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References from Endocrine regulation of uromodulin in aging. Local targets link to admitted publications; unresolved targets remain external evidence.
Uromodulin: from physiology to rare and complex kidney disorders
10.1038/nrneph.2017.101 · 2017 · External reference
Conclusione degli studi intorno all’origine istologica dei cilindri dell’urina
1873 · External reference
Characterization and separation of an inhibitor of viral hemagglutination present in urine
10.3181/00379727-74-17825 · 1950 · External reference
Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women
10.1126/science.2409603 · 1985 · External reference
Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein
10.1126/science.3453112 · 1987 · External reference
The farsighted studies of the Italian Carlo L. Rovida (1844-1877) on the nature of urinary casts
10.1159/000063778 · 2002 · External reference
Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
10.1152/ajprenal.00143.2004 · 2005 · External reference
Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC
10.1016/j.kint.2018.04.021 · 2018 · External reference
Macula densa cells sense luminal NaCl concentration via furosemide sensitive Na+2Cl-K+ cotransport
10.1007/bf00584628 · 1989 · External reference
Macula densa cell signaling
10.1146/annurev.physiol.65.050102.085730 · 2003 · External reference
Advances in uromodulin biology and potential clinical applications
10.1038/s41581-024-00881-7 · 2024 · External reference
Associations of urinary uromodulin with clinical characteristics and markers of tubular function in the general population
10.2215/cjn.04230415 · 2016 · External reference
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
10.7554/elife.08887 · 2015 · External reference
Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly
10.1091/mbc.e08-08-0876 · 2009 · External reference
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain
10.1152/ajprenal.00322.2021 · 2022 · External reference
Uromodulin biology
10.1093/ndt/gfae008 · 2024 · External reference
Recent advances in the clinical significance and physiological functions of uromodulin: a narrative review
10.1186/s12882-026-04853-w · 2026 · External reference
Architecture and function of human uromodulin filaments in urinary tract infections
10.1126/science.aaz9866 · 2020 · External reference
The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism
10.7554/elife.60265 · 2020 · External reference
Evolving concepts in uromodulin biology, physiology, and its role in disease: a tale of two forms
10.1161/hypertensionaha.122.18567 · 2022 · External reference
Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
10.1111/j.1523-1755.2004.00867.x · 2004 · External reference
Uromodulin in mineral metabolism
10.1097/mnh.0000000000000522 · 2019 · External reference
Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract
10.1038/icb.2017.63 · 2017 · External reference
Tamm Horsfall protein binds to a single class of carbohydrate specific receptors on human neutrophils
10.1038/ki.1993.260 · 1993 · External reference
Tamm-Horsfall protein regulates granulopoiesis and systemic neutrophil homeostasis
10.1681/asn.2014070664 · 2015 · External reference
Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism
10.1152/ajprenal.00621.2010 · 2011 · External reference
Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
10.1172/jci22720 · 2005 · External reference
Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome
10.1681/asn.2012040338 · 2012 · External reference
Extratubular polymerized uromodulin induces leukocyte recruitment and inflammation in vivo
10.3389/fimmu.2020.588245 · 2020 · External reference
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
10.1126/scitranslmed.aaw3639 · 2019 · External reference
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling
10.1093/cvr/cvaa081 · 2021 · External reference
Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner
10.1074/jbc.m111.222968 · 2011 · External reference
Hepsin-mediated processing of uromodulin is crucial for salt-sensitivity and thick ascending limb homeostasis
10.1038/s41598-019-48300-3 · 2019 · External reference
Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function
10.1074/jbc.m110.149880 · 2011 · External reference
The urinary excretion of uromodulin is regulated by the potassium channel ROMK
10.1038/s41598-019-55771-x · 2019 · External reference
Marked reduction of Tamm-Horsfall protein synthesis in hyperprostaglandin E-syndrome
10.1038/ki.1993.258 · 1993 · External reference
The uromodulin gene locus shows evidence of pathogen adaptation through human evolution
10.1681/asn.2015070830 · 2016 · External reference
The UMOD locus: insights into the pathogenesis and prognosis of kidney disease
10.1681/asn.2017070716 · 2018 · External reference
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression
10.1038/nm.3384 · 2013 · External reference
Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis
10.1681/asn.2013070781 · 2014 · External reference
Uromodulin gene variant is associated with type 2 diabetic nephropathy
10.1097/hjh.0b013e328349de25 · 2011 · External reference
Association of urinary uromodulin with kidney function decline and mortality: the health ABC study
10.5414/cn109005 · 2017 · External reference
Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1β
10.1152/ajprenal.00582.2012 · 2013 · External reference
An intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene
10.1016/j.juro.2014.02.095 · 2014 · External reference
Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model
10.1242/dmm.047498 · 2021 · External reference
New insights into the role of HNF-1β in kidney (patho)physiology
10.1007/s00467-018-3990-7 · 2019 · External reference
Association of serum uromodulin with mortality and cardiovascular disease in the elderly-the Cardiovascular Health Study
10.1093/ndt/gfz008 · 2020 · External reference
Association of serum and urinary uromodulin and their correlates in older adults-the Cardiovascular Health Study
10.1111/nep.13688 · 2020 · External reference
Association of serum uromodulin with ESKD and kidney function decline in the elderly: the Cardiovascular Health Study
10.1053/j.ajkd.2019.02.024 · 2019 · External reference
Uromucoid in normal urine
10.3109/00365517809108402 · 1978 · External reference
Identification of ageing-associated naturally occurring peptides in human urine
10.18632/oncotarget.5896 · 2015 · External reference
Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults
10.1038/ki.2015.192 · 2015 · External reference
The versatile role of uromodulin in renal homeostasis and its relevance in chronic kidney disease
10.2169/internalmedicine.1342-22 · 2024 · External reference
Urinary excretion of Tamm-Horsfall protein in elderly women
10.1016/s0022-5347(17)37926-0 · 1991 · External reference
Reduced uromucoid excretion in the elderly
10.1093/infdis/152.3.653 · 1985 · External reference
Urinary uromodulin and risk of urinary tract infections: The Cardiovascular Health Study
10.1053/j.ajkd.2016.08.022 · 2017 · External reference
Uromodulin and risk of upper urinary tract infections: A Mendelian randomization study
10.1053/j.ajkd.2024.11.007 · 2025 · External reference
Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL
10.1152/ajprenal.00196.2007 · 2007 · External reference
Molecular regulation of NKCC2 in the thick ascending limb
10.1152/ajprenal.00396.2011 · 2011 · External reference
Thick ascending limb of the loop of Henle
10.2215/cjn.04480413 · 2014 · External reference
Trafficking and regulation of the NKCC2 cotransporter in the thick ascending limb
10.1097/mnh.0000000000000351 · 2017 · External reference
Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent
10.1152/ajprenal.90227.2008 · 2008 · External reference
GPI-anchored protein organization and dynamics at the cell surface
10.1194/jlr.r062885 · 2016 · External reference
Vasopressin induces urinary uromodulin secretion by activating PKA (Protein Kinase A)
10.1161/hypertensionaha.121.17127 · 2021 · External reference
Uromodulin regulates murine aquaporin-2 activity via thick ascending limb-collecting duct cross-talk during water deprivation
10.3390/ijms23169410 · 2022 · External reference
Tamm-Horsfall protein excretion during chronic alterations in urinary concentration and protein intake in the rat
10.1159/000173411 · 1991 · External reference
Interplay between uromodulin excretion and water balance in the general adult population
10.14814/phy2.70844 · 2026 · External reference
Inflammation and vasopressin hypersecretion in aging
10.3389/fendo.2025.1689787 · 2025 · External reference
Vasopressin beyond water: Implications for renal diseases
10.1097/mnh.0b013e32833d35cf · 2010 · External reference
Adrenal corticosteroid action on the thick ascending limb
1990 · External reference
Longitudinal change in cortisol levels across the adult life span
10.1093/gerona/gly279 · 2020 · External reference
Serum uromodulin is associated with impaired glucose metabolism
10.1097/md.0000000000005798 · 2017 · External reference
Exosomal UMOD gene expression and urinary uromodulin level as early noninvasive diagnostic biomarkers for diabetic nephropathy in type 2 diabetic patients
10.1007/s13340-023-00686-2 · 2024 · External reference
Diabetic kidney disease: Challenges, progress, and possibilities
10.2215/cjn.11491116 · 2017 · External reference
Pathogenetic mechanisms of diabetic nephropathy
10.1681/asn.2004110970 · 2005 · External reference
Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: A 21-year longitudinal study
10.2337/dc22-2003 · 2023 · External reference
Tubular effects of insulin
10.1291/hypres.19.supplementi_s41 · 1996 · External reference
Insulin stimulates NaCl transport in isolated perfused MTAL of Henle’s loop of rabbit kidney
10.1152/ajprenal.1994.267.2.f265 · 1994 · External reference
Effects of urine uromodulin levels on the association between sodium intake and ambulatory blood pressure in individuals with chronic kidney disease
10.1016/j.ejim.2026.106903 · 2026 · External reference
Associations of plasma and urine uromodulin with kidney disease progression in persons with chronic kidney disease and hypertension: The Systolic Blood Pressure Intervention Trial
10.1016/j.xkme.2025.101118 · 2025 · External reference
Effects of glucagon and PTH on the loop of Henle of rat juxtamedullary nephrons
10.1038/ki.1986.70 · 1986 · External reference
Effects of glucagon on Na+, Cl-, K+, Mg2+ and Ca2+ transports in cortical and medullary thick ascending limbs of mouse kidney
10.1007/bf00582129 · 1989 · External reference
Glucagon actions on the kidney revisited: Possible role in potassium homeostasis
10.1152/ajprenal.00560.2015 · 2016 · External reference
Role of glucagon and its receptor in the pathogenesis of diabetes
10.3389/fendo.2022.928016 · 2022 · External reference
