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References from Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome. Local targets link to admitted publications; unresolved targets remain external evidence.
Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process
10.1016/s0140-6736(26)00717-8 · 2026 · External reference
Evolving global trends in PCOS burden: a three-decade analysis (1990-2021) with projections to 2036 among adolescents and young adults
10.3389/fendo.2025.1569694 · 2025 · External reference
Polycystic ovary syndrome
10.1038/nrdp.2016.57 · 2016 · External reference
Pregnancy complications in women with polycystic ovary syndrome
10.1093/humupd/dmv029 · 2015 · External reference
A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
10.1093/humupd/dml036 · 2006 · External reference
Implications of polycystic ovary syndrome for pregnancy and for the health of offspring
10.1097/aog.0000000000000852 · 2015 · External reference
Epigenetic inheritance of PCOS by developmental programming and germline transmission
10.1016/j.tem.2024.12.002 · 2025 · External reference
Mechanisms of intergenerational transmission of polycystic ovary syndrome
10.1530/rep-19-0197 · 2020 · External reference
PCOS as a generational disease-risks to mother and children
10.12775/jehs.2023.42.01.007 · 2023 · External reference
Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment
10.3390/ijerph19031336 · 2022 · External reference
Polycystic ovary syndrome: pathophysiology and therapeutic opportunities
10.1136/bmjmed-2023-000548 · 2023 · External reference
Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring
10.1152/ajpendo.00058.2010 · 2010 · External reference
Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment
10.1210/en.2005-1338 · 2006 · External reference
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
10.1038/s41591-019-0666-1 · 2019 · External reference
Transient prenatal androgen exposure produces metabolic syndrome in adult female rats
10.1152/ajpendo.90208.2008 · 2008 · External reference
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
10.1016/j.xcrm.2023.101035 · 2023 · External reference
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process
10.1016/j.cmet.2021.01.004 · 2021 · External reference
Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy
10.1093/humrep/dead050 · 2023 · External reference
Developmental origin of polycystic ovary syndrome - a hypothesis
10.1677/joe.0.1740001 · 2002 · External reference
Endocrine regulation of fetal growth
10.1071/rd9950351 · 1995 · External reference
Metabolomic profile of amniotic fluid and wheezing in the first year of life—a healthy birth cohort study
10.1016/j.jpeds.2018.01.012 · 2018 · External reference
Utilizing amniotic fluid metabolomics to monitor fetal well-being: a narrative review of the literature
10.7759/cureus.36986 · 2023 · External reference
Untargeted metabolomic analysis of amniotic fluid in the prediction of preterm delivery and bronchopulmonary dysplasia
10.1371/journal.pone.0164211 · 2016 · External reference
Non-targeted metabolomic study of fetal growth restriction
10.3390/metabo13060761 · 2023 · External reference
Metabolomic profiling of second-trimester amniotic fluid for predicting preterm delivery: insights from NMR analysis
10.3390/metabo13111147 · 2023 · External reference
Variation in stability of housekeeping genes in endometrium of healthy and polycystic ovarian syndrome women
10.1093/humrep/der363 · 2012 · External reference
Evaluation of housekeeping genes in placental comparative expression studies
10.1016/j.placenta.2004.09.009 · 2005 · External reference
Phospholipid synthesis and transport in mammalian cells
10.1111/tra.12230 · 2015 · External reference
Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing
10.3390/ijms23020583 · 2022 · External reference
Synopsis of arachidonic acid metabolism: a review
10.1016/j.jare.2018.03.005 · 2018 · External reference
Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis
10.1186/1741-7015-10-153 · 2012 · External reference
Insulin resistance and oxidative marker in women with PCOS
10.1080/13813455.2018.1499120 · 2020 · External reference
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes
10.1371/journal.pone.0041456 · 2012 · External reference
Functions of plasmalogen lipids in health and disease
10.1016/j.bbadis.2012.05.008 · 2012 · External reference
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
10.1016/j.cmet.2006.03.007 · 2006 · External reference
Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis
10.1093/humupd/dms059 · 2013 · External reference
Maternal rat metabolomics: amniotic fluid and placental metabolic profiling workflows
10.1021/acs.jproteome.1c00145 · 2021 · External reference
Serum and amniotic fluid metabolic profile changes in response to gestational diabetes mellitus and the association with maternal–fetal outcomes
10.3390/nu13103644 · 2021 · External reference
Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology
10.1074/jbc.m112.434183 · 2013 · External reference
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
10.1038/nature09968 · 2011 · External reference
Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia
10.1016/j.placenta.2008.11.003 · 2009 · External reference
Preterm prelabor rupture of the membranes: a disease of the fetal membranes
10.1053/j.semperi.2017.07.012 · 2017 · External reference
Amniotic fluid: its role in fetal development and beyond
10.1038/s41372-025-02313-1 · 2025 · External reference
Regulation of amniotic fluid volume: evolving concepts
10.1007/978-1-4939-1031-1_5 · 2014 · External reference
Gestational testosterone excess early to mid-pregnancy disrupts maternal lipid homeostasis and activates biosynthesis of phosphoinositides and phosphatidylethanolamines in sheep
10.1038/s41598-024-56886-6 · 2024 · External reference
Metabolomic profiling of pregnancies with polycystic ovary syndrome identifies a unique metabolic signature and potential predictive biomarkers of low birth weight
10.3389/fendo.2021.638727 · 2021 · External reference
Differential lipidomic characteristics of children born to women with polycystic ovary syndrome
10.3389/fendo.2021.698734 · 2021 · External reference
Untargeted lipidomic profiling of amniotic fluid reveals dysregulated lipid metabolism in healthy normal-weight mothers with fetal macrosomia
10.3390/nu16223804 · 2024 · External reference
Children born to women with polycystic ovary syndrome—short-and long-term impacts on health and development
10.1016/j.fertnstert.2019.03.015 · 2019 · External reference
Maternal polycystic ovary syndrome and offspring’s risk of cardiovascular diseases in childhood and young adulthood
10.1038/s41467-024-54795-w · 2024 · External reference
Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the understanding of their biosynthesis, structures, and functions
10.1016/j.plipres.2022.101165 · 2022 · External reference
Is there a role for alpha-linolenic acid in the fetal programming of health
10.3390/jcm5040040 · 2016 · External reference
Metabolic profiles of pregnancy with polycystic ovary syndrome: insights into maternal-fetal metabolic communication
10.1210/clinem/dgaf057 · 2025 · External reference
Circulating sphingolipids and glucose homeostasis: an update
10.3390/ijms241612720 · 2023 · External reference
Alterations of sphingolipid metabolism in different types of polycystic ovary syndrome
10.1038/s41598-019-38944-6 · 2019 · External reference
Physiological and pathological functions of sphingolipids in pregnancy
10.1016/j.cellsig.2021.110041 · 2021 · External reference
Breaking the metabolic–inflammatory vicious cycle in polycystic ovary syndrome: A comparative review of ketogenic and high-fat diets
10.1186/s12944-025-02693-5 · 2025 · External reference
Amniotic fluid testosterone: relationship with cortisol and gestational age
10.1111/j.1365-2265.2007.02955.x · 2007 · External reference
In utero androgen excess: a developmental commonality preceding polycystic ovary syndrome
10.1159/000494899 · 2019 · External reference
Immune dysfunction mediated by the competitive endogenous RNA network in fetal side placental tissue of polycystic ovary syndrome
10.1371/journal.pone.0300461 · 2024 · External reference
Arachidonic acid metabolism in health and disease
10.1002/mco2.363 · 2023 · External reference
