pathways in ovarian cancer: Implications for therapy and resistance

10.1016/j.biopha.2025.118719 · 2025 · External reference

Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment

10.3389/fimmu.2019.01078 · 2019 · External reference

CXCL6 reshapes lipid metabolism and induces neutrophil extracellular trap formation in cholangiocarcinoma progression and immunotherapy resistance

10.1002/advs.202503009 · 2025 · External reference

Unwinding helicase MCM functionality for diagnosis and therapeutics of replication abnormalities associated with cancer: A review

10.1007/s40291-024-00701-5 · 2024 · External reference

Patient derived organoids (PDOs), extracellular matrix (ECM), tumor microenvironment (TME) and drug screening: state of the art and clinical implications of ovarian cancer organoids in the era of precision medicine

10.3390/cancers15072059 · 2023 · External reference

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

10.1186/s12943-024-01932-0 · 2024 · External reference

Comprehensive review of Bcl-2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small molecules

10.1002/ptr.8157 · 2024 · External reference

Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors

10.1186/s13073-022-01093-z · 2022 · External reference

Peroxisome proliferator-activated receptors and the hallmarks of cancer

10.3390/cells11152432 · 2022 · External reference

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

10.1038/s41568-019-0216-7 · 2020 · External reference

Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity

10.1080/19336918.2025.2472308 · 2025 · External reference

Minichromosome maintenance proteins: from DNA replication to the DNA damage response

10.3390/cells14010012 · 2024 · External reference

Knockdown of MCM8 inhibits development and progression of bladder cancer in vitro and in vivo

10.1186/s12935-021-01948-2 · 2021 · External reference

A membrane-associated MHC-I inhibitory axis for cancer immune evasion

10.1016/j.cell.2023.07.016 · 2023 · External reference

The NLR family of innate immune and cell death sensors

10.1016/j.immuni.2024.03.012 · 2024 · External reference

Sphingolipid metabolism and complement signaling in cancer progression

10.1016/j.trecan.2023.07.001 · 2023 · External reference

Systemic analysis of the DNA replication regulator MCM complex in ovarian cancer and its prognostic value

10.3389/fonc.2021.681261 · 2021 · External reference

Role of Serine arginine protein kinase 1 and Minichromosome maintenance protein 2 in predicting epithelial ovarian cancer response to treatment and prognosis

10.4103/ijc.ijc_939_20 · 2024 · External reference

Identification of prevention marker associated with DNA replication in ovarian cancer: Expression of MCM2 protein and bioinformatics analysis

10.1016/j.ijbiomac.2024.135079 · 2024 · External reference

Identifying mitotic kinesins as potential prognostic biomarkers in ovarian cancer using bioinformatic analyses

10.3390/diagnostics12020470 · 2022 · External reference

KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear-cell carcinoma cells

10.3892/or.2018.6401 · 2018 · External reference

Role of KIF20A depletion in inhibiting ovarian cancer progression: Insights from PTEN and M2 macrophage polarization

10.24976/discov.med.202436191.224 · 2024 · External reference

A transcription factor that promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of ovarian cancer cells and its possible mechanisms

10.1186/s12938-021-00919-y · 2021 · External reference

Elevated mRNA expression levels of NCAPG are associated with poor prognosis in ovarian cancer

10.2147/cmar.s253349 · 2020 · External reference

Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway

10.1186/s13048-022-01030-z · 2022 · External reference

NDC80 kinetochore complex serves as a potential prognostic predictor and correlates with immune infiltrates in epithelial ovarian cancer patients

10.2147/ijgm.s450976 · 2024 · External reference

NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes

10.3389/fonc.2022.1057198 · 2022 · External reference

USP7-mediated NUF2 deubiquitination accelerates ovarian cancer progression through regulating SLC7A11 expression

10.1016/j.yexcr.2025.114659 · 2025 · External reference

BUB1B promotes ovarian cancer cell proliferation and metastasis by activating the Wnt/beta-catenin pathway

10.1002/cam4.71311 · 2025 · External reference

Polycomb repressor complex 1 (PRC1) in ovarian cancer: A scoping literature review

10.1016/j.critrevonc.2024.104456 · 2024 · External reference

PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination

10.1016/j.yexcr.2025.114509 · 2025 · External reference

CENPA is one of the potential key genes associated with the proliferation and prognosis of ovarian cancer based on integrated bioinformatics analysis and regulated by MYBL2

10.21037/tcr-21-175 · 2021 · External reference

UHRF1-mediated HIF-1alpha stabilization promotes ovarian cancer through metabolic reprogramming and angiogenesis

10.1038/s41419-025-08033-w · 2025 · External reference

Molecular genetic characteristics of FANCI, a proposed new ovarian cancer predisposing gene

10.3390/genes14020277 · 2023 · External reference

Silencing of FANCI promotes DNA damage and sensitizes ovarian cancer cells to carboplatin

10.2174/1568009622666220331091709 · 2022 · External reference

Evaluation of BRIP-1 (FANCJ) and FANCI protein expression in ovarian cancer tissue

10.3390/biomedicines12122652 · 2024 · External reference

Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis

10.1097/md.0000000000040608 · 2024 · External reference

A bioinformatics approach to identify potential biomarkers of high-grade ovarian cancer

10.4274/jtgga.galenos.2025.2025-1-1 · 2026 · External reference

Identification of RFC4 as a potential biomarker for pan-cancer involving prognosis, tumour immune microenvironment and drugs

10.1111/jcmm.18478 · 2024 · External reference

Copy number variations and protein expression of Cyclin E1 and Epithelial cell transforming sequence 2 genes predict the chemotherapeutic response in patients with serous ovarian carcinoma

10.12669/pjms.39.3.7304 · 2023 · External reference

Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors

10.3389/fcell.2025.1602649 · 2025 · External reference

RACGAP1 knockdown synergizes and enhances the effects of chemotherapeutics on ovarian cancer

10.62347/qnzu1402 · 2024 · External reference

KIF2C promotes doxorubicin resistance in ovarian cancer cells and increases cancer cell glycolysis by upregulating PKM2

10.22514/ejgo.2024.129 · 2024 · External reference

TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability

10.1002/cam4.5683 · 2023 · External reference

RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer

10.1371/journal.pone.0091000 · 2014 · External reference

Extensive mutual influences of SMC complexes shape 3D genome folding

10.1038/s41586-025-08638-3 · 2025 · External reference

Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo

10.4149/neo_2020_190510n419 · 2020 · External reference

Abstract A15: SMC2 role in regulating tumor angiogenesis via FGF signaling

10.1158/1538-7445.tummet15-a15 · 2016 · External reference

Prognostic relevance of SMC family gene expression in human sarcoma

10.18632/aging.202455 · 2020 · External reference

Expression profile and prognostic values of SMC family members in HCC

10.1097/md.0000000000031336 · 2022 · External reference

SMC2 knockdown inhibits Malignant progression of lung adenocarcinoma by upregulating BTG2 expression

10.1016/j.cellsig.2024.111216 · 2024 · External reference

Onvansertib and Navitoclax combination as a new therapeutic option for mucinous ovarian carcinoma

10.3390/ijms26020472 · 2025 · External reference

Intracellular delivery of anti-SMC2 antibodies against cancer stem cells

10.3390/pharmaceutics12020185 · 2020 · External reference