Glucagon levels in normal and diabetic subjects: Use of a specific immunoabsorbent for glucagon radioimmunoassay
10.1007/bf00996319 · 1977 · External reference
Glucagon revisited: Coordinated actions on the liver and kidney
10.1016/j.diabres.2018.10.004 · 2018 · External reference
Aging is a powerful risk factor for type 2 diabetes mellitus independent of body mass index
10.1159/000501745 · 2020 · External reference
Hypertension and aging
10.1016/j.arr.2016.01.007 · 2016 · External reference
UMOD genotype-blinded trial of ambulatory blood pressure response to torasemide
10.1161/hypertensionaha.124.23122 · 2024 · External reference
Thyroid hormone regulation of Na,K-ATPase expression
10.1016/1043-2760(93)90104-m · 1993 · External reference
Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys
10.1007/s00418-004-0638-4 · 2004 · External reference
Response of the medullary thick ascending limb to hypothyroidism in the rat
1985 · External reference
Polyuria of thyrotoxicosis: Downregulation of aquaporin water channels and increased solute excretion
10.1038/sj.ki.5002475 · 2007 · External reference
Thyroid hormone upregulates gene expression, synthesis and release of pro-epidermal growth factor in adult rat kidney
10.1016/0024-3205(95)02121-x · 1995 · External reference
Expression of epidermal growth factor and its receptor in normal and diseased human kidney: An immunohistochemical and in situ hybridization study
10.1038/ki.1996.94 · 1996 · External reference
Expression of epidermal growth factor in the rat kidney: An immunocytochemical and in situ hybridization study
10.1007/bf00266763 · 1991 · External reference
Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections
10.1152/ajprenal.00134.2004 · 2005 · External reference
The distal nephron biomarkers associate with diabetic kidney disease progression
10.1172/jci.insight.186836 · 2025 · External reference
Human urinary epidermal growth factor excretion: Age, sex, and race dependence
10.1210/jcem-67-2-361 · 1988 · External reference
Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice
10.1186/s13044-023-00149-5 · 2023 · External reference
Effects of parathyroid hormone on renal tubular calcium and phosphate handling
10.1111/apha.13959 · 2023 · External reference
Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport
10.1073/pnas.1611684114 · 2017 · External reference
Effects of parathyroid hormone and calcitonin on Na+, Cl-, K+, Mg2+ and Ca2+ transport in cortical and medullary thick ascending limbs of mouse kidney
10.1007/bf00370694 · 1990 · External reference
Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14
10.1073/pnas.1616733114 · 2017 · External reference
Calcium-sensing receptor and regulation of WNK kinases in the kidney
10.3390/cells9071644 · 2020 · External reference
Activation of the Ca 2+ -sensing receptor increases renal claudin-14 expression and urinary Ca 2+ excretion
10.1152/ajprenal.00263.2012 · 2013 · External reference
The excretion of uromodulin is modulated by the calcium-sensing receptor
10.1016/j.kint.2018.07.022 · 2018 · External reference
Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis
10.1038/ki.2013.63 · 2013 · External reference
Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
10.1038/s41467-019-12399-9 · 2019 · External reference
Determinants of urinary excretion of Tamm-Horsfall protein in non-selected kidney stone formers and healthy subjects
10.1093/ndt/15.10.1580 · 2000 · External reference
Serum uromodulin-a marker of kidney function and renal parenchymal integrity
10.1093/ndt/gfw422 · 2018 · External reference
Healthy women have higher systemic uromodulin levels: Identification of uromodulin as an estrogen responsive gene
10.34067/kid.0000000000000197 · 2023 · External reference
Uromodulin and estrogen
10.34067/kid.0000000000000259 · 2023 · External reference
Mouse epidermal growth factor concentrations are altered by gonadectomy and treatments with estradiol and progesterone
10.1016/0024-3205(89)90298-1 · 1989 · External reference
Effects of estradiol and progesterone on epidermal growth factor concentration in plasma, bile, urine, submandibular gland and kidney of the mouse
10.1159/000181104 · 1989 · External reference
The role of the EGF receptor in sex differences in kidney injury
10.1681/asn.2018121244 · 2019 · External reference
Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid
10.1210/mend-2-3-230 · 1988 · External reference
Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients
10.1016/j.ijcard.2016.12.183 · 2017 · External reference
Modulation of hepatic and renal glucocorticoid receptors during aging of mice
10.1023/a:1013218528102 · 2001 · External reference
Effect of aging on urinary concentrating mechanism and vasopressin-dependent cAMP in rats
10.1152/ajprenal.1982.243.2.f121 · 1982 · External reference
Age-associated decrease in vasopressin-induced renal water transport: a role for adenylate cyclase and G protein malfunction
10.1159/000213348 · 1992 · External reference
Aging and the kidneys: Anatomy, physiology and consequences for defining chronic kidney disease
10.1159/000445450 · 2016 · External reference
Hypothyroidism in the elderly: diagnosis and management
10.2147/cia.s23966 · 2012 · External reference
Diabetes and global ageing among 65-99-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas, 9th edition
10.1016/j.diabres.2020.108078 · 2020 · External reference