Research graph
References from Glycemic burden-adjusted urinary glucose excretion deficit is associated with hyperuricemia in patients with type 2 diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients
10.1038/s41598-024-76970-1 · 2024 · External reference
Uric acid-induced pancreatic β-cell dysfunction
10.1186/s12902-021-00698-6 · 2021 · External reference
Exploring the multifaceted nexus of uric acid and health: A review of recent studies on diverse diseases
10.3390/biom13101519 · 2023 · External reference
Cardiometabolic and renal benefits of sodium-glucose cotransporter 2 inhibitors
10.1038/s41574-025-01170-4 · 2025 · External reference
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients attending Jimma Medical Center, Southwestern Ethiopia, 2019
10.2147/dmso.s252825 · 2020 · External reference
The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran
10.1186/s12902-022-00952-5 · 2022 · External reference
Uric acid transport and disease
10.1172/jci42344 · 2010 · External reference
Association of serum uric acid with all-cause and cardiovascular mortality in diabetes
10.2337/dc22-1339 · 2023 · External reference
Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus
10.3389/fendo.2022.890305 · 2022 · External reference
Hyperuricemia is related to the risk of cardiovascular diseases in ethnic Chinese elderly women
10.5334/gh.1102 · 2022 · External reference
Effects of sodium/glucose cotransporter 2 (SGLT2) inhibitors and combined SGLT1/2 inhibitors on cardiovascular, metabolic, renal, and safety outcomes in patients with diabetes: A network meta-analysis of 111 randomized controlled trials
10.1007/s40256-022-00528-7 · 2022 · External reference
Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia
10.1111/dme.13956 · 2019 · External reference
SGLT2 inhibition and uric acid excretion in patients with type 2 diabetes and normal kidney function
10.2215/cjn.11480821 · 2022 · External reference
Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
10.1681/asn.2006040368 · 2006 · External reference
Elevated blood glucose can promote uric acid excretion: A cross-sectional study involving urinary glucose and urinary uric acid in China
10.2147/dmso.s472686 · 2024 · External reference
High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function
10.1007/s40618-021-01513-8 · 2021 · External reference
Sodium-glucose linked transporter-2 inhibitors: Potential for renoprotection beyond blood glucose lowering
10.1038/ki.2013.451 · 2014 · External reference
Uric acid as a biomarker and a therapeutic target in diabetes
10.1016/j.jcjd.2014.10.013 · 2015 · External reference
Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2
10.3389/fgene.2022.1048330 · 2022 · External reference
Identification and characterization of human glucose transporter-like protein-9 (GLUT9): Alternative splicing alters trafficking
10.1074/jbc.m312226200 · 2004 · External reference
Human renal organic anion transporter 4 operates as an asymmetric urate transporter
10.1681/asn.2006040415 · 2007 · External reference
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
10.1074/jbc.m800737200 · 2008 · External reference
Structural basis of urate transport by glucose transporter 9
10.1016/j.celrep.2025.115514 · 2025 · External reference
Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
10.1074/jbc.c800156200 · 2008 · External reference
Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus
10.1152/ajprenal.00555.2014 · 2015 · External reference
Clinical and functional characterization of URAT1 variants
10.1371/journal.pone.0028641 · 2011 · External reference
Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney
10.1146/annurev-physiol-020911-153333 · 2012 · External reference
The clinical benefits of sodium-glucose cotransporter type 2 inhibitors in people with gout
10.1038/s41584-024-01092-x · 2024 · External reference
Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes
10.1016/j.pcd.2020.10.006 · 2021 · External reference
Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12
10.1172/jci186633 · 2025 · External reference
Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus: A 4.5-year cohort study
10.1097/md.0000000000027496 · 2021 · External reference
The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors
10.1155/2021/1470380 · 2021 · External reference
Serum uric acid and risk of CKD in type 2 diabetes
10.2215/cjn.0314031 · 2015 · External reference
Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey
10.1093/rheumatology/ken066 · 2008 · External reference
Effects of sodium/glucose cotransporter 2 (SGLT2) inhibitors and combined SGLT1/2 inhibitors on cardiovascular, metabolic, renal, and safety outcomes in patients with diabetes: A network meta-analysis of 111 randomized controlled trials
10.1007/s40256-022-00528-7 · ExternalCitation · doi-reference
High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function
10.1007/s40618-021-01513-8 · ExternalCitation · doi-reference
Structural basis of urate transport by glucose transporter 9
10.1016/j.celrep.2025.115514 · ExternalCitation · doi-reference
Uric acid as a biomarker and a therapeutic target in diabetes
10.1016/j.jcjd.2014.10.013 · ExternalCitation · doi-reference
Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes
10.1016/j.pcd.2020.10.006 · ExternalCitation · doi-reference
Sodium-glucose linked transporter-2 inhibitors: Potential for renoprotection beyond blood glucose lowering
10.1038/ki.2013.451 · ExternalCitation · doi-reference
Cardiometabolic and renal benefits of sodium-glucose cotransporter 2 inhibitors
10.1038/s41574-025-01170-4 · ExternalCitation · doi-reference
The clinical benefits of sodium-glucose cotransporter type 2 inhibitors in people with gout
10.1038/s41584-024-01092-x · ExternalCitation · doi-reference
Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients
10.1038/s41598-024-76970-1 · ExternalCitation · doi-reference
Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
10.1074/jbc.c800156200 · ExternalCitation · doi-reference
Identification and characterization of human glucose transporter-like protein-9 (GLUT9): Alternative splicing alters trafficking
10.1074/jbc.m312226200 · ExternalCitation · doi-reference
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
10.1074/jbc.m800737200 · ExternalCitation · doi-reference
Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey
10.1093/rheumatology/ken066 · ExternalCitation · doi-reference
Association between uric acid level and incidence of albuminuria in patients with type 2 diabetes mellitus: A 4.5-year cohort study
10.1097/md.0000000000027496 · ExternalCitation · doi-reference
Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia
10.1111/dme.13956 · ExternalCitation · doi-reference
Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney
10.1146/annurev-physiol-020911-153333 · ExternalCitation · doi-reference
Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus
10.1152/ajprenal.00555.2014 · ExternalCitation · doi-reference
The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors
10.1155/2021/1470380 · ExternalCitation · doi-reference
Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12
10.1172/jci186633 · ExternalCitation · doi-reference
Uric acid transport and disease
10.1172/jci42344 · ExternalCitation · doi-reference
Uric acid-induced pancreatic β-cell dysfunction
10.1186/s12902-021-00698-6 · ExternalCitation · doi-reference
The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran
10.1186/s12902-022-00952-5 · ExternalCitation · doi-reference
Clinical and functional characterization of URAT1 variants
10.1371/journal.pone.0028641 · ExternalCitation · doi-reference
Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
10.1681/asn.2006040368 · ExternalCitation · doi-reference
Human renal organic anion transporter 4 operates as an asymmetric urate transporter
10.1681/asn.2006040415 · ExternalCitation · doi-reference
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients attending Jimma Medical Center, Southwestern Ethiopia, 2019
10.2147/dmso.s252825 · ExternalCitation · doi-reference
Elevated blood glucose can promote uric acid excretion: A cross-sectional study involving urinary glucose and urinary uric acid in China
10.2147/dmso.s472686 · ExternalCitation · doi-reference
Serum uric acid and risk of CKD in type 2 diabetes
10.2215/cjn.0314031 · ExternalCitation · doi-reference
SGLT2 inhibition and uric acid excretion in patients with type 2 diabetes and normal kidney function
10.2215/cjn.11480821 · ExternalCitation · doi-reference
Association of serum uric acid with all-cause and cardiovascular mortality in diabetes
10.2337/dc22-1339 · ExternalCitation · doi-reference
Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus
10.3389/fendo.2022.890305 · ExternalCitation · doi-reference
Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2
10.3389/fgene.2022.1048330 · ExternalCitation · doi-reference
Exploring the multifaceted nexus of uric acid and health: A review of recent studies on diverse diseases
10.3390/biom13101519 · ExternalCitation · doi-reference
Hyperuricemia is related to the risk of cardiovascular diseases in ethnic Chinese elderly women
10.5334/gh.1102 · ExternalCitation · doi-reference